公开(公告)号：US20120308615A1

公开(公告)日：2012-12-06

申请号：US13498842

申请日：2010-09-28

申请人： Julio César Aguilar Rubido ,  Yadira Lobaina Mato ,  Dunia Hernández Inguanzo ,  Heidy Trujillo Pérez ,  Freya de los Milagros Freyre Almeida ,  Verena Lucila Muzio González ,  Eduardo Pénton Arias ,  Sonia Gonzalez Blanco ,  Raimundo Ubieta Gómez ,  Gerardo Enrique Guillén Nieto ,  Luis Saturnino Herrera Martinez

发明人： Julio César Aguilar Rubido ,  Yadira Lobaina Mato ,  Dunia Hernández Inguanzo ,  Heidy Trujillo Pérez ,  Freya de los Milagros Freyre Almeida ,  Verena Lucila Muzio González ,  Eduardo Pénton Arias ,  Sonia Gonzalez Blanco ,  Raimundo Ubieta Gómez ,  Gerardo Enrique Guillén Nieto ,  Luis Saturnino Herrera Martinez

IPC分类号： A61K39/29 ,  A61P31/14 ,  C12N5/0781 ,  C12N5/0786 ,  C12N5/0784 ,  A61K9/14 ,  C12N5/078

CPC分类号： A61K9/145 ,  A61K9/10 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/5158 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55505 ,  C12N2730/10134

摘要： The present invention is related with the field of the therapeutic immunization, specifically with the employment of a new formulation of antigens of the Hepatitis B Virus (HBV) for the cellular stimulation. The formulation is formed by the surface antigens (HBsAg) precipitated in suspension and the nucleocapsid (HBcAg) of the HBV. The formulation contains these antigens like suspended particles of sizes less than 500 nm and higher than 500 nm, in a mixture where the proportion among the particles of the mentioned sizes is among 50%-50% and 80%-20%, respectively. The selection of a range of sizes of particles allows that the levels of stimulation of several cellular types are maximized. Additionally, a cellular stimulation method is described with this formulation, and the later passive immunization of patients with chronic Hepatitis B, based on the maximum stimulation in vivo or in vitro using heterologous or autologous cells (dendritic cells, B cells and macrophages). The cells stimulated with this formulation are transferred to patients chronically infected with the HBV.

摘要翻译： 本发明涉及治疗性免疫领域，特别是使用乙型肝炎病毒（HBV）抗原的新配方用于细胞刺激。 该制剂由悬浮液中沉淀的表面抗原（HBsAg）和HBV的核衣壳（HBcAg）形成。 在上述尺寸的颗粒中的比例分别为50％-50％至80％-20％的混合物中，该制剂含有这些抗原，如尺寸小于500nm且高于500nm的悬浮颗粒。 颗粒尺寸范围的选择使得几种细胞类型的刺激水平最大化。 另外，根据体内或体外使用异源或自体细胞（树突状细胞，B细胞和巨噬细胞）的最大刺激，用该配方描述细胞刺激方法，以及慢性乙型肝炎患者随后的被动免疫。 用该制剂刺激的细胞转移到长期感染HBV的患者。

公开(公告)号：US20100093616A1

公开(公告)日：2010-04-15

申请号：US11885330

申请日：2006-02-24

申请人： Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  Jorge Amador Berlanga Acosta ,  Freya de los Milagros Freyre Almeida ,  Danay Cibrian Vera ,  Eduardo Pentón Arias

发明人： Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  Jorge Amador Berlanga Acosta ,  Freya de los Milagros Freyre Almeida ,  Danay Cibrian Vera ,  Eduardo Pentón Arias

IPC分类号： A61K38/18

CPC分类号： A61K38/08 ,  A61K38/1808 ,  A61K38/25 ,  A61K2300/00

摘要： The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.

摘要翻译： 本发明旨在刺激由于自身免疫损伤引起的中枢神经系统的神经再生。 特别地，包含治疗有效浓度的表皮生长因子和生长激素释放肽-6的药物组合被施用于患有多发性硬化症和视神经脊髓炎症状的受试者，并且校正由中枢神经中的自身反应性细胞引起的脱髓鞘 系统。

公开(公告)号：US08283324B2

公开(公告)日：2012-10-09

申请号：US12278990

申请日：2007-02-23

申请人： Maribel Guerra Vallespi ,  Isis del Carmen Torréns Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Gerardo Enrique Guillén Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gómez

发明人： Maribel Guerra Vallespi ,  Isis del Carmen Torréns Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Gerardo Enrique Guillén Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gómez

IPC分类号： A61K38/16 ,  C07K14/00

CPC分类号： C07K14/43509 ,  A61K38/00

摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.

摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。

公开(公告)号：US20110230415A1

公开(公告)日：2011-09-22

申请号：US13150526

申请日：2011-06-01

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61K38/08 ,  A61P17/00 ,  A61P1/16 ,  A61P13/12 ,  A61P25/00 ,  A61P27/16 ,  A61P27/02

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。

公开(公告)号：US08722626B2

公开(公告)日：2014-05-13

申请号：US13150526

申请日：2011-06-01

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61P19/04 ,  A61K38/08 ,  C07K7/06

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。