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公开(公告)号：US08283324B2
公开(公告)日：2012-10-09
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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2.发明授权Cell penetrating peptides and its use fused to biomolecules with therapeutic action 有权细胞穿透肽及其使用与具有治疗作用的生物分子融合公开(公告)号：US08673313B2
公开(公告)日：2014-03-18
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。
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3.发明申请CELL PENETRATING PEPTIDES AND ITS USE FUSED TO BIOMOLECULES WITH THERAPEUTIC ACTION 有权细胞穿刺肽及其用于治疗生物分子的用途公开(公告)号：US20120135021A1
公开(公告)日：2012-05-31
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。
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公开(公告)号：US20090221508A1
公开(公告)日：2009-09-03
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKKYKGKFW的肽的开发，显示出氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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5.发明申请CHIMERICAL PEPTIDIC MOLECULES WITH ANTIVIRAL PROPERTIES AGAINST THE VIRUSES OF THE FLAVIVIRIDAE FAMILY 有权具有抗FLAVIVIRIDIDE家族病毒抗性特性的二肽分子公开(公告)号：US20100273702A1
公开(公告)日：2010-10-28
申请号：US12513085
申请日：2007-10-30
申请人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
发明人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
CPC分类号： A61K47/48315 , A61K38/00 , A61K47/645 , C07K14/005 , C07K2319/04 , C07K2319/10 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.
摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。
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公开(公告)号：US09375459B2
公开(公告)日：2016-06-28
申请号：US14005855
申请日：2012-03-21
申请人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
发明人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
IPC分类号： A61K38/12 , A61K31/4025 , A61K45/06 , C07K7/64 , C07K7/06 , C07K7/08 , A61K47/48 , A61K38/00 , A61K9/00 , A61K9/127 , A61K9/50
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/127 , A61K9/5031 , A61K31/4025 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。
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7.发明申请公开(公告)号：US20110212105A1
公开(公告)日：2011-09-01
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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公开(公告)号：US09205128B2
公开(公告)日：2015-12-08
申请号：US13637845
申请日：2011-04-01
申请人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
发明人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
IPC分类号： A61K38/10 , C12N5/0783 , A61K31/713 , A61K31/19 , A61K38/17 , A61K45/06 , A61K31/7105 , A61K31/5575 , C07K14/47 , C12N15/113
CPC分类号： A61K38/10 , A61K31/19 , A61K31/5575 , A61K31/7105 , A61K31/713 , A61K38/1709 , A61K38/1748 , A61K45/06 , C07K14/47 , C07K14/4741 , C12N5/0636 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N2310/14 , C12N2310/531 , C12N2320/31
摘要： The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.
摘要翻译： 本发明描述了通过负面调节或改变细胞骨架，更精确地形成中间细胞骨架细丝的蛋白质来抑制人免疫缺陷病毒（HIV）复制的方法，其中所述蛋白质是波形蛋白和/或角蛋白-10。 通过介入这些蛋白质的结构，人类细胞中病毒的复制被抑制。 本发明还涉及包含肽和/或干扰RNA和/或脂质化合物的试剂的用途，所述试剂产生细胞骨架的负调节或改变以预防或治疗HIV感染。 本发明提供用于改变细胞的细胞骨架/细丝结构的方法和方法，其结果是HIV的人细胞感染被干扰并且甚至可以被完全抑制。 通过减少波形蛋白和/或角蛋白的量（例如通过使用干扰RNA的转录控制）或通过使用破坏细胞骨架的肽来改变细胞骨架。
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公开(公告)号：US20140206621A1
公开(公告)日：2014-07-24
申请号：US14075276
申请日：2013-11-08
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
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公开(公告)号：US20130130971A1
公开(公告)日：2013-05-23
申请号：US13637845
申请日：2011-04-01
申请人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
发明人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
IPC分类号： A61K38/10 , A61K31/713 , A61K31/7105 , A61K38/17 , A61K45/06 , C12N5/0783 , A61K31/19
CPC分类号： A61K38/10 , A61K31/19 , A61K31/5575 , A61K31/7105 , A61K31/713 , A61K38/1709 , A61K38/1748 , A61K45/06 , C07K14/47 , C07K14/4741 , C12N5/0636 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N2310/14 , C12N2310/531 , C12N2320/31
摘要： The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.
摘要翻译： 本发明描述了通过负面调节或改变细胞骨架，更精确地形成中间细胞骨架细丝的蛋白质来抑制人免疫缺陷病毒（HIV）复制的方法，其中所述蛋白质是波形蛋白和/或角蛋白-10。 通过介入这些蛋白质的结构，人类细胞中病毒的复制被抑制。 本发明还涉及包含肽和/或干扰RNA和/或脂质化合物的试剂的用途，所述试剂产生细胞骨架的负调节或改变以预防或治疗HIV感染。 本发明提供用于改变细胞的细胞骨架/细丝结构的方法和方法，其结果是HIV的人细胞感染被干扰并且甚至可以被完全抑制。 通过减少波形蛋白和/或角蛋白的量（例如通过使用干扰RNA的转录控制）或通过使用破坏细胞骨架的肽来改变细胞骨架。
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