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    Phthalazines containing an aromatic ether or thioether group in the 1-position
    2.
    发明授权
    Phthalazines containing an aromatic ether or thioether group in the 1-position 失效
    在1-位含有芳香醚或硫醚基的酞嗪

    公开(公告)号：US5354750A

    公开(公告)日：1994-10-11

    申请号：US963631

    申请日：1992-10-20

    申请人： Gerhard Scheffler ,  Ilona Fleischhauer ,  Bernhard Kutscher ,  Jurgen Engel ,  Stefan Szelenyi ,  Ulrich Werner

    发明人： Gerhard Scheffler ,  Ilona Fleischhauer ,  Bernhard Kutscher ,  Jurgen Engel ,  Stefan Szelenyi ,  Ulrich Werner

    IPC分类号： A61K31/50 ,  A61K31/502 ,  A61P25/04 ,  A61P29/00 ,  C07D237/30 ,  C07D237/32 ,  C07D401/12 ,  C07D401/14 ,  C07D453/02

    CPC分类号： C07D401/12 ,  C07D237/30 ,  C07D237/32 ,  C07D453/02

    摘要： Pharmacologically active compounds of the General Formula ##STR1## where X is oxygen or sulphur and the radical R represents a quinuclidyl radical, an C.sub.1 -C.sub.6 -alkyl radical, a phenyl radical, a pyridyl radical, a phenyl or pyridyl radical substituted by the radicals R.sub.1, R.sub.2, and/or R.sub.3, a C.sub.1 -C.sub.6 -alkyl radical substituted by pyridyl or alkylpyridyl or a C.sub.1 -C.sub.6 -alkyl radical substituted by phenyl, where each phenyl radical may also be substituted by the radicals R.sub.1, R.sub.2 and/or R.sub.3 and the radicals R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent hydrogen, halogen, trihalogenmethyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, carboxy, Carb-C.sub.1 -C.sub.6 -alkoxy, amino, C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -dialkylamino, C.sub.1 -C.sub.6 -trialkylamino, C.sub.2 -C.sub.6 -alkanoylamino, or C.sub.2 -C.sub.6 -alkanoylamino which contains one more amino group in the alkyl portion, and their physiologically acceptable acid addition salts. The compounds provide analgesic, anti-inflammatory, anti-convulsive and anti-pyretic effects.

    摘要翻译： 其中X是氧或硫，通式R代表奎烷基，C 1 -C 6烷基，苯基，吡啶基，苯基或吡啶基被药物活性化合物 基团R 1，R 2和/或R 3，被吡啶基或烷基吡啶取代的C 1 -C 6烷基或被苯基取代的C 1 -C 6烷基，其中每个苯基也可被基团R 1，R 2和/ 或R 3，基团R 1，R 2和R 3相同或不同，表示氢，卤素，三卤代甲基，C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，羧基，碳 - C 1 -C 6 - 烷氧基，氨基，C 1 -C 6 - 烷基氨基，C 1 -C 6 - 二烷基氨基，C 1 -C 6 - 三烷基氨基，C 2 -C 6 - 烷酰基氨基或在烷基部分中还含有一个氨基的C 2 -C 6 - 烷酰基氨基及其生理上可接受的酸加成盐。 该化合物提供镇痛，抗炎，抗惊厥和抗焦虑作用。

    4-benzyl-1-(2H)-phthalazinone-derivates
    5.
    发明授权
    4-benzyl-1-(2H)-phthalazinone-derivates 失效
    4-苄基-1-（2H） - 酞嗪酮衍生物

    公开(公告)号：US4841047A

    公开(公告)日：1989-06-20

    申请号：US928458

    申请日：1986-11-10

    申请人： Jurgen Engel ,  Gerhard Scheffler

    发明人： Jurgen Engel ,  Gerhard Scheffler

    IPC分类号： C07D237/00 ,  A61K31/50 ,  A61K31/502 ,  A61K31/55 ,  A61P11/06 ,  A61P37/08 ,  C07D237/32 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D451/04 ,  C07D471/08

    CPC分类号： C07D451/04 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06

    摘要： There are provided 4-benzyl-1-(2H)-phthalazinone derivatives having antiallergic activity of the formula ##STR1## wherein R.sub.1 represents fluorine, chlorine, bromine, trifluoromethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alkanoyloxy, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, C.sub.2 -C.sub.6 -alkanoylamino, C.sub.2 -C.sub.6 -alkanoyl-C.sub.1 -C.sub.6 -alkylamino or a nitro group, R.sub.2 represents hydrogen or has one of the meanings given for R.sub.1, whereby R.sub.1 and R.sub.2 may be the same or different, the radicals R.sub.3 and R.sub.4 are the same or different and represent hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, benzyloxy or C.sub.2 -C.sub.6 -alkanoyloxy and A represents an azacycloalkanyl radical, the aza nitrogen of which contains a C.sub.1 -C.sub.6 -alkyl group which is substituted by various radicals, and processes for their manufacture.

    摘要翻译： 提供具有式Ia的抗过敏活性的4-苄基-1-（2H） - 酞嗪酮衍生物，其中R 1表示氟，氯，溴，三氟甲基，C 1 -C 6 - 烷基，羟基，C 1 -C 6 - 烷氧基， C 2 -C 6 - 烷酰氧基，氨基，C 1 -C 6烷基氨基，二-C 1 -C 6烷基氨基，C 2 -C 6烷酰氨基，C 2 -C 6烷酰基-C 1 -C 6烷基氨基或硝基，R 2表示氢或有一个 R 1和R 2可以相同或不同，基团R 3和R 4相同或不同，表示氢，卤素，C 1 -C 6 - 烷基，羟基，C 1 -C 6 - 烷氧基，苄氧基或 C 2 -C 6 - 烷酰氧基，A表示氮杂环烷基，其氮杂氮含有被各种基团取代的C 1 -C 6 - 烷基及其制备方法。

    Method for a programmed controlled ovarian stimulation protocol
    7.
    发明授权
    Method for a programmed controlled ovarian stimulation protocol 有权
    编程控制卵巢刺激方案的方法

    公开(公告)号：US08173592B1

    公开(公告)日：2012-05-08

    申请号：US09523455

    申请日：2000-03-10

    申请人： Jurgen Engel ,  Hilde Riethmuller-Winzen

    发明人： Jurgen Engel ,  Hilde Riethmuller-Winzen

    IPC分类号： A61K38/00 ,  A61K38/24 ,  A61K38/09 ,  A61P15/08 ,  A61P15/16 ,  A61P15/18 ,  A61P5/06 ,  A61P5/24 ,  A61P5/02 ,  C07K14/59

    CPC分类号： A61K38/24 ,  Y10S514/841 ,  A61K38/09 ,  A61K31/565 ,  A61K2300/00

    摘要： A method of therapeutic management of infertility by programming of controlled ovarian stimulation and assisted reproductive procedures is disclosed containing the steps of a) suppression of premature ovulation with an LHRH-antagonist in controlled ovarian stimulation and assisted reproductive techniques with multiple follicle and oocyte development; b) programming the start of controlled ovarian stimulation by the administration to a patient of progestogen only-preparations or, alternatively, combined oral contraceptive preparations; c) exogenous stimulation of the ovarian follicle growth; d) ovulation induction with HCG, native LHRH, LHRH-agonists or recombinant LH; and e) application of assisted reproduction techniques, especially of IVF, ICSI, GIFT, ZIFT or by intrauterine insemination by sperm injection, wherein onset of the patient's menstrual cycle and of controlled ovarian stimulation are programmed in order to perform oocyte pickup and fertilization procedures during Mondays to Fridays.

    摘要翻译： 公开了通过编程控制的卵巢刺激和辅助生殖过程治疗不育症的方法，其包括以下步骤：a）在受控的卵巢刺激中抑制LHRH拮抗剂的过早排卵和具有多次卵泡和卵母细胞发育的辅助生殖技术; b）通过给予仅孕激素制剂的患者或替代地联合的口服避孕制剂来编程控制卵巢刺激的开始; c）外源性刺激卵泡生长; d）用HCG，天然LHRH，LHRH激动剂或重组LH排卵诱导; 和e）应用辅助生殖技术，特别是IVF，ICSI，GIFT，ZIFT或通过精子注射子宫内授精的辅助生殖技术的应用，其中对患者的月经周期和受控的卵巢刺激的发​​作进行编程以在卵母细胞摄取和施肥过程中进行 周一至周五

    Method for the therapeutic management of endometriosis
    9.
    发明申请
    Method for the therapeutic management of endometriosis 失效
    子宫内膜异位症治疗方法

    公开(公告)号：US20060100155A1

    公开(公告)日：2006-05-11

    申请号：US11311363

    申请日：2005-12-20

    申请人： Hilde Riethmuller-Winzen ,  Jurgen Engel ,  Ricardo Felberbaum ,  Klaus Diedrich ,  Wolfgang Kupker

    发明人： Hilde Riethmuller-Winzen ,  Jurgen Engel ,  Ricardo Felberbaum ,  Klaus Diedrich ,  Wolfgang Kupker

    IPC分类号： A61K38/09 ,  A61K31/57 ,  A61K31/56

    CPC分类号： A61K38/08 ,  A61K45/06 ,  A61K2300/00

    摘要： The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction treatment with an LH-RH antagonist for 4 to 12 weeks. According to another aspect of the present invention, the short term LH-RH treatment is followed by the combined or separate administration of one or more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof. According to a further aspect of the present invention a pharmaceutical composition comprising an LHRH antagonist and one ore more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof are provided.

    摘要翻译： 本发明提供了一种通过LH-RH拮抗剂短期诱导治疗4至12周来治疗子宫内膜组织宫外增生，慢性盆腔疼痛和输卵管阻塞的方法。 根据本发明的另一方面，短期LH-RH治疗之后是联合或分开施用一种或多种活性剂，所述活性剂选自避孕药，优选口服避孕药，非类固醇抗生素， 风湿药，止痛剂，除17-α-烷基取代的睾酮以外的雄激素或其任何组合。 根据本发明的另一方面，包含LHRH拮抗剂和一种或多种选自避孕药，优选口服避孕药，非甾体抗风湿药，止痛剂，雄激素的活性剂的药物组合物 提供除17-α-烷基取代的睾酮或其任何组合以外的物质。