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公开(公告)号：US20090012267A1
公开(公告)日：2009-01-08
申请号：US12055108
申请日：2008-03-25
申请人： K. Dane Wittrup , Jack R. Wands , Yik Andy Yeung
发明人： K. Dane Wittrup , Jack R. Wands , Yik Andy Yeung
IPC分类号： C07K16/18
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , G01N33/57407 , G01N2500/00
摘要： Antibodies, or antigen-binding portions thereof, to aspartyl (asparaginyl) β-hydroxylase are provided. The anti-aspartyl (asparaginyl) β-hydroxylase antibodies, or antigen-binding portions thereof, can modulate activity of aspartyl (asparaginyl) β-hydroxylase.
摘要翻译： 提供了天冬氨酰（天冬酰胺酰基）β-羟化酶的抗体或其抗原结合部分。 抗天冬氨酰基（天冬酰胺酰基）β-羟化酶抗体或其抗原结合部分可调节天冬氨酰（天冬酰胺酰基）β-羟化酶的活性。
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公开(公告)号：US20100010203A1
公开(公告)日：2010-01-14
申请号：US12553599
申请日：2009-09-03
申请人： K. Dane Wittrup , Jack R. Wands , Yik Andy Yeung
发明人： K. Dane Wittrup , Jack R. Wands , Yik Andy Yeung
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , G01N33/57407 , G01N2500/00
摘要： Antibodies, or antigen-binding portions thereof, to aspartyl (asparaginyl) β-hydroxylase are provided. The anti-aspartyl (asparaginyl) β-hydroxylase antibodies, or antigen-binding portions thereof, can modulate activity of aspartyl (asparaginyl) β-hydroxylase.
摘要翻译： 提供了天冬氨酰（天冬酰胺酰基）β-羟化酶的抗体或其抗原结合部分。 抗天冬氨酰基（天冬酰胺酰基）β-羟化酶抗体或其抗原结合部分可调节天冬氨酰（天冬酰胺酰基）β-羟化酶的活性。
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公开(公告)号：US07413737B2
公开(公告)日：2008-08-19
申请号：US10989462
申请日：2004-11-15
申请人： K. Dane Wittrup , Yik Andy Yeung , Jack R. Wands
发明人： K. Dane Wittrup , Yik Andy Yeung , Jack R. Wands
IPC分类号： A61K39/00 , A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , G01N33/57407 , G01N2500/00
摘要： Antibodies, or antigen-binding portions thereof, to aspartyl (asparaginyl) β-hydroxylase are provided. The anti-aspartyl (asparaginyl) β-hydroxylase antibodies, or antigen-binding portions thereof, can modulate activity of aspartyl (asparaginyl) β-hydroxylase.
摘要翻译： 提供了天冬氨酰（天冬酰胺酰基）β-羟化酶的抗体或其抗原结合部分。 抗天冬氨酰基（天冬酰胺酰基）β-羟化酶抗体或其抗原结合部分可调节天冬氨酰（天冬酰胺酰基）β-羟化酶的活性。
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4.发明申请公开(公告)号：US20110076290A1
公开(公告)日：2011-03-31
申请号：US12842494
申请日：2010-07-23
申请人： Masafumi Shimoda , Jack R. Wands
发明人： Masafumi Shimoda , Jack R. Wands
IPC分类号： A61K39/00 , C12N5/0784 , A61P35/00
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/545 , C12N5/0639 , C12N9/0071 , C12N2500/90 , C12N2501/22 , C12N2501/23 , C12N2501/24 , C12N2501/52
摘要： A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH-expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ.
摘要翻译： 含有AAH的成熟树突细胞用于治疗哺乳动物受试者中表达AAH的肿瘤的疫苗。 通过使分离的树突状细胞与抗原例如AAH接触来制备引发树突状细胞的方法。 在抗原接触步骤之后，将树突状细胞与细胞因子如GM-CSF和IFN-γ的组合接触。
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公开(公告)号：US07867705B2
公开(公告)日：2011-01-11
申请号：US11575627
申请日：2005-01-05
CPC分类号： C07K14/82 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A61K38/179 , C07K16/28 , C07K2317/34 , C12N2710/22022 , C12N2730/10122 , G01N33/5067 , G01N33/57438 , G01N2500/00
摘要： The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
摘要翻译： 本说明书尤其提供了在癌症诊断和治疗中使用Wnt和FZD蛋白，基因，FZD和Wnt特异性抗体和探针并用于筛选测试化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。
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公开(公告)号：US20080194457A1
公开(公告)日：2008-08-14
申请号：US11575627
申请日：2005-01-05
IPC分类号： A61K38/00 , C12Q1/68 , G01N33/574 , A01K67/027 , A61P1/00 , G01N33/566 , C12N5/06 , A61K31/70
CPC分类号： C07K14/82 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A61K38/179 , C07K16/28 , C07K2317/34 , C12N2710/22022 , C12N2730/10122 , G01N33/5067 , G01N33/57438 , G01N2500/00
摘要： The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
摘要翻译： 本说明书尤其提供了在癌症诊断和治疗中使用Wnt和FZD蛋白，基因，FZD和Wnt特异性抗体和探针并用于筛选测试化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。
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公开(公告)号：US07122541B2
公开(公告)日：2006-10-17
申请号：US10873802
申请日：2004-06-21
申请人： Jack R. Wands , Rolf I. Carlson , Paul Maggio
发明人： Jack R. Wands , Rolf I. Carlson , Paul Maggio
IPC分类号： A61K31/54
CPC分类号： A61K31/549 , Y10S514/893
摘要： The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
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公开(公告)号：US06812206B2
公开(公告)日：2004-11-02
申请号：US09903216
申请日：2001-07-11
IPC分类号： A61K39395
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US5610050A
公开(公告)日：1997-03-11
申请号：US51935
申请日：1993-04-23
申请人： Hubert E. Blum , Tsanyang Liang , Eithan Galun , Jack R. Wands
发明人： Hubert E. Blum , Tsanyang Liang , Eithan Galun , Jack R. Wands
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/02 , C12N7/04 , C12N9/12 , C12N15/113 , C12N7/06 , C07H21/04
CPC分类号： A61K31/70 , A61K48/00 , C07H21/00 , C07K14/005 , C12N15/1131 , C12N7/00 , C12N9/1276 , A61K38/00 , C12N2710/10123 , C12N2730/10122 , C12N2730/10161
摘要： The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA which is in turn complementary to a portion of the minus strand of a hepatitis viral genome, which portion encoding solely part or all of the terminal protein region of the viral polymerase.
摘要翻译： 本发明涉及用于抑制病毒复制的方法和组合物。 特别地，乙型肝炎病毒的复制终止是通过向目标细胞中引入具有与mRNA基本互补的序列的反义寡核苷酸来实现的，所述序列又与肝炎病毒基因组的负链的一部分互补，所述部分编码 仅仅是病毒聚合酶的部分或全部的末端蛋白质区域。
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公开(公告)号：US09687537B2
公开(公告)日：2017-06-27
申请号：US12842494
申请日：2010-07-23
申请人： Masafumi Shimoda , Jack R. Wands
发明人： Masafumi Shimoda , Jack R. Wands
IPC分类号： A61K39/00 , A61K35/00 , C12N5/0784 , C12N9/02
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/545 , C12N5/0639 , C12N9/0071 , C12N2500/90 , C12N2501/22 , C12N2501/23 , C12N2501/24 , C12N2501/52
摘要： A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH-expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ.
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