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    METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS 有权
    治疗和诊断纤维化，肿瘤入侵，血管生成和分化的方法和组合

    公开(公告)号：US20090104201A1

    公开(公告)日：2009-04-23

    申请号：US12185054

    申请日：2008-08-01

    申请人： VICTORIA SMITH ,  SCOTT OGG ,  PETER VAN VLASSELAER ,  VIVIAN E. BARRY ,  DEREK MARSHALL ,  ALISON KAY HOLZER ,  HECTOR RODRIGUEZ ,  MIHO OYASU ,  SCOTT ALAN MCCAULEY ,  CARLOS AURELIO GARCIA ,  DONNA HIROKO TOKUOKA BIERMANN

    发明人： VICTORIA SMITH ,  SCOTT OGG ,  PETER VAN VLASSELAER ,  VIVIAN E. BARRY ,  DEREK MARSHALL ,  ALISON KAY HOLZER ,  HECTOR RODRIGUEZ ,  MIHO OYASU ,  SCOTT ALAN MCCAULEY ,  CARLOS AURELIO GARCIA ,  DONNA HIROKO TOKUOKA BIERMANN

    IPC分类号： A61K39/395 ,  A61K31/7088 ,  G01N33/574 ,  A61P35/04

    CPC分类号： C07K16/40 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12Q1/6886 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57484 ,  G01N2333/90633

    摘要： The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease.

    摘要翻译： 本公开提供了用于预防和治疗与异常细胞增殖，血管生成和纤维化相关的各种疾病的创新方法和相关组合物和试剂盒，其通过使用加工形式的赖氨酰氧化酶或赖氨酰氧化酶样蛋白的抑制剂，LOX和 LOXL抑制剂或LOX或LOXL抑制剂与其它治疗剂组合的协同组合。 还提供了通过将处于上皮 - 间质转化（EMT）状态的细胞与候选药物接触并检测细胞的EMT状态的变化来选择预防或抑制肿瘤侵袭，血管生成和转移的药剂的创新方法。 还提供了通过使用特异性识别LOX或LOXL的加工形式的分子或试剂来诊断或监测与异常细胞增殖，血管发生和纤维化相关的各种疾病的方法和相关组合物和试剂盒。 本文还提供了用包含LOX或LOXL抑制剂的组合物预防或治疗与纤维化相关的各种疾病和病症的方法和相关组合物，医疗装置，系统和试剂盒。 这些疾病或病症包括病理性心血管疾病和高血压，高血压心脏病，心肌梗塞，动脉粥样硬化和再狭窄，肝纤维化，肾纤维化，肺纤维化，皮肤惊厥，瘢痕疙瘩形成和阿尔茨海默氏病等疾病。