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公开(公告)号：US08642740B2
公开(公告)日：2014-02-04
申请号：US13543485
申请日：2012-07-06
Applicant: Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
Inventor： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
CPC classification number: C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
Abstract: The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
Abstract translation: 本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。 抗体包括鼠，嵌合和人源化抗体。
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2.发明授权公开(公告)号：US08551789B2
公开(公告)日：2013-10-08
申请号：US13078728
申请日：2011-04-01
Applicant: Austin L. Gurney
Inventor： Austin L. Gurney
IPC: G01N33/566 , C07K14/435 , C07K7/06 , C07K7/64
CPC classification number: C07K16/30 , C07K14/4702 , C07K14/71 , C07K16/28 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92
Abstract: Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
Abstract translation: 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体和其他多肽。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。 还提供筛选方法。
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公开(公告)号：US08541552B2
公开(公告)日：2013-09-24
申请号：US13026123
申请日：2011-02-11
Applicant: Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
Inventor： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
CPC classification number: C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
Abstract: The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
Abstract translation: 本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。 抗体包括鼠，嵌合和人源化抗体。
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公开(公告)号：US08425903B2
公开(公告)日：2013-04-23
申请号：US13472305
申请日：2012-05-15
Applicant: Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
Inventor： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC: A61K39/395 , A61P35/00 , C07K16/28
CPC classification number: C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
Abstract: The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
Abstract translation: 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US20130095116A1
公开(公告)日：2013-04-18
申请号：US13549050
申请日：2012-07-13
Applicant: Austin L. GURNEY , Fumiko Takada Axelrod , Timothy Charles Hoey , Cecile Chartier-Courtaud
Inventor： Austin L. GURNEY , Fumiko Takada Axelrod , Timothy Charles Hoey , Cecile Chartier-Courtaud
IPC: A61K39/395 , C07K16/18
CPC classification number: C07K16/303 , A61K39/39533 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K16/461 , C07K2317/14 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57415 , G01N33/57423 , G01N33/57449 , G01N2800/52 , A61K2300/00
Abstract: The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
Abstract translation: 本发明涉及RSPO结合剂和使用该药物治疗诸如癌症的疾病的方法。 本发明提供了特异性结合人RSPO蛋白并调节β-连环蛋白活性的抗体。 本发明进一步提供了使用调节RSPO蛋白活性的试剂的方法，例如特异性结合RSPO1，RSPO2和/或RSPO3并抑制肿瘤生长的抗体。 还描述了治疗癌症的方法，其包括向具有肿瘤或癌症的患者施用治疗有效量的本发明的药剂或抗体。
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Patent Agency Ranking
公开(公告)号：US20130045209A1
公开(公告)日：2013-02-21
申请号：US13521331
申请日：2011-01-12
Applicant: Austin L. Gurney
Inventor： Austin L. Gurney
CPC classification number: C07K16/22
Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human Wnt(s) are provided. A conserved domain within Wnt that is suitable as a target for anti-cancer agents is also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
Abstract translation: 提供了与人Wnt结合的新型抗癌剂，包括但不限于抗体。 还鉴定了适合作为抗癌剂靶标的Wnt内的保守结构域。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。
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公开(公告)号：US20130011412A1
公开(公告)日：2013-01-10
申请号：US13543485
申请日：2012-07-06
Applicant: Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
Inventor： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
IPC: A61K39/395 , C07K16/46 , C12N15/13 , C12N15/63 , C12P21/02 , C12N5/10 , A61P1/00 , A61P21/00 , A61P3/10 , A61P1/16 , C12N1/21 , C07K16/24 , C12N5/071
CPC classification number: C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
Abstract: The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
Abstract translation: 本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。 抗体包括鼠，嵌合和人源化抗体。
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公开(公告)号：US08226943B2
公开(公告)日：2012-07-24
申请号：US12499627
申请日：2009-07-08
Applicant: Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
Inventor： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC: A61K39/395 , C07K16/28 , C07K14/705 , C12N5/00
CPC classification number: C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
Abstract: The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
Abstract translation: 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US08216807B2
公开(公告)日：2012-07-10
申请号：US13026069
申请日：2011-02-11
Applicant: Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
Inventor： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
CPC classification number: C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
Abstract: The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
Abstract translation: 本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。 抗体包括鼠，嵌合和人源化抗体。
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10.发明授权Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E 有权IL-17E拮抗剂抗体的药物组合物，试剂盒和治疗用途公开(公告)号：US08034342B2
公开(公告)日：2011-10-11
申请号：US12549497
申请日：2009-08-28
Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
IPC: A61K39/00 , A61K39/395
CPC classification number: C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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