公开(公告)号：US20200371106A1

公开(公告)日：2020-11-26

申请号：US16491768

申请日：2018-03-09

Applicant: Konica Minolta, Inc.

Inventor： Masaru TAKAHASHI ,  Yasuyuki MOTOKUI ,  Noboru KOYAMA

IPC: G01N33/574 ,  A61B5/00 ,  C12Q1/6804

Abstract: Disclosed herein is a method including: acquiring one or more pieces of information including information about expression status of a specific biomarker in a lesion collected from a human by using a laboratory animal transplanted with the lesion; and using the information to estimate therapeutic efficacy through analysis

公开(公告)号：US20210133953A1

公开(公告)日：2021-05-06

申请号：US16472439

申请日：2017-12-18

Applicant: Konica Minolta, Inc.

Inventor： Hiroaki KEMMOCHI ,  Yasuyuki MOTOKUI ,  Noboru KOYAMA

IPC: G06T7/00 ,  G01N21/64

Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.

公开(公告)号：US20190079081A1

公开(公告)日：2019-03-14

申请号：US16084374

申请日：2017-03-01

Applicant: Konica Minolta, Inc.

Inventor： Masaru TAKAHASHI ,  Yasuyuki MOTOKUI

IPC: G01N33/533 ,  G01N33/536 ,  G01N33/58 ,  G01N1/30

Abstract: A fluorescent immunostaining method including a first reaction step of specifically binding and fixing primary antibodies 1a, 1b to an antigen P as a staining subject and a second reaction step of specifically binding a secondary antibody 2a that has been modified by fluorescent nanoparticle 5 or is to be subsequently modified thereby, to the bound and fixed primary antibodies 1a, 1b in which plural secondary antibodies 2a are fixed to the antigen P by way of the primary antibodies 1a, 1b, making it possible to detect lowly-expressed antigens.

公开(公告)号：US20180275134A1

公开(公告)日：2018-09-27

申请号：US15544795

申请日：2016-01-15

Applicant: KONICA MINOLTA, INC.

Inventor： Takeshi ISODA ,  Naoko FURUSAWA ,  Yasuyuki MOTOKUI ,  Kohsuke GONDA ,  Noriaki OHUCHI ,  Mika WATANABE

IPC: G01N33/58 ,  G01N33/68

Abstract: There is provided a biological substance quantitation method of quantitating a biological substance in a sample stained with a staining reagent including a fluorescent particle encapsulating a fluorescent substance, based on a fluorescence of the fluorescent substance. The method includes inputting a fluorescent image representing expression of the biological substance in the sample by a fluorescent bright spot; and quantitating an expression amount of the biological substance based on a fluorescence of the fluorescent bright spot. The biological substance is a nucleoprotein expressed at a cell nucleus. The fluorescent particle binds to the biological substance through a primary antibody which is directed against the biological substance as an antigen.

公开(公告)号：US20170164888A1

公开(公告)日：2017-06-15

申请号：US15115517

申请日：2014-12-08

Applicant: KONICA MINOLTA, INC.

Inventor： Shinya MATSUDA ,  Eiji KURODA ,  Yasuyuki MOTOKUI

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/08 ,  A61B5/026

CPC classification number: A61B5/4552 ,  A61B5/004 ,  A61B5/0077 ,  A61B5/015 ,  A61B5/0261 ,  A61B5/08 ,  A61B5/1032 ,  A61B5/4255 ,  A61B5/4519 ,  A61B5/682 ,  A61B5/6898 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/743 ,  A61B2562/0233 ,  A61B2576/02

Abstract: An organ image capturing device includes an imaging unit to image a tongue of a living body, and a computing unit. The computing unit calculates a numerical value indicating a state of at least one of a plurality of indices pertaining to health by way of computations using chromaticity values that are obtained from captured image data of the tongue acquired by the imaging unit.