公开(公告)号：US20140140264A1

公开(公告)日：2014-05-22

申请号：US14232421

申请日：2012-06-26

申请人： Kaiying Lv ,  Bo Sun ,  Nan Li ,  Jing Jiang ,  Zhiqiang Han ,  Weimin Xing

发明人： Kaiying Lv ,  Bo Sun ,  Nan Li ,  Jing Jiang ,  Zhiqiang Han ,  Weimin Xing

IPC分类号： H04W74/08

CPC分类号： H04W74/0816 ,  H04W74/04 ,  H04W74/0808

摘要： A data transmission method and system are disclosed. The method comprises: a sending station sends a radio frame and notifies group transmission time interval information; a group station receives the radio frame and acquires group transmission time interval information of a group to which the group station belongs; and the group station competes for a sending opportunity within the group transmission time interval of the group to which the group station belongs. In accordance with the scheme provided in embodiments of the disclosure, a sending station allocates specific group transmission time intervals (subsections) to stations of different groups, and in the case of a large number of users stations, user stations in different groups compete for channels within different time intervals, thereby avoiding the simultaneous or approximately simultaneous competition among a large number of users, reducing the probability of collisions and improving the utilization efficiency of wireless resources.

摘要翻译： 公开了一种数据传输方法和系统。 该方法包括：发送台发送无线帧，通知组发送时间间隔信息; 群站接收无线帧，并获取群站所属组的群传输时间间隔信息; 群组在群组所属的群组传输时间间隔内竞争发送机会。 根据本公开的实施例中提供的方案，发送站向不同组的站分配特定组传输时间间隔（子部分），并且在大量用户站的情况下，不同组中的用户站竞争信道 在不同的时间间隔内，从而避免了大量用户同时或大致同时的竞争，降低了冲突的概率，提高了无线资源的利用效率。

公开(公告)号：US09231747B2

公开(公告)日：2016-01-05

申请号：US14118893

申请日：2012-04-16

申请人： Zhiqiang Han ,  Jing Jiang ,  Bo Sun ,  Li Zhang ,  Weimin Xing

发明人： Zhiqiang Han ,  Jing Jiang ,  Bo Sun ,  Li Zhang ,  Weimin Xing

IPC分类号： H04L5/00 ,  H04W72/04 ,  H04W36/38 ,  H04W4/02 ,  H04W36/00 ,  H04W24/02 ,  H04B7/26 ,  H04B7/06

CPC分类号： H04L5/0057 ,  H04B7/0695 ,  H04B7/2643 ,  H04B7/2656 ,  H04W4/02 ,  H04W24/02 ,  H04W36/0088 ,  H04W36/38 ,  H04W72/04 ,  H04W72/0446

摘要： It is disclosed a method for transmitting wireless frame, including: the wireless frame is transmitted by using any access category. The wireless frame is a beginning frame for performing channel information measurement. It is further disclosed an apparatus for transmitting wireless frame, including: a selection unit and a transmitting unit, where the selection unit is configured to select any access category for a beginning frame for performing the channel information measurement; and the transmitting unit is configured to transmit the beginning frame. It is further disclosed a communication network element provided with the apparatus for transmitting wireless frame mentioned above. It is ensured that the wireless frames subsequent to the frame exchange sequence for performing the channel information measurement may be smoothly transmitted, and the channel information measurement may be smoothly performed, and thereby transmitting communication data based on the acquired channel information. The support of each communication network elements to the MIMO and beam forming is further ensured, and an effective supplement to the existing protocols is provided.

摘要翻译： 公开了一种用于发送无线帧的方法，包括：通过使用任何接入类别来发送无线帧。 无线帧是用于执行信道信息测量的起始帧。 进一步公开了一种用于发送无线帧的装置，包括：选择单元和发送单元，其中所述选择单元被配置为选择用于执行信道信息测量的开始帧的任何接入类别; 并且发送单元被配置为发送开始帧。 还公开了一种通信网络元件，其具有用于发送上述无线帧的装置。 确保可以平滑地发送用于执行信道信息测量的帧交换顺序之后的无线帧，并且可以平滑地执行信道信息测量，从而基于获取的信道信息发送通信数据。 进一步确保每个通信网络元件对MIMO和波束形成的支持，并且提供对现有协议的有效补充。

公开(公告)号：US20140126405A1

公开(公告)日：2014-05-08

申请号：US14118893

申请日：2012-04-16

申请人： Zhiqiang Han ,  Jing Jiang ,  Bo Su ,  Li Zhang ,  Weimin Xing

发明人： Zhiqiang Han ,  Jing Jiang ,  Bo Su ,  Li Zhang ,  Weimin Xing

IPC分类号： H04L5/00 ,  H04W24/02

CPC分类号： H04L5/0057 ,  H04B7/0695 ,  H04B7/2643 ,  H04B7/2656 ,  H04W4/02 ,  H04W24/02 ,  H04W36/0088 ,  H04W36/38 ,  H04W72/04 ,  H04W72/0446

摘要： It is disclosed a method for transmitting wireless frame, including: the wireless frame is transmitted by using any access category. The wireless frame is a beginning frame for performing channel information measurement. It is further disclosed an apparatus for transmitting wireless frame, including: a selection unit and a transmitting unit, where the selection unit is configured to select any access category for a beginning frame for performing the channel information measurement; and the transmitting unit is configured to transmit the beginning frame. It is further disclosed a communication network element provided with the apparatus for transmitting wireless frame mentioned above. It is ensured that the wireless frames subsequent to the frame exchange sequence for performing the channel information measurement may be smoothly transmitted, and the channel information measurement may be smoothly performed, and thereby transmitting communication data based on the acquired channel information. The support of each communication network elements to the MIMO and beam forming is further ensured, and an effective supplement to the existing protocols is provided.

摘要翻译： 公开了一种用于发送无线帧的方法，包括：通过使用任何接入类别来发送无线帧。 无线帧是用于执行信道信息测量的起始帧。 还公开了一种用于发送无线帧的装置，包括：选择单元和发送单元，其中所述选择单元被配置为选择用于执行信道信息测量的起始帧的任何接入类别; 并且发送单元被配置为发送开始帧。 还公开了一种通信网络元件，其具有用于发送上述无线帧的装置。 确保可以平滑地发送用于执行信道信息测量的帧交换顺序之后的无线帧，并且可以平滑地执行信道信息测量，从而基于获取的信道信息发送通信数据。 进一步确保每个通信网络元件对MIMO和波束形成的支持，并且提供对现有协议的有效补充。

公开(公告)号：US20070128116A1

公开(公告)日：2007-06-07

申请号：US11460500

申请日：2006-07-27

申请人： Zheng Wang ,  Irene Kazhdan ,  Jian Gao ,  Zhiqiang Han ,  Robert Marciniak

发明人： Zheng Wang ,  Irene Kazhdan ,  Jian Gao ,  Zhiqiang Han ,  Robert Marciniak

IPC分类号： A61K49/00 ,  A61K48/00 ,  A61K31/409 ,  A61K31/555

CPC分类号： A61K51/1018 ,  A61K31/409 ,  A61K31/555 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0056 ,  A61K51/088

摘要： In the broadest sense an inventive conjugate includes a macrocyclic scaffold moiety incorporating at least one nitrogen atom. Through linkages to the ring, nitrogen atoms are bonded to at least one therapeutic species, or one cellular trafficking species, and preferably two or more types of trafficking species. The linkages between ring nitrogen atoms and agents are formed through N—C, N—S, N—O or N—N bonds. It is appreciated that more than one agent or agent species are coupled to a ring nitrogen atom through the inclusion of a branched carbon atom or secondary amine nitrogen within the intermediate between the agent and ring nitrogen atom. A disulfide bond intermediate between an agent and a linkage to the ring nitrogen is preferred in instances where intracellular release of the agent or trafficking species is desired. An optional metal ion is coordinated by the scaffolding moiety.

摘要翻译： 在最广泛的意义上，本发明的缀合物包括并入至少一个氮原子的大环支架部分。 通过与环的连接，氮原子与至少一种治疗物种或一种细胞运输物种结合，优选结合两种或更多种类型的贩运物种。 通过N-C，N-S，N-O或N-N键形成环氮原子和试剂之间的键。 应当理解，通过在试剂和环氮原子之间的中间体中包含支链碳原子或仲胺氮，将多于一种试剂或试剂物质偶联到环氮原子。 在试剂或转运物种的细胞内释放是需要的情况下，优选在试剂与环氮键的中间的二硫键。 任选的金属离子由支架部分配位。

公开(公告)号：US08536322B2

公开(公告)日：2013-09-17

申请号：US12906969

申请日：2010-10-18

申请人： Zhiqiang Han

发明人： Zhiqiang Han

IPC分类号： C07H21/00

CPC分类号： C12N15/1006

摘要： The invention includes a method for separating polynucleotides, such as DNA, RNA and PNA, from a solution containing polynucleotides by reversibly and non-specifically binding the polynucleotides to a solid surface having a functional amide group-coated surface. The materials containing a solid surface can be in the form of microparticles, fibers, beads, membranes, test tubes, pipette tips or microwells and can further comprise a magnetic core portion. The pH, salt and concentration of crowding reagent, such as polyethylene glycol or alcohol, of the solution is adjusted to levels which result in nucleic acid binding to the solid surface. The magnetic microparticles with bound polynucleotides are separated from the solution under mild alkaline conditions and the nucleic acids are eluted from the magnetic microparticles. Solutions having different nucleic acid concentrations can be normalized by restricting the availability of the solid phase surface.

摘要翻译： 本发明包括通过将多核苷酸可逆地和非特异性地结合到具有官能酰胺基团涂覆表面的固体表面上，从含有多核苷酸的溶液中分离多核苷酸如DNA，RNA和PNA的方法。 含有固体表面的材料可以是微粒，纤维，珠，膜，试管，移液管尖或微孔的形式，并且还可以包括磁芯部分。 将溶液的聚合乙二醇或乙醇等的聚合物的pH，盐和浓度调节至与固体表面结合的水平。 具有结合的多核苷酸的磁性微粒在温和的碱性条件下从溶液中分离，核酸从磁性微粒中洗脱出来。 具有不同核酸浓度的溶液可以通过限制固相表面的可用性进行归一化。

公开(公告)号：US20090163431A1

公开(公告)日：2009-06-25

申请号：US12031139

申请日：2008-02-14

申请人： Irene Kazhdan ,  Zhiqiang Han ,  Zheng Jim Wang ,  Ting-Tung Chang ,  Robert A. Marciniak

发明人： Irene Kazhdan ,  Zhiqiang Han ,  Zheng Jim Wang ,  Ting-Tung Chang ,  Robert A. Marciniak

IPC分类号： A61K31/7088 ,  C12N5/06 ,  C12N15/00

CPC分类号： C07K16/18 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

摘要： Methods and compositions for inhibiting PDX-1 are provided according to the present invention. An anti-PDX-1 agent included in inventive methods and compositions includes an antibody, an aptamer, an antisense oligonucleotide, a ribozyme and/or an inhibitory compound. Methods of inhibiting PDX-1 expression in a tumor cell are provided by the present invention which include contacting a tumor cell with an effective amount of an anti-PDX-1 agent highly or completely complementary to a specified region of an RNA molecule encoding PDX-1. Such an agent specifically hybridizes with the RNA molecule encoding PDX-1 and inhibits the expression of a PDX-1 gene in the tumor cell. Compositions including anti-PDX-1 siRNA and/or shRNA are described. Recombinant expression constructs encoding anti-PDX-1 siRNA or shRNA according to the present invention are described.

摘要翻译： 根据本发明提供了用于抑制PDX-1的方法和组合物。 包含在本发明方法和组合物中的抗PDX-1剂包括抗体，适体，反义寡核苷酸，核酶和/或抑制性化合物。 通过本发明提供抑制肿瘤细胞中PDX-1表达的方法，其包括使肿瘤细胞与有效量的抗PDX-1试剂高度或完全互补，所述抗PDX- 1。 这样的试剂与编码PDX-1的RNA分子特异性杂交并抑制肿瘤细胞中PDX-1基因的表达。 描述了包含抗PDX-1 siRNA和/或shRNA的组合物。 描述了编码本发明抗PDX-1 siRNA或shRNA的重组表达构建体。

公开(公告)号：US20110172409A1

公开(公告)日：2011-07-14

申请号：US12906969

申请日：2010-10-18

申请人： Zhiqiang Han

发明人： Zhiqiang Han

IPC分类号： C07H1/06

CPC分类号： C12N15/1006

摘要： The invention includes a method for separating polynucleotides, such as DNA, RNA and PNA, from a solution containing polynucleotides by reversibly and non-specifically binding the polynucleotides to a solid surface having a functional amide group-coated surface. The materials containing a solid surface can be in the form of microparticles, fibers, beads, membranes, test tubes, pipette tips or microwells and can further comprise a magnetic core portion. The pH, salt and concentration of crowding reagent, such as polyethylene glycol or alcohol, of the solution is adjusted to levels which result in nucleic acid binding to the solid surface. The magnetic microparticles with bound polynucleotides are separated from the solution under mild alkaline conditions and the nucleic acids are eluted from the magnetic microparticles. Solutions having different nucleic acid concentrations can be normalized by restricting the availability of the solid phase surface.

摘要翻译： 本发明包括通过将多核苷酸可逆地和非特异性地结合到具有官能酰胺基团涂覆表面的固体表面上，从含有多核苷酸的溶液中分离多核苷酸如DNA，RNA和PNA的方法。 含有固体表面的材料可以是微粒，纤维，珠，膜，试管，移液管尖或微孔的形式，并且还可以包括磁芯部分。 将溶液的聚合乙二醇或乙醇等的聚合物的pH，盐和浓度调节至与固体表面结合的水平。 具有结合的多核苷酸的磁性微粒在温和的碱性条件下从溶液中分离，核酸从磁性微粒中洗脱出来。 具有不同核酸浓度的溶液可以通过限制固相表面的可用性进行归一化。