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    Method for Detecting Conformational Change of Calmodulin, a Method for Screening a Substance Having an Activity that Affects to Conformational Change of Calmodulin
    1.
    发明申请
    Method for Detecting Conformational Change of Calmodulin, a Method for Screening a Substance Having an Activity that Affects to Conformational Change of Calmodulin 审中-公开
    用于检测钙调蛋白构象变化的方法，筛选具有影响钙调蛋白构象变化的活性的物质的方法

    公开(公告)号：US20080115593A1

    公开(公告)日：2008-05-22

    申请号：US11666077

    申请日：2005-11-07

    申请人： Kaname Mogami ,  Hiroshi Kase

    发明人： Kaname Mogami ,  Hiroshi Kase

    IPC分类号： G01L1/04 ,  G01N33/53 ,  C12Q1/48

    CPC分类号： G01N33/6872 ,  G01N19/00 ,  G01N33/53 ,  G01N2333/4727

    摘要： The object of this invention is to provide a method for detecting conformational change of calmodulin easily and simply in a short period, quantitatively and in real-time manner, and to provide a method for screening a substance having an activity that affects to conformational change of calmodulin efficiently among numerous substances. To solve the object, a method is provided and the method comprising; subjecting a test sample to be tested for its activity to a sample film comprising calmodulin, detecting change(s) in tension and/or elasticity of the sample film in comparison with prior to subjecting said test sample using a mechanochemical sensor, thereby it enables real-time and short time measurement of the activity of said test sample to induce or to inhibit conformational change of calmodulin.

    摘要翻译： 本发明的目的是提供一种用于在短期内，定量和实时地容易且简单地检测钙调蛋白的构象变化的方法，并提供一种筛选具有影响构象变化的活性的物质的方法 钙调蛋白有效地在许多物质之中。 为了解决该问题，提供了一种方法，该方法包括： 将测试样品的活性测试为包含钙调蛋白的样品膜，与使用机械化学传感器处理所述测试样品之前相比，检测样品膜的张力和/或弹性变化，从而使得实际 - 时间和短时间测量所述测试样品的活性以诱导或抑制钙调蛋白的构象变化。

    Network system, control apparatus, terminal apparatus, and connection state determining method
    2.
    发明授权
    Network system, control apparatus, terminal apparatus, and connection state determining method 有权
    网络系统，控制装置，终端装置和连接状态判定方法

    公开(公告)号：US08307059B2

    公开(公告)日：2012-11-06

    申请号：US12681163

    申请日：2008-08-12

    申请人： Hiroshi Kase ,  Junji Yoshida ,  Takayuki Fukui

    发明人： Hiroshi Kase ,  Junji Yoshida ,  Takayuki Fukui

    IPC分类号： G06F15/173

    CPC分类号： H04L61/106 ,  G09G5/006 ,  G09G5/12 ,  G09G2370/12 ,  H04L12/40097

    摘要： A network system according to an implementation of the present invention involves: determining whether or not a matching address is found by comparing (i) an apparatus address, of an apparatus connected to an HDMI network, which is obtained via the HDMI network with (ii) an apparatus address, of an apparatus connected to another network, which is obtained via the other network (S44). Here, the matching address represents a match between the apparatuses addresses. When determining that the matching address is found, the implementation of the present invention involves determining that the terminal apparatus having the matching address is connected to a control apparatus via both of the HDMI network and the other network (S46).

    摘要翻译： 根据本发明的实施方式的网络系统包括：通过将通过HDMI网络获得的连接到HDMI网络的设备的装置地址与（ii）所获得的装置地址进行比较来确定是否找到匹配地址 ）连接到另一网络的装置的装置地址，其经由另一网络获得（S44）。 这里，匹配地址表示设备地址之间的匹配。 当确定找到匹配地址时，本发明的实现涉及确定具有匹配地址的终端装置经由HDMI网络和另一网络经由控制装置连接（S46）。

    NETWORK SYSTEM, CONTROL APPARATUS, TERMINAL APPARATUS, AND CONNECTION STATE DETERMINING METHOD
    5.
    发明申请
    NETWORK SYSTEM, CONTROL APPARATUS, TERMINAL APPARATUS, AND CONNECTION STATE DETERMINING METHOD 有权
    网络系统，控制装置，终端装置和连接状态确定方法

    公开(公告)号：US20100223370A1

    公开(公告)日：2010-09-02

    申请号：US12681163

    申请日：2008-08-12

    申请人： Hiroshi Kase ,  Junji Yoshida ,  Takayuki Fukui

    发明人： Hiroshi Kase ,  Junji Yoshida ,  Takayuki Fukui

    IPC分类号： G06F15/173

    CPC分类号： H04L61/106 ,  G09G5/006 ,  G09G5/12 ,  G09G2370/12 ,  H04L12/40097

    摘要： A network system according to an implementation of the present invention involves: determining whether or not a matching address is found by comparing (i) an apparatus address, of an apparatus connected to an HDMI network, which is obtained via the HDMI network with (ii) an apparatus address, of an apparatus connected to another network, which is obtained via the other network (S44). Here, the matching address represents a match between the apparatuses addresses. When determining that the matching address is found, the implementation of the present invention involves determining that the terminal apparatus having the matching address is connected to a control apparatus via both of the HDMI network and the other network (S46).

    摘要翻译： 根据本发明的实施方式的网络系统包括：通过将通过HDMI网络获得的连接到HDMI网络的设备的装置地址与（ii）所获得的装置地址进行比较来确定是否找到匹配地址 ）连接到另一网络的装置的装置地址，其经由另一网络获得（S44）。 这里，匹配地址表示设备地址之间的匹配。 当确定找到匹配地址时，本发明的实现涉及确定具有匹配地址的终端装置经由HDMI网络和另一网络经由控制装置连接（S46）。

    Agents for treating migraine
    7.
    发明申请
    Agents for treating migraine 有权
    药物治疗偏头痛

    公开(公告)号：US20070161663A1

    公开(公告)日：2007-07-12

    申请号：US10587264

    申请日：2005-01-28

    申请人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

    发明人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/08

    摘要： (wherein R1, R2 and R3 are the same or different, and represent a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or a group represented by the above formula (II); and X1 and X2 are the same or different, and represent an oxygen atom or a sulfur atom) The present invention provides, for example, agents for treating migraine comprising, as an active ingredient, a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof.

    摘要翻译： （其中R 1，R 2和R 3相同或不同，表示氢原子，低级烷基，低级烯基或低级 炔基; R 4表示环烷基， - （CH 2 CH 2）n -R 5或由下式表示的基团： 上述式（II）; X 1和X 2相同或不同，表示氧原子或硫原子）本发明提供例如， 用于治疗偏头痛的药剂，其包含作为活性成分的由上式（I）表示的黄嘌呤衍生物或其药学上可接受的盐。

    Methods of treating patients suffering from movement disorders
    8.
    发明申请
    Methods of treating patients suffering from movement disorders 有权

    公开(公告)号：US20060178379A1

    公开(公告)日：2006-08-10

    申请号：US11326414

    申请日：2006-01-06

    申请人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

    发明人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

    IPC分类号： A61K31/522 ,  A61K31/198 ,  A61K31/137

    CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K45/06

    摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.

    Method of treating behavioral disorders
    9.
    发明申请
    Method of treating behavioral disorders 审中-公开
    治疗行为障碍的方法

    公开(公告)号：US20060069107A1

    公开(公告)日：2006-03-30

    申请号：US10539574

    申请日：2003-12-24

    申请人： Shizuo Shiozaki ,  Junichi Shimada ,  Hiroshi Kase ,  Mayumi Shindo

    发明人： Shizuo Shiozaki ,  Junichi Shimada ,  Hiroshi Kase ,  Mayumi Shindo

    IPC分类号： A61K31/52

    CPC分类号： A61K31/52 ,  A61K31/522

    摘要： The present invention provides a method of treating behavioral disorders such as attention deficit hyperactivity disorder, comprising administering an effective amount of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methylxanthine or a pharmaceutically acceptable salt thereof to a patient in need thereof and the like.

    摘要翻译： 本发明提供治疗诸如注意缺陷多动障碍的行为障碍的方法，其包括给予有效量的（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基黄嘌呤或其药学上可接受的 其盐给有需要的患者等。

    Recording system, recording apparatus, recording method, recording program and recording medium
    10.
    发明申请
    Recording system, recording apparatus, recording method, recording program and recording medium 审中-公开
    记录系统，记录装置，记录方法，记录程序和记录介质

    公开(公告)号：US20050238314A1

    公开(公告)日：2005-10-27

    申请号：US11089964

    申请日：2005-03-25

    申请人： Sako Asayama ,  Hiroshi Kase ,  Keiko Tanaka ,  Yasuhiro Kubo ,  Kevin La Chapelle ,  Ian Mercer ,  Brian Walker

    发明人： Sako Asayama ,  Hiroshi Kase ,  Keiko Tanaka ,  Yasuhiro Kubo ,  Kevin La Chapelle ,  Ian Mercer ,  Brian Walker

    IPC分类号： G11B27/034 ,  G06F17/00

    CPC分类号： G11B27/034

    摘要： A recording apparatus reads a content management file from a file information obtaining means, and a data analysis and search means searches for a specified digital content information storing portions from the read content management file and searches for a play list file including specified digital contents in reproduction order based on reference play list information of the content information storing portions. The file information obtaining means reads a relevant play list file, and the data analysis and search means searches for an updated location and notifies a play list file creation means thereof so that the play list file creation means correctly updates the play list file.

    摘要翻译： 记录装置从文件信息获取装置读取内容管理文件，并且数据分析和搜索装置从读取的内容管理文件中搜索指定的数字内容信息存储部分，并在再现中搜索包括指定的数字内容的播放列表文件 基于内容信息存储部分的参考播放列表信息的顺序。 文件信息获取装置读取相关的播放列表文件，并且数据分析和搜索装置搜索更新的位置并通知播放列表文件创建装置，使得播放列表文件创建装置正确地更新播放列表文件。