公开(公告)号：US20070038135A1

公开(公告)日：2007-02-15

申请号：US11438410

申请日：2006-05-22

申请人： Kang-Ping Lin ,  Bor-Iuan Jan ,  Hao-Yu Jan ,  Geng-Hong Lin

发明人： Kang-Ping Lin ,  Bor-Iuan Jan ,  Hao-Yu Jan ,  Geng-Hong Lin

IPC分类号： A61B5/02

CPC分类号： A61B5/02438 ,  A61B5/02405 ,  A61B5/02416 ,  A61B5/7445 ,  A61B2560/0418

摘要： A portable bio parameter detection/display assembly includes an optical sensor for engagement with an operator to acquire a pulse signal, an A/D converter converting the pulse signal into a digital format, a microprocessor for receiving the digital format pulse signal and proceeding with calculation of a pulse rate and at least one heart rate variability parameter, a display to display and a power module to provide necessary electricity to the assembly.

摘要翻译： 便携式生物参数检测/显示组件包括用于与操作者接合以获取脉冲信号的光学传感器，将脉冲信号转换成数字格式的A / D转换器，用于接收数字格式脉冲信号并进行计算的微处理器 脉搏率和至少一个心率变异性参数，显示器和功率模块，以向组件提供必要的电力。

公开(公告)号：US20060287605A1

公开(公告)日：2006-12-21

申请号：US11160281

申请日：2005-06-16

申请人： Kang-Ping Lin ,  Geng-Hong Lin ,  Bor-Iuan Jan

发明人： Kang-Ping Lin ,  Geng-Hong Lin ,  Bor-Iuan Jan

IPC分类号： A61B5/04

CPC分类号： A61B5/02405 ,  A61B5/04017 ,  A61B5/4035

摘要： The invention discloses an heart rate variability (HRV) analyzing device, which integrates the ECG signal measuring and processing technology and combines the HRV analyzing functions. The device adopts sensing electrodes disposed thereon or external sensing electrodes to record a subject's ECG signals. After being amplified, filtered and analog-to-digital converted, the ECG signals are transmitted to a built-in CPU to proceed with time domain and frequency domain analysis, and the results of the analysis are shown on a display unit. In such a way, the signal acquisition, algorithm calculation and display can be completed in the single device of the invention, which simplifies the conventional instruments and equipment, and provides an indication of the subject's health state in the aspect of self-health care.

摘要翻译： 本发明公开了一种心率变异性（HRV）分析装置，其集成了ECG信号测量和处理技术，并结合HRV分析功能。 该装置采用设置在其上的感测电极或外部感测电极来记录被检者的ECG信号。 经过放大，滤波和模数转换后，将ECG信号传输到内置CPU进行时域和频域分析，分析结果显示在显示单元上。 以这种方式，可以在本发明的单个装置中完成信号采集，算法计算和显示，这简化了传统的仪器和设备，并且在自我保健方面提供了受试者的健康状况的指示。

公开(公告)号：US07270636B2

公开(公告)日：2007-09-18

申请号：US11163881

申请日：2005-11-02

申请人： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen

发明人： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen

IPC分类号： A61B5/02

CPC分类号： A61B5/02007 ,  A61B5/0225 ,  A61B5/025 ,  A61B5/4854

摘要： An apparatus and method for pulse detection based on blood pressure measuring stage is disclosed. Both monitoring of blood pressure and blood vessel pulse are integrated and applied to an apparatus. With the components of the blood pressure monitor, such as an inflatable cuff an air pump and a variable flow valve, with a unique sequential pressure control of reduction and regulation of pressure, not only can blood pressure parameters but also pulse signals under various pressures be measured to provide a complete analysis of blood artery/vessel conditions.

摘要翻译： 公开了一种基于血压测量级的脉冲检测装置和方法。 将血压和血管脉搏的监测都集成并应用于装置。 利用血压监测器的组件，例如可充气套管，气泵和可变流量阀，具有减少和调节压力的独特的连续压力控制，不仅血压参数而且在各种压力下的脉搏信号都是 测量以提供血液动脉/血管状况的完整分析。

公开(公告)号：US20060264771A1

公开(公告)日：2006-11-23

申请号：US11306723

申请日：2006-01-09

申请人： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen ,  Chih-Hsiung Yu

发明人： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen ,  Chih-Hsiung Yu

IPC分类号： A61B5/04 ,  A61B5/02

CPC分类号： A61B5/0205 ,  A61B5/022 ,  A61B5/0245 ,  A61B5/0402

摘要： An apparatus is provided for evaluating cardiovascular functions. The apparatus combines the principles of measuring pressure and pulse signals, and monitors blood pressure, pulse wave velocity and electrocardiogram (ECG) signals simultaneously. An inflatable cuff measures blood pressure and pulse wave velocity. The apparatus also calculates systolic pressure, diastolic pressure, mean arterial pressure and other parameters related to blood pressure. The apparatus not only calculates vascular Stiffness Index (SI), vascular Reflection Index (RI) and other arterial related parameters but also Pulse Wave Velocity (PWV), heartbeat, QRS interval, ST segment, and other ECG parameters.

摘要翻译： 提供了一种用于评估心血管功能的装置。 该装置结合了测量压力和脉冲信号的原理，同时监测血压，脉搏波速度和心电图（ECG）信号。 充气袖口测量血压和脉搏波速度。 该装置还计算与血压相关的收缩压，舒张压，平均动脉压和其他参数。 该装置不仅计算血管僵硬指数（SI），血管反射指数（RI）和其他动脉相关参数，而且还计算脉搏波速度（PWV），心跳，QRS间期，ST段和其他ECG参数。

公开(公告)号：US20060229517A1

公开(公告)日：2006-10-12

申请号：US11163881

申请日：2005-11-02

申请人： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen

发明人： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen

IPC分类号： A61B5/02

CPC分类号： A61B5/02007 ,  A61B5/0225 ,  A61B5/025 ,  A61B5/4854

摘要： An apparatus and method for pulse detection based on blood pressure measuring stage is disclosed. Both monitoring of blood pressure and blood vessel pulse are integrated and applied to an apparatus. With the components of the blood pressure monitor, such an inflatable cuff, an air pump and a variable flow valve, with a unique sequential pressure control of reduction and regulation of pressure, not only can blood pressure parameters but also pulse signals under various pressures be measured to provide a complete analysis of blood artery/vessel conditions.

摘要翻译： 公开了一种基于血压测量级的脉冲检测装置和方法。 将血压和血管脉搏的监测都集成并应用于装置。 通过血压监测器的组件，这样一个可充气的袖带，一个气泵和一个可变流量阀，具有独特的顺序压力控制来减少和调节压力，不仅血压参数而且各种压力下的脉搏信号都是 测量以提供血液动脉/血管状况的完整分析。

公开(公告)号：US20060224073A1

公开(公告)日：2006-10-05

申请号：US10907355

申请日：2005-03-30

申请人： Kang-Ping Lin ,  Hao Jan ,  Bor-Iuan Jan

发明人： Kang-Ping Lin ,  Hao Jan ,  Bor-Iuan Jan

IPC分类号： A61B5/0402

CPC分类号： A61B5/6826 ,  A61B5/02007 ,  A61B5/02125 ,  A61B5/0472 ,  A61B5/14551 ,  A61B5/6838

摘要： An integrated physiological signal assessing device integrates electrical signal detecting technology and optical detecting technology to design a sensing interface module for simultaneously measuring ECG signals and PPG signals, and utilizes multiple algorithm processing methods to obtain ECG parameters, such as rhythm of a heart, ST segment, and QRS interval, as well as vascular parameters, such as vascular stiffness index (SI), vascular reflection index (RI), pulse wave velocity (PWV), and pulse oxygen saturation (SpO2), so as to simplify the conventional vascular functions measuring devices, easily understand physiological conditions of a subject, and helpfully apply on diagnosis and prevention of cardiovascular diseases.

摘要翻译： 综合生理信号评估装置集成了电信号检测技术和光检测技术，设计了同时测量心电信号和PPG信号的感应接口模块，并利用多种算法处理方法获得心电图参数，如心律，ST段 ，QRS间隔以及血管参数，如血管刚度指数（SI），血管反射指数（RI），脉搏波速度（PWV）和脉搏血氧饱和度（SpO <2> 2 ）， 简化常规的血管功能测量装置，容易理解受试者的生理状况，有力地应用于心血管疾病的诊断和预防。

公开(公告)号：US07030970B2

公开(公告)日：2006-04-18

申请号：US10743878

申请日：2003-12-24

申请人： Kang-Ping Lin ,  Yuh-Ping Tong ,  Alex Hsieh ,  Mang-Yi Chen

发明人： Kang-Ping Lin ,  Yuh-Ping Tong ,  Alex Hsieh ,  Mang-Yi Chen

IPC分类号： G01P3/36 ,  G01N21/85

CPC分类号： G01P5/26 ,  A61B5/0261 ,  G01S17/58

摘要： An optical apparatus for measuring the velocity of flowing biomaterials is disclosed, which has a coherent light source for projecting a light beam with low coherent length; a reference member having mirrors for periodically reflecting lights thereon; a photo detector for receiving photo signals; a splitter for splitting said light beam from said coherent light source into a reference beam and a detecting beam. The disclosed optical apparatus can save the time for complicate computation and the cost of software or hardware for measuring the flowing velocity of biomaterials, especially the flowing velocity of flowing bloods in vessels.

摘要翻译： 公开了一种用于测量流动生物材料的速度的光学装置，其具有用于投射具有低相干长度的光束的相干光源; 具有用于在其上周期性反射光的反射镜的参考构件; 用于接收光信号的光电检测器; 分离器，用于将来自所述相干光源的所述光束分成参考光束和检测光束。 所公开的光学装置可以节省复杂计算的时间和用于测量生物材料的流动速度的软件或硬件的成本，特别是血管中流动的血液的流动速度。

公开(公告)号：US07504082B2

公开(公告)日：2009-03-17

申请号：US11336347

申请日：2006-01-20

申请人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

发明人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC分类号： B32B5/16 ,  C01F17/00 ,  C01G1/02

CPC分类号： B82Y5/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/183 ,  Y10S977/777 ,  Y10S977/904 ,  Y10S977/915 ,  Y10T428/2982

摘要： Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles are represented as (FewGdx)vZy, wherein w is from 99.9% to 97.5%, x is from 0.1% to 2.5%, Z is an element of the group VIa, and v, y are positive numbers.

摘要翻译： 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒表示为（FewGdx）vZy，其中w为99.9％至97.5％，x为0.1％至2.5％，Z为VIa族元素，v，y为正数。

公开(公告)号：US07396589B2

公开(公告)日：2008-07-08

申请号：US11687697

申请日：2007-03-19

申请人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Achuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

发明人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Achuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC分类号： B32B5/16

CPC分类号： A61K49/183 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/904 ,  Y10T428/2991

摘要： Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as FexMavZy and a shell of an inner-transition element Mb or the compound thereof, wherein Ma is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.

摘要翻译： 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒包含一个表示为Fe x Si x Z y的核， 过渡元素M b或其化合物，其中M a是内部过渡元素，Z是基团Vla的元素，x大于或等于0， v，y为正数。 壳的表面任选地被脂质体，聚合物，脂族化合物，芳族化合物或其组合改性。

公开(公告)号：US20080241963A1

公开(公告)日：2008-10-02

申请号：US11967648

申请日：2007-12-31

申请人： Chin-I Lin ,  Kang-Ping Lin ,  Yuh-Jiuan Lin ,  Sheng-Ming Shih ,  Abraham Joseph K ,  Chao-Kang Chang

发明人： Chin-I Lin ,  Kang-Ping Lin ,  Yuh-Jiuan Lin ,  Sheng-Ming Shih ,  Abraham Joseph K ,  Chao-Kang Chang

IPC分类号： G01N33/543

CPC分类号： B82Y15/00 ,  G01N33/532 ,  G01N33/543 ,  G01N33/553 ,  G01N33/588

摘要： A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-distributed template molecules, finally removing the template molecules from the matrix to reveal a detection group of the matrix, leaving a cavity with specific area.

摘要翻译： 生物化学标签材料及其制造方法。 该制造方法提供多个纳米颗粒，通过分子印迹将纳米颗粒结合到模板分子上，聚合纳米颗粒以形成具有均匀分布的模板分子的基质，最后从基质中除去模板分子以显示基质的检测基团， 留下具有特定面积的空腔。