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公开(公告)号：US20050170353A1
公开(公告)日：2005-08-04
申请号：US10509595
申请日：2003-03-19
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , G01N33/6887 , G01N2800/168
摘要： To provide a gene examination method for predicting the onset risk of glaucoma based on the relation between a glaucoma-associated gene and the onset of glaucoma, the onset of glaucoma in future is predicted by using as an indication mutations in the gene region involving the code region and/or the upstream region of a glaucoma-associated gene. In the base sequence represented by SEQ ID NO:1, mutation(s) in at least one of the following positions are detected, i.e., the 194-, 199-, 324-, 1051-, 1084-, 1627-, 1685-, 1756-, 1853-, 2830-, 3371-, 4037- and 4364-positions.
摘要翻译： 为了提供基于青光眼相关基因与青光眼发生之间的关系来预测青光眼的发病风险的基因检查方法，通过使用涉及代码的基因区域中的指示突变来预测未来的青光眼发作 区域和/或青光眼相关基因的上游区域。 在由SEQ ID NO：1表示的碱基序列中，检测至少一个以下位置的突变，即194-，199-，324-，1051-，1084-，1627-，1685- ，1756-，1853-，2830-，3371-4037-和4364-位。
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公开(公告)号：US5741213A
公开(公告)日：1998-04-21
申请号：US736822
申请日：1996-10-25
申请人： Yasuhiro Kouchi , Kaoru Asano , Ken Ishihara
发明人： Yasuhiro Kouchi , Kaoru Asano , Ken Ishihara
CPC分类号： G06K9/00127 , A61B5/0059
摘要： An apparatus for analyzing blood includes an image capturing device for capturing an image including at least one object blood cell and an analyzer for analyzing the captured image as an image F(x, y) in an x-y coordinate system. The analyzer includes an edge calculator for calculating an edge intensity distribution E(x, y) representing an outline of the image F(x, y); a weight memory for storing in advance a weight distribution W(i, j) corresponding to an average outline of the object cell; an assessment value calculator for obtaining an assessment value C (x, y) at each point (x, y) by calculating a degree of correspondence between the edge intensity distribution E (x, y) and the weight distribution W(i, j) for each point (x, y); and an extractor for extracting a point (x, y) at which the assessment value C(x, y) is larger than a predetermined value, thereby determining that the object blood cell is present at the point (x, y). The apparatus is useful as a device for identifying the object blood cell.
摘要翻译： 用于分析血液的装置包括用于捕获包括至少一个对象血细胞的图像的图像捕获装置和用于在x-y坐标系统中分析捕获图像作为图像F（x，y）的分析器。 分析器包括用于计算表示图像F（x，y）的轮廓的边缘强度分布E（x，y）的边缘计算器。 权重存储器，用于预先存储与所述对象单元的平均轮廓对应的权重分布W（i，j）; 评估值计算器，用于通过计算边缘强度分布E（x，y）和权重分布W（i，j）之间的对应度来获得每个点（x，y）处的评估值C（x，y） 对于每个点（x，y）; 以及提取器，用于提取评估值C（x，y）大于预定值的点（x，y），从而确定所述对象血细胞存在于所述点（x，y）处。 该装置可用作识别对象血细胞的装置。
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3.发明申请公开(公告)号：US20070179771A1
公开(公告)日：2007-08-02
申请号：US11698393
申请日：2007-01-26
CPC分类号： G09B23/00
摘要： A medical simulation system has a replacing section for replacing at least a part of a plurality of biological function state values represented by the biological model and a simulating section for generating post-replacement simulated biological response on the basis of the biological model which reflects the replaced value.
摘要翻译： 一种医疗模拟系统具有替换部分，用于代替由生物模型表示的多个生物功能状态值的至少一部分，以及用于根据反映替换的生物模型产生替代后模拟生物反应的模拟部分 值。
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公开(公告)号：US20070118347A1
公开(公告)日：2007-05-24
申请号：US11602685
申请日：2006-11-21
CPC分类号： G09B23/28
摘要： A medical simulation system includes a biological response inputting section that receives input of biological response information indicating an actual biological response of biological body, a biological model generating section that generates a biological model for reproduction of simulated response simulating the actual biological response, a pathologic condition characteristics acquiring section that acquires pathologic condition characteristics information indicating characteristics of pathologic condition of the biological body based on the generated biological model, and an outputting section that outputs the biological response information and the pathologic condition characteristics information.
摘要翻译： 医疗模拟系统包括：生物反应输入部，其接收表示生物体的实际生物反应的生物反应信息的输入;生物模型生成部，其生成模拟实际生物反应的模拟响应的生物体模型;病理状态 特征获取部，其基于生成的生物体模型获取表示生物体的病理状态的特征的病理状况特征信息，以及输出部，其输出生物反应信息和病理状况特征信息。
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公开(公告)号：US5974338A
公开(公告)日：1999-10-26
申请号：US60080
申请日：1998-04-15
申请人： Kaoru Asano , Yasuhiro Kouchi
发明人： Kaoru Asano , Yasuhiro Kouchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14551
摘要： A non-invasive blood analyzer includes a light source unit for irradiating a portion of a living body, the portion including a blood vessel, and includes an image capturing unit for capturing an image of the irradiated portion. An analyzing unit is included for setting an analysis region in the captured image and analyzing a blood vessel portion in the set analysis region. The image capturing unit captures images of the irradiated portion of the living body a plurality of times and the analyzing unit specifies analysis regions including the same blood vessel portions with respect to the captured images. The analyzing unit determines these regions based upon a position of a feature in sequential images and calculates at least one of blood vessel width, blood component concentration and blood component concentration ratio with respect to the blood vessel portion in each specified analysis region.
摘要翻译： 非侵入性血液分析仪包括用于照射生物体的一部分的光源单元，该部分包括血管，并且包括用于捕获照射部分的图像的图像捕获单元。 包括分析单元，用于设置拍摄图像中的分析区域并分析设定分析区域中的血管部分。 图像拍摄单元多次拍摄生物体的照射部分的图像，并且分析单元针对捕获的图像指定包括相同血管部分的分析区域。 分析单元基于连续图像中的特征的位置来确定这些区域，并且计算每个指定分析区域中的血管部分的血管宽度，血液成分浓度和血液成分浓度比中的至少一个。
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公开(公告)号：US6061583A
公开(公告)日：2000-05-09
申请号：US77743
申请日：1998-06-11
申请人： Ken Ishihara , Kaoru Asano , Yasuhiro Kouchi , Hideo Kusuzawa
发明人： Ken Ishihara , Kaoru Asano , Yasuhiro Kouchi , Hideo Kusuzawa
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14552 , A61B5/6826 , A61B5/6838 , G01N21/4795
摘要： A noninvasive blood analyzer is provided which comprises: a light source for illuminating a part of tissues of a living body including a blood vessel; an image pickup section for picking up an image of the illuminated blood vessel and tissues; and an analyzing section for analyzing the picked image; the analyzing section including an extracting section for extracting image density distribution across the blood vessel in the image as an image density profile, a quantifying section for quantifying configurational characteristics of the image density profile, a computing section for computing the concentration of a blood constituent on the basis of the quantified characteristics, and an outputting section for outputting a computation result. The blood analyzer can measure the concentration of blood hemoglobin and the hematocrit in real time with an improved repeatability without blood sampling.
摘要翻译： PCT No.PCT / JP96 / 03894 Sec。 371日期：1998年6月11日 102（e）1998年6月11日PCT PCT 1996年12月27日PCT公布。 出版物WO97 / 24066 日期1997年7月10日提供了一种无创血液分析仪，其包括：用于照射包括血管的生物体的一部分组织的光源; 用于拾取照明的血管和组织的图像的图像拾取部分; 以及分析部分，用于分析所拾取的图像; 所述分析部分包括提取部分，用于提取图像中的血管中的图像浓度分布作为图像浓度分布;量化部分，用于量化图像浓度分布的结构特征;计算部分，用于计算血液成分的浓度 量化特性的基础，以及用于输出计算结果的输出部分。 血液分析仪可以实时测量血红蛋白浓度和血细胞比容，改善重复性，无需采血。
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7.发明授权公开(公告)号：US06353750B1
公开(公告)日：2002-03-05
申请号：US09403551
申请日：1999-10-25
IPC分类号： A61B500
CPC分类号： A61B5/0031 , A61B5/0261 , G06F19/00 , H04B10/532
摘要： The purpose is to fix a portion of a living body, which is an object of measurement, stably without strain and to acquire accurate inspection results with good reproducibility. An apparatus for capturing an image of a living body includes: a base for mounting a portion of a living body to be inspected; two sidewall members capable of holding the mounted portion of the living body therebetween from both sides; a light source section for supplying a light to the portion of the living body held on the base and between the sidewall members; and a light receiving section for detecting optical information from the portion of the living body supplied with the light, and a non-invasive apparatus for living body inspection including the above apparatus for capturing an image of a living body in which the light receiving section includes an image capturing element, and an analyzing section for calculating information on blood flowing through a blood vessel by analyzing an image of a tissue including the blood vessel obtained by the image capturing element.
摘要翻译： 目的是将作为测量对象的生物体的一部分稳定地固定而不变形，并以良好的再现性获得精确的检查结果。 一种用于捕获生物体图像的装置，包括：用于安装待检查的生物体的一部分的基座; 两侧壁构件能够从两侧保持活体的安装部分; 光源部，用于向保持在基部上的活体和侧壁部件之间的部分供给光; 以及用于从提供有光的生物体的部分检测光学信息的光接收部分，以及用于生物体检查的非侵入性装置，包括用于捕获其中光接收部分包括的生物体的图像的上述装置 图像捕获元件和分析部分，用于通过分析包括由图像捕获元件获得的血管的组织的图像来计算关于血管流动的血液的信息。
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公开(公告)号：US5791345A
公开(公告)日：1998-08-11
申请号：US565046
申请日：1995-11-30
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
CPC分类号： A61B5/1455 , A61B5/0261 , A61B5/14535 , G01N21/53 , A61B5/14532 , A61B5/14546 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer is intended to capture images of a prescribed volume of blood in a blood vessel in a non-invasive manner and with a good contrast without collecting blood from a living body. The non-invasive blood analyzer includes a light application device for illuminating a detection region of vessels contained in a part of a living body, an image capturing device for capturing images of the detection region illuminated by the light application device, and an analyzer for analyzing blood components contained in the detection region by processing the images captured by the image capturing device. The image capturing device includes an object lens for converging the reflected light from the detection region. The light application device illuminates the detection region at an incident angle larger than an aperture angle of the object lens with respect to the detection region to provide dark-field illumination.
摘要翻译： 非侵入性血液分析仪旨在以非侵入性的方式在血管中捕获规定体积的血液的图像，并且具有良好的对比度而不从活体收集血液。 非侵入性血液分析装置包括：照射生物体的一部分容纳的血管的检测区域的照明装置，摄像装置，用于拍摄由光照射装置照射的检测区域的图像;以及分析装置， 通过处理由图像捕获装置拍摄的图像，包含在检测区域中的血液成分。 图像捕获装置包括用于会聚来自检测区域的反射光的物镜。 光应用装置以相对于检测区域大于物镜的孔径角的入射角照射检测区域，以提供暗场照明。
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9.发明申请Treatment effect prediction system, a treatment effect prediction method, and a computer program product thereof 有权治疗效果预测系统，治疗效果预测方法及其计算机程序产品公开(公告)号：US20060265136A1
公开(公告)日：2006-11-23
申请号：US11431594
申请日：2006-05-11
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
摘要： A treatment effect prediction system, comprising: a processor; and a memory, under control of the processor, including instructions enabling the processor to carry out operations comprising: determining a patient pathological condition information, which represents a feature of pathological condition of a patient, based on diagnostic data of the patient; accessing a database of stored pathological condition information and corresponding treatment effects occurring when predetermined treatment is provided; and retrieving, from the database, a specific treatment effect corresponding to the one of the stored pathological condition information that is similar to the patient pathological condition information, is disclosed. A treatment effect prediction method and a computer program product thereof are also disclosed.
摘要翻译： 一种治疗效果预测系统，包括：处理器; 以及在所述处理器的控制下的存储器，包括使得所述处理器能够执行操作的指令，所述指令基于所述患者的诊断数据来确定患者病理状况信息，其表示患者病理状态的特征; 访问存储的病理状况信息的数据库和提供预定治疗时发生的相应治疗效果; 并且从数据库中检索与存储的病理状况信息相对应的与患者病理状况信息相似的特定治疗效果。 还公开了一种治疗效果预测方法及其计算机程序产品。
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10.发明申请METHOD OF MANUFACTURING PLUG USED TO PIERCE AND ROLL METAL MATERIAL, METHOD OF MANUFACTURING METAL PIPE AND PLUG USED TO PIERCE AND ROLL METAL MATERIAL 有权制造用于金属和金属材料的电极的方法，制造用于金属和金属材料的金属管和插入物的方法公开(公告)号：US20100018281A1
公开(公告)日：2010-01-28
申请号：US12533390
申请日：2009-07-31
申请人： YASUYOSHI HIDAKA , Naoya Hirase , Yasuhiro Kouchi
发明人： YASUYOSHI HIDAKA , Naoya Hirase , Yasuhiro Kouchi
摘要： A plug material having a prescribed shape is prepared, the prepared plug material is thermally treated in a heat treatment atmosphere that contains at least 1.0 vol. % oxygen at a heat treatment temperature of at least 950° C. and less than 1050° C. and thus a plug having an oxide scale layer 30 on the surface is manufactured. According to the manufacturing method, pores PO that extend along the surface SF of the plug material are formed under outer scale layer 20 in the oxide scale layer 30, which allows cracks to be more easily propagated in the outer scale layer 20. Therefore, the outer scale layer 20 is more easily peeled off than the conventional one.
摘要翻译： 制备具有规定形状的塞子材料，将所制备的塞子材料在含有至少1.0体积％的热处理气氛中进行热处理。 在氧化处理温度为至少950℃且低于1050℃的氧气中制造氧气，因此制造了表面上具有氧化皮层30的塞子。 根据制造方法，在氧化皮层30中的外标尺层20上形成有沿插塞材料的表面SF延伸的孔PO，这允许裂纹在外标尺层20中更容易传播。因此， 外标层20比常规剥离更容易。
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