公开(公告)号：US6061583A

公开(公告)日：2000-05-09

申请号：US77743

申请日：1998-06-11

申请人： Ken Ishihara ,  Kaoru Asano ,  Yasuhiro Kouchi ,  Hideo Kusuzawa

发明人： Ken Ishihara ,  Kaoru Asano ,  Yasuhiro Kouchi ,  Hideo Kusuzawa

IPC分类号： A61B5/145 ,  A61B5/00 ,  G01N21/47

CPC分类号： A61B5/14535 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/4795

摘要： A noninvasive blood analyzer is provided which comprises: a light source for illuminating a part of tissues of a living body including a blood vessel; an image pickup section for picking up an image of the illuminated blood vessel and tissues; and an analyzing section for analyzing the picked image; the analyzing section including an extracting section for extracting image density distribution across the blood vessel in the image as an image density profile, a quantifying section for quantifying configurational characteristics of the image density profile, a computing section for computing the concentration of a blood constituent on the basis of the quantified characteristics, and an outputting section for outputting a computation result. The blood analyzer can measure the concentration of blood hemoglobin and the hematocrit in real time with an improved repeatability without blood sampling.

摘要翻译： PCT No.PCT / JP96 / 03894 Sec。 371日期：1998年6月11日 102（e）1998年6月11日PCT PCT 1996年12月27日PCT公布。 出版物WO97 / 24066 日期1997年7月10日提供了一种无创血液分析仪，其包括：用于照射包括血管的生物体的一部分组织的光源; 用于拾取照明的血管和组织的图像的图像拾取部分; 以及分析部分，用于分析所拾取的图像; 所述分析部分包括提取部分，用于提取图像中的血管中的图像浓度分布作为图像浓度分布;量化部分，用于量化图像浓度分布的结构特征;计算部分，用于计算血液成分的浓度 量化特性的基础，以及用于输出计算结果的输出部分。 血液分析仪可以实时测量血红蛋白浓度和血细胞比容，改善重复性，无需采血。

公开(公告)号：US5741213A

公开(公告)日：1998-04-21

申请号：US736822

申请日：1996-10-25

申请人： Yasuhiro Kouchi ,  Kaoru Asano ,  Ken Ishihara

发明人： Yasuhiro Kouchi ,  Kaoru Asano ,  Ken Ishihara

IPC分类号： A61B5/00 ,  G06K9/00

CPC分类号： G06K9/00127 ,  A61B5/0059

摘要： An apparatus for analyzing blood includes an image capturing device for capturing an image including at least one object blood cell and an analyzer for analyzing the captured image as an image F(x, y) in an x-y coordinate system. The analyzer includes an edge calculator for calculating an edge intensity distribution E(x, y) representing an outline of the image F(x, y); a weight memory for storing in advance a weight distribution W(i, j) corresponding to an average outline of the object cell; an assessment value calculator for obtaining an assessment value C (x, y) at each point (x, y) by calculating a degree of correspondence between the edge intensity distribution E (x, y) and the weight distribution W(i, j) for each point (x, y); and an extractor for extracting a point (x, y) at which the assessment value C(x, y) is larger than a predetermined value, thereby determining that the object blood cell is present at the point (x, y). The apparatus is useful as a device for identifying the object blood cell.

摘要翻译： 用于分析血液的装置包括用于捕获包括至少一个对象血细胞的图像的图像捕获装置和用于在x-y坐标系统中分析捕获图像作为图像F（x，y）的分析器。 分析器包括用于计算表示图像F（x，y）的轮廓的边缘强度分布E（x，y）的边缘计算器。 权重存储器，用于预先存储与所述对象单元的平均轮廓对应的权重分布W（i，j）; 评估值计算器，用于通过计算边缘强度分布E（x，y）和权重分布W（i，j）之间的对应度来获得每个点（x，y）处的评估值C（x，y） 对于每个点（x，y）; 以及提取器，用于提取评估值C（x，y）大于预定值的点（x，y），从而确定所述对象血细胞存在于所述点（x，y）处。 该装置可用作识别对象血细胞的装置。

公开(公告)号：US5791345A

公开(公告)日：1998-08-11

申请号：US565046

申请日：1995-11-30

申请人： Ken Ishihara ,  Hiroshi Yamamoto ,  Mitsuru Watanabe ,  Kaoru Asano ,  Akio Suzuki ,  Yasunori Maekawa ,  Yasuhiro Kouchi

发明人： Ken Ishihara ,  Hiroshi Yamamoto ,  Mitsuru Watanabe ,  Kaoru Asano ,  Akio Suzuki ,  Yasunori Maekawa ,  Yasuhiro Kouchi

IPC分类号： A61B5/00 ,  A61B5/026 ,  G01N15/00 ,  G01N15/02 ,  G01N21/53 ,  A61B1/04

CPC分类号： A61B5/1455 ,  A61B5/0261 ,  A61B5/14535 ,  G01N21/53 ,  A61B5/14532 ,  A61B5/14546 ,  G01N15/0227 ,  G01N2015/0065 ,  G01N2021/1791

摘要： A non-invasive blood analyzer is intended to capture images of a prescribed volume of blood in a blood vessel in a non-invasive manner and with a good contrast without collecting blood from a living body. The non-invasive blood analyzer includes a light application device for illuminating a detection region of vessels contained in a part of a living body, an image capturing device for capturing images of the detection region illuminated by the light application device, and an analyzer for analyzing blood components contained in the detection region by processing the images captured by the image capturing device. The image capturing device includes an object lens for converging the reflected light from the detection region. The light application device illuminates the detection region at an incident angle larger than an aperture angle of the object lens with respect to the detection region to provide dark-field illumination.

摘要翻译： 非侵入性血液分析仪旨在以非侵入性的方式在血管中捕获规定体积的血液的图像，并且具有良好的对比度而不从活体收集血液。 非侵入性血液分析装置包括：照射生物体的一部分容纳的血管的检测区域的照明装置，摄像装置，用于拍摄由光照射装置照射的检测区域的图像;以及分析装置， 通过处理由图像捕获装置拍摄的图像，包含在检测区域中的血液成分。 图像捕获装置包括用于会聚来自检测区域的反射光的物镜。 光应用装置以相对于检测区域大于物镜的孔径角的入射角照射检测区域，以提供暗场照明。

公开(公告)号：US5934278A

公开(公告)日：1999-08-10

申请号：US442654

申请日：1995-05-16

申请人： Ken Ishihara ,  Kaoru Asano ,  Yasunori Maekawa

发明人： Ken Ishihara ,  Kaoru Asano ,  Yasunori Maekawa

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/026 ,  A61B5/1455 ,  G01N15/14 ,  G01N33/48 ,  A61B6/00

CPC分类号： G01N15/147 ,  A61B5/0261 ,  A61B5/1455

摘要： A non-invasive blood analyzer includes a light applying device for applying light to a detection region including a blood vessel in a living body and a capturing device for capturing an image of the detection region to which the light is applied. Finally, an analyzing device is included for further processing the captured image to analyze blood cells in the blood vessel included in the detection region. Preferably, the analyzing device includes a reference image forming device for forming a reference image by using at least one of a plurality of images which the capturing device repeatedly captures with respect to the same detection region. In addition, it includes a differential image forming device for calculating a difference in pixel information between the reference image and one of the plurality of images to form a differential image by using the calculated difference as pixel information. Finally, a blood cell image detecting device is included for detecting a blood cell image from the differential image.

摘要翻译： 非侵入式血液分析仪包括：用于对包括生物体中的血管的检测区域进行光照射的光施加装置和用于拍摄被施加光的检测区域的图像的拍摄装置。 最后，包括分析装置，用于进一步处理所捕获的图像，以分析检测区域中包括的血管中的血细胞。 优选地，分析装置包括用于通过使用捕获装置相对于相同检测区域重复捕获的多个图像中的至少一个来形成参考图像的参考图像形成装置。 此外，它包括差分图像形成装置，用于通过使用所计算的差分作为像素信息来计算参考图像和多个图像中的一个图像之间的像素信息的差异，以形成差分图像。 最后，包括用于从差分图像检测血细胞图像的血细胞图像检测装置。

公开(公告)号：US5769076A

公开(公告)日：1998-06-23

申请号：US641828

申请日：1996-05-02

申请人： Yasunori Maekawa ,  Kaoru Asano ,  Yasuhiro Kochi ,  Ken Ishihara

发明人： Yasunori Maekawa ,  Kaoru Asano ,  Yasuhiro Kochi ,  Ken Ishihara

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1495

CPC分类号： A61B5/1455

摘要： A non-invasive blood analyzer contains a light applicator for illuminating a detection region under the skin of a living body including a blood vessel; a camera for capturing an image of the illuminated detection region; an analyzer for processing the captured image and analyzing at least a component of blood in the blood vessel; a transparent plate; and a support for supporting the transparent plate and contacting the transparent plate closely with the skin over the detection region. The light applicator and the camera are constructed to illuminate the detection region and capture the image of the detection region through the transparent plate. Further, a drive controller is included for driving the support to move the transparent plate contacted closely with the skin in order to adjust the detection region to thereby compensate for any change in position of the blood vessel.

摘要翻译： 非侵入性血液分析仪包括用于照射包括血管的生物体的皮肤下的检测区域的光施加器; 用于捕获所述被照亮检测区域的图像的照相机; 用于处理所捕获的图像并分析血管中的血液的至少一部分的分析器; 透明板 以及用于支撑透明板并使透明板与检测区域上的皮肤紧密接触的支撑件。 光照射器和相机被构造为照亮检测区域并通过透明板捕获检测区域的图像。 此外，包括用于驱动支撑件的驱动控制器以移动与皮肤紧密接触的透明板，以便调整检测区域，从而补偿血管位置的任何改变。

公开(公告)号：US5722398A

公开(公告)日：1998-03-03

申请号：US557573

申请日：1995-11-14

申请人： Ken Ishihara ,  Kaoru Asano ,  Yasunori Maekawa

发明人： Ken Ishihara ,  Kaoru Asano ,  Yasunori Maekawa

IPC分类号： G01B11/08 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/31 ,  G01N33/49

CPC分类号： A61B5/1455

摘要： An apparatus for measuring a concentration of hemoglobin includes a light application device for applying light to a detection region containing a blood vessel present in a living body; an image capturing device for capturing an image of the detection region to which the light is applied; and an analyzer for analyzing the concentration of hemoglobin in blood flowing through the blood vessel by processing the captured image. The analyzer includes a light intensity detector for detecting a light intensity of a body tissue and a light intensity of blood using the captured image. It further includes a calculator for calculating the concentration of hemoglobin from a ratio of the light intensity of the body tissue relative to the light intensity of blood thus detected.

摘要翻译： 用于测量血红蛋白浓度的装置包括：用于将光照射到存在于生物体内的血管的检测区域的光施加装置; 用于捕获被施加光的检测区域的图像的图像捕获装置; 以及分析器，用于通过处理所捕获的图像分析血液中血红蛋白的浓度。 该分析器包括用于使用捕获的图像检测身体组织的光强度和血液的光强度的光强度检测器。 其还包括计算器，用于根据身体组织的光强度相对于这样检测的血液的光强度的比率计算血红蛋白的浓度。

公开(公告)号：US5598842A

公开(公告)日：1997-02-04

申请号：US296897

申请日：1994-08-29

申请人： Ken Ishihara ,  Hiroshi Yamamoto ,  Mitsuru Watanabe ,  Kaoru Asano ,  Akio Suzuki ,  Yasunori Maekawa

发明人： Ken Ishihara ,  Hiroshi Yamamoto ,  Mitsuru Watanabe ,  Kaoru Asano ,  Akio Suzuki ,  Yasunori Maekawa

IPC分类号： A61B5/026 ,  G01N15/00 ,  G01N15/02 ,  G01N21/53 ,  A61B5/00 ,  A61B1/04

CPC分类号： G01N21/53 ,  A61B5/0261 ,  G01N15/0227 ,  G01N2015/0065 ,  G01N2021/1791

摘要： A non-invasive blood analyzer includes a light application device for applying light to a detection region of vessels contained in part of the living body, an imaging device for imaging the detection region to which light is applied, a fixing device for relatively fixing the imaging device and the part of the living body; a stabilizing device for stabilizing a focus of the imaging device with respect to the detection region; and an analyzer for analyzing the morphology and/or number of blood cells contained in the detection region by processing images captured with the imaging device, the light application device and the imaging device forming one image with a light application and capturing process during an interval of one ten thousandth to one billionth of a second.

摘要翻译： 非侵入性血液分析仪包括：用于将光照射到生物体的一部分容纳的血管的检测区域的光施加装置，对被施加光的检测区域成像的成像装置，用于相对固定成像的定影装置 装置和活体的一部分; 稳定装置，用于相对于所述检测区域稳定所述成像装置的焦点; 以及分析器，用于通过处理由成像装置拍摄的图像，所述光施加装置和所述成像装置在所述检测区域中包含的血细胞的形态和/或数量分析， 万分之一到十分之一秒。

公开(公告)号：US08103489B2

公开(公告)日：2012-01-24

申请号：US12132006

申请日：2008-06-03

申请人： Naoya Ageishi ,  Yoshihiro Tanaka ,  Ken Ishihara

发明人： Naoya Ageishi ,  Yoshihiro Tanaka ,  Ken Ishihara

IPC分类号： G06F17/10 ,  G06F19/00

CPC分类号： G06F17/5018 ,  B60C11/0306 ,  B60C99/006 ,  G06F17/5095

摘要： A tire is designed using a tire FEM model by obtaining an optimal solution for a tire structure which optimizes an objective function with a tread pattern shape kept fixed and performing a numerical optimization for obtaining an optimal solution for the tread pattern shape which optimizes the objective function with the tire structure kept fixed. The optimization for the tire structure is performed using a tire model having a tread pattern shape optimized at the immediately preceding cycle of the operation of optimizing the tread pattern shape. The optimization for the tread pattern shape is performed using a tire model having a tire structure optimized at the preceding cycle of the operation of optimizing the tire structure. The optimizing operations are repeated until convergence of optimal solutions obtained by those operations takes place.

摘要翻译： 使用轮胎FEM模型设计轮胎，通过获得轮胎结构的最佳解决方案，其优化目标函数，其中胎面花纹形状保持固定并执行数值优化，以获得优化目标函数的胎面花纹形状的最优解 轮胎结构保持固定。 轮胎结构的优化使用具有在优化胎面花纹形状的操作的最前一周期优化的胎面花纹形状的轮胎模型来进行。 用轮胎模型进行胎面花纹形状的优化，该轮胎模型具有在优化轮胎结构的操作的前一循环处优化的轮胎结构。 重复优化操作，直到发生由这些操作获得的最优解的收敛。

公开(公告)号：US07110045B2

公开(公告)日：2006-09-19

申请号：US10470018

申请日：2002-01-24

申请人： Ken Ishihara

发明人： Ken Ishihara

IPC分类号： H04N9/78

CPC分类号： H04N9/78

摘要： A Y/C separator improving characteristics of dot crawl elimination and cross-color interference elimination even at a sampling frequency unequal to an integer multiple of a color subcarrier frequency of an NTSC television signal. A received composite color television signal is quantized by a clock signal with a frequency synchronized to the horizontal sync signal of an input signal. Chrominance component values are extracted in various directions of a target sample by using neighboring samples of the target sample. The chrominance component is obtained by selecting and outputting the extracted chrominance component values in accordance with correlation values of the corresponding samples from which the color component is removed. The calculation of the chrominance component extraction value is carried out by detecting the phase rotation angle of the color subcarrier signal per clock near the target sample, and in response to the detected value.

摘要翻译： 即使在不等于NTSC电视信号的彩色副载波频率的整数倍的采样频率的Y / C分离器也改善了点爬行消除和交叉色干扰消除的特性。 接收到的复合彩色电视信号由具有与输入信号的水平同步信号同步的频率的时钟信号量化。 通过使用目标样本的相邻样本，在目标样本的各个方向上提取色度分量值。 通过根据从其中去除颜色分量的相应样本的相关值选择并输出提取的色度分量值来获得色度分量。 色度分量提取值的计算通过检测目标样本附近的每个时钟的彩色副载波信号的相位旋转角度和响应于检测值来进行。

公开(公告)号：US20060203128A1

公开(公告)日：2006-09-14

申请号：US10552968

申请日：2004-04-06

申请人： Hideaki Sasahara ,  Nobuyoshi Ukaji ,  Ken Ishihara

发明人： Hideaki Sasahara ,  Nobuyoshi Ukaji ,  Ken Ishihara

IPC分类号： H04N5/52

CPC分类号： H04N5/52 ,  H03M1/183

摘要： An AGC control section (110) has a first operation mode for controlling the gain of a variable gain amplifier (103) to maintain the amplitude of the sync signal measured by a sync signal amplitude measuring circuit (108) at a constant value, and a second operation mode for preventing the gain from being increased even when the amplitude of the sync signal measured by the video signal processing circuit (109) is smaller than the predetermined first reference value and reducing the gain of the variable gain amplifier (103) only when the amplitude of the video signal exceeds a predetermined second reference value. During operation in the first operation mode, when the amplitude of the sync signal is smaller than the predetermined first reference value and the amplitude of the video signal is greater than the predetermined second reference value, the mode is switched to the second operation mode. During operation in the second operation mode, when the amplitude of the sync signal becomes not less than the predetermined first reference value, the mode is switched from the second operation mode to the first operation mode.

摘要翻译： AGC控制部分（110）具有用于控制可变增益放大器（103）的增益以将由同步信号幅度测量电路（108）测量的同步信号的振幅维持在恒定值的第一操作模式，以及 即使当由视频信号处理电路（109）测量的同步信号的幅度小于预定的第一参考值并且仅当可变增益放大器（103）的增益减小时，防止增益的第二操作模式， 视频信号的幅度超过预定的第二参考值。 在第一操作模式的操作期间，当同步信号的幅度小于预定的第一参考值并且视频信号的幅度大于预定的第二参考值时，该模式切换到第二操作模式。 在第二操作模式的操作期间，当同步信号的振幅变得不小于预定的第一参考值时，模式从第二操作模式切换到第一操作模式。