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1.发明授权Closed-loop process control for electron beam freeform fabrication and deposition processes 有权电子束自由形成和沉积过程的闭环过程控制公开(公告)号：US08452073B2
公开(公告)日：2013-05-28
申请号：US12750991
申请日：2010-03-31
IPC分类号： G06K9/00
CPC分类号： H01J37/304 , H01J37/305 , H01J2237/30455
摘要： A closed-loop control method for an electron beam freeform fabrication (EBF3) process includes detecting a feature of interest during the process using a sensor(s), continuously evaluating the feature of interest to determine, in real time, a change occurring therein, and automatically modifying control parameters to control the EBF3 process. An apparatus provides closed-loop control method of the process, and includes an electron gun for generating an electron beam, a wire feeder for feeding a wire toward a substrate, wherein the wire is melted and progressively deposited in layers onto the substrate, a sensor(s), and a host machine. The sensor(s) measure the feature of interest during the process, and the host machine continuously evaluates the feature of interest to determine, in real time, a change occurring therein. The host machine automatically modifies control parameters to the EBF3 apparatus to control the EBF3 process in a closed-loop manner.
摘要翻译： 用于电子束自由形成（EBF3）处理的闭环控制方法包括在使用传感器的过程中检测感兴趣的特征，连续评估感兴趣的特征，实时地确定其中发生的变化， 并自动修改控制参数来控制EBF3进程。 一种装置提供了该方法的闭环控制方法，并且包括用于产生电子束的电子枪，用于将线材馈送到衬底的送丝器，其中线材熔化并逐渐沉积到衬底上，传感器 （s）和主机。 传感器在过程中测量感兴趣的特征，并且主机连续评估感兴趣的特征，以实时确定其中发生的变化。 主机自动将控制参数修改为EBF3设备，以闭环方式控制EBF3进程。
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2.发明申请Closed-Loop Process Control for Electron Beam Freeform Fabrication and Deposition Processes 有权电子束自由形成和沉积过程的闭环过程控制公开(公告)号：US20100260410A1
公开(公告)日：2010-10-14
申请号：US12750991
申请日：2010-03-31
CPC分类号： H01J37/304 , H01J37/305 , H01J2237/30455
摘要： A closed-loop control method for an electron beam freeform fabrication (EBF3) process includes detecting a feature of interest during the process using a sensor(s), continuously evaluating the feature of interest to determine, in real time, a change occurring therein, and automatically modifying control parameters to control the EBF3 process. An apparatus provides closed-loop control method of the process, and includes an electron gun for generating an electron beam, a wire feeder for feeding a wire toward a substrate, wherein the wire is melted and progressively deposited in layers onto the substrate, a sensor(s), and a host machine. The sensor(s) measure the feature of interest during the process, and the host machine continuously evaluates the feature of interest to determine, in real time, a change occurring therein. The host machine automatically modifies control parameters to the EBF3 apparatus to control the EBF3 process in a closed-loop manner.
摘要翻译： 用于电子束自由形成（EBF3）处理的闭环控制方法包括在使用传感器的过程中检测感兴趣的特征，连续评估感兴趣的特征，实时地确定其中发生的变化， 并自动修改控制参数来控制EBF3进程。 一种装置提供了该方法的闭环控制方法，并且包括用于产生电子束的电子枪，用于将线材馈送到衬底的送丝器，其中线材熔化并逐渐沉积到衬底上，传感器 （s）和主机。 传感器在过程中测量感兴趣的特征，并且主机连续评估感兴趣的特征，以实时确定其中发生的变化。 主机自动将控制参数修改为EBF3设备，以闭环方式控制EBF3进程。
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3.发明申请公开(公告)号：US20100270274A1
公开(公告)日：2010-10-28
申请号：US12751075
申请日：2010-03-31
IPC分类号： B23K15/00
CPC分类号： B23K15/02
摘要： A method for controlling an electron beam process wherein a wire is melted and deposited on a substrate as a molten pool comprises generating the electron beam with a complex raster pattern, and directing the beam onto an outer surface of the wire to thereby control a location of the wire with respect to the molten pool. Directing the beam selectively heats the outer surface of the wire and maintains the position of the wire with respect to the molten pool. An apparatus for controlling an electron beam process includes a beam gun adapted for generating the electron beam, and a controller adapted for providing the electron beam with a complex raster pattern and for directing the electron beam onto an outer surface of the wire to control a location of the wire with respect to the molten pool.
摘要翻译： 一种用于控制电子束工艺的方法，其中将熔丝熔化并沉积在作为熔池的衬底上的方法包括以复杂光栅图案生成电子束，并将光束引导到电线的外表面上，由此控制位置 电线相对于熔池。 引导梁选择性地加热线的外表面并且保持线相对于熔池的位置。 一种用于控制电子束处理的装置包括适于产生电子束的束枪，以及用于向电子束提供复杂光栅图案并用于将电子束引导到线的外表面以控制位置的控制器 的电线相对于熔池。
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4.发明授权公开(公告)号：US08344281B2
公开(公告)日：2013-01-01
申请号：US12751075
申请日：2010-03-31
IPC分类号： B23K15/00
CPC分类号： B23K15/02
摘要： A method for controlling an electron beam process wherein a wire is melted and deposited on a substrate as a molten pool comprises generating the electron beam with a complex raster pattern, and directing the beam onto an outer surface of the wire to thereby control a location of the wire with respect to the molten pool. Directing the beam selectively heats the outer surface of the wire and maintains the position of the wire with respect to the molten pool. An apparatus for controlling an electron beam process includes a beam gun adapted for generating the electron beam, and a controller adapted for providing the electron beam with a complex raster pattern and for directing the electron beam onto an outer surface of the wire to control a location of the wire with respect to the molten pool.
摘要翻译： 一种用于控制电子束工艺的方法，其中将熔丝熔化并沉积在作为熔池的衬底上的方法包括以复杂光栅图案生成电子束，并将光束引导到电线的外表面上，由此控制位置 电线相对于熔池。 引导梁选择性地加热线的外表面并且保持线相对于熔池的位置。 一种用于控制电子束处理的装置包括适于产生电子束的束枪，以及用于向电子束提供复杂光栅图案并用于将电子束引导到线的外表面以控制位置的控制器 的电线相对于熔池。
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公开(公告)号：US08003378B2
公开(公告)日：2011-08-23
申请号：US12398825
申请日：2009-03-05
申请人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene LeBoeuf , Chang Y. Chung , David E. Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene LeBoeuf , Chang Y. Chung , David E. Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C12M1/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译： 用于在液体培养基中培养活细胞的生物反应器。 在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。 生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。 第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。 在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。 控制液体的流动以便向细胞层提供已知的剪切力。 可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。
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公开(公告)号：US5032172A
公开(公告)日：1991-07-16
申请号：US413638
申请日：1989-09-28
申请人： Ruel A. Overfelt , William H. Hofmeister , Robert J. Bayuzick , Michael B. Robinson , David Dillard , Mark Wells
发明人： Ruel A. Overfelt , William H. Hofmeister , Robert J. Bayuzick , Michael B. Robinson , David Dillard , Mark Wells
IPC分类号： B22F9/00
CPC分类号： B22F9/008
摘要： A stream of molten material free falls through a drop tube and impinges on a chill surface adjacent the bottom of the drop tube to form rapidly solidified particulate. The chill surface is so inclined and moved relative to the stream of molten material as to have an upward component of motion counter to the downward direction of fall of the stream to significantly enhance shearing and rapid quenching of molten material striking the chill surface. The resulting solidified particulate is discharged from the chill surface for collection in a particulate collection chamber beneath the chill surface. Production quantities of rapidly solidified particulate can be continuously made.
摘要翻译： 熔融物料流自由落下通过滴管并撞击在靠近滴管底部的冷却表面上以形成快速凝固的颗粒。 冷却表面相对于熔融材料流倾斜和移动，以具有与料流下降方向相反的向上运动分量，以显着增强熔融材料冲击冷却表面的剪切和快速淬火。 所得到的凝固颗粒从冷却表面排出，以收集在冷却表面下面的颗粒收集室中。 可以连续制造快速固化的颗粒的生产量。
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公开(公告)号：US20120003729A1
公开(公告)日：2012-01-05
申请号：US13175659
申请日：2011-07-01
申请人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译： 用于在液体培养基中培养活细胞的生物反应器。 在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。 生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。 第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。 在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。 控制液体的流动以便向细胞层提供已知的剪切力。 可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。
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公开(公告)号：US07534601B2
公开(公告)日：2009-05-19
申请号：US10525559
申请日：2003-08-27
申请人： John P. Wikswo , Franz J. Baudenbacher , Alex Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Alex Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C12M1/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译： 用于在液体培养基中培养活细胞的生物反应器。 在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。 生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。 第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。 在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。 控制液体的流动以便向细胞层提供已知的剪切力。 可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。
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公开(公告)号：US07790443B2
公开(公告)日：2010-09-07
申请号：US10525648
申请日：2003-08-27
申请人： John P. Wikswo , Franz J. Baudenbacher , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Mark A. Stremler , Alissa Weaver
发明人： John P. Wikswo , Franz J. Baudenbacher , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Mark A. Stremler , Alissa Weaver
CPC分类号： B01L3/502761 , B01L3/502723 , B01L3/502746 , B01L2200/0668 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2300/10 , B01L2400/0633 , B01L2400/086 , C12M23/16 , C12M25/14 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46
摘要： A bioreactor with substance injection capability. In one embodiment, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a chamber for receiving cells and a liquid medium. A port is formed in the second substrate between the bottom surface and the first surface of the second substrate. As formed, the port is in fluid communication with the chamber to allow a stream of substance to be introduced into the chamber. The stream of substance is controlled so as to provide a gradient, or a concentration gradient of the substance, to the chamber. The stream of substance includes a substance affecting the growth of cells such as chemokine.
摘要翻译： 具有物质注入能力的生物反应器。 在一个实施例中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。 生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。 第一基板的第一表面被第二基板的第二表面接收以覆盖空腔，以形成用于容纳电池和液体介质的室。 在第二基板的第二基板的底表面和第一表面之间形成端口。 如此形成的，端口与腔室流体连通，以允许物质流被引入腔室。 物质流被控制以便向腔室提供物质的梯度或浓度梯度。 物质流包括影响细胞生长的物质，如趋化因子。
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公开(公告)号：US20090215654A1
公开(公告)日：2009-08-27
申请号：US12398825
申请日：2009-03-05
申请人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译： 用于在液体培养基中培养活细胞的生物反应器。 在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。 生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。 第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。 在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。 控制液体的流动以便向细胞层提供已知的剪切力。 可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。
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