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    Methods for evaluating oligonucleotide probe sequences
    1.
    发明申请
    Methods for evaluating oligonucleotide probe sequences 审中-公开
    评估寡核苷酸探针序列的方法

    公开(公告)号：US20050027461A1

    公开(公告)日：2005-02-03

    申请号：US10877231

    申请日：2004-06-24

    申请人： Karen Shannon ,  Paul Wolber ,  Glenda Delenstarr ,  Peter Webb ,  Robert Kincaid

    发明人： Karen Shannon ,  Paul Wolber ,  Glenda Delenstarr ,  Peter Webb ,  Robert Kincaid

    IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/20 ,  G06F19/24 ,  G06F19/00

    CPC分类号： G16B25/00 ,  G16B40/00

    摘要： Methods are disclosed for predicting the potential of an oligonucleotide to hybridize to a target nucleotide sequence. A predetermined number of unique oligonucleotides is identified. The unique oligonucleotides are chosen to sample the entire length of a nucleotide sequence that is hybridizable with the target nucleotide sequence. At least one parameter that is independently predictive of the ability of each of the oligonucleotides of the set to hybridize to the target nucleotide sequence is determined and evaluated for each of the above oligonucleotides. A subset of oligonucleotides within the predetermined number of unique oligonucleotides is identified based on the evaluation of the parameter. Oligonucleotides in the subset are identified that are clustered along a region of the nucleotide sequence that is hybridizable to the target nucleotide sequence. The method may be carried out with the aid of a computer.

    摘要翻译： 公开了用于预测寡核苷酸与靶核苷酸序列杂交的潜力的方法。 鉴定出预定数量的唯一寡核苷酸。 选择独特的寡核苷酸来对可与靶核苷酸序列杂交的核苷酸序列的整个长度进行采样。 确定并评估每种上述寡核苷酸的至少一个独立地预测该组寡核苷酸与靶核苷酸序列杂交的能力的参数。 基于参数的评估来鉴定预定数量的唯一寡核苷酸内的寡核苷酸的子集。 鉴定了亚群中的寡核苷酸，其沿着与靶核苷酸序列可杂交的核苷酸序列的区域聚集。 该方法可以借助于计算机进行。

    Customized and dynamic association of probe type with feature extraction algorithms
    2.
    发明申请
    Customized and dynamic association of probe type with feature extraction algorithms 审中-公开
    探头类型与特征提取算法的定制和动态关联

    公开(公告)号：US20060247867A1

    公开(公告)日：2006-11-02

    申请号：US11414005

    申请日：2006-04-28

    申请人： Glenda Delenstarr ,  Peter Webb ,  Charles Troup ,  Jayati Ghosh ,  Christian Le Cocq.

    发明人： Glenda Delenstarr ,  Peter Webb ,  Charles Troup ,  Jayati Ghosh ,  Christian Le Cocq.

    IPC分类号： G06F19/00

    CPC分类号： G16B50/00 ,  G16B25/00 ,  G16B40/00 ,  G16B45/00

    摘要： Systems, methods and computer readable media for extracting data from features on a chemical array, using a feature extraction module including feature extraction algorithms configured to calculate characteristics of array features. A reference table is provided that associates probe names of probes contained on the array with at least one additional identifier. The reference table is accessible by the feature extraction module to convert any one of the at least one additional identifiers to the probe names, and the probe names to at least one of the at least one additional identifiers.

    摘要翻译： 使用包括被配置为计算阵列特征的特征的特征提取算法的特征提取模块来从化学阵列上的特征提取数据的系统，方法和计算机可读介质。 提供了一个参考表，将数组中包含的探测器的探测名称与至少一个附加标识符相关联。 所述参考表可由所述特征提取模块访问，以将所述至少一个附加标识符中的任一个转换为所述探测器名称，并将所述探测器名称转换为所述至少一个附加标识符中的至少一个。

    Fiber-Coupled Collimator for Generating Multiple Collimated Optical Beams Having Different Wavelengths
    6.
    发明申请
    Fiber-Coupled Collimator for Generating Multiple Collimated Optical Beams Having Different Wavelengths 有权
    用于产生具有不同波长的多个准直光束的光纤耦合准直器

    公开(公告)号：US20110228404A1

    公开(公告)日：2011-09-22

    申请号：US12729187

    申请日：2010-03-22

    申请人： Peter Webb ,  David Lande

    发明人： Peter Webb ,  David Lande

    IPC分类号： G02B27/30

    CPC分类号： G02B27/30 ,  G02B6/327

    摘要： An apparatus for providing multiple collimated light beams from optical fibers and the method for producing such beams. The apparatus includes first and second optical fibers that carry light of first and second wavelengths, respectively, a fixture that maintains the fibers in a fixed relationship to one another, and a collimating lens. Light from each of the first and second optical fibers diverges from a face of the fixture. The collimating lens produces first and second collimated light beams that are displaced relative to one another from the light leaving the face. The face of the fixture is positioned to correct for chromatic aberration in the lens.

    摘要翻译： 一种用于从光纤提供多个准直光束的装置以及用于产生这种光束的方法。 该装置包括分别承载第一和第二波长的光的第一和第二光纤，将光纤保持彼此固定关系的固定装置和准直透镜。 来自第一和第二光纤中的每一个的光从夹具的表面发散。 准直透镜产生第一和第二准直光束，其相对于彼此离开离开面部的光而相对移动。 固定装置的表面被定位以校正透镜中的色差。

    Fabricating biopolymer arrays
    8.
    发明申请
    Fabricating biopolymer arrays 失效
    制造生物聚合物阵列

    公开(公告)号：US20050106754A1

    公开(公告)日：2005-05-19

    申请号：US10932886

    申请日：2004-09-01

    申请人： Michael Caren ,  Carol Schembri ,  Peter Webb

    发明人： Michael Caren ,  Carol Schembri ,  Peter Webb

    IPC分类号： B01J19/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

    CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  Y10T436/2575

    摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

    摘要翻译： 一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。 头部具有储存室和至少一个可将液滴分配到基底上的射流。 喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。 射流还包括喷射器，其在被激活时使得液滴从孔口喷出。 该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。 负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室 面对并邻近孔口。 头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

    Ultrasound system with nonuniform rotation corrector
    9.
    发明授权
    Ultrasound system with nonuniform rotation corrector 失效
    超声系统与不均匀旋转校正器

    公开(公告)号：US5699806A

    公开(公告)日：1997-12-23

    申请号：US724203

    申请日：1996-10-01

    申请人： Peter Webb ,  Edward Verdonk

    发明人： Peter Webb ,  Edward Verdonk

    IPC分类号： A61B8/12 ,  G01S7/52 ,  G01S15/89

    CPC分类号： A61B8/12 ,  A61B8/587 ,  G01S15/894 ,  G01S7/52049

    摘要： An ultrasound apparatus for imaging tissues from interior of a cavity in the body of a patient is disclosed. The apparatus includes a probe for entering the body to the cavity. The probe has a distal end for entering the body and a proximal end to extend outside the body. At the distal end of the probe is a transducer associated with a rotatable mechanism for transmitting sequential ultrasonic pulses as the rotatable mechanism rotates, forming an angular pattern of transmitted pulses. Ultrasonic energy reflected and scattered from the patient's body tissues is received by an transducer so that each pulse generates a received signal (RF-line). The apparatus has a mechanism for identifying the angular separation between the RF-lines by analyzing the RF-lines caused by reflection and scattering by the body tissues alone. In this way, any distortion caused by the difference between the transmitted angular pattern and the intended angular pattern, if present, can be determined and corrected.

    摘要翻译： 公开了一种用于从患者体内的空腔内部对组织进行成像的超声波装置。 该装置包括用于将身体进入空腔的探针。 探针具有用于进入身体的远端和近端延伸到身体外部。 在探头的远端处是与可旋转机构相关联的换能器，用于在可旋转机构旋转时传送顺序超声波脉冲，形成发射脉冲的角度图案。 通过换能器接收从患者身体组织反射和散射的超声能量，使得每个脉冲产生接收信号（RF线）。 该装置具有通过分析由单独的身体组织的反射和散射引起的RF线来识别RF线之间的角度间隔的机构。 以这种方式，可以确定和校正由传输的角度图案与预期角度图案之间的差异（如果存在）引起的任何失真。