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    Methods and systems for improving of polymer analysis
    2.
    发明申请
    Methods and systems for improving of polymer analysis 审中-公开
    改进聚合物分析的方法和系统

    公开(公告)号：US20050095595A1

    公开(公告)日：2005-05-05

    申请号：US10696177

    申请日：2003-10-29

    申请人： Richard Pittaro ,  Douglas Amorese ,  Carol Schembri ,  Leslie Leonard ,  Nicholas Sampas ,  Michael Caren

    发明人： Richard Pittaro ,  Douglas Amorese ,  Carol Schembri ,  Leslie Leonard ,  Nicholas Sampas ,  Michael Caren

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6837 ,  C12Q2545/101

    摘要： Systems and methods for optimizing polymer analysis are provided. One such system includes a polymer analysis system having a polymer control system. The polymer analysis system is operative to: apply a set of conditions to a sample being analyzed by the polymer array, the set of conditions correspond to at least one characteristic of the polymer array; analyze the at least one characteristic using the polymer control system; and generate polymer array data.

    摘要翻译： 提供了优化聚合物分析的系统和方法。 一种这样的系统包括具有聚合物控制系统的聚合物分析系统。 聚合物分析系统可操作以：将一组条件应用于由聚合物阵列分析的样品，该组条件对应于聚合物阵列的至少一个特性; 使用聚合物控制系统分析至少一个特征; 并生成聚合物阵列数据。

    Hybridization and scanning apparatus
    3.
    发明申请
    Hybridization and scanning apparatus 审中-公开
    杂交和扫描仪器

    公开(公告)号：US20050084867A1

    公开(公告)日：2005-04-21

    申请号：US10687397

    申请日：2003-10-15

    申请人： Michael Caren ,  Richard Pittaro ,  Carol Schembri

    发明人： Michael Caren ,  Richard Pittaro ,  Carol Schembri

    IPC分类号： C12M1/34 ,  C12Q1/68 ,  C40B60/14 ,  G01N35/00 ,  G06K9/00

    CPC分类号： G01N35/00029 ,  B01J2219/00326 ,  B01J2219/0052 ,  B01J2219/00657 ,  B01J2219/00702 ,  C40B60/14 ,  G01N2035/00049 ,  G01N2035/00158

    摘要： Apparatus and methods are disclosed relating to linear arrays. An embodiment of an apparatus comprises a rotatable support for one or more linear arrays, a mechanism for rotating the support, and a device for examining the linear arrays for the results of chemical reactions. Each of the linear arrays comprises a plurality of features for conducting the chemical reactions. Optionally, the apparatus may comprise a heater for heating the linear arrays. Optionally, the apparatus may comprise a fluid dispensing device for dispensing processing fluids such as, for example, wash solutions.

    摘要翻译： 公开了与线性阵列相关的装置和方法。 装置的实施例包括用于一个或多个线性阵列的可旋转支撑件，用于旋转支撑件的机构，以及用于检查用于化学反应结果的线性阵列的装置。 每个线性阵列包括用于进行化学反应的多个特征。 可选地，该装置可以包括用于加热线性阵列的加热器。 可选地，该装置可以包括用于分配处理流体例如洗涤溶液的流体分配装置。

    Fabricating biopolymer arrays
    4.
    发明申请
    Fabricating biopolymer arrays 失效
    制造生物聚合物阵列

    公开(公告)号：US20050106754A1

    公开(公告)日：2005-05-19

    申请号：US10932886

    申请日：2004-09-01

    申请人： Michael Caren ,  Carol Schembri ,  Peter Webb

    发明人： Michael Caren ,  Carol Schembri ,  Peter Webb

    IPC分类号： B01J19/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

    CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  Y10T436/2575

    摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

    摘要翻译： 一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。 头部具有储存室和至少一个可将液滴分配到基底上的射流。 喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。 射流还包括喷射器，其在被激活时使得液滴从孔口喷出。 该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。 负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室 面对并邻近孔口。 头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

    Methods and apparatus for sample mixing
    6.
    发明申请
    Methods and apparatus for sample mixing 审中-公开
    样品混合的方法和装置

    公开(公告)号：US20050084866A1

    公开(公告)日：2005-04-21

    申请号：US10687277

    申请日：2003-10-15

    申请人： Michael Caren ,  Carol Schembri

    发明人： Michael Caren ,  Carol Schembri

    IPC分类号： B01F11/00 ,  B01F13/00 ,  B01L3/00 ,  G01N1/10 ,  C12Q1/68

    CPC分类号： B01F11/0071 ,  B01F13/0059 ,  B01L3/50273 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2400/0481 ,  Y10T436/2575

    摘要： Apparatus and methods for mixing fluids are disclosed. An apparatus comprises a housing or channel having an interior with capillary dimensions and a pressure activated mechanism in fluid communication with the interior. The pressure activated mechanism is activatable to cause motion of fluid in the interior of the housing thereby mixing the fluid in the interior. An apparatus may comprise an activating mechanism for activating the pressure activated mechanism. Typically, at least a portion of the interior of the housing comprises a linear array of features for conducting chemical reactions. Optionally, an apparatus comprises a fluid dispensing device.

    摘要翻译： 公开了用于混合流体的装置和方法。 一种装置包括具有毛细管尺寸内部和与内部流体连通的压力启动机构的壳体或通道。 压力激活机构可激活以引起壳体内部的流体的运动，从而将流体混合在内部。 设备可以包括用于启动压力启动机构的启动机构。 通常，壳体内部的至少一部分包括用于进行化学反应的线性阵列的特征。 可选地，装置包括流体分配装置。

    Methods and apparatus for analyzing arrays
    8.
    发明申请
    Methods and apparatus for analyzing arrays 审中-公开
    分析阵列的方法和装置

    公开(公告)号：US20050112588A1

    公开(公告)日：2005-05-26

    申请号：US10722228

    申请日：2003-11-25

    申请人： Michael Caren ,  Douglas Amorese

    发明人： Michael Caren ,  Douglas Amorese

    IPC分类号： C12M1/34 ,  C12Q1/68

    CPC分类号： C12Q1/6837 ,  C12Q2565/629

    摘要： Devices, apparatus and methods for conducting hybridization reactions are disclosed. An embodiment of a device comprises two chambers in fluid communication. Each of the chambers has an interior wherein one of the chambers has at least one interior dimension that is larger (larger chamber) than at least one interior dimension of the other of the chambers (smaller chamber). Each of the interiors comprises an array of features.

    摘要翻译： 公开了用于进行杂交反应的装置，装置和方法。 装置的一个实施例包括流体连通的两个腔室。 每个室具有内部，其中一个室具有比另一个室（较小室）的至少一个内部尺寸更大（更大的室）的至少一个内部尺寸。 每个内部都包括一组特征。

    Apparatus and methods for printing arrays
    9.
    发明申请
    Apparatus and methods for printing arrays 审中-公开
    打印阵列的装置和方法

    公开(公告)号：US20060051493A1

    公开(公告)日：2006-03-09

    申请号：US10630490

    申请日：2003-07-29

    申请人： Richard Tella ,  William Fisher ,  Michael Caren ,  Lawrence DaQuino ,  Peter Webb

    发明人： Richard Tella ,  William Fisher ,  Michael Caren ,  Lawrence DaQuino ,  Peter Webb

    IPC分类号： A61L33/00 ,  B05D3/00 ,  B05C11/00

    CPC分类号： B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00722 ,  B01L9/52

    摘要： Apparatus and methods are disclosed for printing a plurality of biopolymer features on the surfaces of substrates. An apparatus comprises a substrate mount for receiving a substrate, a dispensing device for dispensing reagents for synthesizing a biopolymer on a surface of the substrate, an optical system for positioning the substrate mount along a y-axis and an optical system for positioning the dispensing device along an x-axis. The apparatus may comprise a touch system for positioning the substrate and the dispensing device along a z-axis. One of the substrate mount or the dispensing device is adapted for translation along the y-axis and for rotation about a central axis that is parallel to a z-axis. The other of the above is adapted to move along the x-axis transversely to the direction of, and independently of, movement of the one adapted for translation along the y-axis. The optical systems cooperate to position the substrate mount and the dispensing device relative to one another. Also disclosed in conjunction with the apparatus and methods are washing stations and loading stations.

    摘要翻译： 公开了用于在基板的表面上印刷多个生物聚合物特征的装置和方法。 一种装置包括用于接收基板的基板支架，用于分配用于在基板的表面上合成生物聚合物的试剂的分配装置，用于沿y轴定位基板支架的光学系统和用于定位分配装置的光学系统 沿x轴。 该装置可以包括用于沿z轴定位衬底和分配装置的触摸系统。 衬底安装件或分配装置中的一个适于沿着y轴平移并围绕平行于z轴的中心轴线旋转。 上述中的另一个适于沿着沿着y轴的适于平移的一个的移动的方向横向移动x轴。 光学系统协作以相对于彼此定位衬底安装件和分配装置。 还结合装置和方法公开的是洗涤站和装载站。

    High resolution chromosomal mapping
    10.
    发明申请
    High resolution chromosomal mapping 有权
    高分辨率染色体定位

    公开(公告)号：US20070238105A1

    公开(公告)日：2007-10-11

    申请号：US11400481

    申请日：2006-04-07

    申请人： Michael Barrett ,  Michael Caren

    发明人： Michael Barrett ,  Michael Caren

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M3/00

    CPC分类号： C12Q1/6841

    摘要： The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. For instance, the oligonucleotides may be at least substantially complementary to the chromosome, e.g., substantially complementary to a specific location of the chromosome.

    摘要翻译： 本发明一般涉及空间和结构基因组分析组合物，其可以用于染色体的定位和染色体重排的结构分析，包括整个染色体以及染色体感兴趣的具体部分或区域。 在一些实施例中，可以区分基因组的多个部分，例如使用不同于第一检测实体的第一检测实体和第二检测实体。 检测实体可以相对于寡核苷酸被固定，寡核苷酸可被选择以结合染色体内的不同位置。 例如，寡核苷酸可以至少基本上与染色体互补，例如与染色体的特定位置基本互补。