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公开(公告)号：US07052514B2
公开(公告)日：2006-05-30
申请号：US09844257
申请日：2001-04-27
申请人： Karin Kellner , Kurt Lang , Apollon Papadimitriou , Ulrike Leser-Reiff , Michaela Schultz , Torsten Blunk , Achim Goepferich
发明人： Karin Kellner , Kurt Lang , Apollon Papadimitriou , Ulrike Leser-Reiff , Michaela Schultz , Torsten Blunk , Achim Goepferich
IPC分类号： A61F3/00 , A61F5/00 , G01N33/567
CPC分类号： A61L27/3852 , A61L27/3612 , A61L27/3654 , A61L27/3843 , A61L2430/06
摘要： The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.
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公开(公告)号：US20060246041A1
公开(公告)日：2006-11-02
申请号：US11396946
申请日：2006-04-03
申请人： Karin Lauer , Kurt Lang , Apollon Papadimitriou , Ulrike Reiff , Michaela Schulz , Torsten Blunk , Achim Goepferich
发明人： Karin Lauer , Kurt Lang , Apollon Papadimitriou , Ulrike Reiff , Michaela Schulz , Torsten Blunk , Achim Goepferich
CPC分类号： A61L27/3852 , A61L27/3612 , A61L27/3654 , A61L27/3843 , A61L2430/06
摘要： The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.
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公开(公告)号：US09579394B2
公开(公告)日：2017-02-28
申请号：US14237445
申请日：2012-08-07
申请人： Achim Goepferich , Matthias Ferstl
发明人： Achim Goepferich , Matthias Ferstl
CPC分类号： A61K47/48246 , A61K47/6455 , C12N15/88
摘要： The subject-matter of the present invention are nanocomplexes of polyanions and cationic peptides which are, e.g., suitable for the transport of drugs into cells and their controlled release in the organism, as well as a complex material in which the nanocomplexes are bonded to a biologically active unit for the selective recognition of tissues, cells or organelles.
摘要翻译： 本发明的主题是聚阴离子和阳离子肽的纳米复合物，其例如适合于将药物输送到细胞中并且其在生物体中的控制释放，以及复合材料，其中纳米复合物结合到 用于选择性识别组织，细胞或细胞器的生物活性单位。
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公开(公告)号：US06676970B2
公开(公告)日：2004-01-13
申请号：US09848638
申请日：2001-05-03
IPC分类号： A61K4738
CPC分类号： A61K9/0024 , A61K9/0019 , A61K31/663 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The invention is concerned with a pharmaceutical preparation for subcutaneous, parenteral administration, which contains bisphosphonic acids or their salts as the active substance, as well as the production of this preparation. By means of the preparation in accordance with the invention it is possible to administer locally relatively high concentrations of bisphosphonates without the occurrence of incompatibilities.
摘要翻译： 本发明涉及皮下，肠胃外给药的药物制剂，其包含双膦酸或其作为活性物质的盐以及该制剂的制备。 通过根据本发明的制备，可以在不发生不相容性的情况下施用局部相对高浓度的双膦酸盐。
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公开(公告)号：US20140171368A1
公开(公告)日：2014-06-19
申请号：US14237445
申请日：2012-08-07
申请人： Achim Goepferich , Matthias Ferstl
发明人： Achim Goepferich , Matthias Ferstl
IPC分类号： A61K47/48
CPC分类号： A61K47/48246 , A61K47/6455 , C12N15/88
摘要： The subject-matter of the present invention are nanocomplexes of polyanions and cationic peptides which are, e.g., suitable for the transport of drugs into cells and their controlled release in the organism, as well as a complex material in which the nanocomplexes are bonded to a biologically active unit for the selective recognition of tissues, cells or organelles.
摘要翻译： 本发明的主题是聚阴离子和阳离子肽的纳米复合物，其例如适合于将药物输送到细胞中并且其在生物体中的控制释放，以及复合材料，其中纳米复合物结合到 用于选择性识别组织，细胞或细胞器的生物活性单位。
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公开(公告)号：US20090041828A1
公开(公告)日：2009-02-12
申请号：US12285707
申请日：2008-10-14
CPC分类号： A61F9/0017
摘要： The invention relates to an insert for the treatment of dry eyes, wherein the insert can be placed on or inserted into the lacrimal sac or the cornea.
摘要翻译： 本发明涉及一种用于治疗干眼症的插入物，其中插入物可以放置在泪囊或角膜上或插入泪囊或角膜中。
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