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公开(公告)号：US07052514B2
公开(公告)日：2006-05-30
申请号：US09844257
申请日：2001-04-27
申请人： Karin Kellner , Kurt Lang , Apollon Papadimitriou , Ulrike Leser-Reiff , Michaela Schultz , Torsten Blunk , Achim Goepferich
发明人： Karin Kellner , Kurt Lang , Apollon Papadimitriou , Ulrike Leser-Reiff , Michaela Schultz , Torsten Blunk , Achim Goepferich
IPC分类号： A61F3/00 , A61F5/00 , G01N33/567
CPC分类号： A61L27/3852 , A61L27/3612 , A61L27/3654 , A61L27/3843 , A61L2430/06
摘要： The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.
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公开(公告)号：US20060246041A1
公开(公告)日：2006-11-02
申请号：US11396946
申请日：2006-04-03
申请人： Karin Lauer , Kurt Lang , Apollon Papadimitriou , Ulrike Reiff , Michaela Schulz , Torsten Blunk , Achim Goepferich
发明人： Karin Lauer , Kurt Lang , Apollon Papadimitriou , Ulrike Reiff , Michaela Schulz , Torsten Blunk , Achim Goepferich
CPC分类号： A61L27/3852 , A61L27/3612 , A61L27/3654 , A61L27/3843 , A61L2430/06
摘要： The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.
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公开(公告)号：US20070299238A1
公开(公告)日：2007-12-27
申请号：US11897176
申请日：2007-08-28
IPC分类号： C08G69/08
CPC分类号： C12N5/0068 , A61K9/1676 , A61K47/593 , A61K47/60 , C08G63/664 , C08L71/02 , C12N2533/40 , C08L2666/18
摘要： The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.
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公开(公告)号：US20070299240A1
公开(公告)日：2007-12-27
申请号：US11897145
申请日：2007-08-28
IPC分类号： C08G63/06
CPC分类号： C12N5/0068 , A61K9/1676 , A61K47/593 , A61K47/60 , C08G63/664 , C08L71/02 , C12N2533/40 , C08L2666/18
摘要： The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.
摘要翻译： 本发明涉及含有：a）疏水性生物可降解聚合物的嵌段共聚物; b）亲水性聚合物和c）至少一个用于表面改性物质d）与亲水性聚合物b）共价结合的反应性基团。 本发明涉及由嵌段共聚物组成的成型体及其利用，特别是作为组织培养和活性物质的载体，以及活性物质的控制释放和靶向施用。
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公开(公告)号：US20090291106A1
公开(公告)日：2009-11-26
申请号：US12505449
申请日：2009-07-17
CPC分类号： C12N5/0068 , A61K9/1676 , A61K47/593 , A61K47/60 , C08G63/664 , C08L71/02 , C12N2533/40 , C08L2666/18
摘要： A block copolymer containing a) a hydrophobic biodegradable polymer, b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b) is disclosed. Shaped bodies are formed to consist of the block copolymer and are utilized as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.
摘要翻译： 含有a）疏水性生物可降解聚合物的嵌段共聚物，b）亲水性聚合物和c）至少一种用于表面改性物质d）与亲水性聚合物b）共价结合的反应性基团。 成型体形成为由嵌段共聚物组成，并用作组织培养和活性物质的载体并用于活性物质的控制释放和靶向施用。
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公开(公告)号：US20050037952A1
公开(公告)日：2005-02-17
申请号：US10457248
申请日：2003-06-09
申请人： Lisa Freed , Keith Gooch , Donald Courter , Torsten Blunk , Alisha Sieminski , Gordana Vunjak-Novakovic
发明人： Lisa Freed , Keith Gooch , Donald Courter , Torsten Blunk , Alisha Sieminski , Gordana Vunjak-Novakovic
CPC分类号： A61L27/3817 , A61L27/18 , A61L27/227 , A61L27/3654 , A61L27/3852 , A61L27/54 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： Compositions and methods comprising at least one active agent chosen from TGF-P superfamily proteins, including BMPs, and GDFs for increasing the growth rate or modulating the development of engineered cartilage are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects, and in related tissue repair.
摘要翻译： 公开了包含至少一种选自TGF-β超家族蛋白（包括BMP）的活性剂和用于增加生长速率或调节工程化软骨发育的GDF的组合物和方法。 该组合物可用于治疗骨关节炎，软骨缺损和相关组织修复。
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公开(公告)号：US20090215166A1
公开(公告)日：2009-08-27
申请号：US12063935
申请日：2006-08-16
申请人： Achim Göpferich , Miriam Breunig , Uta Lungwitz , Torsten Blunk
发明人： Achim Göpferich , Miriam Breunig , Uta Lungwitz , Torsten Blunk
CPC分类号： C08G73/0226 , A61K47/543 , A61K47/6455
摘要： The invention relates to a cationic polymer containing cationic oligomers cross-linkable by fissile linker sequences, wherein said cationic polymers form, together with nucleic acids, polyplexes and can be used for cell transfection and the invention is characterised in that the cationic polymer contains intracellular reductive or enzymatic fissile linker sequences.
摘要翻译： 本发明涉及含有可裂解接头序列可交联的阳离子低聚物的阳离子聚合物，其中所述阳离子聚合物与核酸，复合物一起形成并且可用于细胞转染，本发明的特征在于阳离子聚合物含有细胞内还原 或酶裂解接头序列。
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公开(公告)号：US20070299227A1
公开(公告)日：2007-12-27
申请号：US11897175
申请日：2007-08-28
CPC分类号： C12N5/0068 , A61K9/1676 , A61K47/593 , A61K47/60 , C08G63/664 , C08L71/02 , C12N2533/40 , C08L2666/18
摘要： The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.
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