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    Human Tbx20 gene and uses
    1.
    发明授权
    Human Tbx20 gene and uses 失效
    人类Tbx20基因及用途

    公开(公告)号：US06780595B2

    公开(公告)日：2004-08-24

    申请号：US10082272

    申请日：2002-02-26

    申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

    发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06Q30/0601

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.

    摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等 和心脏和眼睛的条件。

    Full-length serine protein kinase in brain and pancreas
    2.
    发明授权
    Full-length serine protein kinase in brain and pancreas 有权
    脑和胰腺全长丝氨酸蛋白激酶

    公开(公告)号：US06455292B1

    公开(公告)日：2002-09-24

    申请号：US09930181

    申请日：2001-08-16

    申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

    发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

    IPC分类号： C12N912

    CPC分类号： C12N9/1205 ,  G01N33/573 ,  G01N2333/9121

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.

    摘要翻译： 本发明涉及新型多核苷酸的所有方面，其编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学中的应用。 多核苷酸在脑和胰腺中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性 对疾病和病症，特别是与脑和胰腺有关。

    Histamine H2 receptor and uses
    4.
    发明授权
    Histamine H2 receptor and uses 有权
    组胺H2受体和用途

    公开(公告)号：US06953673B2

    公开(公告)日：2005-10-11

    申请号：US10017393

    申请日：2001-12-18

    申请人： Karl F. Kovacs ,  Gilbert Jay

    发明人： Karl F. Kovacs ,  Gilbert Jay

    IPC分类号： C07K14/72 ,  C12N15/12 ,  G01N33/74 ,  C07H21/04 ,  C07K14/00 ,  C12N15/00 ,  C12N15/63

    CPC分类号： G01N33/74 ,  C07K14/723 ,  G01N2500/10

    摘要： The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.

    摘要翻译： 本发明涉及组蛋白H2受体（H2R），G-蛋白偶联的七叶受体家族的成员。 这种新的H2受体编码一个新的羧基末端尾巴，其赋予受体重要的调节功能，例如在下调，信号转导和将H2R的活性与下游效应分子如G-蛋白 - 偶联受体激酶（GRK）。 本发明涉及这种新形式的H2R受体的所有方面，包括编码它的核酸，H2R多肽，与其结合的伴侣，以及其在研究，诊断，药物发现，验证和靶向治疗中的用途 和临床医学。