公开(公告)号：US06780595B2

公开(公告)日：2004-08-24

申请号：US10082272

申请日：2002-02-26

申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06Q30/0601

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.

摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等 和心脏和眼睛的条件。

公开(公告)号：US06455292B1

公开(公告)日：2002-09-24

申请号：US09930181

申请日：2001-08-16

申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

IPC分类号： C12N912

CPC分类号： C12N9/1205 ,  G01N33/573 ,  G01N2333/9121

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，其编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学中的应用。 多核苷酸在脑和胰腺中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性 对疾病和病症，特别是与脑和胰腺有关。

公开(公告)号：US07053193B2

公开(公告)日：2006-05-30

申请号：US10054935

申请日：2002-01-25

申请人： Zairen Sun ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

发明人： Zairen Sun ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

IPC分类号： C07H21/04

CPC分类号： G01N33/57415 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/4702 ,  C12Q1/6886

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.

公开(公告)号：US06953673B2

公开(公告)日：2005-10-11

申请号：US10017393

申请日：2001-12-18

申请人： Karl F. Kovacs ,  Gilbert Jay

发明人： Karl F. Kovacs ,  Gilbert Jay

IPC分类号： C07K14/72 ,  C12N15/12 ,  G01N33/74 ,  C07H21/04 ,  C07K14/00 ,  C12N15/00 ,  C12N15/63

CPC分类号： G01N33/74 ,  C07K14/723 ,  G01N2500/10

摘要： The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.

摘要翻译： 本发明涉及组蛋白H2受体（H2R），G-蛋白偶联的七叶受体家族的成员。 这种新的H2受体编码一个新的羧基末端尾巴，其赋予受体重要的调节功能，例如在下调，信号转导和将H2R的活性与下游效应分子如G-蛋白 - 偶联受体激酶（GRK）。 本发明涉及这种新形式的H2R受体的所有方面，包括编码它的核酸，H2R多肽，与其结合的伴侣，以及其在研究，诊断，药物发现，验证和靶向治疗中的用途 和临床医学。

公开(公告)号：US20050019818A1

公开(公告)日：2005-01-27

申请号：US10921807

申请日：2004-08-20

申请人： Youmin Shu ,  Wufang Fan ,  Karl Kovacs ,  Xuan Li ,  Gilbert Jay

发明人： Youmin Shu ,  Wufang Fan ,  Karl Kovacs ,  Xuan Li ,  Gilbert Jay

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/10 ,  C12P21/04

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06Q30/0601

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.

摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等 和心脏和眼睛的条件。

公开(公告)号：US06657054B1

公开(公告)日：2003-12-02

申请号：US10164595

申请日：2002-06-10

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay

IPC分类号： C07H2104

CPC分类号： C07K14/47 ,  C07K14/515

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are modulated during angiogeneis and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, determining predisposition to, etc., diseases and conditions, such as abnormal, insufficient, excessive, etc., angiogenesis, inflammatory diseases, rheumatoid arthritis, osteoarthritis, asthma, pulmonary fibrosis, age-related macular degeneration (ARMD), diabetic retinopathy, macular degeneration, and retinopathy of prematurity (ROP), endometriosis, cancer, Coats' disease, peripheral retinal neovascularization, neovascular glaucoma, psoriasis, retrolental fibroplasias, angiofibroma, inflammation, etc.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸被调节 在血管新生期间，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病等等的倾向 血管生成，炎症性疾病，类风湿性关节炎，骨关节炎，哮喘，肺纤维化，年龄相关性黄斑变性（ARMD），糖尿病等疾病和病症的易感性 视网膜病变，黄斑变性和早产儿视网膜病变（ROP），子宫内膜异位症，癌症，大衣病，外周视网膜新生血 鳞状，新生血管性青光眼，牛皮癣，复发性纤维瘤，血管纤维瘤，炎症等

公开(公告)号：US07115393B2

公开(公告)日：2006-10-03

申请号：US10164717

申请日：2002-06-10

申请人： Youmin Shu ,  Xuan Li ,  Anthony C. Yee ,  Gilbert Jay

发明人： Youmin Shu ,  Xuan Li ,  Anthony C. Yee ,  Gilbert Jay

IPC分类号： C07K14/72 ,  C12N15/12

CPC分类号： C07K14/47

摘要： The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc.

摘要翻译： 本发明涉及用于黑皮质素-1受体的新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用 多核苷酸可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病等的易感性，以及 特别是与黑皮质素-1有关的病症，如黑素瘤，色素沉着病和病症，炎症等。

公开(公告)号：US20050106579A1

公开(公告)日：2005-05-19

申请号：US10717665

申请日：2003-11-21

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay

IPC分类号： C07K14/47 ,  C07K14/515 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/475 ,  C12N9/64

CPC分类号： C07K14/47 ,  C07K14/515

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are modulated during angiogeneis and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, determining predisposition to, etc., diseases and conditions, such as abnormal, insufficient, excessive, etc., angiogenesis, inflammatory diseases, rheumatoid arthritis, osteoarthritis, asthma, pulmonary fibrosis, age-related macular degeneration (ARMD), diabetic retinopathy, macular degeneration, and retinopathy of prematurity (ROP), endometriosis, cancer, Coats' disease, peripheral retinal neovascularization, neovascular glaucoma, psoriasis, retrolental fibroplasias, angiofibroma, inflammation, etc.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸被调节 在血管新生期间，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病等等的倾向 血管生成，炎症性疾病，类风湿性关节炎，骨关节炎，哮喘，肺纤维化，年龄相关性黄斑变性（ARMD），糖尿病等疾病和病症的易感性 视网膜病变，黄斑变性和早产儿视网膜病变（ROP），子宫内膜异位症，癌症，大衣病，外周视网膜新生血 鳞状，新生血管性青光眼，牛皮癣，复发性纤维瘤，血管纤维瘤，炎症等

公开(公告)号：US20050069886A1

公开(公告)日：2005-03-31

申请号：US10494940

申请日：2002-11-07

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways. including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌中有调节作用，因此在各种方面都是有用的。 包括但不限于作为药物靶标的分子标记，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定前列腺癌的疾病和病症等等。

公开(公告)号：US20060241015A1

公开(公告)日：2006-10-26

申请号：US10502394

申请日：2003-01-24

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan ,  Youmin Shu

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan ,  Youmin Shu

IPC分类号： A61K38/17 ,  G06Q10/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136 ,  G06Q50/22 ,  Y02A90/22 ,  Y02A90/26

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌和乳腺癌中表达，因此可用于多种方式，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性， 等等，癌症。