公开(公告)号：US20130023649A1

公开(公告)日：2013-01-24

申请号：US13519842

申请日：2010-12-30

申请人： Karsten Keller ,  Darrell Marsh ,  Charles Schasteen ,  Barry Tulk ,  Marlene Mekel ,  Jennifer Wu

发明人： Karsten Keller ,  Darrell Marsh ,  Charles Schasteen ,  Barry Tulk ,  Marlene Mekel ,  Jennifer Wu

IPC分类号： C07K1/14 ,  C07K1/26 ,  C07K1/30 ,  C07K1/36 ,  C07K1/16 ,  C07K1/34

CPC分类号： A23L33/185 ,  A23J1/14 ,  A23J3/16 ,  C07K14/415 ,  C07K14/811

摘要： A process for recovering and isolating a KTI product having a total KTI protein concentration of at least 95 wt. % from a processing stream is disclosed.

摘要翻译： 用于回收和分离具有至少95重量％的总KTI蛋白质浓度的KTI产物的方法。 公开了来自处理流的％。

公开(公告)号：US20050089975A1

公开(公告)日：2005-04-28

申请号：US10886863

申请日：2004-07-08

申请人： Steve Lorbert ,  Charles Schasteen ,  Farooq Uraizee ,  Jennifer Wu

发明人： Steve Lorbert ,  Charles Schasteen ,  Farooq Uraizee ,  Jennifer Wu

IPC分类号： A61K31/198 ,  C12P20060101 ,  C12P13/12

CPC分类号： C12P13/12

摘要： The present invention relates to a method of making a methionine preparation, for example for an animal feed additive. The invention also related to methods for increasing the solubility of a methionine preparation.

摘要翻译： 本发明涉及制备例如用于动物饲料添加剂的甲硫氨酸制备方法。 本发明还涉及增加甲硫氨酸制剂的溶解度的方法。

公开(公告)号：US20050009158A1

公开(公告)日：2005-01-13

申请号：US10795790

申请日：2004-03-08

申请人： Arindam Roy ,  Shubhender Kapila ,  Paul Nam ,  Virgil Flanigan ,  Stephen Lorbert ,  Charles Schasteen

发明人： Arindam Roy ,  Shubhender Kapila ,  Paul Nam ,  Virgil Flanigan ,  Stephen Lorbert ,  Charles Schasteen

IPC分类号： A23K1/16 ,  A23K1/18 ,  C12P7/42 ,  C12P41/00

CPC分类号： C12P7/42 ,  A23K20/105 ,  A23K20/147 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  C12P41/005

摘要： The present invention relates to a process for resolving an enantiomeric mixture of a-hydroxy acids or derivatives thereof through esterification and subsequent enzymatic hydrolysis of the α-hydroxy acids or derivatives. The present invention also relates to purified α-hydroxy acids or derivatives and methods of use thereof.

摘要翻译： 本发明涉及通过酯化和随后的α-羟基酸或衍生物的酶水解来拆分α-羟基酸或其衍生物的对映体混合物的方法。 本发明还涉及纯化的α-羟基酸或其衍生物及其使用方法。

公开(公告)号：US20070196448A1

公开(公告)日：2007-08-23

申请号：US11219558

申请日：2005-09-02

申请人： Stephen Lorbert ,  Charles Schasteen ,  Paul Nam ,  Daniel Forciniti ,  Mathur Rajesh ,  Shubhender Kapila

发明人： Stephen Lorbert ,  Charles Schasteen ,  Paul Nam ,  Daniel Forciniti ,  Mathur Rajesh ,  Shubhender Kapila

IPC分类号： A23K1/165 ,  C12P21/06 ,  C12P7/62

CPC分类号： C07K7/06 ,  A23K20/105 ,  A23K20/142 ,  A23K20/147 ,  A23K20/189 ,  A23K50/00 ,  A23K50/10 ,  A23K50/80 ,  C07K2/00 ,  C12P21/00

摘要： An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.

公开(公告)号：US20070010583A1

公开(公告)日：2007-01-11

申请号：US11441490

申请日：2006-05-25

申请人： Julia Dibner ,  Charles Schasteen ,  Mercedes Vazquez-Anon

发明人： Julia Dibner ,  Charles Schasteen ,  Mercedes Vazquez-Anon

IPC分类号： A61K31/19

CPC分类号： A61K31/19

摘要： The invention provides methods for reducing blood homocysteine levels in mammals, and treating or preventing diseases associated with elevated blood homocysteine levels, such as cardiovascular diseases and cognitive disorders. The invention also provides nutritional and pharmaceutical compositions comprising 2-hydroxy-4-(thiomethyl)-butanoic acid, including esters, analogs, derivatives or complex thereof.

摘要翻译： 本发明提供了降低哺乳动物血液中同型半胱氨酸水平的方法，以及治疗或预防与升高的血液同型半胱氨酸水平相关的疾病，如心血管疾病和认知障碍。 本发明还提供包含2-羟基-4-（硫代甲基） - 丁酸的营养和药物组合物，包括酯，类似物，衍生物或复合物。

公开(公告)号：US20050250849A1

公开(公告)日：2005-11-10

申请号：US11119252

申请日：2005-04-29

申请人： Steve Lorbert ,  Charles Schasteen ,  Farooq Uraizee

发明人： Steve Lorbert ,  Charles Schasteen ,  Farooq Uraizee

IPC分类号： A61K31/205

CPC分类号： A23K20/142 ,  A23L33/175

摘要： Simple, cost-effective and convenient compositions comprising basic amino acids and 2-hydroxy-4-methylthiobutanoic acid (HMBA) are disclosed. The compositions have many uses, including as food supplements for animal and human food.

摘要翻译： 公开了包含碱性氨基酸和2-羟基-4-甲硫基丁酸（HMBA）的简单，成本有效且方便的组合物。 该组合物具有许多用途，包括作为动物和人类食物的食品添加剂。

公开(公告)号：US20060287543A1

公开(公告)日：2006-12-21

申请号：US11413529

申请日：2006-04-28

申请人： Michael Trehy ,  Thomas Blackburn ,  John Hume ,  Charles Schasteen

发明人： Michael Trehy ,  Thomas Blackburn ,  John Hume ,  Charles Schasteen

IPC分类号： C07F3/02 ,  C07F3/08

CPC分类号： C07C319/28 ,  C07C323/52

摘要： Disclosed herein are processes for purifying a complex of 2-hydroxy-4-(methylthio)butanoic acid and a cation. The complex purified using the disclosed methods are substantially free of discoloration and can be suitable, for example, as a source of methionine and minerals for animals, including humans, companion animals and agricultural animals.

摘要翻译： 本文公开了纯化2-羟基-4-（甲硫基）丁酸和阳离子的络合物的方法。 使用所公开的方法纯化的复合物基本上没有变色，并且可以适合于例如用于动物（包括人类，伴侣动物和农业动物）的蛋氨酸和矿物质来源。

公开(公告)号：US20060252134A1

公开(公告)日：2006-11-09

申请号：US11300355

申请日：2005-12-14

申请人： Steve Lorbert ,  Charles Schasteen ,  Farooq Uraizee ,  Shubhender Kapila

发明人： Steve Lorbert ,  Charles Schasteen ,  Farooq Uraizee ,  Shubhender Kapila

IPC分类号： C12P13/04 ,  C12P13/24 ,  C12P13/22

CPC分类号： C12P13/04 ,  C12P41/005

摘要： An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.