公开(公告)号：US20130017575A1

公开(公告)日：2013-01-17

申请号：US13298407

申请日：2011-11-17

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T.L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T.L. Smith

IPC分类号： C12N15/13 ,  C12N15/63 ,  C12N1/19 ,  C12N7/01 ,  C12P21/02 ,  C12N1/21 ,  C12N15/62 ,  C12N5/10

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/60 ,  C12N9/64 ,  C12N15/81 ,  C12P21/02

摘要： The invention relates to nucleic acids encoding antibody or antibody fragments that specifically binds to an epitope on an intact human IL-6 polypeptide, which epitope when ascertained by epitopic mapping includes one or more residues comprised in each of the following IL-6 fragments (i) a fragment consisting of amino acid residues 37-51 of human Il-6, (ii) a fragment consisting of amino acid residues 70-84 of human Il-6, (iii) a fragment consisting of amino acid residues 169-183 of human Il-6, (iv) a fragment consisting of amino acid residues 31-45 of human Il-6 and (v) a fragment consisting of amino acid residues 58-72 of human IL-6.

摘要翻译： 本发明涉及编码与完整人IL-6多肽特异性结合表位的抗体或抗体片段的核酸，当通过表位作图确定时，该表位包括一个或多个残基，其包含在以下IL-6片段（i ）由人类II-6的氨基酸残基37-51组成的片段，（ii）由人类II-6的氨基酸残基70-84组成的片段，（iii）由氨基酸残基169-183 人II-6，（iv）由人IL-6的氨基酸残基31-45组成的片段和（v）由人IL-6的氨基酸残基58-72组成的片段。

公开(公告)号：US07935340B2

公开(公告)日：2011-05-03

申请号：US12153612

申请日：2008-05-21

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

IPC分类号： A61K39/395 ,  C07K16/24 ,  C12P21/08

CPC分类号： C07K16/248 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/94

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

公开(公告)号：US09056905B2

公开(公告)日：2015-06-16

申请号：US12153611

申请日：2008-05-21

申请人： Katie Olson ,  Ben Dutzar ,  Anne Elisabeth Carvalho Jensen ,  Leon Garcia-Martinez ,  Ethan Ojala ,  John Latham

发明人： Katie Olson ,  Ben Dutzar ,  Anne Elisabeth Carvalho Jensen ,  Leon Garcia-Martinez ,  Ethan Ojala ,  John Latham

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10

CPC分类号： C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6815 ,  A61K47/6845 ,  A61K49/0002 ,  A61K49/001 ,  A61K51/1021 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/622

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for TNF-α. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-TNF-α antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-TNF-α antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-TNF-α antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with TNF-α.

摘要翻译： 本发明涉及对TNF-α具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗TNF-α抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗TNF-α抗体及其结合片段的方法。 本发明的实施方案还涉及抗TNF-α抗体及其结合片段用于诊断，评估和治疗与TNF-α相关的疾病和病症的用途。

公开(公告)号：US08323649B2

公开(公告)日：2012-12-04

申请号：US12502581

申请日：2009-07-14

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

IPC分类号： A61K38/20 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/39533 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/412

摘要： The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

摘要翻译： 本发明涉及使用IL-6拮抗剂例如Ab1抗体或对IL-6具有结合特异性的抗体片段来预防或治疗疾病或改善有需要的患者的生存能力或生活质量的治疗方法。 在优选实施方案中，这些患者将包括显示（或有发展风险）升高的血清C-反应蛋白水平，降低的血清白蛋白水平，升高的D-二聚体或其他凝血级联相关蛋白，恶病质，发热，虚弱和 /或治疗前的疲劳。 主题疗法还可以包括施用其它活性物质，例如化学治疗剂，抗凝血剂，他汀类药物等。

公开(公告)号：US20110293622A1

公开(公告)日：2011-12-01

申请号：US13152603

申请日：2011-06-03

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T.L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T.L. Smith

IPC分类号： A61K39/395 ,  G01N33/566 ,  C40B30/04 ,  C07K16/24

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/60 ,  C12N9/64 ,  C12N15/81 ,  C12P21/02

摘要： The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段和人源化形式。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

公开(公告)号：US09758579B2

公开(公告)日：2017-09-12

申请号：US13152603

申请日：2011-06-03

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

IPC分类号： C07K16/24 ,  C12P21/04 ,  C07H21/04 ,  A61K39/395 ,  C12N15/00 ,  C12N5/00 ,  C12N9/64 ,  C12N9/60 ,  C12N15/81 ,  C12P21/02 ,  A61K39/00

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/60 ,  C12N9/64 ,  C12N15/81 ,  C12P21/02

摘要： The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

公开(公告)号：US08062864B2

公开(公告)日：2011-11-22

申请号：US12366567

申请日：2009-02-05

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

IPC分类号： C07K16/24 ,  C12P21/08 ,  C07H21/04 ,  A61K39/395

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/60 ,  C12N9/64 ,  C12N15/81 ,  C12P21/02

摘要： The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段和人源化形式。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

公开(公告)号：US20090022659A1

公开(公告)日：2009-01-22

申请号：US12153611

申请日：2008-05-21

申请人： Katie Olson ,  Ben Dutzar ,  Anne Elisabeth Carvalho Jensen ,  Leon Garcia - Martinez ,  Ethan Ojala ,  John Latham

发明人： Katie Olson ,  Ben Dutzar ,  Anne Elisabeth Carvalho Jensen ,  Leon Garcia - Martinez ,  Ethan Ojala ,  John Latham

IPC分类号： A61K51/00 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04 ,  A61P37/00 ,  C12N1/19 ,  C12N1/20 ,  A61K39/395 ,  A61K49/00

CPC分类号： C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6815 ,  A61K47/6845 ,  A61K49/0002 ,  A61K49/001 ,  A61K51/1021 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/622

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for TNF-α. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-TNF-α antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-TNF-α antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-TNF-α antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with TNF-α.

摘要翻译： 本发明涉及对TNF-α具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了与一个或多个功能或可检测部分缀合的抗TNF-α抗体及其结合片段的缀合物。 本发明还考虑制备所述抗TNF-α抗体及其结合片段的方法。 本发明的实施方案还涉及抗TNF-α抗体及其结合片段用于诊断，评估和治疗与TNF-α相关的疾病和病症的用途。

公开(公告)号：US20120142900A1

公开(公告)日：2012-06-07

申请号：US13277390

申请日：2011-10-20

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

IPC分类号： C07K16/24

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76

摘要： The present invention relates to anti-IL-6 antibodies and antibody fragments having a particular epitopic specificity. These antibodies and antibody fragments have clinical therapeutic and diagnostic applications in treating and detecting disease conditions wherein Il-6 levels are elevated.

摘要翻译： 本发明涉及具有特定表位特异性的抗IL-6抗体和抗体片段。 这些抗体和抗体片段在治疗和检测其中Il-6水平升高的疾病状况方面具有临床治疗和诊断应用。

公开(公告)号：US20090297513A1

公开(公告)日：2009-12-03

申请号：US12391717

申请日：2009-02-24

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T.L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T.L. Smith

IPC分类号： A61K39/395 ,  C07K16/24 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76

摘要： The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段和人源化形式。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。