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公开(公告)号：US4145609A
公开(公告)日：1979-03-20
申请号：US744157
申请日：1976-11-22
申请人： Katsumi Takami , Ken Ueda , Fumio Kawaguchi , Teruichi Tomura , Kenji Ishimatsu
发明人： Katsumi Takami , Ken Ueda , Fumio Kawaguchi , Teruichi Tomura , Kenji Ishimatsu
CPC分类号： G01T1/1642
摘要： A scintillator for a gamma ray camera constituted by a crystal of NaI (Tl) having a surface roughness of less than 400 grit and a thickness of less than approximately 9 mm.
摘要翻译： 一种由具有小于400粒度的表面粗糙度和小于约9mm的厚度的NaI（T1）晶体构成的γ射线照相机的闪烁体。
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公开(公告)号：US4090081A
公开(公告)日：1978-05-16
申请号：US709384
申请日：1976-07-28
申请人： Katsumi Takami , Ken Ueda , Fumio Kawaguchi , Teruichi Tomura , Kenji Ishimatsu
发明人： Katsumi Takami , Ken Ueda , Fumio Kawaguchi , Teruichi Tomura , Kenji Ishimatsu
CPC分类号： G01T1/1642
摘要： A scintillator for a gamma ray camera includes a pair of crystals mechanically pressed together. The surfaces of the crystals are roughened so as to form a photo-diffuser for the light generated as a result of scintillation.
摘要翻译： 用于γ射线照相机的闪烁体包括一对机械地压在一起的晶体。 晶体的表面被粗糙化，以形成由于闪烁而产生的光的光漫射体。
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公开(公告)号：US20090118602A1
公开(公告)日：2009-05-07
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/1455
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译： 提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分， 包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中 显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为 在散点图上进行评估，叠加在散点图上。 利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。
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公开(公告)号：US07228166B1
公开(公告)日：2007-06-05
申请号：US10049313
申请日：2000-09-13
IPC分类号： A61B6/00
CPC分类号： A61B5/4094 , A61B5/0073 , A61B5/064 , A61B5/6814
摘要： A biological light measuring instrument for illuminating a subject with a plurality of beams of light from a plurality of illuminating positions, measuring the light beams transmitted through the subject, and creating a topographic image showing ecological information about the inside of the subject, comprising unit for creating three-dimensional coordinate data representing the relationship among the illuminating positions and a reference point on the subject and the relationship between the light measuring position and the reference point, unit for setting the illuminating positions and light measuring position on a three-dimensional shape image of the subject according to the three-dimensional coordinate data, and unit for creating a three-dimensional topographic image according to the three-dimensional coordinate data, and unit for superposing the three-dimensional topographic image on the shape image while maintaining the relationships of the illuminating positions and the light measuring position.
摘要翻译： 一种生物光测量仪器，用于利用来自多个照明位置的多个光束照射被检体，测量透过被检体的光束，以及创建显示关于被检体内部的生态信息的地形图像，其包括： 生成表示被检体的照明位置和基准点之间的关系的三维坐标数据以及光测量位置与基准点之间的关系，用于设置三维形状图像上的照明位置和光测量位置的单元 以及根据三维坐标数据创建三维地形图像的单元，以及用于将三维地形图像叠加在形状图像上的单元，同时保持三维坐标数据的关系 照明位置和灯m 确定位置
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公开(公告)号：US20050171440A1
公开(公告)日：2005-08-04
申请号：US11037338
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
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公开(公告)号：US06282438B1
公开(公告)日：2001-08-28
申请号：US09203610
申请日：1998-12-02
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在生物体的表面上的不同位置处被测量。 在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向 延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。 在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在， 并且可以通过检测设置在被摄体上不同的两个位置（等于光入射点的位置）的两个光检测器检测通过生物体的内部的光线，并且仅分离本地 根据两个检测信号之间的对数差异，从生物体的血液动力学运动的总体变化中改变血流动力学运动。
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公开(公告)号：US5190039A
公开(公告)日：1993-03-02
申请号：US622607
申请日：1990-12-05
申请人： Hiroshi Takeuchi , Fumio Kawaguchi , Yuichi Yamashita , Kazuo Takeda , Yoshitoshi Ito , Yasuhiro Mitsui , Keiichi Nagai
发明人： Hiroshi Takeuchi , Fumio Kawaguchi , Yuichi Yamashita , Kazuo Takeda , Yoshitoshi Ito , Yasuhiro Mitsui , Keiichi Nagai
CPC分类号： A61B5/01 , A61B5/055 , A61B5/14539 , A61B5/14553 , G01R33/4804
摘要： An apparatus and a method for non-invasively measuring oxygen partial pressure in a living body in which light is thrown on a living body to be measured, the oxygen saturation of the living body is obtained from the light absorption spectrum or light scattering spectrum thereof, the temperature and/or pH of the living body is obtained from a nuclear magnetic resonance signal from the living body, and the oxygen partial pressure in the living body, useful for the diagnosis thereof, is determined on the basis of not only the oxygen saturation but also the temperature and/or pH of the living body.
摘要翻译： 从光的吸收光谱或光散射光谱获得生物体的氧饱和度的非活性测定生物体中的氧分压的装置和方法， 从生物体的核磁共振信号得到生物体的温度和/或pH值，根据生物体内的氧饱和度判定生物体的氧分压， 还有生物体的温度和/或pH值。
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公开(公告)号：US07353054B2
公开(公告)日：2008-04-01
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译： 提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。 疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。 通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估该疾病，并且通过应用提取的特征量和存储在存储器中的特征量的特征量之间的相似性的多变量分析来评估疾病 单位12.评估结果以条形图表示与各疾病组相似度的分数。
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公开(公告)号：US07286870B2
公开(公告)日：2007-10-23
申请号：US09900144
申请日：2001-07-09
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US06611698B1
公开(公告)日：2003-08-26
申请号：US09807478
申请日：2001-05-24
申请人： Yuichi Yamashita , Atsushi Maki , Fumio Kawaguchi
发明人： Yuichi Yamashita , Atsushi Maki , Fumio Kawaguchi
IPC分类号： A61B500
CPC分类号： A61B5/14553 , A61B5/00 , A61B2562/02 , A61B2562/046 , G01N21/49
摘要： A highly reliable optical measuring instrument for multi-channel simultaneous measurement has an intensity of light emitted from a light source modulated at different frequencies and the light is applied to multiple positions of a test object. The light which is detected from the test object is converted into electric signals by a photodiode, and modulation signals are detected by a lock-in amplifier module. The signals are processed as information on the test object interior by a processing unit. Light is applied sequentially from a light source in a preparatory measurement step prior to final measuring, and the signal level of the detection light is measured for each light applied position. A control unit controls light intensity and detection signal level to ensure that the difference in detection light levels is kept within a specified range.
摘要翻译： 用于多通道同时测量的高度可靠的光学测量仪器具有从以不同频率调制的光源发射的光的强度，并且将光施加到测试对象的多个位置。 从测试对象检测到的光由光电二极管转换为电信号，调制信号由锁定放大器模块检测。 这些信号由处理单元作为测试对象内部的信息进行处理。 在最终测量之前的准备测量步骤中从光源顺序地施加光，并且针对每个施加位置测量检测光的信号电平。 控制单元控制光强度和检测信号电平，以确保检测光水平的差异保持在指定范围内。
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