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公开(公告)号：US5494790A
公开(公告)日：1996-02-27
申请号：US309985
申请日：1994-09-20
申请人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
CPC分类号： C12N9/1081
摘要： There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译： 提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶，编码α2-> 3唾液酸转移酶的cDNA，通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法 所述cDNA是含有所述cDNA的重组载体，含有所述载体的细胞及其制备方法。
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公开(公告)号：US5384249A
公开(公告)日：1995-01-24
申请号：US991587
申请日：1992-12-16
申请人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
CPC分类号： C12N9/1081
摘要： There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译： 提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶，编码α2-> 3唾液酸转移酶的cDNA，通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法 所述cDNA是含有所述cDNA的重组载体，含有所述载体的细胞及其制备方法。
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公开(公告)号：US20060246468A1
公开(公告)日：2006-11-02
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译： 本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法， 涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。 本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。
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公开(公告)号：US07709234B2
公开(公告)日：2010-05-04
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译： 本发明提供由动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法， 涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。 本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。
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公开(公告)号：US06596523B1
公开(公告)日：2003-07-22
申请号：US08361304
申请日：1994-11-29
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N910
CPC分类号： C12N9/1081
摘要： The invention provides a novel &agr;-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the &agr;-2,8-sialyltransferase, a method of detecting, or suppressing the production of &agr;-2,8-sialyltransferase by using the cDNA, a recombinant vector containing the DNA as an insert and cells harboring the recombinant vector as well as methods of preparing same. The &agr;-2,8-sialyltransferase of the invention is useful, for example, in the production of carbohydrate chains having a useful physiological activity, for example the ganglioside GD3, and modifications thereof.
摘要翻译： 本发明提供由从动物细胞克隆的基因表达的新型α-2,8-唾液酸转移酶，编码α-2,8-唾液酸转移酶的cDNA，检测或抑制α-2,8-唾液酸转移酶的产生的方法， 唾液酸转移酶，使用含有DNA作为插入片段的重组载体和携带重组载体的细胞以及其制备方法。 本发明的α-2,8-唾液酸转移酶可用于例如生产具有有用生理活性的糖链，例如神经节苷脂GD3及其修饰。
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公开(公告)号：US07094530B1
公开(公告)日：2006-08-22
申请号：US08361306
申请日：1994-11-29
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译： 本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法， 涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。 本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。
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公开(公告)号：US07163791B2
公开(公告)日：2007-01-16
申请号：US10430325
申请日：2003-05-07
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
CPC分类号： C12N9/1081
摘要： The invention provides a novel α-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-2,8-sialyltransferase, a method of detecting, or suppressing the production of α-2,8-sialyltransferase by using the cDNA, a recombinant vector containing the DNA as an insert and cells harboring the recombinant vector as well as methods of preparing same. The α-2,8-sialyltransferase of the invention is useful, for example, in the production of carbohydrate chains having a useful physiological activity, for example the ganglioside GD3, and modifications thereof.
摘要翻译： 本发明提供由从动物细胞克隆的基因表达的新型α-2,8-唾液酸转移酶，编码α-2,8-唾液酸转移酶的cDNA，检测或抑制α-2,8-唾液酸转移酶的产生的方法， 唾液酸转移酶，使用含有DNA作为插入片段的重组载体和携带重组载体的细胞以及其制备方法。 本发明的α-2,8-唾液酸转移酶可用于例如生产具有有用生理活性的糖链，例如神经节苷脂GD3及其修饰。
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公开(公告)号：US20060058512A1
公开(公告)日：2006-03-16
申请号：US11228319
申请日：2005-09-19
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/3084 , A61K38/00 , A61K2039/505 , C07K16/18 , C07K16/462 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02
摘要： A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of the humanized chimera antibody, are disclosed.
摘要翻译： 公开了人源化嵌合体抗体，包含人源化嵌合体抗体和药学上可接受的载体的药物组合物，以及治疗癌症的方法，其包括向患者施用药学上可接受量的人源化嵌合体抗体。
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公开(公告)号：US5939532A
公开(公告)日：1999-08-17
申请号：US483528
申请日：1995-06-07
申请人： Kazuyasu Nakamura , Masamichi Koike , Kenya Shitara , Nobuo Hanai , Yoshihisa Kuwana , Mamoru Hasegawa
发明人： Kazuyasu Nakamura , Masamichi Koike , Kenya Shitara , Nobuo Hanai , Yoshihisa Kuwana , Mamoru Hasegawa
CPC分类号： C07K16/18 , C07K16/464 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： Chimeric human antibody expression vectors are constructed by inserting the antibody heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from hybridomas producing a mouse or rat monoclonal antibody reacting with the ganglioside GM.sub.2 respectively into an expression vector for use in animal cells which contains the human antibody heavy chain constant region- or human antibody light chain constant region-encoding cDNA. The expression vectors are introduced into animal cells and the transformant thus obtained is cultured for the production of a chimeric human antibody reacting with the ganglioside GM.sub.2. In contrast to mouse monoclonal antibodies, the chimeric human antibodies of the invention will not cause anti-mouse immunoglobulin antibody production in the patient's body but shows a prolonged blood half-life, with a reduced frequency of adverse effects, so that it can be expected to be superior to mouse monoclonal antibodies in the efficacy in the treatment of human cancer, for instance.
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公开(公告)号：US06965024B2
公开(公告)日：2005-11-15
申请号：US10265713
申请日：2002-10-08
IPC分类号： A61K36/00 , A61K38/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/32 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/13 , C12N15/62 , C12P21/08 , C12R1/91 , C07H21/04
CPC分类号： C07K16/3084 , A61K38/00 , A61K2039/505 , C07K16/18 , C07K16/462 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02
摘要： A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of said humanized chimera antibody, are disclosed.
摘要翻译： 人源化嵌合体抗体，包含人源化嵌合体抗体和药学上可接受的载体的药物组合物，以及治疗癌症的方法，其包括向患者施用药学上可接受量的所述人源化嵌合体抗体。
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