公开(公告)号：US20140154717A1

公开(公告)日：2014-06-05

申请号：US14007105

申请日：2012-03-29

申请人： Katsuya Yamada ,  Hirotaka Onoe ,  Tadashi Teshima ,  Toshihiro Yamamoto

发明人： Katsuya Yamada ,  Hirotaka Onoe ,  Tadashi Teshima ,  Toshihiro Yamamoto

IPC分类号： G01N33/50

CPC分类号： G01N33/5091 ,  A61K49/0052 ,  A61K49/0054 ,  G01N21/6428 ,  G01N33/574 ,  G01N33/582 ,  G01N2800/7028

摘要： The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient.

摘要翻译： 本发明的目的是提供一种高精度地检测癌细胞的方法。 本发明的方法的特征在于包括使用荧光标记的L-葡萄糖衍生物成像。 通过使用根据本发明的方法和成像剂，与使用荧光标记的D-葡萄糖衍生物进行成像的情况相比，可以获得癌细胞与正常细胞之间的高对比度。 此外，根据该方法，不需要空腹进行测定。 因此，可以快速地进行成像，而不会对患者造成负担。

公开(公告)号：US08986656B2

公开(公告)日：2015-03-24

申请号：US13058061

申请日：2009-08-07

申请人： Katsuya Yamada ,  Hideaki Matsuoka ,  Tadashi Teshima ,  Toshihiro Yamamoto

发明人： Katsuya Yamada ,  Hideaki Matsuoka ,  Tadashi Teshima ,  Toshihiro Yamamoto

IPC分类号： G01N33/58 ,  G01N33/50 ,  C12Q1/54 ,  C12Q1/02 ,  G01N33/533

CPC分类号： G01N33/582 ,  C09B51/00 ,  C09B57/00 ,  C12Q1/02 ,  C12Q1/54 ,  G01N33/5005 ,  G01N33/533

摘要： An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.

摘要翻译： 本发明的目的是提供一种用于精确评估D-葡萄糖在细胞中的特异性掺入的方法。 作为实现该目的的手段的本发明的特征在于，使分子中具有荧光发色团的D-葡萄糖衍生物与细胞特异性结合，并且在分子中具有荧光发色团的L-葡萄糖衍生物不同 分别将待分析的具有荧光发色团的D-葡萄糖衍生物发射的荧光发射到具有荧光的L-葡萄糖衍生物发射的荧光的细胞中进行评价的细胞， 并且通过取两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖的细胞特异性掺入细胞。

公开(公告)号：US20110189708A1

公开(公告)日：2011-08-04

申请号：US13058061

申请日：2009-08-07

申请人： Katsuya Yamada ,  Hideaki Matsuoka ,  Tadashi Teshima ,  Toshihiro Yamamoto

发明人： Katsuya Yamada ,  Hideaki Matsuoka ,  Tadashi Teshima ,  Toshihiro Yamamoto

IPC分类号： C12Q1/54 ,  C07H15/26 ,  C07H15/18 ,  C07H1/00 ,  C07H5/06

CPC分类号： G01N33/582 ,  C09B51/00 ,  C09B57/00 ,  C12Q1/02 ,  C12Q1/54 ,  G01N33/5005 ,  G01N33/533

摘要： An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.

摘要翻译： 本发明的目的是提供一种用于精确评估D-葡萄糖在细胞中的特异性掺入的方法。 作为实现该目的的手段的本发明的特征在于，使分子中具有荧光发色团的D-葡萄糖衍生物与细胞特异性结合，并且在分子中具有荧光发色团的L-葡萄糖衍生物不同 分别将待分析的具有荧光发色团的D-葡萄糖衍生物发射的荧光发射到具有荧光的L-葡萄糖衍生物发射的荧光的细胞中进行评价的细胞， 并且通过取两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖的细胞特异性掺入细胞。

公开(公告)号：US08815416B2

公开(公告)日：2014-08-26

申请号：US12746260

申请日：2008-12-24

申请人： Takahiro Kai ,  Junya Ogawa ,  Toshihiro Yamamoto

发明人： Takahiro Kai ,  Junya Ogawa ,  Toshihiro Yamamoto

IPC分类号： H01L51/54 ,  C09K11/06

CPC分类号： H01L51/0067 ,  C07D239/26 ,  C07D239/42 ,  C07D239/48 ,  C07D401/14 ,  C07D403/14 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1044 ,  H01L51/0085 ,  H01L51/5016 ,  H05B33/14

摘要： Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and of simple constitution. Also disclosed is a compound useful for the fabrication of said organic electroluminescent device. This compound for organic electroluminescent device is a bipyrimidyl compound which has a basic skeleton of 2,2′-bipyrimidyl and is substituted by an aromatic hydrocarbon group, an aromatic heterocyclic group, or a substituted amino group. The aforementioned organic electroluminescent device has a light-emitting layer between an anode and a cathode which are piled one upon another on a substrate and the light-emitting layer contains a phosphorescent dopant and the aforementioned bipyrimidyl compound as a host material.

摘要翻译： 公开了一种提高发光效率，完全确保驱动稳定性和简单结构的有机电致发光器件（有机EL器件）。 还公开了可用于制造所述有机电致发光器件的化合物。 该有机电致发光元件用化合物是具有2,2'-联嘧啶基的基本骨架并被芳香族烃基，芳香族杂环基或取代氨基取代的二嘧啶基化合物。 上述有机电致发光器件具有在基板上彼此堆叠的阳极和阴极之间的发光层，并且发光层含有磷光掺杂剂和上述双嘧啶基化合物作为主体材料。

公开(公告)号：US08389131B2

公开(公告)日：2013-03-05

申请号：US13255193

申请日：2010-03-24

申请人： Takahiro Kai ,  Masaki Komori ,  Toshihiro Yamamoto ,  Megumi Matsumoto

发明人： Takahiro Kai ,  Masaki Komori ,  Toshihiro Yamamoto ,  Megumi Matsumoto

IPC分类号： H01L51/50

CPC分类号： H01L51/0072 ,  C07D487/04 ,  C07D487/22 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1059 ,  H01L51/0067 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/5016 ,  H05B33/14

摘要： Provided is an organic electroluminescent device (organic EL device), in which the luminous efficiency of the device is improved, driving stability is sufficiently ensured, and the construction of the device is simple. This organic EL device is an organic electroluminescent device, including a light-emitting layer between an anode and a cathode laminated on a substrate, in which the light-emitting layer contains a phosphorescent light-emitting dopant and an indolocarbazole compound as a host material. Examples of the indolocarbazole compound include a compound represented by the following formula (1). It should be noted that in the formulae: a ring A and a ring B are represented by the formulae (1a) and (1b), respectively; Ar's each represent an aromatic hydrocarbon group or an aromatic heterocyclic group; R's each represent a hydrogen atom, an alkyl group, or a cycloalkyl group; X represents a methine group or a nitrogen atom; A represents an aromatic hydrocarbon group, an alkyl group, a cycloalkyl group, or a group represented by the formula (1c); and n represents 0 or 1.

摘要翻译： 提供了一种有机电致发光器件（有机EL器件），其中器件的发光效率提高，充分确保了驱动稳定性，并且器件的构造简单。 这种有机EL器件是一种有机电致发光器件，其包括层叠在基板上的阳极和阴极之间的发光层，其中发光层含有磷光发光掺杂剂和作为主体材料的吲哚咔唑化合物。 吲哚咔唑化合物的实例包括由下式（1）表示的化合物。 应该注意的是，在下式中：环A和环B分别由式（1a）和（1b）表示： Ar各自表示芳香族烃基或芳香族杂环基; R各自表示氢原子，烷基或环烷基; X表示次甲基或氮原子; A表示芳香族烃基，烷基，环烷基或式（1c）所示的基团。 n表示0或1。

公开(公告)号：US20120001165A1

公开(公告)日：2012-01-05

申请号：US13256363

申请日：2010-03-25

申请人： Masaki Komori ,  Takahiro Kai ,  Toshihiro Yamamoto

发明人： Masaki Komori ,  Takahiro Kai ,  Toshihiro Yamamoto

IPC分类号： H01L51/54 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D403/14 ,  C09K11/06 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/1059 ,  H01L51/0058 ,  H01L51/0072 ,  H01L51/5016 ,  H05B33/14 ,  Y10S428/917

摘要： Provided is an organic electroluminescent device (organic EL device), which has improved luminous efficiency, has sufficient driving stability, and has a simple construction. The organic EL device of the present invention is an organic electroluminescent device, including a light-emitting layer and a hole-transporting layer between an anode and a cathode laminated on a substrate, in which the light-emitting layer contains a phosphorescent light-emitting dopant and an indolocarbazole compound that serves as a host material, or alternatively, the hole-transporting layer contains an indolocarbazole compound. The indolocarbazole compound is represented by the following formula (1). In the formula: A1's each represent an aromatic hydrocarbon group or an aromatic heterocyclic group, provided that at least one of A1's has a fused ring structure; and R1's each represent a hydrogen atom, an alkyl group, an alkoxy group, or an acyl group.

摘要翻译： 提供了一种有机电致发光器件（有机EL器件），其具有改善的发光效率，具有足够的驱动稳定性，并且具有简单的结构。 本发明的有机EL元件是有机电致发光器件，其包括层叠在基板上的阳极和阴极之间的发光层和空穴传输层，其中发光层含有磷光发光 掺杂剂和用作主体材料的吲哚咔唑化合物，或者空穴传输层含有吲哚并咔唑化合物。 吲哚咔唑化合物由下式（1）表示。 式中，A1表示芳香族烃基或芳香族杂环基，只要A1的至少一方具有稠环结构即可。 并且R 1各自表示氢原子，烷基，烷氧基或酰基。

公开(公告)号：US20110284828A1

公开(公告)日：2011-11-24

申请号：US13146238

申请日：2010-02-25

申请人： Takahiro Kai ,  Hideki Tanaka ,  Mitsuru Suda ,  Toshihiro Yamamoto ,  Megumi Matsumoto

发明人： Takahiro Kai ,  Hideki Tanaka ,  Mitsuru Suda ,  Toshihiro Yamamoto ,  Megumi Matsumoto

IPC分类号： H01L51/54

CPC分类号： C09K11/06 ,  C07F9/58 ,  C07F9/65583 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1022 ,  C09K2211/1025 ,  C09K2211/1044 ,  C09K2211/188 ,  H01L51/0059 ,  H01L51/0061 ,  H01L51/0087 ,  H01L51/5016 ,  H01L51/5048 ,  H01L51/5096

摘要： Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of high driving stability, and of a simple structure. The organic EL device is constituted of an anode, organic layers containing a phosphorescent light-emitting layer, and a cathode piled one upon another on a substrate and a phosphine oxide derivative represented by general formula (1) is contained in a phosphorescent light-emitting layer, an electron-transporting layer, a hole-blocking layer, or an exciton-blocking layer. In general formula (1), L1 is a direct bond or an aromatic group with a valence of 1-3 and Ar1 is an aromatic group. The two Ar1 groups linked to the same nitrogen atom may form a nitrogen heterocycle and may further form a fused ring together with the said nitrogen heterocycle.

摘要翻译： 公开了一种提高发光效率，充分确保高驱动稳定性和简单结构的有机电致发光器件（有机EL器件）。 有机EL元件由阳极构成，含有磷光发光层的有机层和在基板上彼此堆叠的阴极和由通式（1）表示的氧化膦衍生物包含在磷光发光 电子传输层，空穴阻挡层或激子阻挡层。 在通式（1）中，L 1为直链或者化合价为1-3的芳基，Ar 1为芳基。 连接到相同氮原子的两个Ar 1基团可以形成氮杂环，并且可以与所述氮杂环一起进一步形成稠环。

公开(公告)号：US20110062429A1

公开(公告)日：2011-03-17

申请号：US12991129

申请日：2009-04-30

申请人： Takahiro Kai ,  Masaki Komori ,  Toshihiro Yamamoto

发明人： Takahiro Kai ,  Masaki Komori ,  Toshihiro Yamamoto

IPC分类号： H01L51/54 ,  C07D487/04 ,  C07D471/04 ,  C07D471/14

CPC分类号： C09K11/06 ,  C07D487/04 ,  C09B47/00 ,  C09B57/00 ,  C09B57/10 ,  C09B67/0033 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/185 ,  H01L51/0072 ,  H01L51/5016 ,  H05B33/20 ,  Y10S428/917

摘要： Disclosed is an organic electroluminescent device (organic EL device) that is improved in the luminous efficiency, fully secured of the driving stability, and of a simple structure and also disclosed is a compound for organic EL device useful for the said device. The compound for organic EL device is, for example, an indolocarbazole derivative represented by the following general formula (3). The organic EL device comprises a light-emitting layer disposed between an anode and a cathode piled one upon another on a substrate and the said light-emitting layer comprises a phosphorescent dopant and the aforementioned indolocarbazole derivative as a host material. In general formula (3), L is an aromatic heterocyclic group of a fused-ring structure with a valence of (n+1), Ar1 to Ar3 each is an alkyl group, an aralkyl group, or a substituted or unsubstituted aromatic hydrocarbon or aromatic heterocyclic group, and n is an integer of 0-5.

摘要翻译： 公开了提高发光效率的有机电致发光器件（有机EL器件），完全确保了驱动稳定性，并且具有简单的结构，并且还公开了一种用于所述器件的有机EL器件的化合物。 有机EL元件用化合物为例如下述通式（3）表示的吲哚咔唑衍生物。 有机EL器件包括设置在基板上彼此堆叠的阳极和阴极之间的发光层，并且所述发光层包含磷光掺杂剂和前述的吲哚并咔唑衍生物作为主体材料。 通式（3）中，L为（n + 1）化合价的稠环结构的芳香族杂环基，Ar 1〜Ar 3分别为烷基，芳烷基或取代或未取代的芳香族烃，或 芳香族杂环基，n为0〜5的整数。

公开(公告)号：US20100044695A1

公开(公告)日：2010-02-25

申请号：US12593126

申请日：2008-03-24

申请人： Takahiro Kai ,  Toshihiro Yamamoto ,  Masanori Hotta ,  Junya Ogawa

发明人： Takahiro Kai ,  Toshihiro Yamamoto ,  Masanori Hotta ,  Junya Ogawa

IPC分类号： H01L51/54 ,  C07D251/18 ,  C07D403/04 ,  C07D401/12

CPC分类号： H01L51/0067 ,  C07D251/18 ,  C07D251/22 ,  C07D251/34 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1092 ,  C09K2211/185 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0085 ,  H01L51/5016

摘要： Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and of simple constitution. Also disclosed is a compound useful for the fabrication of said organic EL device. The organic electroluminescent device comprises organic layers including a light-emitting layer disposed between an anode and a cathode which are piled one upon another on a substrate and said organic layers comprise a compound represented by general formula (1). A light-emitting layer containing a phosphorescent dopant is suitable for an organic layer comprising a compound represented by general formula (1). In general formula (1), X is CR or N; Ar1 to Ar3 each is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group; Ar2, Ar3 and the nitrogen to which Ar2 and Ar3 are joined may together form a nitrogen-containing heterocyclic ring; m and n each is an integer of 1 or 2 and the sum of m and n is 3.

摘要翻译： 公开了一种提高发光效率，完全确保驱动稳定性和简单结构的有机电致发光器件（有机EL器件）。 还公开了可用于制造所述有机EL器件的化合物。 有机电致发光器件包括有机层，其包括设置在阳极和阴极之间的发光层，它们在衬底上彼此堆叠，所述有机层包含由通式（1）表示的化合物。 含有磷光掺杂剂的发光层适用于含有通式（1）表示的化合物的有机层。 通式（1）中，X为CR或N; Ar 1〜Ar 3分别为取代或未取代的芳香族烃基或取代或未取代的芳香族杂环基; Ar 2，Ar 3和Ar 2和Ar 3所连接的氮可以一起形成含氮杂环; m和n各自为1或2的整数，m和n的和为3。

公开(公告)号：US07488200B2

公开(公告)日：2009-02-10

申请号：US11812709

申请日：2007-06-21

申请人： Toshihiro Yamamoto ,  Hirohisa Tanaka

发明人： Toshihiro Yamamoto ,  Hirohisa Tanaka

IPC分类号： H01R31/08

CPC分类号： H01R12/52 ,  H01R12/732 ,  H01R13/428

摘要： This connector assembly comprises a pair of receptacles 1, and an attachment member 2. Each receptacle comprises a housing 10, and substrate terminals 11. The attachment member 2 comprises a pair of holders 20, and connection members 21. The connection members comprise first connection members 21a and second connection members 21b. Each of the first and second connection members have, respectively, a link section 200, 210 disposed between the pair of holders, and connection terminals 201, 211 formed at both ends of the link section. The first connection members connect between the substrate terminals arranged on a side of each housing which is near the opposite housing, and the second connection members connect between the substrate terminals arranged on a side far from the opposite housing. The link section of each first connection member is disposed nearer to the printed circuit boards than the link section each second connection member.

摘要翻译： 该连接器组件包括一对插座1和连接构件2.每个插座包括壳体10和基板端子11.连接构件2包括一对保持件20和连接构件21.连接构件包括第一连接 构件21a和第二连接构件21b。 第一和第二连接构件中的每一个分别具有设置在一对保持器之间的连杆部分200,210和形成在连杆部分两端的连接端子201,211。 第一连接构件连接在布置在每个外壳的靠近相对的壳体的一侧的基板端子之间，并且第二连接构件连接在布置在远离相对壳体的一侧的基板端子之间。 每个第一连接构件的连接部分布置成比每个第二连接构件的连接部分更靠近印刷电路板。