摘要:
The present invention relates to novel quinoline derivatives and quinazoline derivatives represented by the following formula (I): ##STR1## [wherein R.sub.1 and R.sub.2 are each independently H or C.sub.1 -C.sub.4 -alkyl, or R.sub.1 and R.sub.2 together form C.sub.1 -C.sub.3 -alkylene, X is O, S or CH.sub.2, W is CH or N, and Q is a substituted aryl group or substituted heteroaryl group] and their pharmaceutically acceptable salts, having platelet-derived growth factor receptor autophosphorylation inhibitory activity, to pharmaceutical compositions containing these compounds, and to methods for the treatment of diseases associated with abnormal cell growth such as tumors.
摘要:
The present invention relates to a process for producing a 4-quinolone derivative, comprising allowing an o-aminoacetophenone derivative to react with a formic acid in an aprotic solvent in the presence of a suitable base, and adding a protic solvent to the reaction mixture. This is a simple process for producing 4-quinolone derivatives, applicable to large-scale commercial production.
摘要:
An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.
摘要翻译:本发明的目的是提供对巨噬细胞集落刺激因子受体的自磷酸化具有抑制活性的化合物。 本发明的化合物由式(I)表示,其盐和溶剂化物:其中X表示CH或N; Z表示O或S; R 1,R 2,R 3和R 3代表H,任选取代的烷氧基等; R 4表示H; R 5,R 6,R 7和R 8表示H,卤素,烷基,烷氧基,三氟甲基 或类似物; R 9和R 10代表H,烷基等; 并且R 11和R 12中的任何一个代表H,另一个代表烷基,R 13表示任选取代的碳环或杂环或 或者R 11表示H并且R 12和R 13结合在一起以形成双环碳环。
摘要:
An optical network system that performs transmission of N:1 protection includes a node that includes transmission-side operating muxponders that multiplex client signals for every M-channel signal bundle and convert multiplexed signals into optical signals having different wavelengths, transmission-side optical couplers that branch the client signals into two channels of operating and redundant, transmission-side optical switches each selecting one channel from redundant signals as a redundant client signal, and a transmission-side redundant muxponder that performs a predetermined transmission-side process according to an accommodation mode set on the redundant client signal and then multiplexes the redundant client signals, converts the multiplexed signal into an optical signal having a wavelength different from that of the operating signal, thereby making the accommodation mode settable for each channel in an independent manner.
摘要:
An error correction coding apparatus divides transmission information sequences in n subframes (n is an arbitrary natural number) into n1 subframes (n1 is a natural number
摘要:
Setting safety function, as appropriate, according to a user environment is enabled, thereby enhancing safety function. According to selection information from a safety function selection unit 120, a function setting unit 116 sets arbitrary function among a plurality of functions as safety function pertaining to usage of a gas. When operating conditions for safety function are fulfilled, a monitoring unit 112 detects malfunction, which would arise during usage of a gas, and outputs a safety signal to a control unit 114 in accordance with the set safety function. In accordance with a safety signal from the monitoring unit 112, the control unit 114 cuts off a gas supply when an event fulfilling operating conditions for the set function has arisen. When an event fulfilling operating conditions for an unset function has arisen, a communication unit 124 reports occurrence of malfunction pertaining to unset function to the monitoring center 200.
摘要:
An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.
摘要:
An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.
摘要翻译:本发明的目的是提供具有有效抗肿瘤活性的化合物。 根据本发明的化合物是由式(I)表示的化合物或其药学上可接受的盐或溶剂合物:其中X和Z表示CH或N; Y表示O或S; R 1,R 2,R 3和R 3代表H,烷氧基等; R 4表示H; R 5,R 6,R 7和R 8表示H,卤素,烷氧基等; R 9和R 10代表H,烷基等; R 11表示任选取代的唑基。
摘要:
An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
摘要:
A multiple coding apparatus comprises a first encoder for encoding a plurality of input sequences in parallel so as to generate a plurality of output coded sequences in parallel while adding an error-correcting bit sequence to each of the plurality of input sequences. An interleaving circuit interleaves the plurality of output coded sequences applied thereto in parallel from the first encoder without having to use any memory. The interleaving circuit permutes the plurality of input sequences on a bit-by-bit or symbol-by-symbol basis so as to generate a plurality of interleaved coded sequences in parallel. A second encoder then encodes the plurality of interleaved coded sequences applied thereto in parallel from the interleaving circuit so as to generate a plurality of output coded sequences in parallel while adding an error-correcting bit sequence to each of the plurality of interleaved coded sequences.