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公开(公告)号：US4029591A
公开(公告)日：1977-06-14
申请号：US615393
申请日：1975-09-22
Applicant: Kazuo Ohbu , Yuichi Takada , Shigemi Nakamura
Inventor： Kazuo Ohbu , Yuichi Takada , Shigemi Nakamura
CPC classification number: C11D1/29 , C11D3/3956
Abstract: A liquid detersive bleaching composition which comprises 3 to 10 wt.% of sodium hypochlorite (in terms of the amount of available chlorine), 0.5 to 3 wt.% of caustic alkali, 0.3 to 7 wt.% of polyoxyethylene alkylphenyl ether sulfate (a) having the formula (I) and 0.1 to 5 wt.% of polyoxyethylene alkylphenyl ether sulfate sulfonate (b) having the formula (II), wherein the molar ratio of (a) to (b) is in the range of from 20/80 to 85/15 and the total amount of (a) and (b) is in the range of from more than 0.5 wt.% to less than 10 wt.%.Formula (I): ##STR1## (wherein R represents straight-chain or branched-chain alkyl group having 5 to 15 carbon atoms, m is an integer ranging from 3 to 15, and M represents Na or K.)formula (II): ##STR2## (wherein R' represents straight-chain or branched-chain alkyl group having 5 to 15 carbon atoms, n is an integer ranging from 3 to 15, and M represents Na or K.)
Abstract translation: 一种液体洗涤漂白组合物，其包含3至10重量％的次氯酸钠（以可用氯的量计），0.5-3重量％的苛性碱，0.3至7重量％的聚氧乙烯烷基苯基醚硫酸盐（a ）和0.1〜5重量％的具有式（II）的聚氧乙烯烷基苯基醚硫酸酯磺酸酯（b），其中（a）与（b）的摩尔比在20 / 80〜85/15，（a）和（b）的总量在大于0.5重量％至小于10重量％的范围内。
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公开(公告)号：US06810872B1
公开(公告)日：2004-11-02
申请号：US09703794
申请日：2000-11-02
Applicant: Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Yoshiyuki Yazawa , Akira Yanagawa
Inventor： Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Yoshiyuki Yazawa , Akira Yanagawa
IPC: A61M1500
CPC classification number: A61M15/0045 , A61M11/002 , A61M15/0033 , A61M15/0035 , A61M15/0048 , A61M2202/064 , A61M2206/16
Abstract: A blister pack for a inhalant medicator has a plurality of medical powder storage chambers spaced apart from each other in a circumferential direction. The inhalant medicator includes a pricking tool with a pair of parallel pins that prick inflow and outflow holes in one of the medical powder storage chambers during a preliminary operation of inhalant medication. The inflow and outflow holes are spaced apart from each other by a predetermined distance in a direction parallel to a lid panel of the blister pack to produce turbulent airflow within the medical powder storage chamber during inhalation during which the medical powder is inhaled by a patient's breathing. The medical powder storage chambers are dimensioned and designed to properly regulate or control properties of the airflow passing through the medical storage chamber, to ensure the airflow is suitable for the medical powder storage chamber.
Abstract translation: 用于吸入剂的吸塑包装具有沿圆周方向彼此隔开的多个医用粉末储存室。 吸入剂包括具有一对平行销的穿刺工具，其在吸入药物的初步操作期间刺入一个医疗粉末储存室中的流入和流出孔。 流入和流出孔在平行于泡罩包装的盖板的方向上彼此隔开预定距离，以在吸入期间在医用粉末储存室内产生湍流气流，在此期间医疗粉末被患者的呼吸吸入 。 医疗粉末储存室的尺寸设计为适当地调节或控制通过医疗储存室的气流的特性，以确保气流适合于医用粉末储存室。
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公开(公告)号：US06408846B1
公开(公告)日：2002-06-25
申请号：US09623457
申请日：2000-09-11
Applicant: Hisatomo Ohki , Kazunori Ishizeki , Shigemi Nakamura , Yoshiyuki Yazawa , Akira Yanagawa
Inventor： Hisatomo Ohki , Kazunori Ishizeki , Shigemi Nakamura , Yoshiyuki Yazawa , Akira Yanagawa
IPC: A61M1500
CPC classification number: A61M15/0028 , A61M15/0033 , A61M15/0086 , A61M2202/064 , A61M2206/16
Abstract: A diffusion chamber block 14 is provided in a block mounting hole 13A of an inhalant port 13, and a granular medicine diffusion chamber 17 is formed in the diffusion chamber block 14. The granular medicine diffusion chamber 17 is formed at a side of the inhalant port 13 with a granular medicine inflow opening 17A and at a side of a capsule housing hole 9 with a granular medicine outflow opening 17B. A diffusion chamber in flow passage 18 is provided to communicate an outflow air passageway 12 with the granular medicine inflow opening 17A, whereas a diffusion chamber outflow passage is provided to communicate the granular medicine outflow opening 17B with the inhalant port 13. When inhaling granular medicines in the capsule housing hole 9 via the inhalant port 13 by way of breathing action, there results in counter-flow vortex within the granular medicine diffusion chamber 17. The counter-flow cortex acts to finely break and atomize massive granular medicines, thus promoting atomization of the granular medicines.
Abstract translation: 扩散室块14设置在吸入口13的块安装孔13A中，并且在扩散室块14中形成有粒状药物扩散室17.粒状药物扩散室17形成在吸入口侧 13，其具有粒状药物流入口17A，并且在具有粒状药物流出口17B的胶囊容纳孔9的一侧。 设置流路18的扩散室，使流出空气通路12与粒状药剂流入口17A连通，设置扩散室流出通路，使粒状药物流出口17B与吸入口13连通。吸入粒状药物时 通过呼吸作用经由吸入口13在胶囊容纳孔9中，在颗粒状药物扩散室17内产生逆流涡流。逆流皮层用于细粒化颗粒状药物，从而促进雾化 的颗粒状药物。
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公开(公告)号：US5619985A
公开(公告)日：1997-04-15
申请号：US510850
申请日：1995-08-03
Applicant: Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Atsuo Wakayama , Akira Yanagawa
Inventor： Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Atsuo Wakayama , Akira Yanagawa
CPC classification number: A61M15/0028 , A61M15/0033 , A61M2202/064
Abstract: An inhaler type medicine administering device for administering fine granular medicine to the lungs of a patent. The medicine admimistering device comprises a generally cylindrical inhaling piece including a cylindrical holder accommodating section. First and second outside pin insertion holes are formed through the cylindrical wall of the holder accommodating section. A capsule holder is provided to be accommodable within the holder accommodating section of the inhaling piece. The capsule holder is formed with a capsule accommodating hole opened to its end section in which hole a capsule containing medicine is accommodable. First and second inside pin insertion holes are formed extending in the diametrical direction of the capsule holder so as to pass through the capsule accommodating hole. The first inside pin insertion hole is capable of being brought into alignment with the first outside pin insertion hole to form a first pin insertion hole. The second inside pin insertion hole is capable of being brought into alignment with the second outside pin insertion hole to form a second pin insertion hole. An inflow-side passage is located radially outward of the capsule accommodating hole and has a first open end opened at the one end section of the capsule holder, and a second open end connected with the first inside pin insertion hole. An outflow-side passage is located radially outward of the capsule accommodating hole and connects the inside second pin insertion hole to the inhaling opening. Additionally, a perforator is provided including first and second pins which are insertable respectively into the first and second pin insertion holes in order to form holes in the capsule accommodated in the capsule accommodating hole.
Abstract translation: 一种用于向专利的肺部施用细粒状药物的吸入器型给药装置。 药物摄取装置包括大致圆柱形的吸入件，其包括圆柱形保持器容纳部分。 第一和第二外销插入孔穿过保持器容纳部的圆筒形壁。 胶囊保持器设置成容纳在吸入件的保持器容纳部分内。 胶囊保持器形成有向其端部部分开口的胶囊容纳孔，其中容纳有胶囊的胶囊可容纳孔。 第一和第二内销插入孔形成为沿着胶囊保持器的直径方向延伸以穿过胶囊容纳孔。 第一内销插入孔能够与第一外销插入孔对准以形成第一销插入孔。 第二内销插入孔能够与第二外销插入孔对准，以形成第二销插入孔。 流入侧通路位于胶囊容纳孔的径向外侧，具有在胶囊保持架的一端开口的第一开口端和与第一内销插入孔连接的第二开口端。 流出侧通路位于胶囊容纳孔的径向外侧，将内侧的第二销插入孔与吸入口连接。 另外，提供穿孔器，其包括可分别插入到第一和第二销插入孔中的第一和第二销，以便在容纳在胶囊容纳孔中的胶囊中形成孔。
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公开(公告)号：US4306517A
公开(公告)日：1981-12-22
申请号：US101649
申请日：1979-12-10
Applicant: Shigemi Nakamura
Inventor： Shigemi Nakamura
Abstract: A device for detecting and signalling the end of a milking period includes a sensor for detecting variations of the quantity of milk flowing in a milkline connected to a test cup, and providing a corresponding output signal. Circuitry is provided for detecting the output signal of the sensor, and for actuating a signalling device such as an alarm buzzer when the flow of milk in the milk line remains below a certain level over a given period of time.
Abstract translation: 一种用于检测和指示挤奶期结束的装置包括一个传感器，用于检测在连接到测试杯的牛奶中流动的牛奶的量的变化，并提供相应的输出信号。 提供电路用于检测传感器的输出信号，并且用于当牛奶线中的牛奶流在给定的时间段内保持低于一定水平时用于致动诸如报警蜂鸣器的信号装置。
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Patent Agency Ranking
公开(公告)号：US07438700B2
公开(公告)日：2008-10-21
申请号：US10792575
申请日：2004-03-04
Applicant: Kazunori Ishizeki , Hisatomo Ohki , Shigemi Nakamura , Akira Yanagawa
Inventor： Kazunori Ishizeki , Hisatomo Ohki , Shigemi Nakamura , Akira Yanagawa
IPC: A61M13/00
CPC classification number: B05B11/062 , A61M15/08 , A61M16/208 , A61M2202/064 , A61M2205/075
Abstract: A medicine administering device for nasal cavities of a patient suffering from nasal allergy or the like. The medicine administering device comprises a medicine administering device main body including a part defining a powdery medicine accommodating chamber, and a spray nozzle located at a tip end side of the main body. A pump is disposed at a base end side of the medicine administering device main body to discharge air within the pump through the powdery medicine accommodating chamber to the spray nozzle upon being pressed from an outside of the pump. Additionally, a restricting device is disposed within the pump to restrict a displacement amount of the pump in accordance with first and second kinds of pressing positions at which the pump is pressed. The first and second kinds of pressing positions lie respectively in first and second directions which are perpendicular to each other.
Abstract translation: 用于患有鼻过敏等的患者的鼻腔的给药装置。 给药装置包括：给药装置主体，包括限定粉末药剂容纳室的部分和位于主体的前端侧的喷嘴。 泵在配药装置主体的基端侧配置，从泵的外侧按压时，将泵内的空气从粉末药剂收容室排出到喷雾嘴。 此外，限制装置设置在泵内，以根据泵被按压的第一和第二种按压位置来限制泵的位移量。 第一和第二种按压位置分别位于彼此垂直的第一和第二方向上。
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公开(公告)号：US20050048003A1
公开(公告)日：2005-03-03
申请号：US10960575
申请日：2004-10-08
Applicant: Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Yoshiyuki Yazawa , Akira Yanagawa
Inventor： Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Yoshiyuki Yazawa , Akira Yanagawa
CPC classification number: A61M15/0045 , A61M11/002 , A61M15/0033 , A61M15/0035 , A61M15/0048 , A61M2202/064 , A61M2206/16
Abstract: A blister pack for an inhalant medicator has a plurality of medical powder storage chambers spaced apart from each other in a circumferential direction. The inhalant medicator includes a pricking tool with a pair of parallel pins that prick inflow and outflow holes in one of the medical powder storage chambers during a preliminary operation of inhalant medication. The inflow and outflow holes are spaced apart from each other by a predetermined distance in a direction parallel to a lid panel of the blister pack to produce turbulent airflow within the medical powder storage chamber during inhalation during which the medical powder is inhaled by a patient's breathing. The medical powder storage chambers are dimensioned and designed to properly regulate or control properties of the airflow passing through the medical storage chamber, to ensure the airflow is suitable for the medical powder stored in the storage chamber.
Abstract translation: 用于吸入剂的泡罩包装体具有沿圆周方向彼此隔开的多个医用粉末储存室。 吸入剂包括具有一对平行销的穿刺工具，其在吸入药物的初步操作期间刺入一个医疗粉末储存室中的流入和流出孔。 流入和流出孔在平行于泡罩包装的盖板的方向上彼此隔开预定距离，以在吸入期间在医用粉末储存室内产生湍流气流，在此期间医疗粉末被患者的呼吸吸入 。 医疗粉末储存室的尺寸设计成适当地调节或控制通过医疗储存室的气流的特性，以确保气流适用于存储在储存室中的医用粉末。
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公开(公告)号：US06595210B2
公开(公告)日：2003-07-22
申请号：US09908915
申请日：2001-07-20
Applicant: Hisatomo Ohki , Yoshiyuki Yazawa , Shigemi Nakamura , Mitsuru Yokobori , Kazunori Ishizeki
Inventor： Hisatomo Ohki , Yoshiyuki Yazawa , Shigemi Nakamura , Mitsuru Yokobori , Kazunori Ishizeki
IPC: A61M1300
CPC classification number: A61M15/0028 , A61M11/001 , A61M15/003 , A61M15/0033 , A61M2202/064 , A61M2206/16
Abstract: An inhalator including an inhalator body including a powder receiving chamber for receiving a powder, an air-powder mixture reservoir for temporarily storing an air-powder mixture flowing from the powder receiving chamber, and a diluent air passage for introducing a diluent air into the air-powder mixture reservoir. The air-powder mixture is formed within the powder receiving chamber when an air is introduced into the powder receiving chamber. The air-powder mixture within the air-powder mixture reservoir is admixed with a diluent air introduced thereinto through the diluent air passage. The diluted air-powder mixture is discharged from an air-powder mixture outlet into a user's oral or nasal cavity. A powder composition for inhalators includes at least two kinds of fine particles different in particle diameter.
Abstract translation: 一种吸入器，包括：吸入器主体，包括用于接收粉末的粉末接收室;用于临时存储从粉末接收室流出的空气 - 粉末混合物的空气 - 粉末混合物储存器;以及用于将稀释空气引入空气的稀释空气通道 粉末混合物储层。 当空气被引入到粉末接收室中时，空气 - 粉末混合物形成在粉末接收室内。 将空气 - 粉末混合物储存器内的空气 - 粉末混合物与通过稀释剂空气通道引入的稀释空气混合。 稀释的空气 - 粉末混合物从空气 - 粉末混合物出口排出到用户的口腔或鼻腔中。 用于吸入器的粉末组合物包括至少两种粒径不同的细颗粒。
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公开(公告)号：US5921236A
公开(公告)日：1999-07-13
申请号：US727633
申请日：1996-11-01
Applicant: Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Akira Yanagawa
Inventor： Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Akira Yanagawa
CPC classification number: A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/071 , A61M2205/075
Abstract: A capsule holder 2 of a medicine administering device 1 for nasal cavities comprises a movable member 8 which is axially movable, and a fixed member 3, in which the movable member 8 is formed at its outer periphery with an external thread 8D which is to be threadedly engaged with an internal thread 19C of a medicine spraying section 19. An air inflow hole H is formed by a perforating end 27A of a pin 27 when a capsule K is thrust into a one-side capsule hole 11, while the movable member 8 is raised so that the perforating end 27A is extracted from the air inflow hole H1 when the capsule holder 2 and the medicine spraying section 19 are incorporated with each other. An air outflow hole H2 is formed by a pin 28. A perforating tool is housed in the medicine administering device 1, in which a hole formation action for the air inflow hole H1 is also made during installation of the capsule K. The whole body can be made compact since the longitudinal dimension of the pin 27, 28 is decreased while the outer peripheral surface of the capsule holder 2 is covered with a pump section 15.
Abstract translation: PCT No.PCT / JP96 / 00596 Sec。 371日期：1996年11月1日 102（e）1996年11月1日PCT PCT 1996年3月11日PCT公布。 公开号WO96 / 29109 日期1996年9月26日用于鼻腔的给药装置1的胶囊保持器2包括可轴向移动的可动构件8和固定构件3，其中可动构件8在其外周形成有外螺纹 8D，其与药物喷射部19的内螺纹19C螺纹接合。当胶囊K被推入单侧胶囊孔11中时，空气流入孔H由销27的穿孔端27A形成， 同时使可动构件8升高，使得当胶囊保持器2和药物喷射部19彼此结合时，穿孔端部27A从空气流入孔H1抽出。 空气流出孔H2由销28形成。射出工具被容纳在给药装置1中，其中在安装胶囊K期间也进行用于空气流入孔H1的孔形成作用。整体可以 由于销27,28的纵向尺寸减小，同时胶囊保持器2的外周表面被泵部分15覆盖，因此可以紧凑。
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公开(公告)号：US5752505A
公开(公告)日：1998-05-19
申请号：US820654
申请日：1997-03-18
Applicant: Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Yoshiyuki Yazawa , Akira Yanagawa
Inventor： Hisatomo Ohki , Shigemi Nakamura , Kazunori Ishizeki , Yoshiyuki Yazawa , Akira Yanagawa
CPC classification number: A61M15/0028 , A61M15/0015 , A61M15/0036 , A61M2202/064
Abstract: An inhalation type medication delivery device includes a dispenser body having a powder containment chamber at one axial side thereof and an inhalation port for drawing in a powder type medication on the another. An attached lid is provided on the dispenser body for opening and/or closing the powder containment chamber. In addition, an air passage is defined in the body allowing a powder type medication to be introduced into an airflow toward the inhalation port according to inhalation by a user. One end of the air passage opens through the lid towards the outside atmosphere and the other end communicates with the inhalation port while passing through the powder containment chamber. Also, a check valve is installed in the lid to prevent air drawn into said inhalation port from flowing in an outward direction opposite a medication delivery direction toward the inhalation port. Additional efficiency may be achieved by further providing a supplementary passage communicating between the inhalation port and the outside atmosphere independently of the air passage to generate additional suction force during inhalation.
Abstract translation: 吸入型药物输送装置包括：分配器本体，其具有在其一个轴向侧的粉末容纳室和用于吸入粉末型药物的吸入口。 在分配器主体上设置附接的盖，用于打开和/或关闭粉末容纳室。 此外，空气通道被限定在体内，允许粉末型药物根据使用者的吸入被引入朝向吸入口的气流中。 空气通道的一端通过盖朝向外部大气开放，另一端在通过粉末容纳室的同时与吸入口连通。 此外，止回阀安装在盖中，以防止吸入所述吸入口的空气朝向与吸入口相反的药物输送方向的向外方向流动。 通过进一步提供在吸入口和外部气氛之间连通的补充通道，可独立于空气通道来实现额外的效率，以在吸入期间产生额外的吸力。
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