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公开(公告)号:US07070793B1
公开(公告)日:2006-07-04
申请号:US09509744
申请日:1998-09-28
申请人: Kazutoh Takesako , Shigetoshi Mizutani , Masahiro Endo , Junko Ogawa , Takashi Okado , Ikunoshin Kato
发明人: Kazutoh Takesako , Shigetoshi Mizutani , Masahiro Endo , Junko Ogawa , Takashi Okado , Ikunoshin Kato
CPC分类号: C07K14/40 , A61K38/00 , A61K39/00 , Y10S530/824
摘要: To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida albicans. An antigenic protein characterized in that the antigenic protein is recognized by antiserum derived from a mammal having Candida albicans-infection resistance; and a nucleic acid encoding an antigenic protein which is recognized by antiserum derived from a mammal having Candida albicans-infection resistance.
摘要翻译: 提供新型抗原蛋白和编码抗原蛋白的核酸,其可用于预防,治疗和诊断由真菌引起的疾病,包括白色念珠菌。 一种抗原蛋白,其特征在于抗原蛋白由来自具有白念珠菌感染抗性的哺乳动物的抗血清识别; 以及编码由来自具有白念珠菌感染抗性的哺乳动物的抗血清识别的抗原性蛋白质的核酸。
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公开(公告)号:US20050276821A1
公开(公告)日:2005-12-15
申请号:US11119769
申请日:2005-05-03
申请人: Kazutoh Takesako , Shigetoshi Mizutani , Masahiro Endo , Junko Ogawa , Takashi Okado , Ikunoshin Kato
发明人: Kazutoh Takesako , Shigetoshi Mizutani , Masahiro Endo , Junko Ogawa , Takashi Okado , Ikunoshin Kato
IPC分类号: G01N33/50 , A61K38/00 , A61K39/00 , A61K49/00 , A61P13/02 , A61P15/00 , A61P31/04 , C07K14/40 , C07K16/14 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/68 , G01N33/53 , G01N33/569 , C07H21/04 , C12N1/18 , C12N15/74
CPC分类号: C07K14/40 , A61K38/00 , A61K39/00 , Y10S530/824
摘要: To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida albicans. An antigenic protein characterized in that the antigenic protein is recognized by antiserum derived from a mammal having Candida albicans-infection resistance; and a nucleic acid encoding an antigenic protein which is recognized by antiserum derived from a mammal having Candida albicans-infection resistance.
摘要翻译: 提供新型抗原蛋白和编码抗原蛋白的核酸,其可用于预防,治疗和诊断由真菌引起的疾病,包括白色念珠菌。 一种抗原蛋白,其特征在于抗原蛋白由来自具有白念珠菌感染抗性的哺乳动物的抗血清识别; 以及编码由来自具有白念珠菌感染抗性的哺乳动物的抗血清识别的抗原性蛋白质的核酸。
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公开(公告)号:US06294651B1
公开(公告)日:2001-09-25
申请号:US09368431
申请日:1999-08-05
申请人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号: C02N1500
摘要: The invention is directed to isolated DNAs having nucleic acid sequences which encode proteins which regulate aureobasidin sensitivity. Also disclosed are recombinant plasmids containing the DNAs, transformants containing the plasmids, and methods of producing the proteins.
摘要翻译: 本发明涉及具有编码调节金黄担子素敏感性的蛋白质的核酸序列的分离的DNA。 还公开了含有DNA的重组质粒,含有质粒的转化体和产生蛋白质的方法。
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公开(公告)号:US06693174B2
公开(公告)日:2004-02-17
申请号:US09951217
申请日:2001-09-12
申请人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号: C07K1600
摘要: The invention is directed to isolated DNAs having nucleic acid sequences which encode proteins which regulate aureobasidin sensitivity. Also disclosed are recombinant plasmids containing the DNAs, transformants containing the plasmids, and methods of producing the proteins.
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公开(公告)号:US6043051A
公开(公告)日:2000-03-28
申请号:US945994
申请日:1997-11-06
申请人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号: C12N15/09 , C07H21/04 , C07K14/395 , C12N1/19 , C12N15/81 , C12R1/865 , C12P21/00 , C12N1/15 , C12N15/31 , C12N15/63
CPC分类号: C12N15/81 , C07K14/395
摘要: This invention offers a promoter derived from a yeast which can be used in a complete nutrient medium and is transcriptionally controllable by a PDR1 gene product. Thus, this invention offers a DNA which is represented by SEQ ID NO:1 in the Sequence Listing or a part thereof and has a promoter activity in yeast; a DNA which can be transcriptionally controllable by a PDR1 gene product and has the above-mentioned promoter activity; and a DNA which is hybridizable to the above-mentioned DNA and has a promoter activity in yeast.
摘要翻译: PCT No.PCT / JP96 / 01415 Sec。 371日期:1997年11月6日 102(e)1997年11月6日日期PCT提交1996年5月27日PCT公布。 WO96 / 38572 PCT公开号 日期1996年12月5日本发明提供了一种可从完整营养培养基中使用并由PDR1基因产物转录控制的酵母衍生的启动子。 因此,本发明提供由序列表中的SEQ ID NO:1表示的DNA或其一部分,并且在酵母中具有启动子活性; 可以通过PDR1基因产物转录控制并具有上述启动子活性的DNA; 以及与上述DNA杂交并在酵母中具有启动子活性的DNA。
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公开(公告)号:US06194166B1
公开(公告)日:2001-02-27
申请号:US08716873
申请日:1996-09-20
申请人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号: C12N1500
摘要: The invention is directed to isolated DNAs having nucleic acid sequences which encode proteins which regulate aureobasidin sensitivity. Also disclosed are recombinant plasmids containing the DNAs, transformants containing the plasmids, and methods of producing the proteins.
摘要翻译: 本发明涉及具有编码调节金黄担子素敏感性的蛋白质的核酸序列的分离的DNA。 还公开了含有DNA的重组质粒,含有质粒的转化体和产生蛋白质的方法。
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公开(公告)号:US6015689A
公开(公告)日:2000-01-18
申请号:US492459
申请日:1995-06-29
申请人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人: Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号: A61K38/00 , C07K14/37 , C07K14/38 , C07K14/40 , C07K16/14 , C12N15/80 , C12N15/90 , C12N15/00
CPC分类号: C07K14/38 , C07K14/37 , C07K14/40 , C07K16/14 , C12N15/80 , C12N15/90 , A61K38/00 , Y10S530/824
摘要: The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. The invention is useful in the diagnosis and treatment for diseases including mycoses.The invention also provides a novel chromosome integration vector capable of imparting a novel selective marker of a drug resistance to a fungal transformant, a transformant transformed with this vector and a process for producing the same. In particular, it provides a protein capable of imparting the resistance to aureobasidin and acting as a selective marker and a DNA coding for the same.
摘要翻译: 本发明提供调节真菌对抗真菌金黄色列生素的敏感性的蛋白质,编码该蛋白质的基因,其用途,蛋白质的抗体及其用途。 本发明可用于包括真菌病在内的疾病的诊断和治疗。 本发明还提供了一种新颖的染色体整合载体,其能够赋予对真菌转化体的耐药性的新型选择性标记,用该载体转化的转化体及其制备方法。 特别地,它提供能够赋予金黄担子素抗性并作为选择性标记的蛋白质和编码它们的DNA。
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公开(公告)号:US20080069829A1
公开(公告)日:2008-03-20
申请号:US11116371
申请日:2005-04-28
申请人: Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人: Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
CPC分类号: A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要: A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译: 从马拉色氏菌属真菌的基本上纯的,分离的抗原性蛋白质,其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明,可以提供从马拉色霉属,其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外,可以提供用于马拉色氏菌过敏原的诊断剂,治疗剂或预防药物,其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号:US06911208B2
公开(公告)日:2005-06-28
申请号:US10109670
申请日:2002-04-01
申请人: Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人: Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号: A61K38/00 , C07K14/37 , C07K16/14 , C12N15/31 , C12P21/08 , A61K39/35 , A61K39/36 , C12N21/04 , C12N21/06
CPC分类号: A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要: A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergies; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergies, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译: 一种基本上纯的,分离的抗原蛋白,其来源于马拉色氏菌属的真菌,其特征在于所述抗原蛋白具有与过敏患者IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明,可以提供从马拉色霉属,其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外,可以提供用于马拉色氏菌过敏症的诊断剂,治疗剂或预防药物,其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号:US06432407B1
公开(公告)日:2002-08-13
申请号:US09091097
申请日:1998-06-12
申请人: Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人: Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号: A61K3900
CPC分类号: A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要: A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译: 从马拉色氏菌属真菌的基本上纯的,分离的抗原性蛋白质,其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明,可以提供从马拉色霉属,其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外,可以提供用于马拉色氏菌过敏原的诊断剂,治疗剂或预防药物,其中所述药剂包含抗原蛋白或其片段作为活性成分。
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