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公开(公告)号：US09126931B2
公开(公告)日：2015-09-08
申请号：US13377300
申请日：2010-06-09
申请人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yasuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
发明人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yasuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
IPC分类号： C07D207/30 , C07D209/80 , C07D333/50 , C07D307/77 , C07D209/56 , C07D209/88 , C07D307/92 , C07D333/76 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/107
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US20120083488A1
公开(公告)日：2012-04-05
申请号：US13377300
申请日：2010-06-09
申请人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yashuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
发明人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yashuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
IPC分类号： A61K31/454 , C07D405/12 , C07D413/12 , C07D417/10 , C07D403/10 , C07D409/10 , C07D209/80 , C07D471/04 , C07D491/048 , C07D401/10 , C07D401/14 , C07D491/107 , C07D413/14 , C07D417/12 , A61K31/55 , A61K31/343 , A61K31/506 , A61K31/4525 , A61K31/4025 , A61K31/496 , A61K31/443 , A61K31/4178 , A61K31/5377 , A61K31/427 , A61K31/4155 , A61K31/403 , A61K31/4355 , A61K31/407 , A61K31/541 , A61K31/4545 , A61P35/00 , A61P35/04 , A61P25/24 , A61P25/28 , A61K31/437 , C07D307/77
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US07897792B2
公开(公告)日：2011-03-01
申请号：US12161256
申请日：2007-02-09
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： C07D311/00
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译： 本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N =等，Y 3和Y 4选自 - CH等等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，可用于细胞的治疗 增殖性疾病，特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
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公开(公告)号：US08569378B2
公开(公告)日：2013-10-29
申请号：US12669944
申请日：2008-07-18
申请人： Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： A01N41/02 , A01N41/06 , A01N43/16 , A61K31/16 , A61K31/18 , A61K31/35 , C07D311/00 , C07C331/00 , C07C381/00 , C07C303/00 , C07C309/00 , C07C311/00
CPC分类号： C07D405/14 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/052
摘要： The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N═ etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
摘要翻译： 本发明提供了包含下述通式（11）表示的化合物或其药学上可接受的盐作为活性成分的p27蛋白诱导剂：其中，G1，G2，G3和G8各自独立地选自-N =等，环 G6选自二价芳基等，A选自氨基等，G4选自氧等，G5选自氧等，G7选自-CH2-等，R2选自C1- 6烷基等
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公开(公告)号：US20110092700A1
公开(公告)日：2011-04-21
申请号：US12960134
申请日：2010-12-03
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： C07D265/26 , C07D311/16 , C07D409/06 , C07D403/12 , C07D491/14 , C07D417/12 , C07D401/10 , C07D403/10 , C07D403/14 , C07D413/12
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译： 本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N =等，Y 3和Y 4选自 - CH等等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。化合物或盐具有足够高的抗肿瘤活性，可用于细胞的治疗 增殖性疾病，特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
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公开(公告)号：US08278465B2
公开(公告)日：2012-10-02
申请号：US12960134
申请日：2010-12-03
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： C07D311/00
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译： 本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N =等，Y 3和Y 4选自 - CH等等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，可用于细胞的治疗 增殖性疾病，特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
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公开(公告)号：US20110009398A1
公开(公告)日：2011-01-13
申请号：US12669944
申请日：2008-07-18
申请人： Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： A61K31/536 , A61K31/4965 , A61K31/506 , A61K31/436 , A61K31/427 , A61K31/366 , C07D413/02 , C07D405/02 , C07D405/14 , C07D471/02 , C07D417/12 , C07D311/06 , C07D417/14
CPC分类号： C07D405/14 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/052
摘要： The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N═ etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
摘要翻译： 本发明提供一种p27蛋白诱导剂，其含有下述通式（11）表示的化合物或其药学上可接受的盐作为活性成分：其中，G1，G2，G3和G8各自独立地选自-N等。环 G6选自二价芳基等，A选自氨基等，G4选自氧等，G5选自氧等，G7选自-CH2-等，R2选自C1- 6烷基等
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公开(公告)号：US20100004233A1
公开(公告)日：2010-01-07
申请号：US12161256
申请日：2007-02-09
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： A61K31/536 , C07D311/06 , A61K31/352 , C07D405/12 , A61K31/506 , C07D413/12
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译： 本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N-等，Y3和Y4选自 - CH-等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。化合物或盐具有足够高的抗肿瘤活性，可用于治疗细胞 增殖性疾病，特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
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