-
公开(公告)号:US07897792B2
公开(公告)日:2011-03-01
申请号:US12161256
申请日:2007-02-09
申请人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号: C07D311/00
CPC分类号: C07D311/18 , C07D405/12 , C07D417/12
摘要: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译: 本发明提供下述通式(1)表示的化合物或其药学上可接受的盐:其中:X选自杂芳基等,Y1和Y2选自-N =等,Y 3和Y 4选自 - CH等等,A选自磺酰胺等,R1选自氢等,R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性,可用于细胞的治疗 增殖性疾病,特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
-
公开(公告)号:US08569378B2
公开(公告)日:2013-10-29
申请号:US12669944
申请日:2008-07-18
申请人: Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人: Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号: A01N41/02 , A01N41/06 , A01N43/16 , A61K31/16 , A61K31/18 , A61K31/35 , C07D311/00 , C07C331/00 , C07C381/00 , C07C303/00 , C07C309/00 , C07C311/00
CPC分类号: C07D405/14 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/052
摘要: The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N═ etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
摘要翻译: 本发明提供了包含下述通式(11)表示的化合物或其药学上可接受的盐作为活性成分的p27蛋白诱导剂:其中,G1,G2,G3和G8各自独立地选自-N =等,环 G6选自二价芳基等,A选自氨基等,G4选自氧等,G5选自氧等,G7选自-CH2-等,R2选自C1- 6烷基等
-
公开(公告)号:US20110092700A1
公开(公告)日:2011-04-21
申请号:US12960134
申请日:2010-12-03
申请人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号: C07D265/26 , C07D311/16 , C07D409/06 , C07D403/12 , C07D491/14 , C07D417/12 , C07D401/10 , C07D403/10 , C07D403/14 , C07D413/12
CPC分类号: C07D311/18 , C07D405/12 , C07D417/12
摘要: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译: 本发明提供下述通式(1)表示的化合物或其药学上可接受的盐:其中:X选自杂芳基等,Y1和Y2选自-N =等,Y 3和Y 4选自 - CH等等,A选自磺酰胺等,R1选自氢等,R2选自C1-6烷基等。化合物或盐具有足够高的抗肿瘤活性,可用于细胞的治疗 增殖性疾病,特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
-
公开(公告)号:US08278465B2
公开(公告)日:2012-10-02
申请号:US12960134
申请日:2010-12-03
申请人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号: C07D311/00
CPC分类号: C07D311/18 , C07D405/12 , C07D417/12
摘要: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译: 本发明提供下述通式(1)表示的化合物或其药学上可接受的盐:其中:X选自杂芳基等,Y1和Y2选自-N =等,Y 3和Y 4选自 - CH等等,A选自磺酰胺等,R1选自氢等,R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性,可用于细胞的治疗 增殖性疾病,特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
-
公开(公告)号:US20110009398A1
公开(公告)日:2011-01-13
申请号:US12669944
申请日:2008-07-18
申请人: Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人: Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号: A61K31/536 , A61K31/4965 , A61K31/506 , A61K31/436 , A61K31/427 , A61K31/366 , C07D413/02 , C07D405/02 , C07D405/14 , C07D471/02 , C07D417/12 , C07D311/06 , C07D417/14
CPC分类号: C07D405/14 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/052
摘要: The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N═ etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
摘要翻译: 本发明提供一种p27蛋白诱导剂,其含有下述通式(11)表示的化合物或其药学上可接受的盐作为活性成分:其中,G1,G2,G3和G8各自独立地选自-N等。环 G6选自二价芳基等,A选自氨基等,G4选自氧等,G5选自氧等,G7选自-CH2-等,R2选自C1- 6烷基等
-
公开(公告)号:US20100004233A1
公开(公告)日:2010-01-07
申请号:US12161256
申请日:2007-02-09
申请人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号: A61K31/536 , C07D311/06 , A61K31/352 , C07D405/12 , A61K31/506 , C07D413/12
CPC分类号: C07D311/18 , C07D405/12 , C07D417/12
摘要: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译: 本发明提供下述通式(1)表示的化合物或其药学上可接受的盐:其中:X选自杂芳基等,Y1和Y2选自-N-等,Y3和Y4选自 - CH-等,A选自磺酰胺等,R1选自氢等,R2选自C1-6烷基等。化合物或盐具有足够高的抗肿瘤活性,可用于治疗细胞 增殖性疾病,特别是癌症。 本发明还提供含有作为活性成分的化合物或盐的药物组合物。
-
公开(公告)号:US08299252B2
公开(公告)日:2012-10-30
申请号:US11997967
申请日:2006-08-04
申请人: Sawako Ozawa , Nobuhiro Oikawa , Eisaku Mizuguchi , Hirosato Ebiike , Fumio Watanabe , Kenji Morikami , Nobuo Shimma , Nobuya Ishii , Toshiyuki Tsukaguchi
发明人: Sawako Ozawa , Nobuhiro Oikawa , Eisaku Mizuguchi , Hirosato Ebiike , Fumio Watanabe , Kenji Morikami , Nobuo Shimma , Nobuya Ishii , Toshiyuki Tsukaguchi
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04
摘要: It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents —(O)n—R; R represents a C1-C6 alkyl group or the like; n represents 0 or 1; X represents O or the like; R2, R3 and R4 are independently selected from a hydrogen atom or C1-C3 alkyl; or R2 and R3 may join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.
摘要翻译: 旨在提供由式(1)表示的化合物:[其中Ar是选自下式(2)中的被连接的亚芳基:(其中*表示与氮原子的结合位点,**表示 结合位点到T); T表示 - (O)n -R; R表示C1-C6烷基等; n表示0或1; X表示O等; R2,R3和R4独立地选自氢原子或C1-C3烷基; 或者R 2和R 3可以与含有它们所结合的氮原子的脲结合物一起形成5-或6-元杂环; Y表示CH或N],或其药学上可接受的盐或其前药,以及含有该化合物的药物组合物。
-
公开(公告)号:US20100168430A1
公开(公告)日:2010-07-01
申请号:US11997967
申请日:2006-08-04
申请人: Sawako Ozawa , Nobuhiro Oikawa , Eisaku Mizuguchi , Hirosato Ebiike , Fumio Watanabe , Kenji Morikami , Nobuo Shimma , Nobuya Ishii , Toshiyuki Tsukaguchi , Yasuhiro Tamaki , Hidenori Takahashi
发明人: Sawako Ozawa , Nobuhiro Oikawa , Eisaku Mizuguchi , Hirosato Ebiike , Fumio Watanabe , Kenji Morikami , Nobuo Shimma , Nobuya Ishii , Toshiyuki Tsukaguchi , Yasuhiro Tamaki , Hidenori Takahashi
IPC分类号: C07D471/04
CPC分类号: C07D471/04
摘要: It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents —(O)n—R; R represents a C1-C6 alkyl group or the like; n represents 0 or 1; X represents O or the like; R2, R3 and R4 are independently selected from a hydrogen atom or C1-C3 alkyl; or R2 and R3 may join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.
摘要翻译: 旨在提供由式(1)表示的化合物:[其中Ar是选自下式(2)中的被连接的亚芳基:(其中*表示与氮原子的结合位点,**表示 结合位点到T); T表示 - (O)n -R; R表示C1-C6烷基等; n表示0或1; X表示O等; R2,R3和R4独立地选自氢原子或C1-C3烷基; 或者R 2和R 3可以与含有它们所结合的氮原子的脲结合物一起形成5-或6-元杂环; Y表示CH或N],或其药学上可接受的盐或其前药,以及含有该化合物的药物组合物。
-
公开(公告)号:US20120285168A1
公开(公告)日:2012-11-15
申请号:US13555077
申请日:2012-07-20
申请人: Fumio Watanabe
发明人: Fumio Watanabe
IPC分类号: F03G3/00
CPC分类号: F03G3/00
摘要: In a rotation drive device (10), each of rotating units (20) has a swing arm (23) which is supported so as to be swingable around a swing center axis (23A) provided in a support table (22), a weight (24) is provided at a position at which a length of an arm from the swing center axis (23A) of the swing arm (23) is longer, and a connection point in a fluid cylinder (25) side is provided at a position at which the length of the arm from the swing center axis (23A) is shorter.
摘要翻译: 在旋转驱动装置(10)中,每个旋转单元(20)具有摆动臂(23),所述摆动臂(23)被支撑成围绕设置在支撑台(22)中的摆动中心轴线(23A)摆动, (24)设置在从摆臂(23)的摆动中心轴(23A)的臂的长度较长的位置,并且在液压缸(25)侧的连接点设置在位置 其中臂从摆动中心轴线(23A)的长度较短。
-
公开(公告)号:US07332714B2
公开(公告)日:2008-02-19
申请号:US11375063
申请日:2006-03-15
申请人: Fumio Watanabe , Reiki Watanabe
发明人: Fumio Watanabe , Reiki Watanabe
CPC分类号: H01J49/147 , H01J41/10 , H01J49/4215
摘要: In a quadrupole mass spectrometer which measures partial pressure strength according to a gas type in a vacuum system from ion current intensity, a quadrupole mass spectrometer with a total pressure measurement electrode has a total pressure measurement electrode for examining an ion density disposed in a demarcation space which is comprised of a grid electrode and an ion focusing electrode. And, a vacuum system is provided with only the quadrupole mass spectrometer which measures partial pressure strength according to a gas type in the vacuum system from an ion current intensity and does not have an ionization vacuum gauge other than the quadrupole mass spectrometer.
摘要翻译: 在根据离子电流强度根据真空系统中的气体类型测量分压强度的四极杆质谱仪中,具有总压力测量电极的四极质谱仪具有用于检查设置在分界空间中的离子密度的总压力测量电极 其由栅电极和离子聚焦电极组成。 并且,仅具有四极质谱仪的真空系统,其根据离子电流强度根据真空系统中的气体类型测量分压强度,并且除四极质谱仪之外不具有电离真空计。
-
-
-
-
-
-
-
-
-