公开(公告)号：US20130275349A1

公开(公告)日：2013-10-17

申请号：US13976967

申请日：2011-12-28

申请人： Kei Tashiro ,  Shigeru Kinoshita ,  Tomohito Yagi ,  Masakazu Nakano ,  Kazuhiko Mori ,  Yoko Ikeda ,  Morio Ueno ,  Yuichi Tokuda ,  Katsumi Yagi ,  Kengo Yoshii ,  Masahiro Fuwa

发明人： Kei Tashiro ,  Shigeru Kinoshita ,  Tomohito Yagi ,  Masakazu Nakano ,  Kazuhiko Mori ,  Yoko Ikeda ,  Morio Ueno ,  Yuichi Tokuda ,  Katsumi Yagi ,  Kengo Yoshii ,  Masahiro Fuwa

IPC分类号： G06N99/00

CPC分类号： G06N20/00 ,  C12Q1/6886 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

摘要： Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of Case determination procedures or the number of control determination procedures (S330); and it is determined as Case (glaucoma) when the number of Case determination procedures is larger and it is determined as Control (normal person) when the number of Control determination procedures is larger.

摘要翻译： 提供了一种用于以高精度确定哺乳动物的生理属性，包括人类青光眼的发病或进展的技术。 确定基因型日期的结果和细胞因子日期的确定结果由综合确定单位（114）合并; 比较确定哪个更大，判定程序的数量或控制确定程序的数量（S330）; 当判定判定过程的数量较多并且当控制确定过程的数量较大时被确定为控制（普通人）时被确定为病例（青光眼）。

公开(公告)号：US20110207122A1

公开(公告)日：2011-08-25

申请号：US12596462

申请日：2008-04-17

申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US08431345B2

公开(公告)日：2013-04-30

申请号：US12596462

申请日：2008-04-17

申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US20130012408A1

公开(公告)日：2013-01-10

申请号：US13546674

申请日：2012-07-11

申请人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C40B30/04 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.

摘要翻译： 通过体外检测单核苷酸多态性的等位基因和/或基因型来确定青光眼存在或不存在青光眼风险的方法，比较检测到的等位基因和/或基因型与等位基因和/或 具有高风险等位基因的基因型，其中在检测到的等位基因是高风险等位基因的情况下确定青光眼风险的存在，或者在检测到的基因型是纯合子的情况下确定青光眼风险的存在 在高风险等位基因符合显性遗传模型的情况下，包括高风险等位基因或杂合子的基因型的基因型，或者在检测到的基因型是包含高表达的基因型的纯合子的情况下，确定青光眼风险的存在 当高风险等位基因符合隐性遗传模型时，这种等位基因是错误的。

公开(公告)号：US20100196895A1

公开(公告)日：2010-08-05

申请号：US12596258

申请日：2008-04-17

申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至514所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 具有SEQ ID NO：203〜514（步骤B）所示的碱基序列中的含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过对样品中的本发明中的单核苷酸多态性的等位基因或基因型进行分析来确定样品供体中的青光眼的发病风险水平，从而样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US20130210668A1

公开(公告)日：2013-08-15

申请号：US13850453

申请日：2013-03-26

申请人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US20130064520A1

公开(公告)日：2013-03-14

申请号：US13231768

申请日：2011-09-13

申请人： Masakazu Nakano ,  Jason Miller

发明人： Masakazu Nakano ,  Jason Miller

IPC分类号： G02B6/36

CPC分类号： G02B6/3849 ,  G02B6/3898

摘要： A device 10 for organizing an array of optical fiber cables (14) terminated with fiber optic connectors (20). The device includes a base plate (22) having a plurality of mounting sites (24) configured to receive a like plurality of dust covers (20) for the respective fiber optic connectors (18). Two or more base plates (22) may be stacked through use of stacking spacers (42) to increase the number of mounting sites (24). The device 10 maintains the array of optical fiber cables during manufacture, shipping and handling, eliminating snarling of the individual optical fiber cables (14).

摘要翻译： 用于组织由光纤连接器（20）端接的光纤电缆阵列（14）的装置10。 该装置包括具有多个安装位置（24）的基板（22），所述多个安装位置（24）被配置为接收相应的光纤连接器（18）的类似的多个防尘罩（20）。 可以通过使用堆叠间隔物（42）堆叠两个或更多个基板（22），以增加安装位置（24）的数量。 设备10在制造，运输和处理期间维持光纤电缆阵列，消除单个光纤电缆（14）的咆哮。

公开(公告)号：US4758848A

公开(公告)日：1988-07-19

申请号：US934713

申请日：1986-11-25

申请人： Masakazu Nakano

发明人： Masakazu Nakano

IPC分类号： G02B27/00 ,  B23K26/00 ,  B23K26/06 ,  B23K26/067 ,  B23K26/08 ,  B41M5/26 ,  G02F1/13 ,  G06K1/12 ,  H01L23/544

CPC分类号： H01L23/544 ,  B23K26/066 ,  G02F1/1313 ,  G06K1/126 ,  H01L2924/0002

摘要： In a method and apparatus for marking a pattern on an article with a laser, a device for producing a mask pattern in accordance with an electro-optical effect is utilized so that any reflection of laser energy off of the mask pattern is avoided. Further, laser energy not utilized for the marking of the pattern is fed back to a stage previous to the mask pattern stage. Accordingly, the energy efficiency of laser usage is increased and parts used therein is not damaged by undesirable reflection of laser beams.

摘要翻译： 在用激光打印物品上标记图案的方法和装置中，利用根据电光效应产生掩模图案的装置，以避免激光能量离开掩模图案的任何反射。 此外，不用于图案标记的激光能量被反馈到掩模图案阶段之前的阶段。 因此，激光使用的能量效率增加，并且其中使用的部件不被激光束的不期望的反射所损坏。

公开(公告)号：US08877779B2

公开(公告)日：2014-11-04

申请号：US12449874

申请日：2008-02-28

申请人： Masakazu Nakano ,  Masanori Minoguchi ,  Tokushi Hanano ,  Shin-ichiro Ono ,  Hideki Horiuchi ,  Koji Teshima

发明人： Masakazu Nakano ,  Masanori Minoguchi ,  Tokushi Hanano ,  Shin-ichiro Ono ,  Hideki Horiuchi ,  Koji Teshima

IPC分类号： A61K31/445 ,  C07D401/04 ,  C07D417/14 ,  C07D405/14 ,  C07D471/04

CPC分类号： C07D401/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

摘要： Provided is an ORL-1 receptor agonist having improved bioavailability based on superior metabolic stability and strong and high selectivity, as compared to conventional compounds. A compound represented by the formula (I) wherein each symbol is as defined in the claims.

摘要翻译： 本发明提供的ORL-1受体激动剂与常规化合物相比，具有基于优异的代谢稳定性和强和高选择性的改善的生物利用度。 由式（I）表示的化合物，其中每个符号如权利要求中所定义。

公开(公告)号：US07228049B2

公开(公告)日：2007-06-05

申请号：US10608211

申请日：2003-06-30

申请人： Masakazu Nakano ,  Makiko Miura

发明人： Masakazu Nakano ,  Makiko Miura

IPC分类号： G02B6/00

CPC分类号： G02B6/266 ,  G02B6/2551

摘要： A technique for manufacturing optical fixed attenuators in which two fibers are axially cojoined using fusion splicing. The spliced fibers are then captured in either a splice protection splint or cylindrical ferrule that can be housed in an optical adapter. In this process for producing the attenuator, the fusion splicing is preceded by a deformation of the mode field diameters of the ends of the fibers with the cleaning arc function of the splicing unit. The resulting attenuation of the splice is dependent on the amount of deformation of the fiber core and mode field diameter. Such a technique enables precision attenuation with very low wavelength dependent loss to be fabricated. The performance of Dense Wavelength Division Multiplexing systems, as well as test facilities and individual optical components can be improved by the use of such attenuators.

摘要翻译： 一种用于制造光学固定衰减器的技术，其中使用熔接将两根纤维轴向共同连接。 接合的纤维然后被捕获在可以容纳在光学适配器中的接头保护夹板或圆柱形套圈中。 在该衰减器的制造方法中，熔融接合之前是用拼接单元的清洁电弧功能使纤维端部的模场直径发生变形。 所得到的接头衰减取决于纤芯的变形量和模场直径。 这种技术能够制造具有非常低的波长相关损耗的精度衰减。 通过使用这种衰减器可以改善密集波分复用系统的性能，以及测试设备和各个光学部件。