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1.发明申请Composition Containing Vesicle-Silica Complex, And Process For Production Thereof 审中-公开含有囊泡 - 二氧化硅复合物的组合物及其制备方法公开(公告)号：US20100215703A1
公开(公告)日：2010-08-26
申请号：US12675462
申请日：2008-08-27
申请人： Kei Watanabe , Yuko Nagare
发明人： Kei Watanabe , Yuko Nagare
摘要： To provide a vesicle-containing composition wherein the stability is improved and the rate of releasing drug or perfume is sufficiently restricted during administration in vivo or application to the skin surface. Silica polymerization on the outer surfaces of vesicles is facilitated by adding a specifically structured water-soluble silane derivative to an aqueous composition containing the vesicles composed of a surfactant and mixing them together, and vesicle-silica composites having silica-coated outer surfaces can be obtained, resulting in the improved stability of the vesicle-containing composition as well as the improved effect of restricting the rate of releasing drug or perfume during administration in vivo or application to the skin surface.
摘要翻译： 提供一种含囊泡的组合物，其中稳定性得到改善，并且释放药物或香料的速率在体内施用或施用于皮肤表面时被充分地限制。 通过将特定结构的水溶性硅烷衍生物加入含有由表面活性剂构成的囊泡的水性组合物并混合在一起，可以获得囊泡外表面的二氧化硅聚合，并且可以获得具有二氧化硅涂覆的外表面的囊泡 - 二氧化硅复合材料 导致含囊泡组合物的稳定性得到改善，以及在体内施用或施用于皮肤表面时限制释放药物或香料的速率的改进效果。
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公开(公告)号：US20100080832A1
公开(公告)日：2010-04-01
申请号：US12598781
申请日：2008-05-15
申请人： Kei Watanabe , Hidefumi Araki , Yuko Nagare , Yasunari Nakama , Hirokazu Ishino
发明人： Kei Watanabe , Hidefumi Araki , Yuko Nagare , Yasunari Nakama , Hirokazu Ishino
CPC分类号： A61K8/0241 , A61K8/14 , A61K8/34 , A61K8/345 , A61K8/891 , A61K8/894 , A61Q5/12 , A61Q13/00 , A61Q19/00
摘要： To provide a vesicle-containing composition wherein a perfume component is stably incorporated in the vesicle bilayer membrane composed of a silicone surfactant and to provide a simple production method of the vesicle-containing composition wherein a perfume component is stably incorporated. A vesicle-containing composition comprising; (A) a perfume, (B) a silicone oil, (C) a silicone surfactant, (D) one or more selected from the group consisting of ethanol, propylene glycol, dipropylene glycol, and 1,3-butylene glycol, and (E) water; wherein the (C) silicone surfactant forms vesicles, and the (A) perfume and the (B) silicone oil are present in the vesicle bilayer membrane.
摘要翻译： 本发明提供一种含有囊泡的组合物，其中将香料成分稳定地并入由硅氧烷表面活性剂构成的囊泡双层膜中，并提供其中稳定地配合香料成分的含囊泡组合物的简单制造方法。 一种含囊泡的组合物，其包含： （A）香料，（B）硅油，（C）有机硅表面活性剂，（D）选自乙醇，丙二醇，二丙二醇和1,3-丁二醇中的一种或多种，和（D） E）水; 其中（C）硅氧烷表面活性剂形成囊泡，并且（A）香料和（B）硅油存在于泡囊双层膜中。
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3.发明申请Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition 失效通过混合水溶性硅烷衍生物获得的二氧化硅复合胶囊，含有它的组合物和透明的凝胶形式组合物公开(公告)号：US20100016200A1
公开(公告)日：2010-01-21
申请号：US12440614
申请日：2007-09-11
IPC分类号： A61K8/06
CPC分类号： A61Q19/10 , A61K8/0291 , A61K8/0295 , A61K8/042 , A61K8/11 , A61K8/25 , A61K8/585 , A61K2800/262 , A61K2800/412 , A61Q1/02
摘要： The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
摘要翻译： 本发明提供了可以容易地制备的新的二氧化硅复合胶囊，含有二氧化硅复合胶囊的组合物，以及外观透明性和使用质地优异的透明凝胶状组合物，特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合，可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外，通过混合表面活性剂，水，油和具有特定结构的水溶性硅烷衍生物，可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外，通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂，油和水的配方中，可以获得表现出优异的外观透明度，使用质地和清洁性能的透明凝胶状组合物，以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。
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4.发明授权Silica composite capsules obtained by blending water-soluble silane derivative, composition containing the same, and transparent gel-form composition 失效通过混合水溶性硅烷衍生物，含有它们的组合物和透明凝胶状组合物获得的二氧化硅复合胶囊公开(公告)号：US08030267B2
公开(公告)日：2011-10-04
申请号：US12440614
申请日：2007-09-11
CPC分类号： A61Q19/10 , A61K8/0291 , A61K8/0295 , A61K8/042 , A61K8/11 , A61K8/25 , A61K8/585 , A61K2800/262 , A61K2800/412 , A61Q1/02
摘要： The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
摘要翻译： 本发明提供了可以容易地制备的新的二氧化硅复合胶囊，含有二氧化硅复合胶囊的组合物，以及外观透明性和使用质地优异的透明凝胶状组合物，特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合，可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外，通过混合表面活性剂，水，油和具有特定结构的水溶性硅烷衍生物，可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外，通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂，油和水的配方中，可以获得表现出优异的外观透明度，使用质地和清洁性能的透明凝胶状组合物，以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。
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公开(公告)号：US09034375B2
公开(公告)日：2015-05-19
申请号：US13639520
申请日：2011-04-11
申请人： Yuko Nagare , Kazuhiro Yamaguchi
发明人： Yuko Nagare , Kazuhiro Yamaguchi
CPC分类号： A61K8/4966 , A61K8/064 , A61K8/27 , A61K8/894 , A61Q17/04
摘要： A water-in-oil emulsion composition which contains a low water-solubility but oil-soluble ultraviolet absorber, and which exhibits excellent ultraviolet light protection and stability. The composition contains (a) an aqueous dispersion of an oil-soluble ultraviolet absorber; (b) a polyoxyalkylene-modified polysiloxane having a molecular mass of at least 2000; and (c) at most 5 mass % of an ultraviolet scattering agent; and component (a) being contained in the internal phase. Component (a) is preferably an aqueous dispersion of a complex particle of an oil-soluble ultraviolet absorber and an organic polymer.
摘要翻译： 含有低水溶性但油溶性紫外线吸收剂的油包水乳液组合物，其表现出优异的紫外线保护和稳定性。 组合物含有（a）油溶性紫外线吸收剂的水分散体; （b）分子量为2000以上的聚氧化烯改性聚硅氧烷; 和（c）至多5质量％的紫外线散射剂; 并且组分（a）包含在内相中。 组分（a）优选为油溶性紫外线吸收剂和有机聚合物的复合颗粒的水分散体。
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公开(公告)号：US08992955B2
公开(公告)日：2015-03-31
申请号：US13258009
申请日：2010-03-26
申请人： Yosuke Ikebe , Yuko Nagare
发明人： Yosuke Ikebe , Yuko Nagare
摘要： Disclosed is an oil-in-water emulsion base which is stable even when ethanol in an amount of 50% by mass or less is blended therein and which exhibits excellent water resistance after being applied to the skin or the like. Specifically disclosed is an oil-in-water emulsified cosmetic composition which is characterized by containing (A) 0.1-10% by mass of a polyether-modified silicone having an HLB(Si) of 5-10, (B) 5-50% by mass of ethanol, (C) 0.01-3% by mass of a hydrophilic thickening agent and (D) 0.1-15% by mass of a polyol. Preferably, the oil-in-water emulsified cosmetic composition additionally contains a UV absorbent, thereby forming a sunscreen cosmetic composition.
摘要翻译： 公开了一种即使在50质量％以下的乙醇中配合的情况下也稳定的水包油型乳液基质，其涂布于皮肤等后表现出优异的耐水性。 具体公开了一种水包油型乳化化妆品组合物，其特征在于含有（A）0.1-10质量％的HLB（Si）为5-10的聚醚改性的硅氧烷，（B）为5-50％ 的（C）0.01-3质量％的亲水性增稠剂和（D）0.1〜15质量％的多元醇。 优选地，水包油型乳化化妆品组合物另外含有UV吸收剂，从而形成防晒化妆品组合物。
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公开(公告)号：US20120045403A1
公开(公告)日：2012-02-23
申请号：US13258009
申请日：2010-03-26
申请人： Yosuke Ikebe , Yuko Nagare
发明人： Yosuke Ikebe , Yuko Nagare
摘要： Disclosed is an oil-in-water emulsion base which is stable even when ethanol in an amount of 50% by mass or less is blended therein and which exhibits excellent water resistance after being applied to the skin or the like. Specifically disclosed is an oil-in-water emulsified cosmetic composition which is characterized by containing (A) 0.1-10% by mass of a polyether-modified silicone having an HLB(Si) of 5-10, (B) 5-50% by mass of ethanol, (C) 0.01-3% by mass of a hydrophilic thickening agent and (D) 0.1-15% by mass of a polyol. Preferably, the oil-in-water emulsified cosmetic composition additionally contains a UV absorbent, thereby forming a sunscreen cosmetic composition.
摘要翻译： 公开了一种即使在50质量％以下的乙醇中配合的情况下也稳定的水包油型乳液基质，其涂布于皮肤等后表现出优异的耐水性。 具体公开了一种水包油型乳化化妆品组合物，其特征在于含有（A）0.1-10质量％的HLB（Si）为5-10的聚醚改性的硅氧烷，（B）为5-50％ 的（C）0.01-3质量％的亲水性增稠剂和（D）0.1〜15质量％的多元醇。 优选地，水包油型乳化化妆品组合物另外含有UV吸收剂，从而形成防晒化妆品组合物。
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公开(公告)号：US20110135587A1
公开(公告)日：2011-06-09
申请号：US13057329
申请日：2009-08-07
摘要： The present invention provides an easily-handled hair conditioning composition with a very low water content. The hair conditioning composition of the present invention is a composition comprising: (a) 10 to 90% by mass of one or more components selected from higher alcohols, higher fatty acids, and derivatives thereof, (b) 5 to 35% by mass of a cationic surfactant, and (c) a polyhydric alcohol and/or polyethylene glycol having a melting point of 155° C. or less, characterized in that the endothermic peak of a gel which is formed from (a) and (b) in the composition is 50° C. or more as measured by a differential scanning calorimeter (DSC) and that the water content is 10% by mass or less.
摘要翻译： 本发明提供了一种容易处理的具有非常低含水量的头发调理组合物。 本发明的头发调理组合物是包含：（a）10〜90质量％的选自高级醇，高级脂肪酸及其衍生物的一种或多种成分，（b）5〜35质量％ 阳离子表面活性剂，和（c）熔点为155℃以下的多元醇和/或聚乙二醇，其特征在于，在（a）和（b）中形成的凝胶的吸热峰 组成为差示扫描量热计（DSC）测定的50℃以上，含水率为10质量％以下。
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公开(公告)号：US20130336908A1
公开(公告)日：2013-12-19
申请号：US13979404
申请日：2012-01-31
申请人： Kazuhiro Yamaguchi , Yuko Nagare
发明人： Kazuhiro Yamaguchi , Yuko Nagare
CPC分类号： A61K8/062 , A61K8/4966 , A61K8/891 , A61K8/894 , A61K2800/594 , A61Q17/04
摘要： Provided is a sunscreen cosmetic composition that effectively protects from both UVA and UVB, has moist and cool feeling on use as well as excellent stability, and is able to form a film having a good ultraviolet protection effect when applied to skin. An oil-in-water sunscreen cosmetic composition comprising: (a) an aqueous dispersion of an oil-soluble ultraviolet absorbent; (b) one or two or more of crosslinked polyether-modified silicones and crosslinked alkyl polyether-modified silicones; (c) a low-viscosity silicone oil; and (d) water. The aqueous dispersion of the oil-soluble ultraviolet absorbent is preferably an aqueous dispersion of composite particles of bis-ethylhexyloxyphenol methoxyphenyl triazine and an organic polymer. Furthermore, methylene bisbenzotriazolyl tetramethylbutylphenol is preferably further added.
摘要翻译： 本发明提供一种能够有效地保护UVA和UVB的防晒化妆品组合物，在使用时具有潮湿和凉爽的感觉以及优异的稳定性，并且能够在施用于皮肤时形成具有良好的紫外线防护效果的膜。 一种水包油防晒化妆品组合物，其包含：（a）油溶性紫外线吸收剂的水分散体; （b）交联聚醚改性硅氧烷和交联的烷基聚醚改性硅氧烷中的一种或两种以上; （c）低粘度硅油; 和（d）水。 油溶性紫外线吸收剂的水分散体优选为双 - 乙基己氧基苯酚甲氧基苯基三嗪和有机聚合物的复合粒子的水分散体。 此外，优选进一步加入亚甲基双苯并三唑基四甲基丁基苯酚。
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公开(公告)号：US20120183480A1
公开(公告)日：2012-07-19
申请号：US12674033
申请日：2009-09-29
申请人： Yuko Nagare , Yosuke Ikebe , Momo Yabu , Kazuhiro Yamaguchi
发明人： Yuko Nagare , Yosuke Ikebe , Momo Yabu , Kazuhiro Yamaguchi
CPC分类号： A61K8/06 , A61K8/062 , A61K8/26 , A61K8/35 , A61K8/361 , A61K8/40 , A61K8/411 , A61K8/4966 , A61Q17/04
摘要： The present invention is an oil-in-water emulsified composition and a sunscreen cosmetic characteristically comprising the following (a)-(j): (a) Octocrylene (b) Bis ethylhexyloxyphenol methoxyphenyl triazine (c) Hexyl diethylaminohydroxybenzoylbenzoate (d) 4-tert-butyl-4′-methoxybenzoylmethane (e) Water soluble polymer (f) Water-swelling clay mineral (g) Oil component having IOB of 0.05 or more (h) Higher fatty acid (i) Surfactant (j) Water The object of the present invention is to provide a sunscreen cosmetic that manifests a superior ultraviolet absorption effect and is superior in terms of the emulsification stability and the sensation during use.
摘要翻译： 本发明是一种水包油乳化组合物和防晒化妆品，其特征在于包含以下（a） - （j）：（a）奥屈曲宁（b）双乙基己氧基苯酚甲氧基苯基三嗪（c）己基二乙基氨基羟基苯甲酰基苯甲酸酯（d） 丁基-4'-甲氧基苯甲酰甲烷（e）水溶性聚合物（f）水溶性粘土矿物（g）IOB为0.05以上的油成分（h）高级脂肪酸（i）表面活性剂（j）水 本发明提供一种表现出优异的紫外线吸收效果的防晒化妆品，在使用时的乳化稳定性和感觉方面优异。
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