-
公开(公告)号:US09328137B2
公开(公告)日:2016-05-03
申请号:US14113057
申请日:2012-04-20
IPC分类号: A61K9/00 , A61K47/42 , C07K5/062 , A61K9/06 , C07K5/083 , C07K5/097 , C07K5/103 , C07K5/117 , A61K8/64 , A61Q19/00 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368
CPC分类号: C07K5/06026 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/64 , A61K9/06 , A61K47/42 , A61K2800/48 , A61Q19/00 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024
摘要: There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group which optionally has a C1-2 branched chain; R3 is a —(CH2)n—X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.
摘要翻译: 提供了一种水凝胶形成材料,可以用较简单的方法和较温和的条件从中形成水凝胶。 一种水凝胶形成材料,其包含脂族肽型胶凝剂,其由选自下式(1)的化合物中的至少一种形成:其中R 1为C 9-23脂族基团; R2是氢原子或任选具有C1-2支链的C1-4烷基; R3是 - (CH2)n-X基团; n是从1到4的数字; X是氨基,胍基,-CONH 2基或5元环基或6元环基,或含有5元环和6元环的稠环基, 任选地含有1至3个氮原子,以及其相似的化合物或其药学上可用的盐; 水; 和包含有机酸或有机酸盐的添加剂。
-
公开(公告)号:US20140094420A1
公开(公告)日:2014-04-03
申请号:US14113057
申请日:2012-04-20
IPC分类号: C07K5/062
CPC分类号: C07K5/06026 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/64 , A61K9/06 , A61K47/42 , A61K2800/48 , A61Q19/00 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024
摘要: There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group which optionally has a C1-2 branched chain; R3 is a —(CH2)n—X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.
摘要翻译: 提供了一种水凝胶形成材料,可以用较简单的方法和较温和的条件从中形成水凝胶。 一种水凝胶形成材料,其包含脂族肽型胶凝剂,其由选自下式(1)的化合物中的至少一种形成:其中R 1为C 9-23脂族基团; R2是氢原子或任选具有C1-2支链的C1-4烷基; R3是 - (CH2)n-X基团; n是从1到4的数字; X是氨基,胍基,-CONH 2基或5元环基或6元环基,或含有5元环和6元环的稠环基, 任选地含有1至3个氮原子,以及其相似的化合物或其药学上可用的盐; 水; 和包含有机酸或有机酸盐的添加剂。
-
公开(公告)号:US20120253012A1
公开(公告)日:2012-10-04
申请号:US13394243
申请日:2010-09-07
IPC分类号: C07K1/02
CPC分类号: A61K47/48046 , A61K38/05 , A61K47/543 , C07K1/026 , C07K1/107 , C07K1/1072 , C07K1/1075 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/06052
摘要: There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): is produced by reacting an ester compound of formula (1): with an α-amino acid compound of formula (2): in the presence of a base and within a solvent containing a nonpolar organic solvent.
摘要翻译: 提供了一种制备脂肽化合物的实用方法,该方法能够廉价地批量生产而不需要复杂的操作。 式(3)的脂肽化合物:通过使式(1)的酯化合物与式(2)的α-氨基酸化合物在碱的存在下和含有非极性有机溶剂的溶剂 。
-
公开(公告)号:US09180201B2
公开(公告)日:2015-11-10
申请号:US13394243
申请日:2010-09-07
CPC分类号: A61K47/48046 , A61K38/05 , A61K47/543 , C07K1/026 , C07K1/107 , C07K1/1072 , C07K1/1075 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/06052
摘要: There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): is produced by reacting an ester compound of formula (1): with an α-amino acid compound of formula (2): in the presence of a base and within a solvent containing a nonpolar organic solvent.
摘要翻译: 提供了一种制备脂肽化合物的实用方法,该方法能够廉价地批量生产而不需要复杂的操作。 式(3)的脂肽化合物:通过使式(1)的酯化合物与式(2)的α-氨基酸化合物在碱的存在下和含有非极性有机溶剂的溶剂 。
-
-
-