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公开(公告)号：US09328137B2
公开(公告)日：2016-05-03
申请号：US14113057
申请日：2012-04-20
IPC分类号： A61K9/00 , A61K47/42 , C07K5/062 , A61K9/06 , C07K5/083 , C07K5/097 , C07K5/103 , C07K5/117 , A61K8/64 , A61Q19/00 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368
CPC分类号： C07K5/06026 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/64 , A61K9/06 , A61K47/42 , A61K2800/48 , A61Q19/00 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024
摘要： There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group which optionally has a C1-2 branched chain; R3 is a —(CH2)n—X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.
摘要翻译： 提供了一种水凝胶形成材料，可以用较简单的方法和较温和的条件从中形成水凝胶。 一种水凝胶形成材料，其包含脂族肽型胶凝剂，其由选自下式（1）的化合物中的至少一种形成：其中R 1为C 9-23脂族基团; R2是氢原子或任选具有C1-2支链的C1-4烷基; R3是 - （CH2）n-X基团; n是从1到4的数字; X是氨基，胍基，-CONH 2基或5元环基或6元环基，或含有5元环和6元环的稠环基， 任选地含有1至3个氮原子，以及其相似的化合物或其药学上可用的盐; 水; 和包含有机酸或有机酸盐的添加剂。
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公开(公告)号：US20140094420A1
公开(公告)日：2014-04-03
申请号：US14113057
申请日：2012-04-20
IPC分类号： C07K5/062
CPC分类号： C07K5/06026 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/64 , A61K9/06 , A61K47/42 , A61K2800/48 , A61Q19/00 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024
摘要： There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group which optionally has a C1-2 branched chain; R3 is a —(CH2)n—X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.
摘要翻译： 提供了一种水凝胶形成材料，可以用较简单的方法和较温和的条件从中形成水凝胶。 一种水凝胶形成材料，其包含脂族肽型胶凝剂，其由选自下式（1）的化合物中的至少一种形成：其中R 1为C 9-23脂族基团; R2是氢原子或任选具有C1-2支链的C1-4烷基; R3是 - （CH2）n-X基团; n是从1到4的数字; X是氨基，胍基，-CONH 2基或5元环基或6元环基，或含有5元环和6元环的稠环基， 任选地含有1至3个氮原子，以及其相似的化合物或其药学上可用的盐; 水; 和包含有机酸或有机酸盐的添加剂。
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公开(公告)号：US09480772B2
公开(公告)日：2016-11-01
申请号：US13885099
申请日：2011-11-11
IPC分类号： A61L26/00 , A61K9/00 , A61K9/06 , A61K8/65 , A61K8/73 , A61Q19/00 , A61K8/81 , A61K8/02 , A61K9/70 , A61K8/49 , A61K8/04
CPC分类号： A61L26/0095 , A61K8/0216 , A61K8/042 , A61K8/4946 , A61K8/65 , A61K8/73 , A61K8/8129 , A61K9/0014 , A61K9/06 , A61K9/7015 , A61K2800/10 , A61L26/0052 , A61L26/008 , A61Q19/00
摘要： There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.
摘要翻译： 提供了具有高生物相容性和安全性的凝胶片，可以含有亲水药剂和疏水性药剂，并且在施用于人皮肤或其它物质时提供了极好的使用感。 1.一种凝胶片，其特征在于，包括：脂质肽凝胶剂，其包含分子量为1000以下的低分子量脂质肽或所述脂质肽的药学上可用的盐; 和聚合物，其中相对于凝胶片的总质量，聚合物的含量大于1％（w / w）且小于50％（w / w）。
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公开(公告)号：US20130296761A1
公开(公告)日：2013-11-07
申请号：US13885099
申请日：2011-11-11
IPC分类号： A61L26/00
CPC分类号： A61L26/0095 , A61K8/0216 , A61K8/042 , A61K8/4946 , A61K8/65 , A61K8/73 , A61K8/8129 , A61K9/0014 , A61K9/06 , A61K9/7015 , A61K2800/10 , A61L26/0052 , A61L26/008 , A61Q19/00
摘要： There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.
摘要翻译： 提供了具有高生物相容性和安全性的凝胶片，可以含有亲水药剂和疏水性药剂，并且在施用于人皮肤或其它物质时提供了极好的使用感。 1.一种凝胶片，其特征在于，包括：脂质肽凝胶剂，其包含分子量为1000以下的低分子量脂质肽或所述脂质肽的药学上可用的盐; 和聚合物，其中相对于凝胶片的总质量，聚合物的含量大于1％（w / w）且小于50％（w / w）。
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