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1.发明授权公开(公告)号：US07384645B2
公开(公告)日：2008-06-10
申请号：US10499063
申请日：2002-12-17
申请人： Keith Alan Foster , Andrew Richard Gorringe , Michael John Hudson , Karen Margaret Reddin , Andrew Robinson
发明人： Keith Alan Foster , Andrew Richard Gorringe , Michael John Hudson , Karen Margaret Reddin , Andrew Robinson
IPC分类号： A61K39/095 , A61K39/116 , A61K39/02 , A61K39/00 , A61K38/00 , C07K1/00
CPC分类号： A61K39/095 , A61K31/739 , A61K35/74 , A61K2039/55555 , A61K2039/55594 , Y02A50/478 , Y10S530/825
摘要： A composition is prepared from a mixture of different vesicles, such as outer membrane vesicles (OMVs) and vaccines are based thereon. Another composition comprises in a single vesicle a combination of antigens and/or other vesicle components deriving from separate vesicles; again vaccines are prepared therefrom.
摘要翻译： 由不同囊泡的混合物制备组合物，例如外膜囊泡（OMV），并且基于疫苗。 另一种组合物在单个泡囊中包含来自分开的囊泡的抗原和/或其他囊泡成分的组合; 再次从其制备疫苗。
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公开(公告)号：US10967045B2
公开(公告)日：2021-04-06
申请号：US12758315
申请日：2010-04-12
申请人： Andrew Robinson , Margaret Robinson , Andrew Richard Gorringe , Michael John Hudson , Karen Margaret Reddin
IPC分类号： A61K39/095 , C07K14/22 , A61K35/74 , A61K38/16 , A61K39/00
摘要： A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.
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公开(公告)号：US06821521B1
公开(公告)日：2004-11-23
申请号：US09830854
申请日：2001-08-29
IPC分类号： A61K39095
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , A61K2300/00
摘要： A composition comprising Transferrin binding proteins A and B is described (TbpA and TbpB). The composition is suitable for use in vaccines and for treatment of Gram negative bacterial infection, particularly meningococcal infection, demonstrating a broad spectrum of protection to a number of different bacterial pathogens. Also described are compositions comprising Tbps and other components, such as neisserial outer membrane vesicles and Cu,Zn-Superoxide dismutase. Methods for preparation of these compositions and their uses in vaccination against disease are further provided.
摘要翻译： 描述了包含转铁蛋白结合蛋白A和B的组合物（TbpA和TbpB）。 该组合物适用于疫苗和用于治疗革兰氏阴性细菌感染，特别是脑膜炎球菌感染，证明了许多不同细菌病原体的广谱保护。 还描述了包含Tbps和其它组分的组合物，例如奈瑟氏外膜囊泡和Cu，Zn-超氧化物歧化酶。 还提供了这些组合物的制备方法及其在疫苗接种中的用途。
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公开(公告)号：US07157245B2
公开(公告)日：2007-01-02
申请号：US09942583
申请日：2001-08-31
申请人： Andrew Robinson , Andrew Richard Gorringe , Michael John Hudson , Philippa Bracegirdle , John Simon Kroll , Paul Richard Langford , Steven Anthony Rochford Webb , Keith Cartwright , Cliona Anne O'Dwyer , Karen Margaret Reddin
发明人： Andrew Robinson , Andrew Richard Gorringe , Michael John Hudson , Philippa Bracegirdle , John Simon Kroll , Paul Richard Langford , Steven Anthony Rochford Webb , Keith Cartwright , Cliona Anne O'Dwyer , Karen Margaret Reddin
CPC分类号： C07K14/22 , A61K39/095 , A61K39/12 , A61K39/165 , A61K2039/505 , A61K2039/521 , A61K2039/523 , A61K2039/55566 , Y02A50/412
摘要： Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.
摘要翻译： 用于治疗微生物感染，特别是脑膜炎球菌疾病的方法和组合物包含共生奈瑟氏球菌或共生的奈瑟氏球菌的提取物。 其他方法和组合物包含共表达奈瑟氏球菌，其表达来自奈瑟氏球菌的毒性菌株的基因和/或来自非奈及利亚源的异源基因产物。 这种组合物用于治疗微生物感染的疫苗制剂中。
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公开(公告)号：US20110033491A1
公开(公告)日：2011-02-10
申请号：US12758315
申请日：2010-04-12
申请人： Andrew Robinson , Margaret Robinson , Andrew Richard Gorringe , Michael John Hudson , Karen Margaret Reddin
发明人： Andrew Robinson , Margaret Robinson , Andrew Richard Gorringe , Michael John Hudson , Karen Margaret Reddin
IPC分类号： A61K39/095 , A61P31/04 , C12P19/34
CPC分类号： A61K38/164 , A61K35/74 , A61K39/095 , A61K2039/55572 , C07K14/22 , A61K2300/00
摘要： A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.
摘要翻译： 提供了包含脑膜炎奈瑟氏球菌外膜囊泡的组合物，其中所述外膜囊泡富含至少一种抗原成分。 该组合物适用于疫苗和治疗感染，特别是脑膜炎球菌感染，表现出广泛的保护作用。 描述了许多优选的抗原成分，包括来自脑膜炎奈瑟氏球菌的抗原蛋白和蛋白聚糖。
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公开(公告)号：US20090148469A1
公开(公告)日：2009-06-11
申请号：US12289098
申请日：2008-10-20
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , A61K2300/00
摘要： A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.
摘要翻译： 提供了包含脑膜炎奈瑟氏球菌外膜囊泡的组合物，其中所述外膜囊泡富含至少一种抗原成分。 该组合物适用于疫苗和治疗感染，特别是脑膜炎球菌感染，表现出广泛的保护作用。 描述了许多优选的抗原成分，包括来自脑膜炎奈瑟氏球菌的抗原蛋白和蛋白聚糖。
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公开(公告)号：US07081244B2
公开(公告)日：2006-07-25
申请号：US10185769
申请日：2002-07-01
申请人： Andrew Robinson , Andrew Richard Gorringe , Michael John Hudson , Philippa Bracegirdle , John Simon Kroll , Paul Richard Langford , Steven Anthony Rochford Webb , Keith Cartwright , Cliona Anne O'Dwyer
发明人： Andrew Robinson , Andrew Richard Gorringe , Michael John Hudson , Philippa Bracegirdle , John Simon Kroll , Paul Richard Langford , Steven Anthony Rochford Webb , Keith Cartwright , Cliona Anne O'Dwyer
IPC分类号： A61K39/02 , A61K39/095 , A61K39/116 , A61K39/38 , C07K1/00
CPC分类号： A61K39/165 , A61K39/095 , A61K39/12 , A61K2039/505 , A61K2039/521 , A61K2039/523 , C07K14/22 , Y10S530/825
摘要： Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise conimensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.
摘要翻译： 用于治疗微生物感染，特别是脑膜炎球菌疾病的方法和组合物包含共生奈瑟氏球菌或共生的奈瑟氏球菌的提取物。 其他方法和组合物包括表达从奈瑟氏球菌毒性菌株和/或非奈瑟氏菌来源的异源基因产物的基因的相关奈瑟氏球菌。 这种组合物用于治疗微生物感染的疫苗制剂中。
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公开(公告)号：US10226704B2
公开(公告)日：2019-03-12
申请号：US15008447
申请日：2016-01-28
申请人： Mark Krietzman , Andrew Robinson
发明人： Mark Krietzman , Andrew Robinson
IPC分类号： A63F13/69 , A63F13/35 , A63F13/216 , A63F13/92
摘要： A method and system to leverage a gaming infrastructure to encourage actions in a non-virtual environment to achieve virtual world benefits, comprising having a participant install an application on smart phone; the participant sets up an account on Gameco servers; application interacts with Gameco servers; Gameco servers provide participant opportunities to acquire virtual world benefits by visiting specific geographic locations which may include businesses; participants visits specified location; and, participant is provided a virtual reward by Gameco.
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公开(公告)号：US08917965B2
公开(公告)日：2014-12-23
申请号：US13577781
申请日：2011-08-10
申请人： Allen D. Seftel , Andrew Robinson , Robert Morton , Christopher Floury , Ronald George Litke, Jr. , Spencer William Shore
发明人： Allen D. Seftel , Andrew Robinson , Robert Morton , Christopher Floury , Ronald George Litke, Jr. , Spencer William Shore
CPC分类号： G02B6/444 , A61B18/22 , A61B50/30 , A61B90/57 , A61B2018/2205 , A61B2090/049 , A61N2005/063
摘要： A laser optical fiber storage device (10,100) for temporarily storing a free end (12a) of an elongated flexible laser optical fiber (12). A storage housing (14,114) with an open end (116) has an elongated flexible tube (28,128) disposed therein to receive the elongated flexible laser optical fiber so as to prevent laser light from escaping the storage housing. A restrictor (32, 117a, 117b) within the storage housing reduces the inner diameter of the elongated flexible tube. Further, a laser optical fiber storage device (40,100) for temporarily storing a free end (12a) of an elongated flexible laser optical fiber (12) is provided with a clamp (42,123). The storage housing (41,114) has an open end (41a, 116) and an elongated flexible tube (28,128) disposed within the storage housing to receive the elongated flexible laser optical fiber so as to prevent laser light from escaping the storage housing. A laser fiber clamp (42,123) is mounted to the open end to secure the laser optical fiber.
摘要翻译： 一种用于临时存储细长柔性激光光纤（12）的自由端（12a）的激光光纤存储装置（10,100）。 具有开口端（116）的存储壳体（14,114）具有设置在其中的细长柔性管（28,128），以容纳细长的柔性激光光纤，以防止激光从存储壳体逸出。 存储壳体内的节流器（32,117a，117b）减小了细长柔性管的内径。 此外，用于临时存储细长柔性激光光纤（12）的自由端（12a）的激光光纤存储装置（40,100）设置有夹具（42,123）。 存储壳体（41,114）具有设置在存储壳体内的开口端（41a，116）和细长柔性管（28,128），以容纳细长的柔性激光光纤，以防止激光从存储壳体逸出。 激光光纤夹具（42,123）安装在开口端以固定激光光纤。
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公开(公告)号：US07889471B2
公开(公告)日：2011-02-15
申请号：US11399050
申请日：2006-04-05
CPC分类号： G01R22/063 , G01R21/133
摘要： A power supply providing current interruption based on the energy from the supply over a sliding window of time is disclosed. The output current from the supply is periodically reestablished.
摘要翻译： 公开了一种基于来自供应的能量通过滑动窗口提供电流中断的电源。 电源的输出电流定期重新建立。
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