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    Methods and compounds for the treatment of mucus hypersecretion
    2.
    发明授权
    Methods and compounds for the treatment of mucus hypersecretion 失效
    用于治疗粘液分泌过多的方法和化合物

    公开(公告)号：US06632440B1

    公开(公告)日：2003-10-14

    申请号：US09763669

    申请日：2001-05-29

    申请人： Conrad Padraig Quinn ,  Keith Alan Foster ,  John Andrew Chaddock

    发明人： Conrad Padraig Quinn ,  Keith Alan Foster ,  John Andrew Chaddock

    IPC分类号： A61K3968

    CPC分类号： A61K47/62 ,  Y10S424/81

    摘要： A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a compound that inhibits exocytosis in mucus secreting cells or neurones that control or direct mucus secretion. Also described is a compound, for use in the treatment of hypersecretion of mucus, which inhibits mucus secretion by inhibiting mucus secreting cells, and/or inhibiting neurotransmitter release from neuronal cells controlling or directing mucus secretion.

    摘要翻译： 一种治疗粘液分泌过多症的方法，慢性阻塞性肺疾病（COPD），哮喘和其它涉及COPD的临床病症的因素包括给予抑制或分泌粘液分泌细胞或神经元中的胞吐作用的化合物。 还描述了一种用于治疗粘液分泌过高的化合物，其通过抑制粘液分泌细胞抑制粘液分泌，和/或抑制神经递质从控制或引导粘液分泌的神经细胞释放。

    Use of a lectin or conjugates for modulation of c-fibre activity
    3.
    发明授权
    Use of a lectin or conjugates for modulation of c-fibre activity 失效
    使用凝集素或共轭物调节c-纤维活性

    公开(公告)号：US07208466B1

    公开(公告)日：2007-04-24

    申请号：US09937484

    申请日：2000-03-31

    申请人： Keith Alan Foster ,  John Andrew Chaddock ,  Conrad Padraig Quinn

    发明人： Keith Alan Foster ,  John Andrew Chaddock ,  Conrad Padraig Quinn

    IPC分类号： A61K38/00 ,  A61K51/00 ,  A61M36/14 ,  C07K16/00 ,  C07K17/00

    CPC分类号： C07K14/42 ,  A61K38/168 ,  A61K47/6415 ,  A61K48/00

    摘要： The present invention relates to the treatment of pain and to compounds that modulate C-fibre activity. In particular, the present invention relates to the use of a lectin in the manufacture of a medicament for modulation of C-fibre neuron activity, and to lectin conjugates. The lectin conjugates comprise a lectin coupled to a peptide or protein, wherein the peptide or protein is substantially free of Clostridial neurotoxin enzyme activity. The present invention also concerns methods for manufacturing conjugates. The compounds and compositions described have particular application in the treatment of diseases of which C-fibre activity is a component. Such diseases include pain, inflamation, psoriasis and other C-fibre related conditions.

    摘要翻译： 本发明涉及疼痛的治疗以及调节C-纤维活性的化合物。 特别地，本发明涉及凝集素在制备用于调节C-纤维神经元活性的药物和凝集素缀合物中的用途。 凝集素缀合物包含与肽或蛋白质偶联的凝集素，其中肽或蛋白质基本上不含梭菌神经毒素酶活性。 本发明还涉及制造缀合物的方法。 所述的化合物和组合物特别适用于治疗其C-纤维活性为组分的疾病。 这些疾病包括疼痛，炎症，牛皮癣和其他C纤维相关病症。

    Recombinant toxin fragments
    5.
    发明授权
    Recombinant toxin fragments 有权
    重组毒素片段

    公开(公告)号：US06461617B1

    公开(公告)日：2002-10-08

    申请号：US09255829

    申请日：1999-02-23

    申请人： Clifford Charles Shone ,  Conrad Padraig Quinn ,  Keith Alan Foster

    发明人： Clifford Charles Shone ,  Conrad Padraig Quinn ,  Keith Alan Foster

    IPC分类号： A61K3902

    CPC分类号： C12N15/62 ,  A61K38/00 ,  A61K39/00 ,  A61K39/08 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/627 ,  C07K14/33 ,  C07K14/475 ,  C07K14/65 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/23 ,  C07K2319/50 ,  C07K2319/55 ,  C07K2319/705 ,  C07K2319/75 ,  C12N9/52 ,  Y02A50/469 ,  Y10S530/825

    摘要： A polypeptide has first and second domains which enable the polypeptide to be translocated into a target cell or which increase the solubility of the polypeptide, or both, and further enable the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.

    摘要翻译： 多肽具有使多肽能够转位到靶细胞中或者增加多肽或两者的溶解度的第一和第二结构域，并且进一步使多肽能够切割一种或多种胞吐作用所必需的囊泡或质膜相关蛋白 。 因此，该多肽结合梭菌毒素如肉毒杆菌或破伤风毒素的有用性质，而不与天然分子相关的毒性。 多肽还可以含有将其靶向特定细胞的第三结构域，使得多肽可用于抑制靶细胞中的胞吐作用。 还提供了包含多肽的融合蛋白，编码多肽的核酸和制备多肽的方法。 多肽的受控活化是可能的，并且多肽可以并入疫苗和毒素测定中。

    Methods and compounds for the treatment of mucus hypersecretion
    6.
    发明申请
    Methods and compounds for the treatment of mucus hypersecretion 审中-公开
    用于治疗粘液分泌过多的方法和化合物

    公开(公告)号：US20080152667A1

    公开(公告)日：2008-06-26

    申请号：US11808057

    申请日：2007-06-06

    申请人： Conrad Padraig Quinn ,  Keith Alan Foster ,  John Chaddock

    发明人： Conrad Padraig Quinn ,  Keith Alan Foster ,  John Chaddock

    IPC分类号： A61K39/08 ,  A61K39/00 ,  C12N15/63 ,  A61P25/00

    CPC分类号： A61K38/4886 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/33

    摘要： A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a compound that inhibits exocytosis in mucus secreting cells or neurones that control or direct mucus secretion. Also described is a compound, for use in the treatment of hypersecretion of mucus, which inhibits mucus secretion by inhibiting mucus secretion by mucus secreting cells, and/or inhibiting neurotransmitter release from neuronal cells controlling or directing mucus secretion.

    摘要翻译： 一种治疗粘液分泌过多症的方法，慢性阻塞性肺疾病（COPD），哮喘和其它涉及COPD的临床病症的因素包括给予抑制或分泌粘液分泌细胞或神经元中的胞吐作用的化合物。 还描述了一种用于治疗粘液分泌过高的化合物，其通过抑制由分泌分泌细菌的粘液分泌而抑制粘液分泌，和/或抑制神经递质从控制或引导粘液分泌的神经元细胞释放。

    Methods and compounds for the treatment of mucus hypersecretion
    9.
    发明授权
    Methods and compounds for the treatment of mucus hypersecretion 失效
    用于治疗粘液分泌过多的方法和化合物

    公开(公告)号：US07727538B2

    公开(公告)日：2010-06-01

    申请号：US11518213

    申请日：2006-09-11

    申请人： Conrad Padraig Quinn ,  Keith Alan Foster ,  John Chaddock

    发明人： Conrad Padraig Quinn ,  Keith Alan Foster ,  John Chaddock

    IPC分类号： A61K39/68 ,  A61K39/00 ,  C07K14/00

    CPC分类号： A61K38/4886 ,  A61K47/62 ,  C07K14/33 ,  C07K2319/33

    摘要： A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a compound that inhibits exocytosis in mucus secreting cells or neurones that control or direct mucus secretion. Also described is a compound, for use in the treatment of hypersecretion of mucus, which inhibits mucus secretion by inhibiting mucus secretion by mucus secreting cells, and/or inhibiting neurotransmitter release from neuronal cells controlling or directing mucus secretion.

    摘要翻译： 一种治疗粘液分泌过多症的方法，慢性阻塞性肺疾病（COPD），哮喘和其它涉及COPD的临床病症的因素包括给予抑制或分泌粘液分泌细胞或神经元中的胞吐作用的化合物。 还描述了一种用于治疗粘液分泌过高的化合物，其通过抑制由分泌分泌细菌的粘液分泌而抑制粘液分泌，和/或抑制神经递质从控制或引导粘液分泌的神经元细胞释放。

    Recombinant toxin fragments
    10.
    发明授权
    Recombinant toxin fragments 失效
    重组毒素片段

    公开(公告)号：US07674470B2

    公开(公告)日：2010-03-09

    申请号：US11077550

    申请日：2005-03-11

    申请人： Charles Clifford Shone ,  Conrad Padraig Quinn ,  Keith Alan Foster ,  John Chaddock ,  Philip Marks ,  J. Mark Sutton ,  Patrick Stancombe ,  Jonathan Wayne

    发明人： Charles Clifford Shone ,  Conrad Padraig Quinn ,  Keith Alan Foster ,  John Chaddock ,  Philip Marks ,  J. Mark Sutton ,  Patrick Stancombe ,  Jonathan Wayne

    IPC分类号： A61K39/08 ,  A61K39/085 ,  A61K39/40 ,  A61K39/02 ,  A61K38/00 ,  A61K39/38 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00 ,  C07K4/00 ,  C07K1/00

    CPC分类号： C12N15/62 ,  A61K38/00 ,  A61K39/00 ,  A61K39/08 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/627 ,  C07K14/33 ,  C07K14/475 ,  C07K14/65 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/23 ,  C07K2319/50 ,  C07K2319/55 ,  C07K2319/705 ,  C07K2319/75 ,  C12N9/52 ,  Y02A50/469 ,  Y10S530/825

    摘要： Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain HN portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated HC thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides.The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.

    摘要翻译： 提供抗原组合物，其包含包含第一和第二结构域的单链多肽，其中所述第一结构域是梭菌神经毒素轻链或其片段或变体，并且能够切割一种或多种与胞吐作用必需的相关蛋白或质膜相关蛋白; 并且所述第二结构域是梭菌神经毒素重链HN部分或其片段或变体，其中所述第二结构域能够（i）将多肽转位到细胞中，或（ii）与溶解度相比增加多肽的溶解度 或（iii）将多肽转移到细胞中并且与第一结构域本身的溶解度相比增加多肽的溶解度; 并且其中所述第二结构域缺少称为HC的梭菌神经毒素重链的功能性C-末端部分，从而使所述多肽不能结合作为天然梭菌神经毒素结合的天然细胞表面受体的细胞表面受体。 还提供了结合多肽的抗体和包含这些抗体的组合物，DNA疫苗也包括编码这些多肽的多核苷酸。 抗原和抗体组合物和DNA疫苗组合物可用于通过向该受试者施用治疗有效量的组合物来免疫或治疗受试者的梭菌神经毒素中毒的方法。