公开(公告)号：US06180024B2

公开(公告)日：2001-01-30

申请号：US09254073

申请日：1999-02-26

申请人： Keith M Blackwood ,  Michelle Jones ,  David Lacey ,  Alan W Hall ,  Kenneth J Toyne ,  Steven Pringle

发明人： Keith M Blackwood ,  Michelle Jones ,  David Lacey ,  Alan W Hall ,  Kenneth J Toyne ,  Steven Pringle

IPC分类号： C09K1952

CPC分类号： C09K19/3895 ,  C08F246/00 ,  C09K19/3842 ,  C09K19/3852 ,  Y10T428/10

摘要： Methods, based on the Wittig-Horner reaction, are provided for the synthesis of compounds of formula (I) where m is from 5-150, X and Y are independently selected from: CN, H, OH, COCH3, CO2H, CO2H, CO2R1, where R1 is C1-12 alkyl, NCS, SCN, CF3, CH2X where X is F, Cl, Br, OH, CHF2 and formula (IB), where J for each X and Y group is independently selected from: CH2, single covalent bond, OOC, CO2, O, CH2O, OCH2, CH2CO2, CH2OOC; p=1-20; L for each X and Y group is independently selected from: O, CH2OCO, CO2, S, NH; (a) is defined by formula (IC), where rings A, B and C are independently selected from phenyl, cyclohexyl, pyridine and pyrimidine and may be independently of each other substituted with at least one of Cl or F; linking groups A and B may be selected from single bond, CO2, OOC, CH2O, OCH2, CH2CH2, C≡C; Z is selected from CN, F, Cl, NO2, R, OR, CO2R, CF3, OOCR, NCS, SCN, where R=straight chain or branched chain alkyl and may include from 1-16 carbon atoms and including where one or more non-adjacent CH2 groups may be substituted by CH(CN), CH(CF3), CH(Cl), CH(CH3) in chiral or non-chiral form; provided that at least one of X and Y is selected from (IB); the method polymerizing a compound of general formula (II), where X and Y are defined as formula (I).

摘要翻译： 提供了基于Wittig-Horner反应的合成式（I）化合物，其中m为5-150，X和Y独立地选自：CN，H，OH，COCH 3，CO 2 H，CO 2 H， CO 2 R 1，其中R 1是C 1-12烷基，NCS，SCN，CF 3，CH 2 X，其中X是F，Cl，Br，OH，CHF 2和式（IB），其中每个X和Y基团的J独立地选自：CH 2， 单共价键，OOC，CO 2，O，CH 2 O，OCH 2，CH 2 CO 2，CH 2 OOC; p = 1-20; 每个X和Y基团的L独立地选自：O，CH 2 OCO，CO 2，S，NH; （a）由式（IC）定义，其中环A，B和C独立地选自苯基，环己基，吡啶和嘧啶，并且可以彼此独立地被Cl或F中的至少一个取代; 连接基团A和B可以选自单键，CO 2，OOC，CH 2 O，OCH 2，CH 2 CH 2，C = C; Z选自CN，F，Cl，NO 2，R，OR，CO 2 R，CF 3，OOCR，NCS，SCN，其中R =直链或支链烷基，并且可以包括1-16个碳原子，并且包括其中一个或多个 不相邻的CH2基可以被手性或非手性形式的CH（CN），CH（CF 3），CH（Cl），CH（CH 3）取代; 条件是X和Y中的至少一个选自（IB）; 聚合通式（II）的化合物的方法，其中X和Y定义为式（I）。

公开(公告)号：US20070278397A1

公开(公告)日：2007-12-06

申请号：US11718213

申请日：2005-11-03

申请人： Robert Bateman ,  Kevin Giles ,  Steven Pringle ,  Jason Wildgoose

发明人： Robert Bateman ,  Kevin Giles ,  Steven Pringle ,  Jason Wildgoose

IPC分类号： H01J49/34 ,  H01J49/42

CPC分类号： G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/02 ,  H01J49/062 ,  H01J49/065 ,  H01J49/066 ,  H01J49/40 ,  H01J49/401 ,  H01J49/42

摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion guide (6) so that ions received from the ion mobility spectrometer or separator (4) become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator (4). The potential wells are translated along the length of the ion guide (6).

摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器（4）和布置在离子迁移谱仪或分离器（4）的下游的离子导向器（6）。 在离子导向器（6）中产生多个轴向势阱，使得从离子迁移谱仪或分离器（4）接收的离子被限制在单独的轴向势阱中。 潜在的孔维持从离子迁移谱仪或分离器（4）接收的离子的保真度和/或组成。 潜在的井沿离子导向件（6）的长度平移。

公开(公告)号：US20090072136A1

公开(公告)日：2009-03-19

申请号：US12092313

申请日：2006-11-01

申请人： Steven Pringle ,  Jason Lee Wildgoose

发明人： Steven Pringle ,  Jason Lee Wildgoose

IPC分类号： B01D59/44

CPC分类号： H01J49/062 ,  H01J49/004 ,  H01J49/4235 ,  H01J49/427

摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of seudo-potential corrugations are created along the axis of the mass analyser (2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of mass to charge ratio.

摘要翻译： 提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。 沿着质量分析器（2）的轴线产生多个潜在的波纹。 伪电位波纹的振幅或深度与离子的质荷比成反比。 为了沿着质量分析器（2）的长度推动离子，一个或多个瞬态直流电压被施加到质量分析器（2）的电极。 施加到电极的瞬态直流电压的幅度随着时间而增加，并且使质子分析器（2）以与质荷比相反的顺序发射离子。

公开(公告)号：US09184039B2

公开(公告)日：2015-11-10

申请号：US12092313

申请日：2006-11-01

申请人： Steven Pringle ,  Jason Lee Wildgoose

发明人： Steven Pringle ,  Jason Lee Wildgoose

IPC分类号： H01J49/36 ,  H01J49/06 ,  H01J49/00 ,  H01J49/42

CPC分类号： H01J49/062 ,  H01J49/004 ,  H01J49/4235 ,  H01J49/427

摘要： A mass analyzer (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of seudo-potential corrugations are created along the axis of the mass analyzer (2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyzer (2) in order to urge ions along the length of the mass analyzer (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyzer (2) in reverse order of mass to charge ratio.

摘要翻译： 提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。 沿着质量分析器（2）的轴线产生多个潜在的波纹。 伪电位波纹的振幅或深度与离子的质荷比成反比。 为了沿着质量分析器（2）的长度推动离子，一个或多个瞬态直流电压被施加到质量分析器（2）的电极。 施加到电极的瞬态直流电压的幅度随着时间而增加，并且使质子分析器（2）以与质荷比相反的顺序发射离子。

公开(公告)号：US20070284521A1

公开(公告)日：2007-12-13

申请号：US10599572

申请日：2005-04-04

申请人： Martin Green ,  Jason Wildgoose ,  Steven Pringle ,  Kevin Giles

发明人： Martin Green ,  Jason Wildgoose ,  Steven Pringle ,  Kevin Giles

IPC分类号： H01J49/04 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/06 ,  Y10T436/24

摘要： A mass spectrometer is disclosed comprising an ion beam attenuator which attenuates an ion beam repeatedly switching between a zero transmission mode of operation during a time period ΔT1 and a non-zero transmission mode of operation during a time period ΔT2. The degree of attenuation of the ion beam can be varied by varying the mark space ratio ΔT2/ΔT1. The ion beam attenuator may release ions in packets or pulses but the packets or pulses of ions may be converted into a continuous ion beam by a relatively high pressure ion guide or gas collision cell arranged downstream of the ion beam attenuator.

摘要翻译： 公开了一种质谱仪，其包括离子束衰减器，该离子束衰减器在时间段ΔT1期间衰减离子束在时间段ΔT1内的零传输模式和在时间段ΔT2期间的非零传输模式之间重复切换。 SUB>。 离子束的衰减程度可以通过改变标记空间比DeltaT 2 /ΔT1 <1>而改变。 离子束衰减器可以以分组或脉冲的形式释放离子，但是离子束或脉冲可以通过布置在离子束衰减器下游的相对高压的离子导向器或气体碰撞元件转换为连续的离子束。