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    Anxiolytic drug
    1.
    发明授权
    Anxiolytic drug 失效
    溶血药

    公开(公告)号：US5219855A

    公开(公告)日：1993-06-15

    申请号：US839737

    申请日：1992-02-19

    申请人： Ken-Ichi Saito ,  Akihiro Tobe ,  Heitaro Iwata ,  Akemichi Baba ,  Toshio Matsuda

    发明人： Ken-Ichi Saito ,  Akihiro Tobe ,  Heitaro Iwata ,  Akemichi Baba ,  Toshio Matsuda

    IPC分类号： A61K31/495 ,  A61K31/505 ,  C07D317/64 ,  C07D319/18 ,  C07D321/10 ,  C07D405/12

    CPC分类号： C07D405/12 ,  A61K31/495 ,  A61K31/505 ,  C07D317/64 ,  C07D319/18 ,  C07D321/10

    摘要： Disclosed herein are anxiolytic drugs containing as an active ingredient a piperazine derivative represented by the following general formula (I): ##STR1## wherein m represents an integer from 2 to 4,X represents ##STR2## Ar represents a pyridyl group, a pyrimidinyl group, or a phenyl group which may be substituted with halogen atom, trifluoromethyl group, alkoxy group or alkyl group, andR.sub.1, R.sub.2 and R.sub.3 which may be identical or different represent lower alkoxy groups, or R.sub.3 is a hydrogen atom and R.sub.1 when taken together with R.sub.2 forms ##STR3## (n=1, 2 or 3); and its acid addition salt.The anxiolytic drugs disclosed herein have the high binding capacities to 5-HT.sub.1A receptor which is one of the receptors for 5-hydroxytryptamine (5-HT), thereby exerting anxiolytic effects.

    摘要翻译： 本文公开了含有作为活性成分的由以下通式（I）表示的哌嗪衍生物的抗焦虑药物：其中m表示2至4的整数，X表示Ar表示 吡啶基，嘧啶基或可被卤素原子，三氟甲基，烷氧基或烷基取代的苯基，并且可以相同或不同的R 1，R 2和R 3表示低级烷氧基，或者R 3为氢 原子和R1与R2一起形成（n = 1,2或3）; 及其酸加成盐。 本文公开的抗焦虑药物具有对5-HT1A受体的高结合能力，其为5-羟色胺（5-HT）的受体之一，从而发挥抗焦虑作用。

    Neurotrophic factor production accelerator
    4.
    发明申请
    Neurotrophic factor production accelerator 审中-公开
    神经营养因子生成促进剂

    公开(公告)号：US20060069104A1

    公开(公告)日：2006-03-30

    申请号：US10509336

    申请日：2003-04-03

    申请人： Toshio Matsuda ,  Akemichi Baba ,  Yutaka Koyama

    发明人： Toshio Matsuda ,  Akemichi Baba ,  Yutaka Koyama

    IPC分类号： A61K31/495 ,  A61K31/445

    CPC分类号： C07D295/32 ,  A61K31/495 ,  A61K38/4866

    摘要： The present invention relates to an a neurotrophic factor production accelerator comprising, as an active ingredient, a compound represented by the formula (I) below: wherein R1 is lower alkyl, aryl, ar(lower)alkoxy, or a heterocyclic group, and the above groups may be substituted with halogen, R2 is a hydrogen atom or lower alkyl, R3 is cyclo(lower)alkyl, aryl or ar(lower)alkyl, and the above groups may be substituted with halogen, A is —CO—, —SO2— or lower alkylene, X is N or CH, Y is —CO—, —SO2— or —CONH—, a salt, a prodrug or a solvate thereof. According to the present invention, a neurotrophic factor production accelerator, which is useful for the prophylaxis or treatment of a motor nervous system or peripheral nervous system disease, can be provided.

    摘要翻译： 本发明涉及一种神经营养因子生成促进剂，其包含作为活性成分的下式（I）表示的化合物：

    Food additive composition and process for preparation thereof
    6.
    发明授权
    Food additive composition and process for preparation thereof 失效
    食品添加剂组合物及其制备方法

    公开(公告)号：US4168323A

    公开(公告)日：1979-09-18

    申请号：US801320

    申请日：1977-05-27

    申请人： Shigeo Inamine ,  Toshio Matsuda ,  Takeo Shimomura

    发明人： Shigeo Inamine ,  Toshio Matsuda ,  Takeo Shimomura

    IPC分类号： A21D2/16 ,  A21D2/18 ,  A21D2/32 ,  A23B4/20 ,  A23L1/035 ,  A23L1/09 ,  A23L1/314 ,  A23L1/325 ,  A23L1/272

    CPC分类号： A23B4/20 ,  A21D2/16 ,  A21D2/181 ,  A21D2/32 ,  A23L13/42 ,  A23L13/428 ,  A23L17/00 ,  A23L17/70 ,  A23L29/10 ,  A23L29/30

    摘要： A food additive composition admixed with fish mince consisting of a hydrophilic powdery colloidal solid having a particle size smaller than 20 mesh and comprising 60 to 99% of a sugar alcohol or a sugar, 30 to 0.5% of a food-grade surface-active agent and 30 to 0% of an edible oil or fat. The food additive can be prepared by adding a food-grade surface-active agent and an oil or fat to a melt or aqueous solution of a sugar alcohol or a sugar to dissolve them or disperse them in a fine particlar form, optionally adding a sugar alcohol or a sugar as a seed crystal, solidifying the solution or dispersion to form a colloidal solid, stabilizing the colloidal solid by crystallization, optionally drying the stablized solid, and pulverizing it to a particle size smaller than 20 mesh.

    摘要翻译： 一种食品添加剂组合物，其与鱼粉混合，所述食品添加剂组合物由粒度小于20目的亲水性粉末状胶态固体组成，包含60-99％的糖醇或糖，30至0.5％的食品级表面活性剂 和30〜0％的食用油或脂肪。 可以通过将食品级表面活性剂和油或脂肪添加到糖醇或糖的熔体或水溶液中以溶解它们或将它们分散成细颗粒形式，任选地加入糖来制备食品添加剂 酒精或糖作为晶种，固化溶液或分散体以形成胶态固体，通过结晶稳定胶态固体，任选地干燥稳定的固体，并将其粉碎至小于20目的粒度。

    Semiconductor laser apparatus and production method thereof
    7.
    发明授权
    Semiconductor laser apparatus and production method thereof 失效
    半导体激光装置及其制造方法

    公开(公告)号：US07075960B2

    公开(公告)日：2006-07-11

    申请号：US10753953

    申请日：2004-01-09

    申请人： Naoki Kohara ,  Nobuyuki Iwamoto ,  Akira Takamori ,  Toshio Matsuda

    发明人： Naoki Kohara ,  Nobuyuki Iwamoto ,  Akira Takamori ,  Toshio Matsuda

    IPC分类号： H01S3/04

    CPC分类号： H01S5/02248 ,  H01L2224/48464 ,  H01L2224/73265 ,  H01S5/005 ,  H01S5/0071 ,  H01S5/02272 ,  H01S5/02292 ,  H01S5/02469 ,  H01S5/02476

    摘要： A semiconductor blue-light-laser apparatus for emitting laser beams with high positional accuracy, which is achieved by mounting a semiconductor laser element on a semiconductor substrate with high accuracy and reliability, and a production method of the apparatus. A recess in a surface of the substrate has a p-type layer 100, which is coated with the SiN layer 105, Ti layers 110a and 110b, Au layers 111a and 111b, heat sink layer 113, and solder layer 114. Semiconductor laser element 10 is placed and fixed on Au layer 111b. Heat sink layer 113 is inserted between Au layer 111a and Ti layer 110b and is approximately 20 μm thick. Reflection unit 50 for reflecting laser beams LB includes at the surface thereof Al layer 116 and dielectric layer 117 as a reflection layer that provides a high refractive index for blue light laser beams.

    摘要翻译： 一种用于以高精度和可靠性将半导体激光元件安装在半导体衬底上而实现的具有高定位精度的激光束的半导体蓝光激光装置及其制造方法。 衬底的表面中的凹部具有涂覆有SiN层105，Ti层110a和110b，Au层111a和111b，散热层113和焊料层114的p型层100 。 将半导体激光元件10放置并固定在Au层111b上。 散热层113插入在Au层111a和Ti层110b之间并且厚度约为20μm。 用于反射激光束LB的反射单元50在其表面上包括作为对蓝色光激光束提供高折射率的反射层的Al层116和介电层117。

    Battery charger
    8.
    发明授权
    Battery charger 失效
    充电器

    公开(公告)号：US5274321A

    公开(公告)日：1993-12-28

    申请号：US819978

    申请日：1992-01-13

    申请人： Toshio Matsuda

    发明人： Toshio Matsuda

    IPC分类号： H02J7/00 ,  H02J7/04

    CPC分类号： H02J7/008 ,  Y10S320/19

    摘要： A battery charger is disclosed comprising a pair of charging terminals to which a secondary battery may be connected, a power source for supplying the charging terminals with a charging voltage, a recharging detector for detecting the degree of recharging on the secondary battery on the strength of the voltage between the charging terminals, and a timer operative to measure a predetermined time beginning when the recharging detector detects that the degree of recharging on the second battery has reached a predetermined degree set within a range from seventy percent to ninety percent of full recharging. The invention further includes a first recharging indicator, for example an LED, which indicates that the secondary battery is being charged up until the timing operation commences. Once the timing operation begins, a second recharging indicator, for example a differently colored LED, indicates that the secondary battery has been charged to the predetermined degree and is receiving a final charge during the timing operation.

    Process for inhibiting growth of Clostridium botulinum and formation of nitrosamines in meat
    9.
    发明授权
    Process for inhibiting growth of Clostridium botulinum and formation of nitrosamines in meat 失效
    抑制肉毒杆菌生长和肉中亚硝胺形成的方法

    公开(公告)号：US4342789A

    公开(公告)日：1982-08-03

    申请号：US165077

    申请日：1980-07-01

    申请人： Ryuzo Ueno ,  Toshio Matsuda ,  Shigeo Inamine ,  Tatsuo Kanayama ,  Yatsuka Fujita

    发明人： Ryuzo Ueno ,  Toshio Matsuda ,  Shigeo Inamine ,  Tatsuo Kanayama ,  Yatsuka Fujita

    IPC分类号： A23B4/023 ,  A23B4/10 ,  A23B4/28 ,  A23B4/30 ,  A23B4/02 ,  A23B4/14

    CPC分类号： A23B4/285 ,  A23B4/0235 ,  A23B4/10 ,  A23B4/305

    摘要： A process for inhibiting growth of Clostridium botulinum and formation of nitrosamines in pork which comprises separately adding to the pork (A) a liquid or powdery additive composition containing sorbic acid or potassium sorbate and optionally (A') a powdery or liquid additive composition containing at least one of such reducing agents as ascorbic acid or its salts, erythorbic acid or its salts, higher fatty acid esters of ascorbic acid and erythorbic acid, higher acetals of ascorbic acid and erythorbic acid and tocopherols, and (B) a liquid or powdery curing agent containing nitrite.

    摘要翻译： 一种用于抑制肉毒杆菌生长和猪肉中亚硝胺形成的方法，其包括向猪肉（A）中单独加入含有山梨酸或山梨酸钾和任选的（A'）粉末或液体添加剂组合物的液体或粉末添加剂组合物，所述组合物含有 至少一种还原剂如抗坏血酸或其盐，异抗坏血酸或其盐，抗坏血酸和异抗坏血酸的高级脂肪酸酯，抗坏血酸和异抗坏血酸的高级缩醛和生育酚，和（B）液体或粉末状固化 含亚硝酸盐的药剂。

    Food additive composition and process for preparation thereof
    10.
    发明授权
    Food additive composition and process for preparation thereof 失效
    食品添加剂组合物及其制备方法

    公开(公告)号：US4252834A

    公开(公告)日：1981-02-24

    申请号：US2318

    申请日：1979-01-10

    申请人： Shigeo Inamine ,  Toshio Matsuda ,  Takeo Shimomura

    发明人： Shigeo Inamine ,  Toshio Matsuda ,  Takeo Shimomura

    IPC分类号： A21D2/16 ,  A21D2/18 ,  A21D2/32 ,  A23B4/20 ,  A23L1/035 ,  A23L1/09 ,  A23L1/314 ,  A23L1/325 ,  A23B4/14

    CPC分类号： A23B4/20 ,  A21D2/16 ,  A21D2/181 ,  A21D2/32 ,  A23L13/42 ,  A23L13/428 ,  A23L17/00 ,  A23L17/70 ,  A23L29/10 ,  A23L29/30

    摘要： A food additive composition consisting of a hydrophilic powdery colloidal solid having a particle size smaller than 20 mesh and comprising 60 to 99% of a sugar alcohol or a sugar, 30 to 0.5% of a food-grade surface-active agent and 30 to 0% of an edible oil or fat. The food additive can be prepared by adding a food-grade surface-active agent and an oil or fat to a melt or aqueous solution of a sugar alcohol or a sugar to dissolve them or disperse them in a fine particler form, optionally adding a sugar alcohol or a sugar as a seed crystal, solidifying the solution or dispersion to form a colloidal solid, stabilizing the colloidal solid by crystallization, optionally drying the stabilized solid, and pulverizing it to a particle size smaller than 20 mesh.

    摘要翻译： 一种食品添加剂组合物，其由粒径小于20目的亲水性粉末状胶态固体组成，包含60至99％的糖醇或糖，30至0.5％的食品级表面活性剂和30至0 ％的食用油或脂肪。 食品添加剂可以通过将食品级表面活性剂和油或脂肪添加到糖醇或糖的熔体或水溶液中来溶解或分散成细颗粒形式，任选地加入糖 酒精或糖作为晶种，固化溶液或分散体以形成胶体固体，通过结晶使胶体固体稳定，任选地干燥稳定的固体，并将其粉碎至小于20目的粒度。