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1.发明申请Methods and apparatus for monitoring physiological responses to steady state activity 审中-公开监测对稳态活动的生理反应的方法和装置公开(公告)号：US20070021678A1
公开(公告)日：2007-01-25
申请号：US11184327
申请日：2005-07-19
申请人： Kenneth Beck , Lemont Baker , Donald Hopper
发明人： Kenneth Beck , Lemont Baker , Donald Hopper
CPC分类号： A61B5/0245 , A61B5/0215 , A61B5/029 , A61B5/0816 , A61B5/1116 , A61B5/145 , A61B5/686 , A61B2560/0468 , A61B2562/0219 , A61N1/36585 , A61N1/37
摘要： This document discusses, among other things, methods of monitoring physiological responses to steady state activity. In an example, a physical activity signal is detected from a human or animal subject using an implantable medical device. A different, other physiological signal is also detected from the subject using the implantable medical device. The physical activity signal is processed to define first and second time periods associated with first and second steady-state physical activity levels of the subject. A first indicator is obtained by combining data from the other physiological signal obtained during the first time period. A second indicator is obtained by combining data from the other physiological signal obtained during the second time period. The first and second indicators are used provide a diagnostic indicator.
摘要翻译： 本文件还讨论了监测对稳态活动的生理反应的方法。 在一个示例中，使用可植入医疗装置从人或动物受试者检测身体活动信号。 使用可植入医疗装置也可以从对象检测不同的其他生理信号。 处理身体活动信号以定义与受试者的第一和第二稳态身体活动水平相关联的第一和第二时间段。 通过组合来自第一时间段期间获得的其他生理信号的数据获得第一指示符。 通过组合来自在第二时间段期间获得的其他生理信号的数据获得第二指示符。 使用第一和第二指标提供诊断指标。
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2.发明申请Cardiopulmonary functional status assessment via heart rate response dectection by implantable cardiac device 有权通过植入式心脏装置的心率反应检查进行心肺功能状态评估公开(公告)号：US20060030892A1
公开(公告)日：2006-02-09
申请号：US10914632
申请日：2004-08-09
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61B5/0205 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.
摘要翻译： 可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。 可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。 然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。
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3.发明授权Cardiopulmonary functional status assessment via heart rate response detection by implantable cardiac device 有权通过植入式心脏装置的心率响应检测进行心肺功能状态评估公开(公告)号：US07269458B2
公开(公告)日：2007-09-11
申请号：US10914632
申请日：2004-08-09
CPC分类号： A61N1/365 , A61B5/0205 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.
摘要翻译： 可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。 可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。 然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。
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4.发明授权Cardiopulmonary functional status assessment via heart rate response detection by implantable cardiac device 有权通过植入式心脏装置的心率响应检测进行心肺功能状态评估公开(公告)号：US07869877B2
公开(公告)日：2011-01-11
申请号：US11852845
申请日：2007-09-10
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61B5/0205 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.
摘要翻译： 可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。 可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。 然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。
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5.发明申请CARDIOPULMONARY FUNCTIONAL STATUS ASSESSMENT VIA HEART RATE RESPONSE DECTECTION BY IMPLANTABLE CARDIAC DEVICE 有权通过可注射心脏装置的心率反应评估进行的心脏功能状态评估公开(公告)号：US20080004668A1
公开(公告)日：2008-01-03
申请号：US11852845
申请日：2007-09-10
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61B5/0205 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.
摘要翻译： 可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。 可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。 然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。
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6.发明授权公开(公告)号：US07480528B2
公开(公告)日：2009-01-20
申请号：US10897856
申请日：2004-07-23
IPC分类号： A61B5/0402
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
摘要翻译： 系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。 基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。 如果没有检测到心源性肺水肿，则基于由可植入或非可行性肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病， 植入式传感器。 在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。
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7.发明申请公开(公告)号：US20090132000A1
公开(公告)日：2009-05-21
申请号：US12319642
申请日：2009-01-08
IPC分类号： A61N1/365
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
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8.发明申请公开(公告)号：US20060020295A1
公开(公告)日：2006-01-26
申请号：US10897856
申请日：2004-07-23
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
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公开(公告)号：US09079033B2
公开(公告)日：2015-07-14
申请号：US12356289
申请日：2009-01-20
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/0816 , A61N1/36521 , A61N1/36592 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3418 , G16H10/20 , G16H40/63 , G16H50/30
摘要： Changes in patient status are assessed based at least in part on respiration parameters. A user can make selections regarding alert criteria options to be used in assessing patient status. Respiration is implantably sensed and respiration data is stored by an implantable device. A respiration parameter, such as respiration rate, is measured from the respiration data. The change in patient status is assessed by comparing the respiration parameter to the configured alert criteria. If the comparison of the respiration parameter and the configured alert criteria indicates a significant change in patient status, an alert signal is generated.
摘要翻译： 至少部分地基于呼吸参数来评估患者状态的变化。 用户可以对用于评估患者状态的警报标准选项进行选择。 呼吸被植入式感测，呼吸数据由可植入装置储存。 从呼吸数据测量呼吸参数，如呼吸速率。 通过将呼吸参数与配置的警报标准进行比较来评估患者状态的变化。 如果呼吸参数和配置的警报标准的比较表示患者状态的显着变化，则产生警报信号。
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10.发明申请公开(公告)号：US20090299159A1
公开(公告)日：2009-12-03
申请号：US12538553
申请日：2009-08-10
IPC分类号： A61B5/0205
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。
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