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87 条记录 (耗时 0.068 秒)

    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR
    1.
    发明申请
    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR 审中-公开
    白细胞介素-17F抗体及其他IL-17F信号拮抗剂及其用途

    公开(公告)号：US20110033451A1

    公开(公告)日：2011-02-10

    申请号：US12827199

    申请日：2010-06-30

    申请人： Beatriz M. Carreno ,  Mary Collins ,  Jill F. Wright ,  Neil M. Wolfman ,  Maya Arai ,  Kenneth Jacobs ,  Zhijian Lu ,  Yongjing Guo ,  Yongchang Qiu

    发明人： Beatriz M. Carreno ,  Mary Collins ,  Jill F. Wright ,  Neil M. Wolfman ,  Maya Arai ,  Kenneth Jacobs ,  Zhijian Lu ,  Yongjing Guo ,  Yongchang Qiu

    IPC分类号： A61K39/395 ,  A61K33/24 ,  A61K38/02 ,  A61K31/7088 ,  A61P11/06 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06

    CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/55527 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/2866 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1138 ,  G01N33/6869

    摘要： The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling.

    摘要翻译： 本发明提供与IL-17F信号通路相关的分离和纯化的多核苷酸和多肽。 本发明还提供了对IL-17F同源二聚体和IL-17A / IL-17F异二聚体的抗体，以及从天然来源分离和纯化IL-17家族成员（包括IL-17A / IL-17F异源二聚体）的方法。 本发明还涉及用于诊断，预后，监测与IL-17F信号传导相关的疾病的进展和/或预防的新方法，即IL-17F相关疾病，包括但不限于炎性 诸如自身免疫性疾病（例如关节炎（包括类风湿性关节炎），牛皮癣，系统性红斑狼疮和多发性硬化症），呼吸系统疾病（例如COPD，囊性纤维化，哮喘，过敏），移植排斥（包括实体器官移植排斥 ）和炎症性肠病或疾病（IBD，例如溃疡性结肠炎，克罗恩病）。 本发明还涉及新的治疗和治疗靶标，以及筛选和评估用于干预（治疗）的试验化合物和预防与IL-17F信号传导相关的紊乱的方法。

    SYSTEM AND METHOD FOR CONTROLLING 3D VIEWING SPECTACLES
    6.
    发明申请
    SYSTEM AND METHOD FOR CONTROLLING 3D VIEWING SPECTACLES 有权
    用于控制三维视图的系统和方法

    公开(公告)号：US20080043203A1

    公开(公告)日：2008-02-21

    申请号：US11928152

    申请日：2007-10-30

    申请人： Kenneth Jacobs ,  Ronald Karpf

    发明人： Kenneth Jacobs ,  Ronald Karpf

    IPC分类号： G03B35/16

    CPC分类号： G03B35/16

    摘要： This invention directs to a video/motion picture displaying apparatus for viewing via 3D spectacles with an internal 3D synchronizing unit including an image capturing means, a synchronizing means to identify synchronization events according to a set of synchronization rules, and a transmitting unit. It further directs to a 2D video/motion picture embedded with synchronizing signals produced with the same synchronization rules. The invention also discloses a 3D synchronizing signal composing/embedding device for embedding synchronizing signals to a 2D video/motion picture including a data capturing means, a converting means, a synchronizing means and a composing means or an embedding means. It also teaches a related 3D control device configured to acquire and utilize the embedded synchronizing signals to control the transmission of light of the 3D spectacles.

    摘要翻译： 本发明涉及一种用于通过3D眼镜观看的视频/电影显示装置，其具有内部3D同步单元，该内部3D同步单元包括图像捕获装置，根据一组同步规则识别同步事件的同步装置和发送单元。 它进一步指向嵌入同步信号的2D视频/运动图像，同步信号由相同的同步规则生成。 本发明还公开了一种用于将同步信号嵌入到包括数据捕获装置，转换装置，同步装置和合成装置或嵌入装置的2D视频/运动图像的3D同步信号组合/嵌入装置。 它还教导了一种相关的3D控制设备，其被配置为获取和利用嵌入式同步信号来控制3D眼镜的光的传输。

    System and method for a 3-D phenomenoscope
    8.
    发明申请
    System and method for a 3-D phenomenoscope 有权

    公开(公告)号：US20060268105A1

    公开(公告)日：2006-11-30

    申请号：US11372723

    申请日：2006-03-10

    申请人： Kenneth Jacobs ,  Ronald Karpf

    发明人： Kenneth Jacobs ,  Ronald Karpf

    IPC分类号： H04N13/04

    CPC分类号： G02B27/2221 ,  H04N13/144 ,  H04N13/261 ,  H04N13/341 ,  H04N13/359 ,  H04N13/398 ,  H04N2213/002

    摘要： This invention discloses a 3-D Phenomenoscope through which any 2-dimensional motion picture with passages of horizontal screen movement can be viewed with a 3-dimensional visual effect. The 3-dimensional visual effect is produced by the 3-D Phenomenoscope regardless of whether the motion picture was shot on regular or digital film; regardless of whether the presentation media is film, digital film, VCR tape, or DVD, and; regardless of whether the motion picture is viewed in the movie theater, home TV, Cable TV, or on a PC monitor. No special processing during production or showing of a motion picture is required to achieve the visual effect of the 3-D Phenomenoscope—so no new constraints are placed on the owner, producer, distributor, or projectionist in creating, distributing or displaying motion pictures. The 3-D Phenomenoscope are completely self-contained computer-actuated battery-powered spectacles or glasses that a viewer wears when watching a motion picture. When the 3-D Phenomenoscope glasses are activated the viewer will see lateral motion in a motion picture in 3-dimensions. When the 3-D Phenomenoscope is not activated or the glasses are turned off, or if the viewer is not wearing the 3-D Phenomenoscope glasses, then the viewer will see the motion picture unchanged and without any special effects. The preferred embodiment of the invention presents a method and system for a 3-D Phenomenoscope to view 3-dimensional special effects in motion pictures, and disclose a system by which ordinary 2-dimensional motion pictures can be viewed as a 3-dimensionsal experience. The 3-D Phenomenoscope achieves this by taking advantage of the well-known Pulfrich effect, by which passages of lateral motion of an ordinary motion picture will appear to the viewer in 3-Dimensions if the motion picture is viewed through right and left lenses that are configured with a clear lens and a light-reducing or darker lens. Ordinary eyeglasses are configured with: (a) Right and left lenses for which the degree of clarity or darkening of the lens can be individually controlled (b) Digital photo sensors (a digital camera) that can capture the viewed motion picture as successive images and convert the captured frames to digital images for processing (c) Computer processor to process the successive images and identify lateral motion synchronization events, and (d) Ability to provide individual control for the light-reduction or darkening of the right or left lens based on the identified synchronization events. In this way, the 3-D Phenomenoscope provides a fully self-contained apparatus that allow any motion picture to be viewed with the visual effect of 3-dimensions.

    Top guide for sliding doors
    10.
    发明授权
    Top guide for sliding doors 失效
    滑动门顶部导轨

    公开(公告)号：US06449906B1

    公开(公告)日：2002-09-17

    申请号：US09704827

    申请日：2000-11-03

    申请人： Kenneth Jacobs

    发明人： Kenneth Jacobs

    IPC分类号： E05D1300

    CPC分类号： E05F7/04 ,  E05D15/0656 ,  E05D15/0691 ,  E05Y2201/692 ,  E05Y2900/132

    摘要： A top guide is disclosed for mounting an upper portion of a door panel assembly with respect to track. The top guide includes an integrally molded plastic mounting structure having connecting portions constructed and arranged to enable the mounting structure to be connected to a door panel assembly. The mounting structure also includes first and second roller mounting portions. First and second rollers are mounted for rotation on the first and second roller mounting portions. The first roller mounting portion is formed on a portion of the integrally molded plastic mounting structure which is resiliently biased to enable the first roller mounted thereon to be in biased engagement with one of the track surfaces when the top guide is mounted with respect to the track.

    摘要翻译： 公开了用于安装门板组件相对于轨道的上部的顶部引导件。 顶部引导件包括一体模制的塑料安装结构，其具有构造和布置成使得安装结构能够连接到门板组件的连接部分。 安装结构还包括第一和第二辊安装部分。 第一和第二辊安装成在第一和第二辊安装部分上旋转。 第一辊安装部分形成在整体模制的塑料安装结构的一部分上，该部分被弹性偏置，以使得当顶部导向件相对于轨道安装时，安装在其上的第一辊与其中一个轨道表面偏置接合 。