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公开(公告)号：US07348440B2
公开(公告)日：2008-03-25
申请号：US10517559
申请日：2003-06-12
申请人： Kenneth L. Arrington , Paul J. Coleman , Christopher D. Cox , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , William F. Hoffman , Edward S. Tasber
发明人： Kenneth L. Arrington , Paul J. Coleman , Christopher D. Cox , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , William F. Hoffman , Edward S. Tasber
IPC分类号： C07D207/00 , C07D403/00 , C07D213/00 , C07D401/00 , C07D271/00 , C07D277/20 , C07D261/06 , C07D285/14 , C07D249/08 , C07D231/00 , A61K31/535 , A61K31/497 , A01N43/40 , A01N43/82 , A01N43/80 , A01N43/64 , A01N43/56 , A01N43/36
CPC分类号： C07D401/12 , C07D207/14 , C07D207/20 , C07D207/48 , C07D265/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20090258852A1
公开(公告)日：2009-10-15
申请号：US11988394
申请日：2006-06-30
申请人： Kenneth L. Arrington , Vadim Y. Dudkin , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Shaei Y. Huang , Constantine Kreatsoulas , Edward S. Tasber
发明人： Kenneth L. Arrington , Vadim Y. Dudkin , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Shaei Y. Huang , Constantine Kreatsoulas , Edward S. Tasber
IPC分类号： A61K31/5377 , A61K31/473 , C07D413/14 , C07D401/02
CPC分类号： C07D401/06 , C07D221/12 , C07D401/04 , C07D401/12 , C07D413/04 , C07D498/06
摘要： The instant invention provides for compounds which comprise benzoisoquinolinones and aza derivatives that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供了包含抑制CHK1活性的苯并异喹啉酮和氮杂衍生物的化合物。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制CHK1活性的方法。
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公开(公告)号：US07632833B2
公开(公告)日：2009-12-15
申请号：US11630231
申请日：2005-06-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
IPC分类号： C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/542
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的根据式（I）的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080287414A1
公开(公告)日：2008-11-20
申请号：US11630231
申请日：2005-06-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
IPC分类号： A61K31/5383 , A61P35/00 , A61K31/551 , A61K31/542 , C07D498/04
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的根据式（I）的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07329762B2
公开(公告)日：2008-02-12
申请号：US10559857
申请日：2004-06-08
IPC分类号： C07D207/00 , C07D405/00 , C07D295/00 , A01N43/36 , A61K31/40
CPC分类号： C07D401/12 , C07D207/20 , C07D209/48 , C07F9/572 , C07F9/65586
摘要： The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及二氢吡咯化合物的磷酸酯前体药物，其可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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6.发明授权Fluorinated 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP 失效有丝分裂驱动蛋白KSP的氟化2,4-二芳基-2,5-二氢吡咯抑制剂公开(公告)号：US07465746B2
公开(公告)日：2008-12-16
申请号：US10915743
申请日：2004-08-11
IPC分类号： A61K31/4468
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07622489B2
公开(公告)日：2009-11-24
申请号：US10539512
申请日：2003-12-16
IPC分类号： A61K31/445 , C07D221/082
CPC分类号： C07D401/04 , C07D211/70
摘要： The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US07732472B2
公开(公告)日：2010-06-08
申请号：US11660349
申请日：2005-08-15
IPC分类号： A61K31/42 , C07D261/04
CPC分类号： C07D261/04 , C07D413/12
摘要： The present invention relates to dihydroisoxazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢异恶唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07723365B2
公开(公告)日：2010-05-25
申请号：US11660288
申请日：2005-08-15
IPC分类号： A61K31/4245 , C07D271/10
CPC分类号： C07D271/107
摘要： The present invention relates to oxadiazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的恶二唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080153887A1
公开(公告)日：2008-06-26
申请号：US11660288
申请日：2005-08-15
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/107
摘要： The present invention relates to oxadiazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的恶二唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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