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公开(公告)号：US07632833B2
公开(公告)日：2009-12-15
申请号：US11630231
申请日：2005-06-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
IPC分类号： C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/542
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的根据式（I）的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07622489B2
公开(公告)日：2009-11-24
申请号：US10539512
申请日：2003-12-16
IPC分类号： A61K31/445 , C07D221/082
CPC分类号： C07D401/04 , C07D211/70
摘要： The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US20080287414A1
公开(公告)日：2008-11-20
申请号：US11630231
申请日：2005-06-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
IPC分类号： A61K31/5383 , A61P35/00 , A61K31/551 , A61K31/542 , C07D498/04
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的根据式（I）的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07608739B2
公开(公告)日：2009-10-27
申请号：US10593504
申请日：2005-03-18
IPC分类号： C07C211/00
CPC分类号： C07C215/50 , C07C211/53 , C07C215/16 , C07C215/20 , C07C215/24 , C07C229/18 , C07C229/30 , C07C237/06 , C07C237/10 , C07C237/12 , C07C2601/02 , C07D211/26 , C07D231/12 , C07D261/08 , C07D295/04
摘要： The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的N-取代苄基苯胺衍生物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080234281A1
公开(公告)日：2008-09-25
申请号：US10593504
申请日：2005-03-18
IPC分类号： A61K31/495 , C07C211/52 , C07D241/04 , C07D211/26 , A61K31/445 , A61K31/167
CPC分类号： C07C215/50 , C07C211/53 , C07C215/16 , C07C215/20 , C07C215/24 , C07C229/18 , C07C229/30 , C07C237/06 , C07C237/10 , C07C237/12 , C07C2601/02 , C07D211/26 , C07D231/12 , C07D261/08 , C07D295/04
摘要： The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的N-取代苄基苯胺衍生物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07348440B2
公开(公告)日：2008-03-25
申请号：US10517559
申请日：2003-06-12
申请人： Kenneth L. Arrington , Paul J. Coleman , Christopher D. Cox , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , William F. Hoffman , Edward S. Tasber
发明人： Kenneth L. Arrington , Paul J. Coleman , Christopher D. Cox , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , William F. Hoffman , Edward S. Tasber
IPC分类号： C07D207/00 , C07D403/00 , C07D213/00 , C07D401/00 , C07D271/00 , C07D277/20 , C07D261/06 , C07D285/14 , C07D249/08 , C07D231/00 , A61K31/535 , A61K31/497 , A01N43/40 , A01N43/82 , A01N43/80 , A01N43/64 , A01N43/56 , A01N43/36
CPC分类号： C07D401/12 , C07D207/14 , C07D207/20 , C07D207/48 , C07D265/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20090258852A1
公开(公告)日：2009-10-15
申请号：US11988394
申请日：2006-06-30
申请人： Kenneth L. Arrington , Vadim Y. Dudkin , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Shaei Y. Huang , Constantine Kreatsoulas , Edward S. Tasber
发明人： Kenneth L. Arrington , Vadim Y. Dudkin , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Shaei Y. Huang , Constantine Kreatsoulas , Edward S. Tasber
IPC分类号： A61K31/5377 , A61K31/473 , C07D413/14 , C07D401/02
CPC分类号： C07D401/06 , C07D221/12 , C07D401/04 , C07D401/12 , C07D413/04 , C07D498/06
摘要： The instant invention provides for compounds which comprise benzoisoquinolinones and aza derivatives that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供了包含抑制CHK1活性的苯并异喹啉酮和氮杂衍生物的化合物。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制CHK1活性的方法。
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公开(公告)号：US08906904B2
公开(公告)日：2014-12-09
申请号：US14016452
申请日：2013-09-03
申请人： Jehrod Burnett Brenneman , John Ginn , Michael D. Lowe , Christopher Ronald Sarko , Edward S. Tasber , Zhonghua Zhang
发明人： Jehrod Burnett Brenneman , John Ginn , Michael D. Lowe , Christopher Ronald Sarko , Edward S. Tasber , Zhonghua Zhang
IPC分类号： C07D401/14 , C07D405/14 , C07D498/04
CPC分类号： C07D401/14 , C07D405/14 , C07D493/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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