公开(公告)号：US20120294947A1

公开(公告)日：2012-11-22

申请号：US13519193

申请日：2010-12-28

申请人： Kennichiro Kuninobu ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Kennichiro Kuninobu ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K9/14 ,  A61K31/437 ,  A61J3/10 ,  A61K31/4422 ,  A61P25/28 ,  A61K31/445 ,  A61K31/519

CPC分类号： A61K31/445 ,  A61K9/2077 ,  A61K9/2846 ,  A61K31/437 ,  A61K31/4422 ,  A61K31/519

摘要： Provided is an oral preparation that contains a medicinal component having an unpleasant taste and that has better qualities, for example, generation of an analogue can be reduced, better than oral preparations that are produced by conventional techniques and that contain a medicinal component having an unpleasant taste. This objective is achieved by adding a coating agent on the medicinal component and a disintegrator that has a carboxymethyl group.

摘要翻译： 本发明提供含有具有令人不快的味道并且具有更好质量的药物成分的口服制剂，例如可以减少类似物的产生，优于常规技术制备的含有不愉快的药物成分的口服制剂 味道。 该目的通过在药物成分上添加涂布剂和具有羧甲基的崩解剂来实现。

公开(公告)号：US20080166769A1

公开(公告)日：2008-07-10

申请号：US11921329

申请日：2006-06-01

申请人： Tadayuki Uno ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Tadayuki Uno ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： C12N15/63 ,  C12N1/21

CPC分类号： C12N15/70 ,  C07K14/805 ,  C12N15/69 ,  C12P21/02

摘要： Provided is a high-copy-number, high-expression vector capable of producing a protein having satisfactory functions and activity of the same level as that of a natural form of the protein, in a large quantity and in a simple manner. Also provided is a vector including: (A) a target gene or a cloning site of the target gene, (B) a sequence element necessary for the high copying of the target gene, (C) a sequence element necessary for the expression of the target gene and a methionine aminopeptidase gene; a method of producing the vector; a transformant having the vector introduced therein; and a process for producing a protein using the transformant.

摘要翻译： 提供了能够以大量和简单的方式产生具有与天然形式的蛋白质相同水平的令人满意的功能和活性的蛋白质的高拷贝数高表达载体。 还提供了载体，其包括：（A）靶基因的靶基因或克隆位点，（B）靶基因的高拷贝所必需的序列元件，（C）表达所需靶序列所需的序列元件 靶基因和甲硫氨酸氨基肽酶基因; 生成载体的方法; 其中引入载体的转化体; 以及使用该转化体生产蛋白质的方法。

公开(公告)号：US20080311195A1

公开(公告)日：2008-12-18

申请号：US12099688

申请日：2008-04-08

申请人： Shiho SAKURAGI ,  Naomi Ohmichi ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Shiho SAKURAGI ,  Naomi Ohmichi ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K9/20 ,  A61K9/14

CPC分类号： A61K9/0056 ,  A61K9/2081

摘要： A basis particle comprises a basic or acidic basis particle coated by a water-insoluble coating film, wherein the water-insoluble coating film contains a substance that is acidic with respect to the basic basis or basic with respect to the acidic basis. According to the basis particles (i.e., a main ingredient or an active drug)of the present invention, it is possible to temporarily adjust pH occurring in the immediate proximity of the basis particles by using a coating film, elution of the basis particles is suppressed and superior elution is exhibited without dependence on bodily pH. It is also possible to mask tastes such as the bitterness of the basis and it is possible to ingest drugs without sensing any bitterness.

摘要翻译： 基础颗粒包含由水不溶性涂膜包衣的碱性或酸性基质颗粒，其中所述水不溶性涂膜含有相对于碱性基础为酸性的物质或相对于酸性基质为碱性的物质。 根据本发明的基础颗粒（即主要成分或活性药物），可以通过使用涂膜临时调节在基础颗粒附近发生的pH，抑制基础颗粒的洗脱 并且在不依赖于身体pH的情况下表现出优异的洗脱。 也可以掩盖基础的苦味，并且可以摄取药物而不感觉到任何苦味。

公开(公告)号：US07417118B2

公开(公告)日：2008-08-26

申请号：US10819352

申请日：2004-04-07

申请人： Toshiya Kai ,  Naohisa Katayama ,  Yuko Azuma ,  Junichi Yokoe ,  Yoshinori Kida ,  Ippei Hukutomi ,  Makoto Sato ,  Eishun Tsuchida ,  Shinji Takeoka ,  Teruyuki Komatsu ,  Hiromi Sakai ,  Keitaro So

发明人： Toshiya Kai ,  Naohisa Katayama ,  Yuko Azuma ,  Junichi Yokoe ,  Yoshinori Kida ,  Ippei Hukutomi ,  Makoto Sato ,  Eishun Tsuchida ,  Shinji Takeoka ,  Teruyuki Komatsu ,  Hiromi Sakai ,  Keitaro So

IPC分类号： C07K1/00

CPC分类号： A61K9/0026 ,  A01N1/02 ,  A01N1/0226 ,  A61K9/127 ,  A61K9/1271 ,  A61K38/42 ,  A61K47/6949 ,  B82Y5/00

摘要： A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.

摘要翻译： 一种含有人造氧载体的药物组合物，其具有高的氧气携带效率; 并具有所需的胶体渗透压，适当的晶体渗透压，pH和电解质平衡。 通过将至少一种选自由能够提供胶体渗透压的化合物，电解质，糖类，氨基酸，抗氧化剂，pH调节剂和等渗剂组成的组中选择的物质适当添加至 包括其中血红蛋白包封在脂质体中的脂质体包封的血红蛋白的制剂或包含卟啉 - 铁络合物和白蛋白的缀合物的制剂。

公开(公告)号：US20080254120A1

公开(公告)日：2008-10-16

申请号：US12099668

申请日：2008-04-08

申请人： Shiho Sakuragi ,  Jun-ichi Yokoe ,  Naohisa Katayama ,  Toshiya Kai

发明人： Shiho Sakuragi ,  Jun-ichi Yokoe ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K9/26

CPC分类号： A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095

摘要： An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

摘要翻译： 口腔崩解片包含主剂，糖醇粉和糖醇颗粒，其中口腔崩解片的硬度为30N以上。 根据本发明，使用普通压片机，颊腔的机械强度和崩解性能均匀且不使用特殊的装置和舌头和口感的口感崩解片是平滑吞咽口腔崩解片， 有利的。

公开(公告)号：US20060249456A1

公开(公告)日：2006-11-09

申请号：US11403188

申请日：2006-04-13

申请人： Ippei Fukutomi ,  Toshiya Kai ,  Naohisa Katayama ,  Takeshi Nizuka ,  Yoshinori Kida

发明人： Ippei Fukutomi ,  Toshiya Kai ,  Naohisa Katayama ,  Takeshi Nizuka ,  Yoshinori Kida

IPC分类号： C07K14/80 ,  C02F1/44

CPC分类号： B01D61/20 ,  A61K9/0026 ,  A61K38/42 ,  B01D19/0005 ,  B01D19/0031 ,  B01D61/36

摘要： A method of removing carbon monoxide from an oxygen carrier including setting a carbon monoxide bonded oxygen carrier solution across a separation membrane from an oxygen-dissolved solution; and exposing the setting part to the light and a method of removing carbon monoxide from an oxygen carrier including setting a carbon monoxide oxygen carrier solution across a hollow fiber separation membrane from an oxygen-dissolved solution; and exposing the setting part to light.

公开(公告)号：US20060166861A1

公开(公告)日：2006-07-27

申请号：US11337473

申请日：2006-01-24

申请人： Yoshinori Kida ,  Ippei Fukutomi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Yoshinori Kida ,  Ippei Fukutomi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K38/41 ,  C07D487/22 ,  C07K14/765

CPC分类号： B82Y5/00 ,  A61K47/643 ,  A61K47/6949

摘要： A novel inclusion compound obtained by including in albumin a tetraphenylporphyrin metal complex represented by the following chemical formula (1) and having 2-position side chains: where R1 is a cyclohexyl group or the like; R2 represents a substituent; M represents a transition metal atom or metal ion belonging to Groups 6 to 10 of the periodic table; X− represents a halogen ion; and the number of X− is obtained by subtracting 2 from a valence of the metal ion.

摘要翻译： 通过在白蛋白中含有由下列化学式（1）表示的具有2-位侧链的四苯基卟啉金属络合物，其中R1是环己基等，得到的新型包合物; R2表示取代基; M表示属于周期表第6至10族的过渡金属原子或金属离子; X - 表示卤素离子; 并且通过从金属离子的化合价中减去2来获得X 的数量。

公开(公告)号：US07893212B2

公开(公告)日：2011-02-22

申请号：US12201825

申请日：2008-08-29

申请人： Masaki Otagiri ,  Keisuke Nakajo ,  Naohisa Katayama ,  Toshiya Kai

发明人： Masaki Otagiri ,  Keisuke Nakajo ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： C07K16/00

CPC分类号： C07K14/76

摘要： The present invention provides an S-nitroso group-containing albumin, comprising an S-nitroso group introduced to at least one lysine in the amino acid sequence for albumin. The S-nitro group has been introduced into a lysine in the S-nitroso group-containing albumin of the invention to allow more S-nitroso groups to be included in the albumin, thus ensuring more potent inhibition of cancer cells in NO groups.

摘要翻译： 本发明提供含有S-亚硝基的白蛋白，其包含引入白蛋白氨基酸序列中的至少一个赖氨酸的S-亚硝基。 已将S-硝基引入本发明的含S-亚硝基基团的白蛋白中的赖氨酸中，以允许更多的S-亚硝基被包括在白蛋白中，从而确保NO组中对癌细胞的更有效的抑制。

公开(公告)号：US20070231395A1

公开(公告)日：2007-10-04

申请号：US10594613

申请日：2005-03-30

申请人： Toshiya Kai ,  Naohisa Katayama ,  Jun-ichi Yokoe ,  Makoto Sato

发明人： Toshiya Kai ,  Naohisa Katayama ,  Jun-ichi Yokoe ,  Makoto Sato

IPC分类号： A61K9/16 ,  A61K33/06 ,  A61K33/10 ,  A61P7/08 ,  A61K33/14

CPC分类号： A61K9/1611 ,  A61K9/0095 ,  A61K9/1682 ,  A61K31/191 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06 ,  A61K33/14 ,  A61K45/06 ,  A61M1/1654 ,  A61M1/287 ,  A61K2300/00

摘要： A solid pharmaceutical preparation for dialysis which does not contain any acetic acid and a production process thereof. The solid pharmaceutical preparation for dialysis contains two pharmaceutical preparations: a solid pharmaceutical preparation (A) composed of particles having an average particle size of about 100 μm to 1,500 μm and containing one or more electrolytes selected from sodium chloride, calcium chloride, magnesium chloride, and potassium chloride, and an organic acid other than acetic acid and/or a salt of the organic acid; and a solid pharmaceutical preparation (B) containing sodium bicarbonate.

摘要翻译： 不含任何乙酸的透析用固体药物制剂及其制造方法。 用于透析的固体药物制剂包含两种药物制剂：由平均粒径为约100〜1,500μm的粒子构成的固体药物制剂（A），含有一种或多种选自氯化钠，氯化钙，氯化镁， 和氯化钾，以及除乙酸以外的有机酸和/或有机酸的盐; 和含有碳酸氢钠的固体药物制剂（B）。

公开(公告)号：US07253259B2

公开(公告)日：2007-08-07

申请号：US11044265

申请日：2005-01-28

申请人： Masaki Otagiri ,  Yoshinori Kida ,  Naohisa Katayama ,  Toshiya Kai

发明人： Masaki Otagiri ,  Yoshinori Kida ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： C07K1/00

CPC分类号： C07K14/765

摘要： A protein produced by gene recombinant technology, including at least one domain selected from domains I, II, and III of serum albumin but having a different structure from that of native albumin; and a method of producing the protein. The protein has an enhanced functional activity or activities selected from among various functional activities or serum albumin including antibacterial activity, antioxidative effect, inflammation inhibitory effect, in vivo substance transporting action, and enzymatic activity.

摘要翻译： 由基因重组技术产生的蛋白质，其包括至少一个选自血清白蛋白结构域I，II和III的结构域，但与天然白蛋白结构不同的结构域; 和蛋白质的制造方法。 蛋白质具有增强的功能活性或选自各种功能活性或血清白蛋白的活性，包括抗菌活性，抗氧化作用，炎症抑制作用，体内物质运输作用和酶活性。