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    CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
    2.
    发明申请
    CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 有权
    环状磷脂寡聚物，药物组合物及其使用方法

    公开(公告)号：US20140274916A1

    公开(公告)日：2014-09-18

    申请号：US14208235

    申请日：2014-03-13

    申请人： Kent Kirshenbaum ,  Mia L. Huang

    发明人： Kent Kirshenbaum ,  Mia L. Huang

    IPC分类号： C07K7/64

    CPC分类号： C07K7/64 ,  A61K38/12 ,  Y02A50/463 ,  Y02A50/475 ,  Y02A50/483

    摘要： Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: wherein R1 and n are as described herein. The peptoids demonstrate antimicrobial and antimalarial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial or malarial infection is involved. The present cyclic peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.

    摘要翻译： 公开了具有由下式I表示的分子式的新型拟肽低聚物：其中R 1和n如本文所述。 拟肽表现出抗微生物和抗疟疾活性，并且可以制备成药物组合物并用于预防或治疗包括涉及微生物或疟疾感染的人的哺乳动物中的各种病症。 本发明的环状拟肽特别有价值，因为它们的作用是快速的，光谱广泛的，并且对标准抗生素引发的抗性几乎无关。

    Method for site-specific polyvalent display on polymers
    3.
    发明授权
    Method for site-specific polyvalent display on polymers 有权
    聚合物上位点特异性多价显示的方法

    公开(公告)号：US09107959B2

    公开(公告)日：2015-08-18

    申请号：US14016392

    申请日：2013-09-03

    申请人： Kent Kirshenbaum ,  Justin M. Holub

    发明人： Kent Kirshenbaum ,  Justin M. Holub

    IPC分类号： A61K47/48 ,  C07K1/107

    CPC分类号： A61K47/48315 ,  A61K47/641 ,  C07K1/1077

    摘要： The present invention relates to novel complex peptidomimetic products comprising multiple homogeneous or heterogeneous pendant groups that are site-specifically positioned along a linear oligomer or polymer scaffold and methods of making thereof. More specifically, the invention relates to N-substituted glycine peptoid oligomers or peptoids and their use as substrates for azide-alkyne[3+2]-cycloaddition conjugation reactions and subsequent additional rounds of oligomerization and cycloaddition. The methods of the invention may also be used to generate peptoid-peptide hybrid or peptide products comprising multiple homogeneous or heterogeneous pendant groups, which are positioned precisely along the linear oligomer or polymer scaffold.

    摘要翻译： 本发明涉及新的复合肽模拟产物，其包含沿着线性低聚物或聚合物支架位点特异性定位的多个均相或异构侧基及其制备方法。 更具体地，本发明涉及N-取代的甘氨酸类似物低聚物或拟肽，并且它们用作叠氮炔 - 炔[3 + 2] - 环加成偶联反应和随后的另外一轮低聚和环加成的底物。 本发明的方法还可用于产生包含多个均质或异构侧基的拟肽 - 肽杂交体或肽产物，其准确地沿着线性低聚物或聚合物支架定位。

    Peptoid compositions and methods of using the same
    4.
    发明申请
    Peptoid compositions and methods of using the same 审中-公开
    胡椒粉组合物及其使用方法

    公开(公告)号：US20090318667A1

    公开(公告)日：2009-12-24

    申请号：US12454381

    申请日：2009-05-15

    申请人： Kent Kirshenbaum ,  Galia Maayan ,  Michael Ward

    发明人： Kent Kirshenbaum ,  Galia Maayan ,  Michael Ward

    IPC分类号： C07K7/06 ,  C07K5/10 ,  C07K5/08

    CPC分类号： C07K7/06 ,  C07K7/64

    摘要： Novel peptoids are disclosed that have a formula represented by the following formulae Ia and Ib: wherein X, Y, R, and n are as described herein. The peptoids demonstrate catalytic activity and are useful in substrate-selective catalytic transformations, including asymmetric catalytic transformations.

    摘要翻译： 公开了具有由下式Ia和Ib表示的分子式的新型拟肽：其中X，Y，R和n如本文所述。 拟肽显示催化活性，并且可用于底物选择性催化转化，包括不对称催化转化。

    MERINGUE COMPOSITION AND METHODS OF PREPARATION
    5.
    发明申请
    MERINGUE COMPOSITION AND METHODS OF PREPARATION 审中-公开
    合成组合物和制备方法

    公开(公告)号：US20160183553A1

    公开(公告)日：2016-06-30

    申请号：US14237319

    申请日：2012-08-03

    申请人： Kent Kirshenbaum ,  Alizee Guegan

    发明人： Kent Kirshenbaum ,  Alizee Guegan

    IPC分类号： A23G3/48 ,  A23G3/34 ,  A23G3/52 ,  A23G3/42

    CPC分类号： A23G3/48 ,  A23G3/0004 ,  A23G3/42 ,  A23G3/52 ,  A23V2002/00 ,  A23V2200/264 ,  A23V2250/21 ,  A23V2250/628

    摘要： A meringue composition is disclosed, which may be prepared without the inclusion of egg or egg byproduct material as an ingredient. The meringue is prepared from a mixture consisting essentially of saponin, a sugar or sugar substitute, and water. The meringue is capable of being prepared to a self-sustaining, baked product. The final meringue product may be prepared by a variety of heating methods, including microwave heating. Further, the nature of the final product may be controlled by the extent of heating, so that a product more flowable or creamy may be achieved by a reduction in the heating time. The meringue of the invention is suitable for strict vegetarians (‘vegans’) and individuals who are allergic to eggs and egg bi-products.

    摘要翻译： 公开了一种蛋白甜饼组合物，其可以在不包含蛋或卵副产物材料作为成分的情况下制备。 蛋白甜饼由基本上由皂苷，糖或糖替代物和水组成的混合物制备。 蛋白甜饼能够准备一个自给自足的烘焙食品。 最终的蛋白酥皮产品可以通过各种加热方法制备，包括微波加热。 此外，最终产品的性质可以通过加热的程度来控制，使得可以通过减少加热时间来实现更可流动或者奶油的产品。 本发明的蛋白甜饼适合严格的素食者（“素食者”）和对鸡蛋和鸡蛋产品过敏的个体。

    Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same
    8.
    发明申请
    Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same 有权
    胡椒和合成低聚物，药物组合物及其使用方法

    公开(公告)号：US20120015883A1

    公开(公告)日：2012-01-19

    申请号：US13134547

    申请日：2011-06-09

    申请人： Martin J. Sadowski ,  Kent Kirshenbaum

    发明人： Martin J. Sadowski ,  Kent Kirshenbaum

    IPC分类号： A61K38/08 ,  A61P25/28 ,  C07K7/06

    CPC分类号： A61K31/135 ,  A61K38/08 ,  A61K38/12 ,  A61K38/16 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00

    摘要： Novel peptide/peptoid oligomers are disclosed that have a formula represented by the following formula Ia or Ib: The peptide/peptoid oligomers demonstrate the ability to inhibit fibrillization and oligomerization of Aβ and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals, including humans, associated with Aβ oligomerization. The present peptidomimetic oligomers are particularly valuable for the treatment of subjects with AD.

    摘要翻译： 公开了具有由下式Ia或Ib表示的式的新型肽/拟肽低聚物：肽/拟肽低聚物表现出抑制A＆bgr的纤维化和低聚的能力; 并且可以制备为药物组合物并用于预防或治疗与A＆Bgr相关的哺乳动物（包括人）中的各种病症; 低聚。 本发明的拟肽低聚物对于治疗AD患者特别有价值。

    Methods for enzyme-mediated coupling of oligomers
    9.
    发明申请
    Methods for enzyme-mediated coupling of oligomers 审中-公开
    酶介导的寡聚体偶联方法

    公开(公告)号：US20070054298A1

    公开(公告)日：2007-03-08

    申请号：US11504533

    申请日：2006-08-14

    申请人： Kent Kirshenbaum ,  Barney Yoo

    发明人： Kent Kirshenbaum ,  Barney Yoo

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12P21/06 ,  C12P17/00

    CPC分类号： C12P21/00 ,  C07K1/1075

    摘要： The present invention is directed to a method for synthesizing sequence specific short and long chain length heteropolymers. More specifically, the method is directed to enzyme-mediated ligation of telechelic sequence specific oligomers to generate abiotic linked oligomers and concatenated synthetic oligomers. The invention also encompasses abiotic linked oligomers and abiotic concatenated oligomers comprising greater than 65 monomer units.

    摘要翻译： 本发明涉及一种合成序列特异性短链和长链杂聚物的方法。 更具体地，该方法涉及酶介导的遥爪序列特异性寡聚体的连接以产生非生物连接的寡聚体和连接的合成低聚物。 本发明还包括非生物连接的寡聚体和包含大于65个单体单元的非生物连接的低聚物。