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    Fine ultraviolet screening particles, process for preparing the same, and cosmetic preparation
    1.
    发明授权
    Fine ultraviolet screening particles, process for preparing the same, and cosmetic preparation 有权
    精细的紫外线筛选颗粒，其制备方法和化妆品制备

    公开(公告)号：US06197282B1

    公开(公告)日：2001-03-06

    申请号：US09194199

    申请日：1998-11-20

    申请人： Kentaro Oshima ,  Shunji Kozaki ,  Yoshinobu Imaizumi ,  Toshio Miyake ,  Keiichi Tsuto ,  Kazuhiro Yamaki ,  Satoshi Sugawara

    发明人： Kentaro Oshima ,  Shunji Kozaki ,  Yoshinobu Imaizumi ,  Toshio Miyake ,  Keiichi Tsuto ,  Kazuhiro Yamaki ,  Satoshi Sugawara

    IPC分类号： A61K742

    CPC分类号： C01G23/047 ,  A61K8/0241 ,  A61K8/27 ,  A61K8/29 ,  A61K2800/412 ,  A61K2800/624 ,  A61Q17/04 ,  C01G9/02 ,  C01P2004/62 ,  C09C1/3684

    摘要： The present invention provides a method for producing a material dispersed with ultraviolet shielding fine particles, characterized by subjecting a starting material liquid mixture comprising particles comprising one or more inorganic substances having shielding abilities against ultraviolet light, one or more silicone dispersants selected from modified silicones and reactive silicones, and a silicone oil to a mill treatment and/or a high-pressure dispersion treatment; and ultraviolet shielding fine particles or a material dispersed therewith, characterized by being produced by the above method. Also, the present invention provides a method of producing a powdery product of ultraviolet shielding fine particles, characterized by drying the material dispersed with ultraviolet shielding fine particles obtainable by the above method. Further, the present invention provides cosmetics comprising a material dispersed with ultraviolet shielding fine particles or a powdery product of the ultraviolet shielding fine particles. The material dispersed with ultraviolet shielding fine particles of the present invention is characterized in that the ultraviolet shielding fine particles comprise particles comprising one or more inorganic substances having shielding abilities against ultraviolet light, surfaces thereof being coated with one or more silicone dispersants selected from modified silicones and reactive silicones, and that at least a part of the ultraviolet shielding fine particles is dispersed in a silicone oil as aggregated particles of the particles comprising inorganic substances.

    摘要翻译： 本发明提供一种分散有紫外线屏蔽微粒的材料的制造方法，其特征在于，将包含一种或多种具有屏蔽能力的无机物质的紫外线的原料液体混合物，一种或多种选自改性硅酮的有机硅分散剂和 反应性硅氧烷和硅油进行研磨处理和/或高压分散处理; 和紫外线屏蔽微粒或其分散的材料，其特征在于通过上述方法制备。 另外，本发明提供一种紫外线屏蔽微粒的粉末状制品的制造方法，其特征在于，使用通过上述方法得到的紫外线屏蔽微粒分散的材料进行干燥。 此外，本发明提供了包含分散有紫外线屏蔽微粒的材料或紫外线屏蔽微粒的粉末状产品的化妆品。 用本发明的紫外线屏蔽微粒分散的材料的特征在于，紫外线屏蔽微粒包括包含一种或多种具有对紫外线的屏蔽能力的无机物质的颗粒，其表面涂覆有一种或多种选自改性有机硅的硅氧烷分散剂 和反应性硅氧烷，并且至少一部分紫外线屏蔽细颗粒作为包含无机物质的颗粒的凝集颗粒分散在硅油中。

    Ultraviolet-screening composite particulate and process for the production thereof
    3.
    发明授权
    Ultraviolet-screening composite particulate and process for the production thereof 失效
    紫外线筛选复合颗粒及其制备方法

    公开(公告)号：US6090373A

    公开(公告)日：2000-07-18

    申请号：US125463

    申请日：1998-08-19

    申请人： Kentaro Oshima ,  Shunji Kozaki ,  Yoshinobu Imaizumi ,  Toshio Miyake ,  Keiichi Tsuto

    发明人： Kentaro Oshima ,  Shunji Kozaki ,  Yoshinobu Imaizumi ,  Toshio Miyake ,  Keiichi Tsuto

    IPC分类号： A61K8/04 ,  A61K8/11 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/00 ,  A61K9/14 ,  C09C1/36 ,  C09B14/00

    CPC分类号： A61K8/26 ,  A61K8/0283 ,  A61K8/11 ,  A61K8/19 ,  A61K8/25 ,  A61K8/27 ,  A61Q17/04 ,  A61K2800/413

    摘要： Ultraviolet shielding composite fine particles having transparency in a visible light region, comprising matrix particles comprising an aggregate of primary particles having an average particle size of from 0.001 to 0.3 .mu.m, the aggregate being formed while the primary particles retain their shapes; and daughter particles having an average particle size of from 0.001 to 0.1 .mu.m, the daughter particles being dispersed in and supported by the matrix particles, wherein the daughter particles have a smaller band gap energy than the particles constituting the matrix particles and are capable of absorbing ultraviolet light, and wherein the surfaces of the composite fine particles are coated with one or more silicones selected from the group consisting of modified silicones, reactive silicones, and silicone-modified copolymers, and wherein the ultraviolet shielding composite fine particles have substantially no catalytic activities. By forming composite fine particles comprising the ultrafine particles having the ultraviolet shielding ability, the composite fine particles of the present invention have substantially no catalytic activities, high transparency in the visible light region, and high shielding ability in the ultraviolet light region.

    摘要翻译： PCT No.PCT / JP97 / 00420 Sec。 371日期1998年8月19日 102（e）1998年8月19日PCT PCT 1997年2月17日PCT公布。 出版物WO97 / 3093400 日期：1997年8月28日在可见光区域具有透明度的紫外线屏蔽复合微粒，其包含基质颗粒，其包含平均粒径为0.001〜0.3μm的一次粒子的聚集体， 形状; 平均粒径为0.001〜0.1μm的子粒子，分散在母体粒子中并由基体粒子支撑的子粒子，其中，子粒子具有比构成基体粒子的粒子更小的带隙能量，能够 吸收紫外光，其中复合微粒的表面涂覆有一种或多种选自改性硅氧烷，反应性硅氧烷和硅氧烷改性共聚物的硅氧烷，并且其中紫外线屏蔽复合微粒基本上不催化 活动 通过形成包含具有紫外线屏蔽能力的超微粒子的复合微粒，本发明的复合微粒基本上不具有催化活性，可见光区域的透明度高，紫外线区域的屏蔽能力高。

    METHOD FOR QUANTIFICATION OF TITER OF NEUTRALIZING ANTIBODY TO NEUROTOXIN
    6.
    发明申请
    METHOD FOR QUANTIFICATION OF TITER OF NEUTRALIZING ANTIBODY TO NEUROTOXIN 审中-公开
    中性抗体对神经毒素的定量的方法

    公开(公告)号：US20110105940A1

    公开(公告)日：2011-05-05

    申请号：US12673980

    申请日：2008-08-20

    申请人： Yasushi Torii ,  Tetsuhiro Harakawa ,  Yoshitaka Goto ,  Akihiro Ginnaga ,  Ryuji Kaji ,  Shunji Kozaki ,  Motohide Takahashi

    发明人： Yasushi Torii ,  Tetsuhiro Harakawa ,  Yoshitaka Goto ,  Akihiro Ginnaga ,  Ryuji Kaji ,  Shunji Kozaki ,  Motohide Takahashi

    IPC分类号： A61B5/0488

    CPC分类号： G01N33/6854 ,  A61B5/0488 ,  G01N2333/33 ,  G01N2469/20

    摘要： A method for quantification of a titer of a neutralizing antibody to a neurotoxin is disclosed. The method comprises the steps: (a) mixing a standard sample containing a fixed amount of a neurotoxin and a test sample containing a neutralizing antibody to said neurotoxin; (b) administering the mixture obtained in step (a) into the muscle of a non-human mammal; (c) applying electric stimulus to said non-human mammal; (d) measuring a compound muscle action potential (CMAP) due to contraction of the muscle of said mammal by application of electric stimulus with an electromyograph; and (e) analyzing CMAP amplitude data obtained in step (d) for an extent of decrease in amplitude by a non-neutralized neurotoxin to thereby quantify a titer of the neutralizing antibody contained in the test sample.

    摘要翻译： 公开了定量神经毒素中和抗体滴度的方法。 该方法包括以下步骤：（a）将含有固定量的神经毒素的标准样品和含有中和抗体的测试样品与所述神经毒素混合; （b）将步骤（a）中获得的混合物给予非人哺乳动物的肌肉; （c）对所述非人哺乳动物施加电刺激; （d）通过用肌电图仪施加电刺激来测量由于所述哺乳动物的肌肉收缩引起的复合肌肉动作电位（CMAP）; 和（e）通过未中和的神经毒素分析在步骤（d）中获得的CMAP振幅数据的幅度减小，从而定量测试样品中所含的中和抗体的滴度。

    TYPE A2 BOTULINUM TOXIN PREPARATION
    7.
    发明申请
    TYPE A2 BOTULINUM TOXIN PREPARATION 审中-公开
    A2型BOTULINUM毒素制剂

    公开(公告)号：US20110033431A1

    公开(公告)日：2011-02-10

    申请号：US12935769

    申请日：2009-03-31

    申请人： Shinji Nakahira ,  Yasushi Torii ,  Yoshitaka Goto ,  Miho Shinmura ,  Satomi Munechika ,  Sachio Okuda ,  Shunji Kozaki

    发明人： Shinji Nakahira ,  Yasushi Torii ,  Yoshitaka Goto ,  Miho Shinmura ,  Satomi Munechika ,  Sachio Okuda ,  Shunji Kozaki

    IPC分类号： A61K35/74 ,  A61P21/00 ,  C12N1/20 ,  C07K14/33

    CPC分类号： A61K38/164 ,  A61K38/4893 ,  Y02A50/469

    摘要： A pharmaceutical preparation for use in a patient who has a neutralizing antibody to a botulinum toxin from type A1 Clostridium botulinum (type A1 botulinum toxin), said preparation comprising as an active ingredient 150 kDa type A neurotoxin from type A2 Clostridium botulinum (A2 NTX); a medicament for treating a disease with muscle overactivity for use in a patient who has a neutralizing antibody to a type A1 botulinum toxin, said medicament comprising as an active ingredient said A2 NTX; a method for treating a patient who has a neutralizing antibody to a type A1 botulinum toxin, said method comprising administering said A2 NTX to the patient; and a method for use of A2 NTX in a patient who has said neutralizing antibody. In accordance with the present invention, a problem can be solved of decrease in clinical response caused by a neutralizing antibody to a type A1 botulinum toxin produced when a patient is treated with a pharmaceutical preparation comprising a type A1 botulinum toxin.

    摘要翻译： 一种用于患有来自A1型肉毒毒素（A1型肉毒杆菌毒素）的肉毒毒素中和抗体的患者的药物制剂，所述制剂包含来自A2型肉毒毒素（A2NTX）的150kDa A型神经毒素作为活性成分， ; 用于治疗患有肌肉过度活动的疾病的药物，所述疾病用于患有A1型肉毒杆菌毒素的中和抗体的患者，所述药物包含所述A2NXX的活性成分; 用于治疗对A1型肉毒杆菌毒素具有中和抗体的患者的方法，所述方法包括向患者施用所述A2NXX; 以及在具有所述中和抗体的患者中使用A2NTX的方法。 根据本发明，当患者用包含A1型肉毒杆菌毒素的药物制剂治疗时，可以解决由中和抗体对产生的A1型肉毒杆菌毒素引起的临床反应降低的问题。