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1.发明申请公开(公告)号：US20100059414A1
公开(公告)日：2010-03-11
申请号：US12509175
申请日：2009-07-24
IPC分类号： B03B5/00
CPC分类号： B03B5/00 , B01L3/502753 , G01N27/44791 , G01N30/0005 , G01N30/6069 , G01N30/6095 , G01N2030/528
摘要： The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
摘要翻译： 本公开涉及用于按尺寸分离颗粒群的障碍物阵列装置（也称为凸块阵列装置）。 通过使跨越障碍物之间的间隙的流体速度分布相对于平分该间隙并且平行于体积流体流动方向的平面不对称来实现对先前障碍物阵列装置的改进。 这种不对称性可以通过选择围绕间隙的障碍物的形状来实现，使得障碍物的上游，下游或桥接最窄部分的障碍物的部分相对于该平面是不对称的。 通过使用具有边界限制边界的障碍物来实现改进。 通过选择障碍物形状来实现其他改进，使得由两个不同流体流动方向上的间隙限定的临界粒子尺寸不同。
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2.发明申请公开(公告)号：US20130098813A1
公开(公告)日：2013-04-25
申请号：US13708425
申请日：2012-12-07
IPC分类号： B03B5/00
CPC分类号： B03B5/00 , B01L3/502753 , G01N27/44791 , G01N30/0005 , G01N30/6069 , G01N30/6095 , G01N2030/528
摘要： The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from or bridging the narrowest portion of the gap are asymmetrical with respect to that plane.Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
摘要翻译： 本公开涉及用于按尺寸分离颗粒群的障碍物阵列装置（也称为凸块阵列装置）。 通过使跨越障碍物之间的间隙的流体速度分布相对于平分该间隙并且平行于体积流体流动方向的平面不对称来实现对先前障碍物阵列装置的改进。 这种不对称性可以通过选择限定间隙的障碍物的形状来实现，使得障碍物的上游，下游或桥接该间隙的最窄部分的部分相对于该平面不对称。 通过使用具有边界限制边界的障碍物来实现改进。 通过选择障碍物形状来实现其他改进，使得由两个不同流体流动方向上的间隙限定的临界粒子尺寸不同。
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3.发明授权公开(公告)号：US08579117B2
公开(公告)日：2013-11-12
申请号：US12509175
申请日：2009-07-24
IPC分类号： B03B5/00
CPC分类号： B03B5/00 , B01L3/502753 , G01N27/44791 , G01N30/0005 , G01N30/6069 , G01N30/6095 , G01N2030/528
摘要： The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
摘要翻译： 本公开涉及用于按尺寸分离颗粒群的障碍物阵列装置（也称为凸块阵列装置）。 通过使跨越障碍物之间的间隙的流体速度分布相对于平分该间隙并且平行于体积流体流动方向的平面不对称来实现对先前障碍物阵列装置的改进。 这种不对称性可以通过选择围绕间隙的障碍物的形状来实现，使得障碍物的上游，下游或桥接最窄部分的障碍物的部分相对于该平面是不对称的。 通过使用具有边界限制边界的障碍物来实现改进。 通过选择障碍物形状来实现其他改进，使得由两个不同流体流动方向上的间隙限定的临界粒子尺寸不同。
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公开(公告)号：US20130019773A1
公开(公告)日：2013-01-24
申请号：US13356541
申请日：2012-01-23
CPC分类号： B65G47/96 , B65G17/345
摘要： A sortation system where control and operation is facilitated by a contact-free, wireless communication configuration. Wireless communication is accomplished in a line-of-sight (LOS) manner while the cars of the sortation system are continuously moving along the track at operational speed. Each car is configured to operate independently with respect to how a car is instructed to accept and deliver packages. The sortation system provides for the cars to act as messengers between the bin stations and the system controller with respect to the status and health of the bin stations.
摘要翻译： 一种分拣系统，其中通过无接触的无线通信配置促进了控制和操作。 无线通信以视线（LOS）方式实现，而分拣系统的车辆以操作速度沿着轨道连续移动。 每辆汽车都配置为独立运行，关于汽车如何被指示接受和交付包裹。 分拣系统提供汽车作为垃圾站和系统控制器之间的信使，相对于垃圾站的状态和健康状况。
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公开(公告)号：US20080023399A1
公开(公告)日：2008-01-31
申请号：US11809559
申请日：2007-05-31
申请人： David Inglis , John Davis , Robert Austin , James Sturm
发明人： David Inglis , John Davis , Robert Austin , James Sturm
IPC分类号： B01D29/00
CPC分类号： G01N33/54366 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0864 , B01L2300/0867 , B01L2400/0472 , B01L2400/086 , G01N35/025 , G01N2001/4072 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/149 , G01N2035/00465
摘要： The invention is directed to an apparatus and a method of separating particles, such as cells, from a heterogeneous fluid, such as blood, where the particles have a large range of sizes.
摘要翻译： 本发明涉及从诸如血液的异质流体分离诸如细胞的颗粒的装置和方法，其中颗粒具有大范围的尺寸。
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公开(公告)号：US20070181818A1
公开(公告)日：2007-08-09
申请号：US11350240
申请日：2006-02-08
申请人： Robert Austin
发明人： Robert Austin
IPC分类号： G01J1/42
CPC分类号： G01N21/03 , G01N21/33 , G01N23/227 , G01N2201/0806
摘要： A device for detecting impurities in a noble gas includes a detection chamber and a source of pulsed ultraviolet light. The pulse of the ultraviolet light is transferred into the detection chamber and onto a photocathode, thereby emitting a cloud of free electrons into the noble gas within the detection chamber. The cloud of electrons is attracted to the opposite end of the detection chamber by a high positive voltage potential at that end and focused onto a sensing anode. If there are impurities in the noble gas, some or all of the electrons within the cloud will bond with the impurity molecules and not reach the sensing anode. Therefore, measuring a lower signal at the sensing anode indicates a higher level of impurities while sensing a higher signal indicates fewer impurities. Impurities in the range of one part per billion can be measured by this device.
摘要翻译： 用于检测惰性气体中的杂质的装置包括检测室和脉冲紫外光源。 紫外光的脉冲被传送到检测室和光电阴极上，从而将自由电子云发射到检测室内的惰性气体中。 电子云被吸收到检测室的另一端，在该端处具有高的正电压电位并聚焦到感测阳极上。 如果稀有气体中存在杂质，云中的部分或全部电子将与杂质分子结合，而不会到达感应阳极。 因此，在感测阳极处测量较低的信号指示较高水平的杂质，同时感测较高的信号表示较少的杂质。 该装置可以测量十亿分之一的杂质。
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公开(公告)号：US08776694B2
公开(公告)日：2014-07-15
申请号：US13356541
申请日：2012-01-23
IPC分类号： B61J3/00
CPC分类号： B65G47/96 , B65G17/345
摘要： A sortation system where control and operation is facilitated by a contact-free, wireless communication configuration. Wireless communication is accomplished in a line-of-sight (LOS) manner while the cars of the sortation system are continuously moving along the track at operational speed. Each car is configured to operate independently with respect to how a car is instructed to accept and deliver packages. The sortation system provides for the cars to act as messengers between the bin stations and the system controller with respect to the status and health of the bin stations.
摘要翻译： 一种分拣系统，其中通过无接触的无线通信配置促进了控制和操作。 无线通信以视线（LOS）方式实现，而分拣系统的车辆以操作速度沿着轨道连续移动。 每辆汽车都配置为独立运行，关于汽车如何被指示接受和交付包裹。 分拣系统提供汽车作为垃圾站和系统控制器之间的信使，相对于垃圾站的状态和健康状况。
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公开(公告)号：US20070157501A1
公开(公告)日：2007-07-12
申请号：US11330294
申请日：2006-01-11
申请人： Matthew Cammenga , John Cammenga , Robert Austin
发明人： Matthew Cammenga , John Cammenga , Robert Austin
IPC分类号： F41A9/61
CPC分类号： F41A9/67
摘要： A magazine for a firearm includes an elongated containing body and a closure member adapted to hold cartridges. The closure member longitudinally slides on the containing body and is extendable to open a side of the containing body for cartridge loading. The closure member has opposing sidewalls forming an integral handle surface that can be grasped for moving it. A follower and spring bias cartridges toward one end of the magazine. A latching mechanism is provided for holding the follower in a disengaged position when the closure member is extended, and is configured to release when the closure member is closed. Preferably, the containing body and closure member are constructed to include integrally formed features that cooperate with an automatic latching mechanism, thus minimizing parts.
摘要翻译： 用于枪支的杂志包括细长的容纳主体和适于保持盒的封闭构件。 封闭构件在容纳体上纵向滑动并且可延伸以打开用于盒装载的容纳主体的一侧。 封闭构件具有形成整体手柄表面的相对侧壁，该手柄表面可被抓住以便移动。 随动件和弹簧偏压药筒朝向刀库的一端。 提供了一种闭锁机构，用于当关闭构件延伸时将从动件保持在脱离位置，并且构造成当关闭构件关闭时释放。 优选地，容纳体和闭合构件被构造成包括与自动闭锁机构配合的整体形成的特征，从而使部件最小化。
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9.发明申请GRADIENT STRUCTURES INTERFACING MICROFLUIDICS AND NANOFLUIDICS, METHODS FOR FABRICATION AND USES THEREOF 有权接触微流控和纳米级的梯度结构，其制造方法及其用途公开(公告)号：US20070020772A1
公开(公告)日：2007-01-25
申请号：US11536178
申请日：2006-09-28
申请人： Han Cao , Jonas Tegenfeldt , Stephen Chou , Robert Austin
发明人： Han Cao , Jonas Tegenfeldt , Stephen Chou , Robert Austin
IPC分类号： H01L21/00
CPC分类号： G01N21/6486 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/027 , B01L2200/0663 , B01L2200/12 , B01L2300/0654 , B01L2300/0896 , B01L2400/0415 , B01L2400/086 , B81B2201/058 , B81C1/00119 , B81C2201/0157 , B81C2201/0159 , B82Y30/00 , G01N33/48721 , G03F7/2008 , Y10T436/143333
摘要： The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.
摘要翻译： 本发明涉及适用于进行高通量大分子分析的纳米流体和微流体组分的界面装置。 衍射梯度光刻（DGL）用于在微流体区域和纳流体区域之间形成梯度界面。 梯度界面面积减小了在纳米流体区域形成的纳米通道的局部熵阻挡。 在一个实施例中，梯度界面区域由横向空间梯度结构形成，用于使从微米到纳米长度尺度的值的横截面变窄。 在另一个实施例中，梯度界面区域由垂直倾斜梯度结构形成。 此外，梯度结构可以提供横向和垂直梯度。
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10.发明申请公开(公告)号：US20060269483A1
公开(公告)日：2006-11-30
申请号：US11494157
申请日：2006-07-27
申请人： Robert Austin , Shuang Lim , Robert Riehm
发明人： Robert Austin , Shuang Lim , Robert Riehm
IPC分类号： A61K49/00
CPC分类号： A61K49/0067 , H01J2237/2808
摘要： Methods for high resolution tissue imaging in which a tissue to be imaged is labeled with UCP's coupled to probes that bind specifically to biological markers on the tissue; the UCP's are then excited with electrons so that the UCP's emit cathodoluminescent photons; after which the photon emission is converted to a visible image. Methods for measuring water content, blood content or blood oxygenation in tumor tissue are also disclosed.
摘要翻译： 用于高分辨率组织成像的方法，其中待成像组织的UCP与特异性结合组织上的生物学标记的探针偶联; 然后UCP被电子激发，使得UCP发射阴极发光光子; 之后将光子发射转换成可见光。 还公开了测量肿瘤组织中含水量，血液含量或血氧饱和度的方法。
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