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公开(公告)号：US20090192474A1
公开(公告)日：2009-07-30
申请号：US12171125
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US20090234277A1
公开(公告)日：2009-09-17
申请号：US12171168
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
IPC分类号： A61B17/70
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
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公开(公告)号：US20090157087A1
公开(公告)日：2009-06-18
申请号：US12205539
申请日：2008-09-05
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US09358113B2
公开(公告)日：2016-06-07
申请号：US12171125
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
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公开(公告)号：US09333082B2
公开(公告)日：2016-05-10
申请号：US12205539
申请日：2008-09-05
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US08202539B2
公开(公告)日：2012-06-19
申请号：US12254619
申请日：2008-10-20
申请人： Keyvan Behnam , Guobao Wei , James Beisser
发明人： Keyvan Behnam , Guobao Wei , James Beisser
CPC分类号： A61L27/3608 , A61L27/3683 , A61L27/50 , A61L27/54 , A61L2300/414
摘要： Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed.
摘要翻译： 提供骨基质组合物，更具体地说，具有增强的骨诱导能力的去矿物质骨基质（DBM）及其生产方法。 具体地，提供了从骨的骨膜层衍生自皮质骨的DBM。 提供了包含由衍生自骨膜和/或中间骨层的骨制备的不相称量的DBM的组合物。 公开了骨膜DBM组合物的制备和使用方法。
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公开(公告)号：US20110054408A1
公开(公告)日：2011-03-03
申请号：US12705330
申请日：2010-02-12
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp , Sigurd Berven , Randal R. Betz , Michael F. O'Brien , Alexis Shelokov , Robert Cohen , Alexander Vaccaro , Scott Boden , Harvinder Sandhu , Daryl R. Sybert , Munish Chandra Gupta , Georgiana Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp , Sigurd Berven , Randal R. Betz , Michael F. O'Brien , Alexis Shelokov , Robert Cohen , Alexander Vaccaro , Scott Boden , Harvinder Sandhu , Daryl R. Sybert , Munish Chandra Gupta , Georgiana Shelokov
CPC分类号： A61F2/28 , A61B17/68 , A61B17/7022 , A61B17/7059 , A61B17/7097 , A61B17/8085 , A61F2/0095 , A61F2/2846 , A61F2/3099 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2878 , A61F2002/30576 , A61F2002/30581 , A61F2002/30622 , A61F2002/3068 , A61F2002/30971 , A61F2250/0068
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施例中，覆盖物适用于各种程序特定用途。 可以提供植入工具用于将覆盖物放置在手术部位。 可以提供包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具的套件。
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公开(公告)号：US20090226523A1
公开(公告)日：2009-09-10
申请号：US12254619
申请日：2008-10-20
申请人： Keyvan Behnam , Guobao Wei , James Beisser
发明人： Keyvan Behnam , Guobao Wei , James Beisser
CPC分类号： A61L27/3608 , A61L27/3683 , A61L27/50 , A61L27/54 , A61L2300/414
摘要： Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed.
摘要翻译： 提供骨基质组合物，更具体地说，具有增强的骨诱导能力的去矿物质骨基质（DBM）及其生产方法。 具体地，提供了从骨的骨膜层衍生自皮质骨的DBM。 提供了包含由衍生自骨膜和/或中间骨层的骨制备的不相称量的DBM的组合物。 公开了骨膜DBM组合物的制备和使用方法。
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公开(公告)号：US20090130173A1
公开(公告)日：2009-05-21
申请号：US12140044
申请日：2008-06-16
申请人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译： 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。 在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物，并将所述组织衍生的提取物加入到部分去矿物质 骨。 在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。
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公开(公告)号：US08357384B2
公开(公告)日：2013-01-22
申请号：US12140044
申请日：2008-06-16
申请人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , Todd M. Boyce , Lawrence A. Shimp
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , Todd M. Boyce , Lawrence A. Shimp
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译： 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。 在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理部分去矿物质的骨以破坏骨的胶原结构，以及任选地提供组织衍生的提取物，并将组织衍生的提取物加入到部分去矿物质 骨。 在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。
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