利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

60 条记录 (耗时 0.022 秒)

    Hydantoin derivatives for treating complications of diabetes
    7.
    发明授权
    Hydantoin derivatives for treating complications of diabetes 失效
    用于治疗糖尿病并发症的乙内酰脲衍生物

    公开(公告)号：US4985573A

    公开(公告)日：1991-01-15

    申请号：US355623

    申请日：1989-05-23

    申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

    发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

    IPC分类号： C07D311/24 ,  C07D491/10 ,  C07D495/10

    CPC分类号： C07D491/10 ,  C07D311/24 ,  C07D495/10

    摘要： Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group, in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitrogen or oxygen atom, ##STR3## in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group,X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group.The derivatives and salts thereof are useful for the treatment of complications of diabetes.

    摘要翻译： 乙内酰脲衍生物及其盐，其中间体，其制备方法和含有该衍生物的药物，其中所述衍生物具有式“IMAGE”，其中V和W之一是氢，另一个是卤代甲基，1H-四唑 - 其中R为氢原子，烷基， - （CH 2 CH 2 O）n CH 3基（n为1至113的整数）或取代的苯基，其中R 1和R 2相同的-COOR基团 或独立地不同，各自为氢原子，烷基，取代的苯基或 - （CH 2 CH 2 O）n CH 3基团（n具有所述的含义）或R 1可以与R 2和氮或氧原子一起形成杂环， 其中R3和R4独立地相同或不同，各自为氢原子或烷基，X为氧或硫原子，Y和Z独立地相同或不同，各自为氢原子，卤素原子，烷基，烷氧基 基团，烷基巯基，硝基或-NHR 5基团 ch R5是氢原子或酰基。 其衍生物和盐可​​用于治疗糖尿病并发症。