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    Motlin-like polypeptide and use thereof
    3.
    发明授权
    Motlin-like polypeptide and use thereof 失效
    Motlin样多肽及其用途

    公开(公告)号：US5432261A

    公开(公告)日：1995-07-11

    申请号：US943992

    申请日：1992-09-11

    申请人： Masayasu Kurono ,  Takahiko Mitani ,  Haruo Takahashi ,  Kenichi Tanaka ,  Katsuya Fujimura ,  Yuji Hayashi ,  Yohei Kobayashi ,  Kiichi Sawai

    发明人： Masayasu Kurono ,  Takahiko Mitani ,  Haruo Takahashi ,  Kenichi Tanaka ,  Katsuya Fujimura ,  Yuji Hayashi ,  Yohei Kobayashi ,  Kiichi Sawai

    IPC分类号： A61K38/00 ,  C07K14/63 ,  C12N15/16 ,  C07K14/00

    CPC分类号： C07K14/63 ,  A61K38/00 ,  C07K2319/02

    摘要： A pharmaceutical composition for stimulating peristaltic contraction in the intestinal canal which contains a pharmaceutically acceptable carrier or excipient and an effective amount of a polypeptide, or a salt thereof, having a pharmacological activity similar to motilin. The polypeptide has the formula B.sub.1 -Z.sub.1 -A.sub.1 -Z.sub.2 -B.sub.2 -Thr-B.sub.3 -A.sub.2 -Glu-Z.sub.3 -C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-E-Y, with Z.sub.1,Z.sub.2 and Z.sub.3 each being an amino acid residue having a hydrophobic side-chain, A.sub.1 and A.sub.2 each being an amino acid residue such as Pro, Gly, Asn and Ser, B.sub.1, B.sub.2 and B.sub.3 are each an amino acid residue having a side-chain with an aromatic ring, C is Gln, Glu or Asp, D is Asn, Glu or Asp, X' is an amino acid residue other than Met, E is Gln, Lys or Arg, and Y is homoserine, homoserine-lactone or a peptide chain having amino acid residues not exceeding 10 and containing homoserine or homoserine-lactone at the C-terminal where the first amino acid of said peptide chain is other than Lys, Arg or Pro.

    摘要翻译： 一种用于刺激肠道蠕动收缩的药物组合物，其含有药学上可接受的载体或赋形剂和有效量的具有与胃动素相似的药理活性的多肽或其盐。 该多肽具有式B1-Z1-A1-Z2-B2-Thr-B3-A2-Glu-Z3-C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-EY， Z 1，Z 2和Z 3各自为具有疏水侧链的氨基酸残基，A1和A2各自为氨基酸残基，例如Pro，Gly，Asn和Ser，B1，B2和B3各自为具有 具有芳环的侧链，C是Gln，Glu或Asp，D是Asn，Glu或Asp，X'是Met以外的氨基酸残基，E是Gln，Lys或Arg，Y是高丝氨酸，高丝氨酸 β-内酯或氨基酸残基不超过10的肽链，并且在所述肽链的第一个氨基酸不是Lys，Arg或Pro的C末端含有高丝氨酸或高丝氨酸 - 内酯。

    Vasoactive intestinal polypeptide analogues and use thereof
    6.
    发明授权
    Vasoactive intestinal polypeptide analogues and use thereof 失效
    血管活性肠多肽类似物及其用途

    公开(公告)号：US5428015A

    公开(公告)日：1995-06-27

    申请号：US201092

    申请日：1994-02-24

    申请人： Masayasu Kurono ,  Takahiko Mitani ,  Haruo Takahashi ,  Kiichi Sawai

    发明人： Masayasu Kurono ,  Takahiko Mitani ,  Haruo Takahashi ,  Kiichi Sawai

    IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K7/08

    CPC分类号： C07K14/57563 ,  A61K38/00

    摘要： Vasoactive intestinal polypeptide (VIP) analogues and use thereof are disclosed. The VIP analogues are shown by the formula ofHis-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Ywherein X is a residue of amino acid other than methionine (Met); and Y is homoserine, homoserine-lactone, amidized homoserine, a residue reacted homoserine-lactone with a primary alkyl amine having carbon atoms not exceeding 20, or an optional polypeptide chain and containing an amidized homoserine at C-terminal.Each of the VIP analogues is employed as an effective ingredient for various medicines and a hair tonic, and more particularly curing an asthma and impotence.

    摘要翻译： 公开了血管活性肠肽（VIP）类似物及其用途。 VIP类似物以His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys -Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Y其中X是甲硫氨酸以外的氨基酸残基（Met）; 并且Y是高丝氨酸，高丝氨酸 - 内酯，酰胺化高丝氨酸，残基与高丝氨酸 - 内酯与碳原子数不超过20的伯烷基胺反应，或任选的多肽链，并且在C-末端含有酰胺化的高丝氨酸。 每种VIP类似物被用作各种药物和头发补品的有效成分，更特别地治疗哮喘和阳。。