公开(公告)号：US5376637A

公开(公告)日：1994-12-27

申请号：US868906

申请日：1992-04-16

申请人： Kiichi Sawai ,  Masayasu Kurono ,  Takahiko Mitani ,  Makoto Sato ,  Haruo Takahashi ,  Hiroyuki Ohwaki

发明人： Kiichi Sawai ,  Masayasu Kurono ,  Takahiko Mitani ,  Makoto Sato ,  Haruo Takahashi ,  Hiroyuki Ohwaki

IPC分类号： A61K38/22 ,  A61K38/55 ,  A61K47/42 ,  A61P1/00 ,  A61P1/04 ,  A61P5/00 ,  A61P9/08 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  G11C13/04 ,  A61K37/00 ,  A61K37/02 ,  C07K5/00 ,  C07K7/00

CPC分类号： G11C13/04 ,  A61K31/24 ,  A61K38/2278

摘要： There is disclosed a pharmaceutical preparation which contains vasoactive intestinal polypeptide (VIP), its analogue or a salt thereof, and a surfactant. The preparation shall contains further a peptidase inhibitor. The composition is administrated to suppress allergies, reduce blood pressure, increase secretion of tear, cure asthma and impotence and others.

摘要翻译： 公开了含有血管活性肠多肽（VIP），其类似物或其盐和表面活性剂的药物制剂。 该制剂还含有肽酶抑制剂。 施用组合物以抑制过敏，降低血压，增加泪液分泌，治愈哮喘和阳ence等。

公开(公告)号：US5468728A

公开(公告)日：1995-11-21

申请号：US117653

申请日：1993-09-08

申请人： Kiichi Sawai ,  Masayasu Kurono ,  Takahiko Mitani ,  Makoto Sato ,  Hiroyuki Oowaki ,  Bunkichi Kato ,  Haruo Takahashi

发明人： Kiichi Sawai ,  Masayasu Kurono ,  Takahiko Mitani ,  Makoto Sato ,  Hiroyuki Oowaki ,  Bunkichi Kato ,  Haruo Takahashi

IPC分类号： A61K9/00 ,  A61K38/22 ,  A61K47/20 ,  A61K47/26 ,  A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

CPC分类号： A61K47/26 ,  A61K38/2214 ,  A61K47/20 ,  A61K9/0043

摘要： A readily absorbable type of motilin preparation containing a motilin-like active substance and a surface active agent is provided, in which the motilin-like active substance is mainly L-leucine-13-motilin-homoserine, and the surface active agent is selected from the group consisting of a bile salt, saponin and a polyethylene glycol higher-alcohol ether for nasal administration purposes and is a peptide lytic enzyme inhibitor for oral administration purposes.

摘要翻译： 提供了含有胃动素样活性物质和表面活性剂的易吸收型胃动素制剂，其中胃动素样活性物质主要是L-亮氨酸-13-促胃动素高丝氨酸，表面活性剂选自 由胆汁盐，皂苷和聚乙二醇高级醇醚组成的组，用于鼻腔给药目的，并且是用于口服给药目的的肽溶解酶抑制剂。

公开(公告)号：US5279835A

公开(公告)日：1994-01-18

申请号：US906465

申请日：1992-06-30

申请人： Kiichi Sawai ,  Masayasu Kurono ,  Takahiko Mitani ,  Yasuaki Kondo ,  Makoto Sato ,  Yoshiro Ishiwata ,  Syoji Yokochi ,  Toshiyuki Kouzaki

发明人： Kiichi Sawai ,  Masayasu Kurono ,  Takahiko Mitani ,  Yasuaki Kondo ,  Makoto Sato ,  Yoshiro Ishiwata ,  Syoji Yokochi ,  Toshiyuki Kouzaki

IPC分类号： A61K9/20 ,  A61K31/28 ,  A61K31/80 ,  A61K47/02 ,  A61K47/26 ,  A61P43/00

CPC分类号： A61K31/80 ,  A61K31/28 ,  A61K9/2009 ,  A61K9/2018

摘要： A 3-oxygermylpropionic acid preparation is provided, which activates the action of 3-oxygermylpropionic acid having the general formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH]n wherein n=an integer of at least 1 and is readily solubilized and disintegrated in vivo. The present preparation is manufactured by compression-molding at high pressure a composition comprising 3-oxygermylpropionic acid and two or more low-molecular substance of high solubility in water. The low-molecular substances are selected from the group consisting of white sugar, sorbitol, fructose, sucrose, glucose, lactose, mannitol and sodium chloride.

摘要翻译： 提供了3-氧基甲基丙酸制剂，其活化具有以下通式的3-氧基甲基丙酸的作用：（（O1 / 2）3GeCH2CH2COOH）n，其中n =至少为1的整数，并且在体内容易溶解和分解。 本制剂通过高压压缩成型制备，该组合物包含3-氧基甲基丙酸和两种或更多种在水中的高溶解度的低分子量物质。 低分子物质选自白糖，山梨糖醇，果糖，蔗糖，葡萄糖，乳糖，甘露醇和氯化钠。

公开(公告)号：US5155125A

公开(公告)日：1992-10-13

申请号：US600872

申请日：1990-10-22

申请人： Kiichi Sawai ,  Masayasu Kurono ,  Kazumasa Nakano ,  Makoto Sato ,  Noboru Kuboyama ,  Takashi Ito ,  Yoshiya Kondo

发明人： Kiichi Sawai ,  Masayasu Kurono ,  Kazumasa Nakano ,  Makoto Sato ,  Noboru Kuboyama ,  Takashi Ito ,  Yoshiya Kondo

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K31/00 ,  A61K31/415 ,  A61K31/425 ,  A61K31/50 ,  A61K45/00 ,  A61P17/00 ,  A61P43/00

CPC分类号： A61K31/50 ,  A61K31/00 ,  A61K31/415 ,  A61K31/425 ,  Y10S514/926

摘要： A therapeutic preparation for ulcers contains as a primary ingredient a compound having an aldose reductase inhibitory activity and can accelerate dermal metabolism. That compound may be d-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2-carboxyamide, d-2-chloromethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione and d-2-bromomethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione.

公开(公告)号：US5308836A

公开(公告)日：1994-05-03

申请号：US116682

申请日：1993-09-07

申请人： Kiichi Sawai ,  Masayasu Kurono ,  Yasuaki Kondo ,  Makoto Sato ,  Toshiyuki Kouzaki

发明人： Kiichi Sawai ,  Masayasu Kurono ,  Yasuaki Kondo ,  Makoto Sato ,  Toshiyuki Kouzaki

IPC分类号： A61K9/08 ,  A61K38/22 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42 ,  A61P1/00 ,  C07K1/00 ,  C07K14/00 ,  C07K14/575 ,  A61K37/24 ,  A61K37/36

CPC分类号： A61K38/2214

摘要： There is disclosed a pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-Hse. The composition comprises at least one of organic acids and salts thereof, as a first stabilizer, and pH thereof is adjusted in a range of 5.5-8.0. The composition may contain at least one of substances selected from saccharides, amino acids, proteins and salts thereof, as a second stabilizer. Conversion of [Leu.sup.13 ]-motilin-Hse into [Leu.sup.13 ]-motilin-Hse-lactone is suppressed by increasing pH value and deamidization in asparagine residue at 19-position is suppressed by the presence of the organic acid or salt thereof.

摘要翻译： 公开了一种稳定的[Leu13] -Motilin-Hse的药物组合物。 该组合物包含至少一种有机酸及其盐作为第一稳定剂，其pH调节在5.5-8.0的范围内。 该组合物可以含有选自糖，氨基酸，蛋白质和盐的至少一种物质作为第二稳定剂。 通过增加pH值可以抑制[Leu13] -motilin-Hse转化为[Leu13] - 肌动蛋白-Hse-内酯，并且通过存在有机酸或其盐来抑制在19位的天冬酰胺残基中的脱酰胺化。

公开(公告)号：US5260064A

公开(公告)日：1993-11-09

申请号：US680723

申请日：1991-04-04

申请人： Takashi Nakagawa ,  Hiroko Tsukahara ,  Masayasu Kurono ,  Makoto Sato ,  Tsutomu Ishida ,  Kazushi Tokita ,  Mitsuji Nakano

发明人： Takashi Nakagawa ,  Hiroko Tsukahara ,  Masayasu Kurono ,  Makoto Sato ,  Tsutomu Ishida ,  Kazushi Tokita ,  Mitsuji Nakano

IPC分类号： A61K9/70 ,  A61K31/21 ,  A61K47/14 ,  A61L15/58 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K31/21 ,  A61K9/7061 ,  A61L15/58

摘要： A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains an alkyl (meth)acrylate (co)polymer in the concentration of 35-85% by weight, nitroglycerin in the concentration of 10-30% by weight, and a silicic acid anhydride in the concentration of 5-20% by weight, said (co)polymer contains as major (co)polymer components alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexyl methacrylate in the concentration of 40-100% by weight based on the total weight of said alkyl (meth)acrylates. The preparation makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for a long period of time. Also, even a compact preparation can supply a sufficient amount of nitroglycerin. Moreover, the preparation can be manufactured at low cost without any complicated process.

公开(公告)号：US4971799A

公开(公告)日：1990-11-20

申请号：US175820

申请日：1988-03-31

申请人： Takashi Nakagawa ,  Masayasu Kurono ,  Makoto Sato ,  Tsutomu Ishida ,  Kazushi Tokita ,  Katsuhiko Takahashi ,  Masato Azuma ,  Satoshi Uenoyama

发明人： Takashi Nakagawa ,  Masayasu Kurono ,  Makoto Sato ,  Tsutomu Ishida ,  Kazushi Tokita ,  Katsuhiko Takahashi ,  Masato Azuma ,  Satoshi Uenoyama

IPC分类号： A61K9/70 ,  A61K31/21 ,  A61L15/58 ,  A61P9/08 ,  A61P9/10

CPC分类号： A61K9/7061 ,  A61K31/21 ,  A61K9/7076 ,  A61L15/58

摘要： A percutaneous-administration-type pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of the backing, wherein the pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and the nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as major copolymer components alkyl (meth)acrylate with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexylmethacrylate in the concentration of 40-90% by weight based on the total weight of said alkyl (meth)acrylates, and the copolymer has a rolling ball tack value of 2 or less. The preparation obtained makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for long periods of time.

公开(公告)号：US08542275B2

公开(公告)日：2013-09-24

申请号：US12880626

申请日：2010-09-13

申请人： Masahiro Kiyohara ,  Makoto Sato ,  Haruo Takahashi ,  Junichi Tashiro

发明人： Masahiro Kiyohara ,  Makoto Sato ,  Haruo Takahashi ,  Junichi Tashiro

IPC分类号： H04N7/18

CPC分类号： G01N23/2255

摘要： A cross-section processing and observation method includes: forming a first cross section in a sample by etching processing using a focused ion beam; obtaining image information of the first cross section by irradiating the focused ion beam to the first cross section; forming a second cross section by performing etching processing on the first cross section; obtaining image information of the second cross section by irradiating the focused ion beam to an irradiation region including the second cross section; displaying image information of a part of a display region of the irradiation region from the image information of the second cross section; displaying the image information of the first cross section by superimposing it on the image information being displayed; and moving the display region within the irradiation region. Observation images in which display regions are aligned can be obtained while reducing damage to the sample.

摘要翻译： 截面处理和观察方法包括：通过使用聚焦离子束的蚀刻处理在样品中形成第一横截面; 通过将聚焦的离子束照射到第一横截面来获得第一横截面的图像信息; 通过对所述第一横截面进行蚀刻处理形成第二横截面; 通过将聚焦离子束照射到包括第二横截面的照射区域来获得第二横截面的图像信息; 从第二横截面的图像信息中显示照射区域的显示区域的一部分的图像信息; 通过将第一横截面的图像信息叠加在正在显示的图像信息上来显示图像信息; 并且在照射区域内移动显示区域。 可以获得显示区域对准的观察图像，同时减少对样品的损伤。

公开(公告)号：US20110052044A1

公开(公告)日：2011-03-03

申请号：US12873886

申请日：2010-09-01

申请人： Haruo Takahashi ,  Masahiro Kiyohara ,  Makoto Sato ,  Junichi Tashiro

发明人： Haruo Takahashi ,  Masahiro Kiyohara ,  Makoto Sato ,  Junichi Tashiro

IPC分类号： G06T7/00

CPC分类号： G01N23/2255 ,  H01J2237/221

摘要： A cross-section processing and observation method includes: forming a cross section in a sample by a focused ion beam through etching processing; obtaining a cross-section observation image through cross-section observation by the focused ion beam; and forming a new cross section by performing etching processing in a region including the cross section and obtaining a cross-section observation image of the new cross section. A surface observation image of a region including a mark on the sample and the cross section is obtained. A position of the mark is recognized in the surface observation image and etching processing is performed on the cross section by setting, in reference to the position of the mark, a focused ion beam irradiation region in which to form the new cross section. Cross-section processing and observation is thus enabled continuously and efficiently using a focused ion beam apparatus having no SEM apparatus.

摘要翻译： 截面处理和观察方法包括：通过蚀刻处理通过聚焦离子束在样品中形成横截面; 通过聚焦离子束的横截面观察获得横截面观察图像; 并且通过在包括横截面的区域中进行蚀刻处理并获得新横截面的横截面观察图像来形成新的横截面。 获得包括样品上的标记和横截面的区域的表面观察图像。 在表面观察图像中识别标记的位置，并且通过关于标记的位置设置形成新横截面的聚焦离子束照射区域来对截面进行蚀刻处理。 因此，使用不具有SEM装置的聚焦离子束装置，能够连续有效地进行横截面加工和观察。

公开(公告)号：US09625037B2

公开(公告)日：2017-04-18

申请号：US14726042

申请日：2015-05-29

申请人： Raymond Young ,  Marc Maloney ,  Roger Brown ,  Makoto Sato

发明人： Raymond Young ,  Marc Maloney ,  Roger Brown ,  Makoto Sato

IPC分类号： F16J15/02 ,  B65H45/02 ,  B60J10/00 ,  B60P3/34

CPC分类号： F16J15/027 ,  B60J10/00 ,  B60P3/34 ,  B65H45/02

摘要： A seal useful in sealing slide out rooms used in recreational vehicles. The seal may be used singularly or in pairs to straddle a wall through which the opening is located. A bulb is attached to the base in a cantilevered manner over the base. The bulb has an outer arcuate portion that is integrally joined to opposing sidewall portions. The sidewall portions extend into an inner wall that defines an enclosed space within the bulb portion. The bulb portion may also have a protrusion that can touch the base. A wiper extends from the base substantially co-linearly to the base and opposite the offsetting member. A locating leg extending from the base is movable between a first position and a second position. The first position has the locating leg perpendicular to the base and the second position places the locating leg parallel to the base.