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公开(公告)号：US20070265303A1
公开(公告)日：2007-11-15
申请号：US11725335
申请日：2007-03-19
申请人： Kim James , Lyn Jones , David Price
发明人： Kim James , Lyn Jones , David Price
IPC分类号： A61K31/135 , A61K31/18 , A61K31/195 , A61K31/47 , A61P11/06 , C07C211/26 , C07C233/00 , C07C311/00 , C07D215/227
CPC分类号： C07C311/08 , C07C215/54 , C07C217/48 , C07C217/62 , C07C223/02 , C07C233/43 , C07C255/13 , C07C271/16 , C07C271/66 , C07D215/26 , C07D215/60 , C07F7/1804
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050234097A1
公开(公告)日：2005-10-20
申请号：US11083265
申请日：2005-03-16
申请人： Alan Brown , Charlotte Lane , Paul Glossop , David Price , Russell Lewthwaite , Mark Bunnage , Kim James , Graham Lunn
发明人： Alan Brown , Charlotte Lane , Paul Glossop , David Price , Russell Lewthwaite , Mark Bunnage , Kim James , Graham Lunn
IPC分类号： A61K31/138 , A61K31/4035 , A61K31/47
CPC分类号： C07D217/06 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36 , C07C311/46 , C07C323/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2603/74 , C07D213/40 , C07D235/14 , C07D239/26 , C07D295/088 , C07D295/13 , C07D295/26
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050222128A1
公开(公告)日：2005-10-06
申请号：US11086132
申请日：2005-03-21
申请人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
发明人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
IPC分类号： A61K31/165 , A61K31/401 , A61K31/4035 , A61K31/4747 , A61K31/495 , A61K31/537 , A61K31/551
CPC分类号： C07C237/20 , C07C237/30 , C07C255/60 , C07C311/46 , C07C323/41 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D211/58 , C07D213/40 , C07D213/75 , C07D217/06 , C07D231/40 , C07D413/04
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050215590A1
公开(公告)日：2005-09-29
申请号：US11086035
申请日：2005-03-21
申请人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
发明人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
IPC分类号： A61K31/165 , A61K31/4035 , A61K31/404 , A61K31/4353 , A61K31/44 , A61K31/445 , A61P11/06 , C07C217/60 , C07C233/43 , C07C237/20 , C07C237/24 , C07C237/30 , C07C237/32 , C07C311/46 , C07C317/32 , C07C323/41 , C07C323/42 , C07D209/04 , C07D211/06 , C07D213/40 , C07D215/16 , C07D217/06 , C07D217/16 , C07D221/24 , C07D295/192 , C07D335/02
CPC分类号： C07C237/20 , C07C237/30 , C07C237/32 , C07C255/60 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D209/48 , C07D211/32 , C07D213/38 , C07D213/40 , C07D217/06 , C07D217/16 , C07D221/22 , C07D221/24 , C07D295/192 , C07D335/02
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050215542A1
公开(公告)日：2005-09-29
申请号：US11086036
申请日：2005-03-21
申请人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
发明人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
IPC分类号： A61K31/4439 , A61K31/4545 , A61K31/4747 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D213/65 , C07D401/12 , C07D413/02 , C07D43/02
CPC分类号： C07D401/12 , C07D213/65
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds of the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050182091A1
公开(公告)日：2005-08-18
申请号：US11038452
申请日：2005-01-19
申请人： Alan Brown , Mark Bunnage , Paul Glossop , Kim James , Charlotte Lane , Russel Lewthwaite , Ian Moses , David Price , Nicholas Thomson
发明人： Alan Brown , Mark Bunnage , Paul Glossop , Kim James , Charlotte Lane , Russel Lewthwaite , Ian Moses , David Price , Nicholas Thomson
IPC分类号： C07C311/08 , C07D217/06 , A61K31/47 , A61K31/18 , A61K31/4035 , A61K31/4439 , A61K31/455
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
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公开(公告)号：US07612084B2
公开(公告)日：2009-11-03
申请号：US11725335
申请日：2007-03-19
申请人： Kim James , Lyn Howard Jones , David Anthony Price
发明人： Kim James , Lyn Howard Jones , David Anthony Price
IPC分类号： A61K31/44
CPC分类号： C07C311/08 , C07C215/54 , C07C217/48 , C07C217/62 , C07C223/02 , C07C233/43 , C07C255/13 , C07C271/16 , C07C271/66 , C07D215/26 , C07D215/60 , C07F7/1804
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20090197912A1
公开(公告)日：2009-08-06
申请号：US12420206
申请日：2009-04-08
申请人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
发明人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
IPC分类号： A61K31/472 , A61K31/18 , A61P11/00
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US07547731B2
公开(公告)日：2009-06-16
申请号：US11773012
申请日：2007-07-03
申请人： Alan Daniel Brown , Mark Edward Bunnage , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Paul Alan Glossop , Kim James , David Anthony Price
发明人： Alan Daniel Brown , Mark Edward Bunnage , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Paul Alan Glossop , Kim James , David Anthony Price
IPC分类号： A61K31/167 , C07C233/24
CPC分类号： C07C237/20 , C07C237/30 , C07C237/32 , C07C255/60 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D209/48 , C07D211/32 , C07D213/38 , C07D213/40 , C07D217/06 , C07D217/16 , C07D221/22 , C07D221/24 , C07D295/192 , C07D335/02
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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10.发明授权3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors 失效可用作原胶原C-蛋白酶抑制剂的3-氧（adi）唑基丙酰异羟肟酸公开(公告)号：US07214694B2
公开(公告)日：2007-05-08
申请号：US10731707
申请日：2003-12-09
IPC分类号： A61K31/541 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D417/02 , C07D413/02
CPC分类号： C07D263/16 , A61K31/421 , A61K31/422 , A61K31/4245 , C07C235/74 , C07C259/14 , C07C311/06 , C07C2601/14 , C07D205/04 , C07D211/60 , C07D211/96 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D263/34 , C07D271/06 , C07D271/07 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I): wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP.
摘要翻译： 式（I）化合物：其中取代基如本文所定义，其盐，溶剂合物和前药是用于治疗由PCP介导的病症的前胶原C-蛋白酶（PCP）抑制剂。
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